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Household catastrophic health expenditure and depressive mood among Chinese adults, children, and adolescents: a population-based panel study

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BMC PSYCHIATRY 2025年第1期25卷 1-12页

作者： Li, shuwen Fang, Kailu Zhang, Yu Lin, Yushi Zheng, Luyan wu, Jie Zhejiang Univ State Key Lab Diag & Treatment Infect Dis Natl Clin Res Ctr Infect DisAffiliated Hosp 1Col Collaborat Innovat Ctr Diag & Treatment Infect Dis Hangzhou 310003 Peoples R China Zhejiang Univ Sch Med Affiliated Hosp 2 Dept Infect Dis Hangzhou Peoples R China

BackgroundNumerous studies have suggested that catastrophic health expenditure (CHE) is associated with depressive mood. However, most published studies have examined the relationship between CHE and depressive mood only among middle-aged and older people who are already susceptible to depressive mood. The objective of our analysis was to determine the associations between household CHE and depressive mood among adults and children/*** study population consisted of Chinese residents who participated in the 2016 CFPS, 2018 CFPS, and 2020 CFPS. Our analytical sample was restricted to children/adolescents aged 10-17 years and adults aged 18 years and older. We utilized multilevel random effects multivariate logistic regression models to investigate the associations between CHE and depressive mood among both adults and children/*** study revealed that 15% of adults and 12.61% of children/adolescents had experienced CHE and that CHE was positively associated with depressive mood among adults (OR = 1.34, 95% CI: 1.21, 1.50) and among children/adolescents (OR = 1.48, 95% CI: 1.12, 1.96) after adjustment for potential confounding factors. This positive association persisted in different subgroup analyses. In addition, we found that being insured with either urban or rural health insurance was associated with decreased odds of depressive *** study indicated that CHE is common in Chinese families and may increase the risk of depressive mood for both adults and children/adolescents. These findings emphasize the need to focus on expanding health insurance coverage, as well as implementing family-based mental health resources and financial literacy programs to reduce the psychological impact of CHE across all age groups.

关键词： Catastrophic health expenditure Depressive mood Panel data China Multilevel model

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Radiotherapy plus temozolomide with or without anlotinib in H3K27M-mutant diffuse midline glioma: A retrospective cohort study

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CNS NEUROSCIENCE & THERAPEUTICS 2024年第4期30卷 e14730页

作者： Liu, Chao Kuang, shuwen Huang, Tianxiang wu, Jun Zhang, Longbo Gong, Xuan Cent South Univ Xiangya Hosp Dept Oncol Changsha Peoples R China Cent South Univ Xiangya Hosp Dept Neurosurg Changsha Peoples R China

Background: Besides the hallmark of H3K27M mutation, aberrant amplifications of receptor tyrosine kinases (RTKs) are commonly observed in diffuse midline glioma (DMG), a highly malignant brain tumor with dismal prognosis. Here, we intended to evaluate the efficacy and safety of a multitarget RTK inhibitor anlotinib in patients with H3K27M-DMG. Methods: A total of 40 newly diagnosed H3K27M-DMG patients including 15 with anlotinib and 25 without anlotinib treatment were retrospectively enrolled in this cohort. Progression-free survival (PFS), overall survival (OS), and toxicities were assessed and compared. Results: The median PFS and OS of all patients in this cohort were 8.5 months (95% CI, 6.5-11.3) and 15.5 months (95% CI, 12.6-17.1), respectively. According to the Response Assessment in Neuro-Oncology (RANO) criteria, the disease control rate in the anlotinib group [93.3%, 95% confidence interval (CI), 70.2-98.8] was significantly higher than those without anlotinib (64%, 95% CI: 40.5-79.8, p = 0.039). The median PFS of patients with and without anlotinib was 11.6 months (95% CI, 7.8-14.3) and 6.4 months (95% CI, 4.3-10.3), respectively. Both the median PFS and OS of DMG patients treated with anlotinib were longer than those without anlotinib in the infratentorial patients (PFS: 10.3 vs. 5.4 months, p = 0.006;OS: 16.6 vs. 8.7 months, p = 0.016). Multivariate analysis also indicated anlotinib (HR: 0.243, 95% CI: 0.066-0.896, p = 0.034) was an independent prognosticator for longer OS in the infratentorial subgroup. In addition, the adverse events of anlotinib administration were tolerable in the whole cohort. Conclusions: This study first reported that anlotinib combined with Stupp regimen is a safe and feasible regimen for newly diagnosed patients with H3K27M-DMG. Further, anlotinib showed significant efficacy for H3K27M-DMG located in the infratentorial region.

关键词： adverse events anlotinib prognosis survival targeted therapy

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Bacterial imaging in tumour diagnosis

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MICROBIAL BIOTECHNOLOGY 2024年第6期17卷 e14474页

作者： Chu, Jian Yu, Xiang Jiang, Gaofei Tao, Ye wu, Wei Han, shuwen Huzhou Univ Huzhou Cent Hosp Affiliated Cent Hosp 1558 Sanhuan North Rd Huzhou 313000 Zhejiang Peoples R China Key Lab Multi Res & Clin Transformat Digest Canc Huzhou Peoples R China Zhejiang Chinese Med Univ Huzhou Cent Hosp Sch Clin Med 5 Huzhou Peoples R China Nanjing Agr Univ Key Lab Organ Based Fertilizers China Jiangsu Prov Key Lab Solid Organ Waste Utilizat Nanjing Peoples R China Shanghai BIOZERON Biotechnol Co Ltd Shanghai Peoples R China

Some bacteria, such as Escherichia coli (E. coli) and Salmonella typhimurium (S. typhimurium), have an inherent ability to locate solid tumours, making them a versatile platform that can be combined with other tools to improve the tumour diagnosis and treatment. In anti-cancer therapy, bacteria function by carrying drugs directly or expressing exogenous therapeutic genes. The application of bacterial imaging in tumour diagnosis, a novel and promising research area, can indeed provide dynamic and real-time monitoring in both pre-treatment assessment and post-treatment detection. Different imaging techniques, including optical technology, acoustic imaging, magnetic resonance imaging (MRI) and nuclear medicine imaging, allow us to observe and track tumour-associated bacteria. Optical imaging, including bioluminescence and fluorescence, provides high-sensitivity and high-resolution imaging. Acoustic imaging is a real-time and non-invasive imaging technique with good penetration depth and spatial resolution. MRI provides high spatial resolution and radiation-free imaging. Nuclear medicine imaging, including positron emission tomography (PET) and single photon emission computed tomography (SPECT) can provide information on the distribution and dynamics of bacterial population. Moreover, strategies of synthetic biology modification and nanomaterial engineering modification can improve the viability and localization ability of bacteria while maintaining their autonomy and vitality, thus aiding the visualization of gut bacteria. However, there are some challenges, such as the relatively low bacterial abundance and heterogeneously distribution within the tumour, the high dimensionality of spatial datasets and the limitations of imaging labeling tools. In summary, with the continuous development of imaging technology and nanotechnology, it is expected to further make in-depth study on tumour-associated bacteria and develop new bacterial imaging methods for tumour diagnosis. Wi

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Redox-activated photosensitizers for visualizing precise diagnosis and potentiating cancer therapy

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COORDINATION CHEMISTRY REVIEWS 2024年 507卷

作者： Fu, shuwen Chen, Zixuan Li, Li wu, Yinwei Liao, Yalan Li, Xingshu Fuzhou Univ Coll Chem Fujian Prov Key Lab Canc Metastasis Chemoprevent & Fuzhou 350108 Peoples R China

Cancer still threats human health rigorously. Most current options of photosensitizers (PSs) are plagued with "always on", accounting for limited signal-to-noise ratio in the lesions and undesired side effects in normal tissues. Inspired by the redox imbalance of tumor microenvironment, redox-activated PSs (RA-PSs) are coming to frontiers that enhance diagnosis accuracy and treatment efficiency. Herein, the progress of PSs-based therapy is outlined. Furthermore, the design strategies of RA-PSs are discussed, including potential mechanism and linkage to obtain on -demand switchable optical signals. Moreover, versatile RA-PSs for real-time visualization and therapy are highlighted. Finally, future prospects and challenges are spotlighted.

关键词： Redox imbalance Activatable photosensitizer Precise tumor imaging Cancer therapy

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Charting the Uncharted: Building and Analyzing a Multifaceted Chart Question Answering Dataset for Complex Logical Reasoning Process 7th

Charting the Uncharted: Building and Analyzing a Multifacete...

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7th Chinese Conference on Pattern Recognition and Computer Vision

作者： wu, Anran Yang, shuwen Xia, Yujia wu, Xingjiao Ma, Tianlong He, Liang East China Normal Univ Shanghai 200062 Peoples R China Fudan Univ Shanghai 200433 Peoples R China

ISBN: (纸本)9789819786190;9789819786206

Charts, as a vital part of visualization language, are omnipresent in real-world. Understanding charts is crucial for unveiling implicit data insights. The evolution of large-scale models has marked significant milestones in chart comprehension. However, comprehending multiple charts jointly remains challenging due to the complexities of multi-chart reasoning and the intricate dataset construction involving multiple charts. In this study, we introduce DGE, a sophisticated logic-based multi-chart question-answering dataset generation engine that, with only simple data input, generates diverse joint charts and questions with complex logic. It employs logical templates to guide question generation, ensuring excellent scalability. Leveraging the DGE engine, we propose MCQA, the inaugural large-scale dataset for joint reasoning question-answering involving multiple charts, which includes 22,860 chart pairs and 100,331 complex questions, each annotated with an inference process. Finally, we evaluate several baselines on the MCQA dataset, establishing a research foundation for the chart question answering community. The MCQA dataset is available at github (https://***/ICALK-CVU/MCQA).

关键词： Chart Question Answering Dataset Generation Multiple Chart Reasoning

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Materials space-tectonics methodology of conductive mesoporous carbon nanohorns embedded graphene aerogels anchoring Pd nanocrystalline for an efficient ethanol oxidation reaction

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INTERNATIONAL JOURNAL OF HYDROGEN ENERGY 2024年 56卷 621-628页

作者： Zhao, Jinjuan Zhao, Zhizhong Meng, Jianqi wu, Jie Li, Ruxia Yang, Honglei Li, shuwen Lanzhou Univ Coll Chem & Chem Engn State Key Lab Appl Organ Chem SKLAOC Lanzhou 730000 Peoples R China

Materials space-tectonics (MST) methodology is a powerful strategy to design catalytic materials synthesis to overcome the limitation of monotonous pore geometries and develop functional structures with surface-specific functions. Based on the MST, herein, carbon nanohorns (CNH) as "spacers" inserted into three-dimensional (3D) nitrogen-doped graphene aerogel (NG) anchoring Pd nanocrystalline (Pd/CNH@NG) was constructed through a facile hydrothermal approach and wet chemical reduction method without surfactant and employed as electrocatalyst for ethanol oxidation reaction (EOR). The introduction of CNH can provide important mesopore and macropore characters and generate more active sites to anchor Pd nanocrystalline on the basis of unique internal and interstitial nanopore structures, high surface area and conductive graphitic structure, then enhancing the electrocatalytic efficiency, stability and poison tolerance of catalysts. Meanwhile, the role of CNH doped NG also includes accelerating the reaction of the intermediate (CH3COads) manufactured on the Pd-based aerogels surface with adsorbed hydroxyl (OHads) due to coordination effect from Pyridinic-nitrogen and pyrrolic-nitrogen species. The electrochemical results reveal that the specific and mass activities of the obtained Pd/CNH@NG-2 aerogel (the mass ratio of graphene oxide and CNH is 1:3) are 1.38 and 2.86 times higher than those of the commercial Pd/C for EOR. Simultaneously, the current density of Pd/CNH@NG-2 still maintains 70 % after 500 cycles of complete CV, but commercial Pd/C only maintains 22.6 % of the initial activity. The synthesis of Pd/CNH@NG not only offers a porous three-dimensional aerogel for the EOR but also optimizes a facile strategy to fabricate superior supports for promoting the commercialization of DEFCs.

关键词： Carbon nanohorns Ethanol electrooxidation reaction Nitrogen -doped graphene Pd nanocrystalline Porous three-dimensional aerogels

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Highly efficient blue-emitting phosphor via charge compensation strategy and its application for white LED lighting

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JOURNAL OF THE AMERICAN CERAMIC SOCIETY 2024年第2期107卷 909-919页

作者： Xu, Yonghui Yin, shuwen wu, Xiudi Zhong, Chuansheng Zhang, Xibao Zhou, Liang You, Hongpeng Chinese Acad Sci Changchun Inst Appl Chem State Key Lab Rare Earth Resource Utilizat Changchun Peoples R China Univ Sci & Technol China Hefei Peoples R China Chinese Acad Sci Ganjiang Innovat Acad Ganzhou Peoples R China

Highly efficient phosphors are indispensable for near-ultraviolet (n-UV) pumped white light emitting diodes (WLEDs). In this work, a novel blue emitting Sr6GdSc(BO3)(6):0.08Ce(3+) phosphor was synthesized, exhibiting a broadband blue emission (full width at half-maximum (FWMH) = 133 nm) excited by 375 nm. Furthermore, the blue emission of Sr6GdSc(BO3)(6):0.08Ce(3+) was enhanced by 3.9 times through codoping Na+ ions due to the influence of charge compensation and micromorphology and size of phosphor particles. At the same time, the internal quantum efficiency was improved from 45.4% to 98.6% and the external quantum efficiency up to 75.0%. Finally, the 365 nm excited two WLED devices were constructed by integrating Sr6GdSc(BO3)(6):0.08Ce(3+), Sr6GdSc(BO3)(6):0.08Ce(3+),0.08Na(+), commercial green and red phosphors with high color rendering index. These results reveal that the phosphors have prospective application in high-quality warm white lighting.

关键词： Ce3+ ion defects luminescence phosphor

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Effects of different interventions on insomnia in adults: Systematic review and network meta-analysis

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JOURNAL OF PSYCHIATRIC RESEARCH 2023年第1期165卷 140-149页

作者： Wang, shuwen Lan, Yueyan Liu, Zixiu Xu, Shuang wu, Xiaomei China Med Univ Hosp 1 Dept Clin Epidemiol Shenyang Liaoning Peoples R China China Med Univ Hosp 1 Ctr Evidence Based Med Shenyang Liaoning Peoples R China China Med Univ Lib Shenyang Liaoning Peoples R China China Med Univ Hosp 1 Dept Clin Epidemiol 155 Nanjing Bei St Shenyang Liaoning Peoples R China China Med Univ Hosp 1 Ctr Evidence Based Med 155 Nanjing Bei St Shenyang Liaoning Peoples R China

Objective: Insomnia is a common sleep disorder. There are many clinical-intervention methods for treating this condition, but thus far, the most effective method has not been ***: We conducted a network meta-analysis by including random evidence of insomnia improvement in people over 18 years old, without other physical diseases. From January 1, 1990 to June 15, 2022, we searched multiple electronic databases for randomized controlled trials of different insomnia-related, clinical-intervention methods. R software was used to analyze 10 indices, in order to evaluate the effect of sleep improvement. Pri-mary outcomes comprised Pittsburgh sleep quality-index (PSQI) scores and insomnia severity-index (ISI) ***: Finally, 122 randomized controlled trials were included in our study. For the PSQI scores, we found the sequence of intervention measures by effect to be as follows: electroacupuncture, acupuncture, repetitive transcranial magnetic stimulation (rTMS), essential oils, herbal medicine, traditional Western medicine, Tai Chi and Baduanjin, music, supplements, cognitive behavioral therapy for insomnia (CBT-I), and exercise. The results for ISI were similar to those for PSQI, but with slight ***: Our research results indicate that various measures have a certain effect on improving sleep, among which the effect of instruments is more prominent. The curative effect of placebo groups was better than that of blank control groups. There is essentially no statistical difference in detailed classification within the same intervention category.

关键词： Insomnia Network meta-analysis Treatment Sleep disorder PSQI

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Ultra-broadband near infrared phosphor with wide spectral range and long peak wavelength achieved by double-site occupation

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Journal of Rare Earths 2023年第11期41卷 1670-1677,I0001页

作者： shuwen Yuan Fugen wu Jin Wang Lulu Lou Shuang Zhao Daoyun Zhu Zhongfei Mu School of Materials and Energy Guangdong University of TechnologyGuangzhou 510006China Guangdong Provincial Key Laboratory of Information Photonics Technology Guangdong University of TechnologyGuangzhou 510006China Experimental Teaching Department Guangdong University of TechnologyGuangzhou 510006China

The miniaturization and intelligence of near infrared(NIR)devices urgently require an excellent broadband NIR ***,emission spectra of most NIR phosphors cover less than 1200 nm with a full width at half maximum(FWHM)less than 200 nm and a peak wavelength less than 900 ***,we successfully developed ultra-broadband NIR phosphors ScNbO_(4):Cr^(3+)which can overcome the above shortcomings based on a double-site occupancy *** phosphors achieve ultra-broadband NIR emission from 800 to 1400 nm with a peak wavelength at 980 *** FWHM is up to 217 *** valence state of Cr ions in phosphors was *** double-site occupancy of Cr^(3+)ions in the host and the relationship between host structure and optical properties are discussed in *** light transmission experiments show that phosphors have potential application value in non-destructive *** work develops an excellent NIR luminescent material and provides an efficient method to obtain ultra-broadband NIR phosphors with longer peak wavelength.

关键词： Double-site Ultra-broadband Near infrared Cr^(3+) Rare earths

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Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)/Cas9-mediated kif15 mutations accelerate axonal outgrowth during neuronal development and regeneration in zebrafish

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TRAFFIC 2019年第1期20卷 71-81页

作者： Dong, Zhangji wu, shuwen Zhu, Chenwen Wang, Xueting Li, Yuanyuan Chen, Xu Liu, Dong Qiang, Liang Baas, Peter W. Liu, Mei Nantong Univ Coinnovat Ctr Neuroregenerat Key Lab Neuroregenerat Jiangsu 19 Qixiu Rd Nantong 226001 Peoples R China Nantong Univ Coinnovat Ctr Neuroregenerat Minist Educ 19 Qixiu Rd Nantong 226001 Peoples R China Nantong Univ Inst Naut Med Coinnovat Ctr Neuroregenerat Nantong Peoples R China Drexel Univ Coll Med Dept Neurobiol & Anat Philadelphia PA 19104 USA

KIF15, the vertebrate kinesin-12, is best known as a mitotic motor protein, but continues to be expressed in neurons. Like KIF11 (the vertebrate kinesin-5), KIF15 interacts with microtubules in the axon to limit their sliding relative to one another. Unlike KIF11, KIF15 also regulates interactions between microtubules and actin filaments at sites of axonal branch formation and in growth cones. Our original work on these motors was done on cultured rat neurons, but we are now using zebrafish to extend these studies to an in vivo model. We previously studied kif15 in zebrafish by injecting splice-blocking morpholinos injected into embryos. Consistent with the cell culture work, these studies demonstrated that axons grow faster and longer when KIF15 levels are reduced. In the present study, we applied CRISPR/Cas9-based knockout technology to create kif15 mutants and labeled neurons with Tg(mnx1:GFP) transgene or transient expression of elavl3:EGFP-alpha tubulin. We then compared by live imaging the homozygotic, heterozygotic mutants to their wildtype siblings to ascertain the effects of depletion of kif15 during Caudal primary motor neuron and Rohon-Beard (R-B) sensory neuron development. The results showed, compared to the kif15 wildtype, the number of branches was reduced while axon outgrowth was accelerated in kif15 homozygotic and heterozygotic mutants. In R-B sensory neurons, after laser irradiation, injured axons with loss of kif15 displayed significantly greater regenerative velocity. Given these results and the fact that kif15 drugs are currently under development, we posit kif15 as a novel target for therapeutically augmenting regeneration of injured axons.

关键词： axon kif15 (kinesin-12) laser injury regeneration zebrafish

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