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Development and validation of prediction models for nosocomial infection and prognosis in hospitalized patients with cirrhosis

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ANTIMICROBIAL RESISTANCE AND INFECTION CONTROL 2024年第1期13卷 85页

作者： Li, shuwen Zhang, Yu Lin, Yushi Zheng, Luyan Fang, Kailu wu, Jie Zhejiang Univ Affiliated Hosp 1 Collaborat Innovat Ctr Diag & Treatment Infect Dis State Key Lab Diag & Treatment Infect DisSch Med Hangzhou 310003 Peoples R China Zhejiang Univ Affiliated Hosp 2 Sch Med Dept Infect Dis Hangzhou Peoples R China

Background Nosocomial infections (NIs) frequently occur and adversely impact prognosis for hospitalized patients with cirrhosis. This study aims to develop and validate two machine learning models for NIs and in-hospital mortality risk prediction. Methods The Prediction of Nosocomial Infection and Prognosis in Cirrhotic patients (PIPC) study included hospitalized patients with cirrhosis at the Qingchun Campus of the First Affiliated Hospital of Zhejiang University. We then assessed several machine learning algorithms to construct predictive models for NIs and prognosis. We validated the best-performing models with bootstrapping techniques and an external validation dataset. The accuracy of the predictions was evaluated through sensitivity, specificity, predictive values, and likelihood ratios, while predictive robustness was examined through subgroup analyses and comparisons between models. Results We enrolled 1,297 patients into derivation cohort and 496 patients into external validation cohort. Among the six algorithms assessed, the Random Forest algorithm performed best. For NIs, the PIPC-NI model achieved an area under the curve (AUC) of 0.784 (95% confidence interval [CI] 0.741-0.826), a sensitivity of 0.712, and a specificity of 0.702. For in-hospital mortality, the PIPC- mortality model achieved an AUC of 0.793 (95% CI 0.749-0.836), a sensitivity of 0.769, and a specificity of 0.701. Moreover, our PIPC models demonstrated superior predictive performance compared to the existing MELD, MELD-Na, and Child-Pugh scores. Conclusions The PIPC models showed good predictive power and may facilitate healthcare providers in easily assessing the risk of NIs and prognosis among hospitalized patients with cirrhosis.

关键词： Nosocomial infection Cirrhosis Machine learning In-hospital mortality

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An efficient blue-violet phosphor: an advanced material designed for high-quality full-spectrum lighting

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DALTON TRANSACTIONS 2024年第10期53卷 4564-4573页

作者： wu, Xiudi Xu, Yonghui Yin, shuwen Zhong, Chuansheng Zhang, Xibao Zhou, Liang You, Hongpeng Chinese Acad Sci Changchun Inst Appl Chem State Key Lab Rare Earth Resource Utilizat Changchun 130022 Peoples R China Univ Sci & Technol China Hefei 230026 Peoples R China Ganjiang Innovat Acad Chinese Acad Sci Ganzhou 341000 Peoples R China

A highly efficient phosphor with exceptional luminescence properties is crucial for achieving high-quality solid-state white-light illumination. Here, this paper presents a groundbreaking discovery, an innovative blue-violet emitting Ba1.31Sr3.69(BO3)3Cl:Ce3+ (BSBCl:Ce3+) phosphor designed with remarkable thermal stability and quantum efficiency for full spectrum white light-emitting diodes (WLEDs). By employing a high-temperature solid-phase method, we synthesized various BSBCl:xCe3+ phosphors with different Ce3+ doping concentrations. Remarkably, BSBCl:0.03Ce3+ displays a broad excitation band from 250 nm to 400 nm, rendering it compatible with commercial near-ultraviolet (UV) LED chips. Under 330 nm excitation, this phosphor emits blue light with an astonishing 88.2% internal quantum efficiency (IQE) and an impressive 60.9% external quantum efficiency (EQE). Notably, when employed in the temperature range of 298-473 K, the synthesized BSBCl:0.03Ce3+ phosphor exhibits exceptional color stability and thermal stability (I423 K/I298 K = 83%). Utilizing BSBCl:0.03Ce3+ as the blue-violet emitting component in the fabrication of WLED devices has demonstrated significant advancements in the color rendering index. These findings underscore the potential of BSBCl:Ce3+ phosphors for a wide range of applications in health-oriented indoor illumination. Under 330 nm excitation, the BSBCl:xCe3+ emits blue light with three distinct emission centers. WLED devices with an ultra-high color rendering index were obtained using a combination of NUV chips, BSBCl:xCe3+ and commercial phosphors.

关键词： Phosphors

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Third-generation PacBio sequencing to explore gut bacteria and gender in colorectal cancer

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MICROBIAL PATHOGENESIS 2024年 192卷 106684页

作者： Yu, Sheng Chu, Jian wu, Yinhang Zhuang, Jing Qu, Zhanbo Song, Yifei wu, Xinyue Han, shuwen Huzhou Univ Huzhou Cent Hosp Affiliated Cent Hosp Huzhou Zhejiang Peoples R China Zhejiang Chinese Med Univ Huzhou Cent Hosp Sch Clin Med 5 Huzhou Zhejiang Peoples R China Key Lab Multi Res & Clin Transformat Digest Canc H Huzhou Zhejiang Peoples R China 1558 Sanhuan North Rd Huzhou 313000 Zhejiang Peoples R China

Background: Gut bacteria have an important influence on colorectal cancer (CRC). The differences of gut bacteria between genders have been the hot spots. Objective: To analyze the relationship between gut bacteria and gender differences in patients with CRC. Methods: A total of 212 patients with CRC and 212 healthy volunteers were recruited. The subjects ' fecal samples were obtained, and the fecal microorganisms were analyzed by the third -generation sequencing PacBio. The composition of gut bacteria was analyzed. Linear discriminant analysis Effect Size (LEfSe) was used to analyze the differences in gut bacteria. Pearson coefficient was used to calculate the correlation between differential bacteria. CRC risk prediction models were used to rank the importance of effective differential bacteria. Results: Escherichia flexneri and Phocaeicola vulgatus were the most frequent bacteria in both male and female CRC patients. Bacteroides , Verrucomicrobia and Akkermansiaceae were highly enriched in male CRC group, while Bacteroidetes , Phocaeicola and Tissierellales were highly enriched in female CRC group. Peptostreptococcus anaerobius and Phocaeicola vulgatus were important CRC related bacteria in males and females, respectively. Peptostreptococcus anaerobius was the most important characteristic bacterium of males (AUC = 0.951), and the sensitivity and specificity of the discovery set were 78.74 % and 93.98 %, respectively. Blautia stercoris was the most important characteristic bacterium of females (AUC = 0.966), and the sensitivity and specificity of the discovery set were 90.63 % and 90.63 %, respectively. Conclusion: Gut bacteria varied in different genders. Therefore, gender should be considered when gut bacteria are applied in the diagnose and prevention of CRC.

关键词： Colorectal cancer Gender Gut bacteria Risk prediction Escherichia flexneri

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A 107.6 dB-DR Three-Step Incremental ADC for Motion-Tolerate Biopotential Signals Recording

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IEEE TRANSACTIONS ON BIOMEDICAL CIRCUITS AND SYSTEMS 2024年第1期18卷 111-122页

作者： Fang, Lairong Zhang, shuwen Li, Yijie wu, Shunmin Zeng, Xiaoyang Hong, Zhiliang Xu, Jiawei Fudan Univ State Key Lab Integrated Chips & Syst Shanghai 201203 Peoples R China Beijing Smartchip Microelect Technol Co Ltd Beijing 102100 Peoples R China

This article describes a power-efficient, high dynamic range (DR) incremental ADC (IADC) for wearable biopotential signals recording, where DC and low-frequency disturbances such as electrode offset, 50/60 Hz interference and motion artifact must be tolerated. To achieve a wide DR, the IADC performs a three-step conversion by combining zoom-SAR and extended counting (EC) on top of a second-order incremental delta-sigma modulator (Delta Sigma M). The hybrid architecture notably reduces the oversampling ratio (OSR) with respect to conventional incremental Delta Sigma Ms, while using the EC further improves the Signal-to-Noise-and-Distortion Ratio (SNDR) by 7.4 to 25.6 dB. Fabricated in a 0.18-mu m CMOS technology, the IADC achieves 107.6-dB DR, 104.9-dB peak SNR, and 99.3-dB peak SNDR at 2 kS/s while dissipating 130 mu W from 1.8-V (analog) / 1.2-V (digital) supply. This translates to a highly competitive FoM(DR) of 176.5 dB. The high-DR IADC reduces the gain of the preceding instrumentation amplifier (IA) such that significant DC and low-frequency disturbances can be tolerated. The advantages of high DR have been demonstrated by wearable Electrocardiography (ECG) and Electroencephalography (EEG) recordings under motion artifact.

关键词： Motion artifacts Electrocardiography Thermal noise Recording Quantization (signal) Electrodes Redundancy Extended counting hybrid Delta Sigma modulator incremental ADC motion artifact SAR zoom

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Improved thermal stability and quantum efficiency of novel cyan phosphors toward full-visible-spectrum lighting

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CERAMICS INTERNATIONAL 2024年第1期50卷 1159-1165页

作者： Xu, Yonghui Yin, shuwen wu, Xiudi Zhong, Chuansheng Zhang, Xibao Zhou, Liang You, Hongpeng Chinese Acad Sci Changchun Inst Appl Chem Changchun 130022 Peoples R China Univ Sci & Technol China Sch Appl Chem & Engn Hefei 230026 Peoples R China Chinese Acad Sci Ganjiang Innovat Acad Ganzhou 341000 Peoples R China

Highly efficient cyan phosphors have been identified as essential components in addressing the cyan gap present in the emission spectra of traditional white light emitting diodes. Here, we report novel Ba4Ca1-yLay(PO4)3Cl: Eu2+ (y = 0-0.15) phosphors with broadband cyan emission based on an efficient and positive cationic heterovalent substitution strategy. Under the near ultraviolet excitation, the quantum yield and thermal stability are progressively enhanced by introducing La3+ to replace the Ca2+ ions, owing to the band gap and killer centers engineering. The Ba3.92Ca0.9La0.1(PO4)3Cl:0.08Eu2+ phosphor exhibits a pronounced emission band in the cyangreen spectral range with a high internal quantum efficiency of 88.0% and an impressive external quantum efficiency of 72.1%. The utilization of Ba3.92Ca0.9La0.1(PO4)3Cl:0.08Eu2+ as the cyan emitting component in the fabrication of white light-emitting diode (WLED) has demonstrated remarkable advancements in the color rendering index value, emphasizing the potential of these phosphors for future implementation in the next generation full-visible-spectrum WLED lighting. Our findings offer evidences that defect engineering techniques effectively enhance the performance of light-emitting diode (LED) phosphors.

关键词： Phosphors

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Analytical Solution of the Stress Intensity Factors of Multiple Closed Collinear Cracks

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JOURNAL OF VIBRATION ENGINEERING & TECHNOLOGIES 2023年第8期11卷 3737-3745页

作者： Peng, Shaochi Jing, Laiwang Li, shuwen wu, Di Jing, Wei Anhui Univ Sci & Technol Sch Civil Engn & Architecture Huainan 232001 Peoples R China

Purpose According to the interaction between multiple cracks, a method for calculating the stress intensity factors of multiple closed collinear cracks in an infinite plate is proposed. In addition, the effects of the crack angle, crack length, crack spacing, lateral pressure coefficient and crack surface friction coefficient on the stress intensity factors are analyzed. Method The integral equation of the stress intensity factors is derived by the superposition principle, and the approximate solution of the integral equation is derived by the Chebyshev polynomial. The results obtained are compared with the finite element solutions of the same problem and the solutions of other scholars to verify the correctness of the equation. Results The results show that the intensity factor solution obtained by the proposed method is in good agreement with the finite element solution and other scholars' solutions. A larger crack length, smaller crack spacing, smaller friction coefficient and smaller lateral pressure coefficient can produce larger stress intensity factors, and the stress intensity factors are maximized when the crack angle is 45 degrees. Conclusions It is proved that the method based on the initial solution and superposition principle can be effectively applied to the calculation of the stress intensity factors of multiple collinear cracks.

关键词： Closed crack Stress intensity factors Collinear crack Superposition principle Chebyshev polynomial

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Mg(II)-Doped Perovskite-like Cs3Cu2I5 Single Crystals with High Quantum Yield for Efficient X-ray Detection

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CRYSTAL GROWTH & DESIGN 2025年第3期25卷 663-671页

作者： wu, Tong Shi, Yun Zuo, Xiaoyi Chen, Mingyue Ran, Hongbing Zhao, shuwen Chen, Junfeng Tang, Yiwen Cent China Normal Univ Coll Phys Sci & Technol Wuhan 430079 Peoples R China Chinese Acad Sci Shanghai Inst Ceram Shanghai 201899 Peoples R China Univ Chinese Acad Sci Ctr Mat Sci & Optoelect Engn Beijing 100049 Peoples R China

Cs3Cu2I5 halide perovskites doped with luminescence activators have unique optical and electronic properties;however, they tend to combine with slow scintillation decay, which leads to ghosting or blurriness during X-ray imaging. In this study, we produced magnesium (Mg2+)-doped Cs3Cu2I5 single crystals (SCs) with blue emission at 440 nm, and the photoluminescence quantum yields ranged from 72.4 to 81.7%. Moreover, enhanced radioluminescence (RL) intensity and light output were achieved without deteriorating scintillation decay compared to those of pure Cs3Cu2I5 SCs. Mg doping can strengthen electron-phonon coupling, and the emission (2.15 eV) at a low temperature (80-290 K) showed the presence of additional carrier capture channels of Mg-related defect levels in the band gap, which can help reduce the probability of nonradiative recombination. Therefore, flexible X-ray scintillator films with excellent hydrophobicity were fabricated using Mg2+-doped Cs3Cu2I5 SC powders, and their spatial resolution (2.5 Lp/mm) met the resolution requirements of commercial spiral computed tomography. This study found an effective strategy for enhancing the self-trapped exciton emission of metal copper-based halide scintillators and highlighted their applicability in low-dose flexible X-ray detection and imaging.

关键词： Perovskite

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板栗壳提取物对SD大鼠的致畸毒性研究

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癌变．畸变．突变 2022年第6期34卷 463-466页

作者：江丹伍淑文陈志元田辉孙代华樊柏林劲牌持正堂药业有限公司湖北黄石435100 阳新县疾病预防控制中心湖北黄石435200 湖北省疾病预防控制中心应用毒理湖北省重点实验室湖北武汉430079

目的:研究板栗壳提取物对SD大鼠的致畸毒性。方法:将受孕SD大鼠随机分为低、中、高3个剂量板栗壳提取物组,阴性对照组和阳性对照组,每组18~20只。低、中、高剂量组分别按0.37、1.11和3.33 g/kg给予板栗壳提取物;阴性对照组给予蒸馏水;... 详细信息

目的:研究板栗壳提取物对SD大鼠的致畸毒性。方法:将受孕SD大鼠随机分为低、中、高3个剂量板栗壳提取物组,阴性对照组和阳性对照组,每组18~20只。低、中、高剂量组分别按0.37、1.11和3.33 g/kg给予板栗壳提取物;阴性对照组给予蒸馏水;阳性对照组按13 mg/kg给予维生素A。于妊娠期的第6~15天灌胃给予受试物或对照物,第20天麻醉后处死孕鼠。观察母鼠和胎鼠的生长发育、受孕率、生殖能力、外观、内脏和骨骼畸形等指标。结果:与阴性对照组比较,阳性对照组第9天至第20天孕鼠体质量偏低,体质量增量降低,胎鼠体质量减轻、身长明显降低,其胎鼠外观畸形率、外观畸形窝数率、内脏畸形率、内脏畸形窝数率、骨骼畸形率、畸形窝数率明显升高,差异有统计学意义(P<0.05),表明阳性对照维生素A对大鼠致畸作用明显,模型成功建立。与阴性对照组比较,板栗壳提取物各剂量未观察到对母鼠及胎鼠的毒性和生殖力的影响,未观察到外观、内脏和骨骼畸形,差异均无统计学差异(P>0.05)。结论:在本试验条件下,板栗壳提取物对大鼠母体毒性和胚胎发育毒性未观察到有害作用剂量(NOAEL)大于3.33 g/kg,对大鼠无致畸作用。

关键词：板栗壳提取物致畸毒性 SD大鼠致畸试验

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Enhancing Out-of-Distribution Generalization in VQA through Gini Impurity-guided Adaptive Margin Loss

Enhancing Out-of-Distribution Generalization in VQA through ...

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IEEE International Conference on Multimedia and Expo (ICME)

作者： Yang, shuwen Huai, Tianyu wu, Anran wu, Xingjiao Hu, Wenxin He, Liang East China Normal Univ Shanghai Peoples R China Fudan Univ Shanghai Peoples R China

ISBN: (纸本)9798350390155;9798350390162

In the Visual Question Answering (VQA) task context, most methods are influenced by language bias, resulting in poor performance on out-of-distribution data. Recently, some works attempted to use the adaptive margin loss to address this bias issue. However, these works typically consider only the frequency of answer labels when designing margin loss, leading to some samples being overly emphasized or lacking sufficient attention during model training. To address this issue, we propose a novel margin loss guided by the Gini-impurity for VQA debiasing. By comprehensively considering label distribution and instance complexity, we use Gini impurity to adjust the margin values in margin loss, balancing the attention of the model to different samples. Importantly, our method is plug-and-play and can be directly applied to any baseline. In the VQA-CP v2 task, our evaluation results across various baselines surpass the current state-of-the-art methods.

关键词： Index Terms-Visual question answering Margin loss Language bias

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Analysis of Spatiotemporal Characteristics of Taxi Traffic Violations 24

Analysis of Spatiotemporal Characteristics of Taxi Traffic V...

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24th COTA International Conference of Transportation Professionals: Resilient, Intelligent, Connected, and Lowcarbon Multimodal Transportation, CICTP 2024

作者： Yan, Lixin Yu, shuwen Li, Huangchengcheng wu, Qian School of Transportation Engineering East China JiaoTong Univ. Nanchang China Jiangxi Provincial Communications Investment Group Co. Ltd. Nanchang China

ISBN: (数字)9780784485484

ISBN: (纸本)9780784485484

Traffic violations are a significant factor contributing to road traffic accidents. Taxis are a crucial component of urban traffic. Studying taxi traffic violations is helpful to reduce the occurrence of urban road traffic violation events. In order to study the spatiotemporal characteristics of taxi violations, an empirical analysis was conducted using the raw data of 43,622 taxi traffic violations from July 2020 to June 2021 in Nanchang City. The ArcGIS kernel density analysis tool was employed to visually analyze spatiotemporal characteristics of taxi traffic violations. The results show that taxis were more likely to commit traffic violations near hospitals, schools, and intersections. The highest incidence of serious violations is concentrated in the afternoon and before dawn. The conclusion of this study can provide insightful suggestions for the traffic enforcement department to adjust the patrol plans according to the periods. © ASCE.

关键词： Roads and streets

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