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Association Between Nocturnal Hypoxemia Parameters and Coronary Microvascular Dysfunction: A Cross-Sectional Study

NATURE AND SCIENCE OF SLEEP 2024年 16卷 2279-2288页

作者： Feng, Lanxin Zhao, Xin Song, Jianqiao Yang, shuwen xiang, Jianping Zhang, Min Tu, Chenchen Song, Xiantao Tu, Chenchen Capital Med Univ Beijing Anzhen Hosp Dept Cardiol Beijing Peoples R China Sun Yat Sen Univ Zhongshan Sch Med Guangzhou Peoples R China ArteryFlow Technol Co Ltd Hangzhou Peoples R China

Objective: There is a connection between obstructive sleep apnea (OSA) and coronary microvascular dysfunction (CMD), but the underlying mechanisms remain unclear. This study aims to evaluate the correlation between OSA-related nocturnal hypoxemia parameters and CMD. Methods: This is an observational, single-center study that included patients who underwent polysomnography and coronary angiography during hospitalization. The presence of CMD was determined by angio-based index of microcirculatory resistance (AccuIMR). Categorical variables were compared using chi-square test or Fisher exact test. The t-test and Mann-Whitney U-test were used to compare normally and non-normally distributed continuous variables, respectively. Univariate and multivariable logistic regression analyses were performed to evaluate the relationship between nocturnal hypoxemia parameters and CMD. Results: A total of 133 patients were included in this study, of whom 72 (54.14%) had evidence of CMD. Patients with CMD exhibited a higher prevalence of OSA and experienced more severe nocturnal hypoxia. After adjusting for potential confounding factors, minimum oxygen saturation (minSpO2) <= 90% (OR 5.89;95% CI 1.73-19.99;P=0.004) and the percentage of time spent with oxygen saturation below 90% (T90) >= 5% (OR 3.13;95% CI 1.05-9.38;P=0.041) were independently associated with CMD. However, no significant association was observed between apnea-hypopnea index (AHI) and CMD. Conclusion: Parameters of nocturnal hypoxemia are associated with CMD. Hypoxemia parameters may more sensitively reflect the correlation between OSA and CMD than AHI.

关键词： obstructive sleep apnea coronary microvascular dysfunction nocturnal hypoxemia cardiology dentistry

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Comparative analysis of the organelle genomes of Aconitum carmichaelii revealed structural and sequence differences and phylogenetic relationships

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BMC GENOMICS 2024年第1期25卷 1-14页

作者： Zhang, Rongxiang xiang, Niyan Qian, Changjiang Liu, shuwen Zhao, Yuemei Zhang, Guiyu Wei, Pei Li, Jianfeng Yuan, Tao Guizhou Educ Univ Sch Biol Sci Guiyang 550018 Peoples R China Tibet Univ Sch Ecol & Environm Lhasa 850000 Peoples R China Guizhou Educ Univ Key Lab Dev & Utilizat Biol Resources Coll & Univ Guiyang 550018 Peoples R China Wuhan Univ Coll Life Sci State Key Lab Hybrid Rice Lab Plant Systemat & Evolutionary Biol Wuhan 430072 Peoples R China

In this study, we conducted an assembly and analysis of the organelle genomes of Aconitum carmichaelii. Our investigation encompassed the examination of organelle genome structures, gene transfer events, and the environmental selection pressures affecting A. carmichaelii. The results revealed distinct evolutionary patterns in the organelle genomes of A. carmichaelii. Especially, the plastome exhibited a more conserved structure but a higher nucleotide substitution rate (NSR), while the mitogenome displayed a more complex structure with a slower NSR. Through homology analysis, we identified several instances of unidirectional protein-coding genes (PCGs) transferring from the plastome to the mitogenome. However, we did not observe any events which genes moved from the mitogenome to the plastome. Additionally, we observed multiple transposable element (TE) fragments in the organelle genomes, with both organelles showing different preferences for the type of nuclear TE insertion. Divergence time estimation suggested that rapid differentiation occurred in Aconitum species approximately 7.96 million years ago (Mya). This divergence might be associated with the reduction in CO2 levels and the significant uplift of the Qinghai-Tibet Plateau (QTP) during the late Miocene. Selection pressure analysis indicated that the dN/dS values of both organelles were less than 1, suggested that organelle PCGs were subject to purification selection. However, we did not detect any positively selected genes (PSGs) in Subg. Aconitum and Subg. Lycoctonum. This observation further supports the idea that stronger negative selection pressure on organelle genes in Aconitum results in a more conserved amino acid sequence. In conclusion, this study contributes to a deeper understanding of organelle evolution in Aconitum species and provides a foundation for future research on the genetic mechanisms underlying the structure and function of the Aconitum plastome and mitogenome.

关键词： Aconitum carmichaelii Chloroplast genome Mitochondrial genome Ranunculaceae family Phylogenetic analysis

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Phase State Regulates Photochemical HONO Production from NaNO3/Dicarboxylic Acid Mixtures

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ENVIRONMENTAL SCIENCE & TECHNOLOGY 2024年第17期58卷 7516-7528页

作者： Li, Qiong Ma, Shuaishuai Liu, Yu Wu, Xinyuan Fu, Hongbo Tu, xiang Yan, shuwen Zhang, Liwu George, Christian Chen, Jianmin Fudan Univ Dept Environm Sci & Engn Shanghai Key Lab Atmospher Particle Pollut Prevent Shanghai 200433 Peoples R China Nanjing Univ Informat Sci & Technol Collaborat Innovat Ctr Atmospher Environm & Equipm Nanjing 210044 Peoples R China Inst Ecochongming SIEC Shanghai 202162 Peoples R China Quzhou Univ Coll Chem & Mat Engn Quzhou 324000 Peoples R China Jiangxi Acad Ecoenvironm Sci & Planning Jiangxi Key Lab Environm Pollut Control Nanchang 330000 Peoples R China Univ Claude Bernard Lyon 1 Univ Lyon CNRS IRCELYON F-69626 Villeurbanne France

Field observations of daytime HONO source strengths have not been well explained by laboratory measurements and model predictions up until now. More efforts are urgently needed to fill the knowledge gaps concerning how environmental factors, especially relative humidity (RH), affect particulate nitrate photolysis. In this work, two critical attributes for atmospheric particles, i.e., phase state and bulk-phase acidity, both influenced by ambient RH, were focused to illuminate the key regulators for reactive nitrogen production from typical internally mixed systems, i.e., NaNO3 and dicarboxylic acid (DCA) mixtures. The dissolution of only few oxalic acid (OA) crystals resulted in a remarkable 50-fold increase in HONO production compared to pure nitrate photolysis at 85% RH. Furthermore, the HONO production rates (P HONO) increased by about 1 order of magnitude as RH rose from <5% to 95%, initially exhibiting an almost linear dependence on the amount of surface absorbed water and subsequently showing a substantial increase in P HONO once nitrate deliquescence occurred at approximately 75% RH. NaNO3/malonic acid (MA) and NaNO3/succinic acid (SA) mixtures exhibited similar phase state effects on the photochemical HONO production. These results offer a new perspective on how aerosol physicochemical properties influence particulate nitrate photolysis in the atmosphere.

关键词： nitrate photolysis HONO dicarboxylic acids phase state bulk-phase acidity atmosphericaerosols

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Repurposing Xylan Biowastes for Sustainable Household Detergents

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ACS SUSTAINABLE CHEMISTRY & ENGINEERING 2023年第7期11卷 2949-2958页

作者： Wang, Hairong Li, Xupeng Zhao, shuwen Liu, Qiaoling Li, Nan Su, Zhenhua Ren, Junli Hao, xiang Peng, Feng China Natl Pulp & Paper Res Inst Beijing 100102 Peoples R China South China Univ Technol State Key Lab Pulp & Paper Engn Guangzhou 510640 Peoples R China Beijing Forestry Univ MOE Engn Res Ctr Forestry Biomass Mat & Energy Beijing Key Lab Lignocellulos Chem Beijing 100083 Peoples R China

Seeking sustainable and biocompatible detergent remains a big challenge. In this work, we report a new type of polysaccharide nanocrystal that is extracted from available industrial xylan biowastes via mild ammonium persulfate (APS) aqueous oxidation, which subsequently serves as a sustainable household detergent. By carefully adjusting the oxidation conditions (similar to 0.5 M, 60 degrees C), plate xylan hydrated nanocrystals (XNCs) can be accessed in reasonable yield (similar to 23%) with diameters of 30-50 nm and thicknesses of 5-12 nm. In comparison to the cellulose nanocrystal (CNC), the crystalline structure of XNCs demonstrates remarkable humidity-dependent behavior. Additionally, the acetylated xylan nanocrystals (AXNCs) exhibit high surface/interface activity to form stable Pickering emulsions, intriguing cleaning efficiency in removing stains from fabric surfaces, and the capability to de-wet oil from various types of tableware material. Seed germination, crop growth, and aquatic ecotoxicological evaluation demonstrate that AXNCs show no toxicity toward plants and zebrafish (median lethal concentration > 20,000 mg/L) with which they can be applied either as eco-friendly laundry or kitchen detergents. Our work presents a new avenue for converting industrial biowastes into sustainable household materials.

关键词： industrial xylan biowastes acetylated xylan nanocrystals (AXNCs) household detergents no toxicity sustainable

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Long-term stable and catalytic 2D MXene nanosheets wrapped with dialdehyde xylan for ultrafast gelation

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GREEN CHEMISTRY 2023年第11期25卷 4309-4318页

作者： Li, Nan Shao, Lupeng Xia, Qiang Tan, Shujun Zhao, shuwen Li, XuPeng Su, Zhenhua Hao, xiang Peng, Feng Beijing Forestry Univ MOE Engn Res Ctr Forestry Biomass Mat & Energy Beijing Key Lab Lignocellulos Chem Beijing 100083 Peoples R China Qilu Univ Technol Shandong Acad Sci Key Lab Pulp & Paper Sci & Technol Minist Educ Jinan 250353 Peoples R China China Natl Pulp & Paper Res Inst Beijing 100102 Peoples R China

Developing aqueous stable and catalytic Ti3C2Tx MXene suspensions remains a grand challenge. MXene nanosheets always undergo rapid degradation when exposed to water and oxygen, and the incorporation of reducing or capping agents may deteriorate the intrinsic characteristics of MXenes. Here, we coupled dialdehyde xylan (DAX) with MXene nanosheets to significantly increase the long-term storage of MXene in an aqueous solution (>3 months) with a dramatic enhancement of their room temperature catalytic activity for ultrafast gelation. DAX can form thick and smooth layers on the nanosheets via multiple hydrogen bonds, providing a reduction environment to prevent the occurrence of oxidation. Meanwhile, DAX can accelerate the generation of free radicals from the potassium persulfate (KPS)/MXene pair, reducing the polymerization time of vinyl monomers from similar to 30 min to similar to 90 s. Moreover, the DAX layer is capable of serving as additional crosslinks by leveraging Schiff base bonds with chitosan (CS), with the elongation at break increasing from 100% to 909%. The resultant MXene-based hydrogel can be further explored as a sustainable sensor for real-time physical signal monitoring. This work offers an enticing prospect for the development of eco-friendly and high-performance MXene-based materials.

关键词： Nanosheets

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Asymptotic behaviours and stability of zero dynamics in nonlinear discrete-time systems using Taylor approach and multirate input

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INTERNATIONAL JOURNAL OF SYSTEMS SCIENCE 2017年第7期48卷 1556-1568页

作者： Zeng, Cheng xiang, shuwen Liang, Shan Guizhou Inst Technol Coll Sci Guiyang Guizhou Peoples R China Guizhou Univ Coll Comp Sci & Technol Guiyang Guizhou Peoples R China Chongqing Univ Coll Automat Chongqing Peoples R China

It is well known that the existence of unstable sampled zero dynamics is recognised as a major barrier in many control problems. When the usual digital control with zero-order hold (ZOH) or fractional-order hold (FROH) input is used, unstable sampled zero dynamics inevitably appear in the discrete-time model even though the continuous-time system with relative degree more than or equal to three is of minimum phase. In this paper, we show how an approximate sampled-data model can be obtained for nonlinear systems by the use of multirate input and hold such as a generalised sample hold function (GSHF) in order that discrete zero dynamics of the resulting model can be arbitrarily placed. Furthermore, the properties of sampled zero dynamics are studied and the conditions for ensuring the stability of sampling zero dynamics of the desired model are derived. The results presented here generalise well-known notion of sampling zero dynamics from the linear case to nonlinear systems, and GSHF can provide some advantages over ZOH or FROH in terms of stability of discrete system zero dynamics.

关键词： Nonlinear systems stability discrete time systems zero dynamics generalised sample hold function

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A novel condition for stable nonlinear sampled-data models using higher-order discretized approximations with zero dynamics

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ISA TRANSACTIONS 2017年 68卷 73-81页

作者： Zeng, Cheng Liang, Shan xiang, shuwen Guizhou Inst Technol Coll Sci Guiyang 550003 Guizhou Peoples R China Guizhou Univ Coll Comp Sci & Technol Guiyang 550025 Guizhou Peoples R China Chongqing Univ Coll Automat Chongqing 400044 Peoples R China

Continuous-time systems are usually modelled by the form of ordinary differential equations arising from physical laws. However, the use of these models in practice and utilizing, analyzing or transmitting these data from such systems must first invariably be discretized. More importantly, for digital control of a continuous-time nonlinear system, a good sampled-data model is required. This paper investigates the new consistency condition which is weaker than the previous similar results presented. Moreover, given the stability of the high-order approximate model with stable zero dynamics, the novel condition presented stabilizes the exact sampled-data model of the nonlinear system for sufficiently small sampling periods. An insightful interpretation of the obtained results can be made in terms of the stable sampling zero dynamics, and the new consistency condition is surprisingly associated with the relative degree of the nonlinear continuous-time system. Our controller design, based on the higher-order approximate discretized model, extends the existing methods which mainly deal with the Euler approximation. (C) 2017 ISA. Published by Elsevier Ltd. All rights reserved.

关键词： Consistency condition Exact sampled-data plant Higher-order approximation discretized model Zero dynamics Controller design

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Great Enhancing Overall Performances of YSO:Ce Scintillation Crystals by Ni Codoping

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CRYSTAL GROWTH & DESIGN 2024年第17期24卷 7166-7172页

作者： Zhang, Zhe Zhao, shuwen Xue, Zhongjun Shi, Junjie Zhang, Aochen Zheng, xiang Li, Chengyi Qiu, Peng Shi, Hongsheng Xiao, JiaWen Ding, Dongzhou Shanghai Univ Sch Microelect Shanghai 201800 Peoples R China Chinese Acad Sci Shanghai Inst Ceram Shanghai 201899 Peoples R China Chinese Acad Sci Res Ctr Crystal Mat State Key Lab Funct Mat & Devices Special Environm Xinjiang Key Lab Funct Crystal MatXinjiang Tech I Urumqi 830011 Peoples R China Beijing Univ Technol Coll Mat Sci & Engn Beijing Key Lab Microstruct & Property Adv Mat Beijing 100124 Peoples R China

Cerium-doped yttrium oxyorthosilicate (YSO:Ce) scintillation crystals are widely used in mixed radiation field detection, radioactive isotope monitoring, and other fields due to their excellent scintillation properties and low cost. However, the poor coincidence time resolution severely limits their further promotion. In order to resolve this problem, this work first designed and conducted research on Ni2+-codoped YSO:Ce crystals, and a series of YSO:Ce,xNi (x = 0, 0.3, 0.6, and 1.5 atom %) crystals were grown using the Czochralski method. It is found that codoping with 0.6 atom % Ni2+ can improve the overall scintillation performances of YSO:Ce crystals. In particular, the ratio of light output to scintillation decay time significantly improved by 71%, which is currently the best optimization result reported in the orthosilicate-based scintillation crystals systems. In addition, the afterglow level has been optimized by 2 orders of magnitude, and the energy resolution has been improved from 9.2% to 6.7%, greatly enhancing its potential commercial applications. This is mainly attributed to Ni2+ codoping, significantly reducing the concentration of carrier traps in YSO:Ce,xNi crystals, reducing the emission proportion of the slow-emitting center Ce2, and introducing the fast scintillation center Ce4+ into the crystals. Based on the experimental results, the possible mechanisms of the above phenomenon were discussed in the article.

关键词： Scintillation

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Highly efficient prevention of radiation dermatitis using a PEGylated superoxide dismutase dissolving microneedle patch

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EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS 2024年 201卷 114347页

作者： Ma, Zhenchao Chen, Yingrong Tang, Kaixian Yang, Hongxia Tian, Mengli Xi, Xiaoyuan Han, shuwen Yang, Shuixin Ru, Lixin Yu, xiang Zhejiang Chinese Med Univ Huzhou Cent Hosp Sch Clin Med 5 Huzhou 313000 Zhejiang Peoples R China Huzhou Univ Affiliated Cent Hosp Huzhou Cent Hosp Huzhou 313000 Zhejiang Peoples R China Huzhou Inst Food & Drug Control Huzhou 313002 Zhejiang Peoples R China

PEGylated superoxide dismutase (PEG-SOD) is commonly used as a cytoprotective agent in radiotherapy. However, its effectiveness in preventing radiation dermatitis is limited owing to its poor skin permeability. To address this issue, a PEG-SOD-loaded dissolving microneedle (PSMN) patch was developed to effectively prevent radiation dermatitis. Initially, PSMN patches were fabricated using a template mold method with polyvinylpyrrolidone K90 as the matrix material. PSMNs exhibited a conical shape with adequate mechanical strength to penetrate the stratum corneum. More than 90 % of PEG-SOD was released from the PSMN patches within 30 min. Notably, the PSMN patches showed a significantly higher drug skin permeation than the PEG-SOD solutions, with a 500-fold increase. In silico simulations and experiments on skin pharmacokinetics confirmed that PSMN patches enhanced drug permeation and skin absorption, in contrast to PEG-SOD solutions. More importantly, PSMN patches efficiently mitigated ionizing radiation-induced skin damage, accelerated the healing process of radiation-affected skin tissues, and exhibited highly effective radioprotective activity for DNA in the skin tissue. Therefore, PSMN patches are promising topical remedy for the prevention of radiation dermatitis.

关键词： Radiation dermatitis Microneedles Transdermal delivery PEGylated superoxide dismutase Ionizing radiation

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Identification of the 4CL family in cassava (Manihot esculenta Crantz) and expression pattern analysis of the Me4CL32 gene

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BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 2024年 735卷 150731页

作者： Ran, Fangfang xiang, Chunyu Wang, Changyi Zang, Yuwei Liu, Liangwang Wu, shuwen Wang, Congcong Cai, Jie Wang, Dayong Min, Yi Hainan Univ Collaborat Innovat Ctr One Hlth Sch Life & Hlth Sci Hainan Prov Key Lab One Hlth Haikou 570228 Hainan Peoples R China Hainan Univ Sch Pharmaceut Sci Lab Biopharmaceut & Mol Pharmacol 58 Peoples Rd Haikou 570228 Hainan Peoples R China Chinese Acad Trop Agr Sci Trop Crops Genet Resources Inst Key Lab Agr Germplasm Resources Conservat & Utiliz Haikou 571101 Peoples R China

The 4-coumarate coenzyme A ligase (4CL) plays a critical role in the phenylpropane metabolic pathway and is a key enzyme in plant growth metabolism and stress responses. Using bioinformatics methods, 50 Me4CL gene were identified within the cassava genome u, and a comprehensive analysis of the cassava 4CL gene family was conducted. The results showed that these 50 4CL proteins are divided into four subfamilies, with members within the same subfamily sharing similar or identical gene structures. Co-linearity analysis revealed that cassava and rubber trees have the highest number of homologous genes, indicating a close homologous relationship between them. Analysis of 20 cis-acting elements in the promoter region of Me4CL32 revealed the presence of hormoneresponsive elements such as gibberellin, auxin, abscisic acid, and as well as elements related to meristematic tissue regulation. results Quantitative real-time PCR (qRT-PCR) results showed that Me4CL32 gene expression changes in response to abiotic stressors (drought, salt, cold, heat) and hormonal stimuli(GA3 and ABA), indicating that Me4CL32 can respond to both environmental pressures and hormone signals. RNA-seq transcriptome and single-cell transcriptome analyses were used to examine the expression patterns of Me4CLs. Additionally, subcellular localization studies demonstrated that the Me4CL32 protein is confined to the chloroplasts of cassava *** the functionality of this gene family aids in comprehending plant growth, development, and stress resistance mechanisms. Furthermore, it furnishes a theoretical basis for future research on developing resilient cassava germplasm and the enhancing cassava's environmental tolerance.

关键词： Cassava 4CL family Expression pattern Me4CL32 Single cell transcriptome

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