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HDAC3 single-nucleotide polymorphism rs2530223 is associated with increased susceptibility and severity of primary immune thrombocytopenia

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INTERNATIONAL JOURNAL OF LABORATORY HEMATOLOGY 2022年第5期44卷 875-882页

作者： Liu, Yan Wang, Yin Zhang, Cheng Feng, Qi Hou, Ming Peng, Jun Hu, xiang Wang, shuwen Shandong Univ Qilu Hosp Cheeloo Coll Med Dept Hematol 107 Wenhuaxi Rd Jinan 250012 Peoples R China Shandong Univ Cheeloo Coll Med Jinan Peoples R China Shandong Univ Qilu Hosp Cheeloo Coll Med Shandong Prov Key Lab Immunohematol 107 Wenhuaxi Rd Jinan 250012 Peoples R China

Introduction Primary immune thrombocytopenia (ITP) is an autoimmune hemorrhagic disorder characterized by a low platelet count and increased risk of bleeding. We previously reported that low-dose chidamide, a histone deacetylase (HDAC) inhibitor, restores immune tolerance in patients with ITP. This study aimed to evaluate the association of a single-nucleotide polymorphism (SNP) rs2530223 in the HDAC3 gene with susceptibility to ITP and its clinical features. Methods Patients with ITP and age-matched healthy participants were recruited for this case-control study. Genotyping of the HDAC3 rs2530223 polymorphism was performed using MassARRAY platform. Results Individuals with T allele of HDAC3 rs2530223 exhibited a 1.472-fold increased risk of ITP susceptibility (OR 1.472;95% CI 1.100-1.969;p = .009), while ones with the TT genotype under the codominant and recessive models, and the TC/TT genotypes under the dominant model all revealed increased risk of ITP susceptibility (dominant odds ratio[OR] 1.965;95% CI: 1.046-3.656;p = .036;codominant OR 2.264;95% CI 1.175-4.360;p = .015;and recessive OR 1.512;95% CI 1.028-2.224;p = .036, respectively). Regarding platelet counts in ITP patients, we observed that the TC/TT genotypes exhibited a 3.932-fold increased risk for platelet (PLT) <30 x 10(9)/L (OR 3.932;95% CI 1.426-10.842;p = .008). Conclusion This study indicates that HDAC3 rs2530223 may be an important genetic factor related to ITP susceptibility and platelet count in ITP patients, providing new perspectives on disease progression, new therapeutic targets, and severity prediction.

关键词： HDAC3 platelet count primary immune thrombocytopenia single-nucleotide polymorphism susceptibility

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Liver tumor imaging staging: a multi-institutional study of a preoperative staging tool for hepatocellular carcinoma

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ABDOMINAL RADIOLOGY 2024年 1-13页

作者： Liu, Qiupng Li, xiang Yang, Kailan Sun, shuwen Xu, Xun Qu, Kai Xiao, Jiaqi Liu, Chenyue Yu, Hangqi Lu, Yinying Qu, Jinrong Zhang, Yudong Zhang, Yuelang Jiangsu Prov Hosp Dept Hematol Nanjing Peoples R China Nanjing Med Univ Affiliated Hosp 1 Nanjing Peoples R China Xi An Jiao Tong Univ Affiliated Hosp 1 Dept Radiol Xian Peoples R China Zhengzhou Univ Affiliated Canc Hosp Dept Radiol Zhengzhou Peoples R China Henan Canc Hosp Zhengzhou Peoples R China Xi An Jiao Tong Univ Affiliated Hosp 2 Dept Radiol Xian Peoples R China Peoples Liberat Army Gen Hosp Beijing Peoples R China Shenzhen Univ Coll Life Sci & Oceanog Guangdong Key Lab Plant Epigenet Shenzhen Peoples R China

Background & aims The current staging system has limitations in preoperatively assessing hepatocellular carcinoma (HCC) and in precise detailed treatment allocation. This study aims to propose a new Liver Tumor Imaging Staging (LTIS) method for HCC. Methods 1295 patients who underwent CT or MRI and curative liver resection during January 2012 and October 2020 were retrospectively recruited from three independent institutions. All images were interpreted by two abdominal and a board-certified radiologist. LTIS was designed to discriminate low-grade (absence of microvascular invasion [MVI] and Edmondson-Steiner grade III/IV), intermediate (MVI + or Edmondson-Steiner grade III/IV but not both) and high-grade HCC (MVI + and Edmondson-Steiner grade III/IV) upon CT and MRI. Model was constructed in 578 derivation cohort (center 1) and validated in internal center 1 test cohort (n = 291), and external center 2 (n = 226) and center 3 (n = 200), respectively. Cronbach's alpha statistics were determined to assess interobserver agreement. Net clinical benefit of LTIS on recurrence-free survival (RFS) and overall survival (OS) was analyzed with a Cox proportional hazards model. Results LTIS shows good inter-reader agreements in both CT and MRI datasets, with a Cronbach's alpha coefficient of 0.86 and 0.85, respectively. In independent test, LTIS achieved agreement of 73.2% (281/384), 18.9% (100/528), and 69.2% (265/383) for determining low, intermediate, and high-grade HCCs with "ground truth" results. In the Cox analysis, LTIS was comparable to "ground truth" grade for predicting RFS (hazards ratio (HR), 1.30 vs. ground truth grade, 1.36 and 1.56) and OS (HR, 1.76 vs. ground truth grade, 2.00 and 3.03) of patients after surgery. In patients conventionally classified as having low-grade tumors (serum alpha-fetoprotein < 400 ng/mL, stage T1), 47.4% and 35.6% were reclassified as high-grade tumors upon LTIS restaging. The resulting LTIS subgroups showed a significant difference i

关键词： Hepatocellular carcinoma Liver tumor imaging staging Disease prediction Clinical decision support

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Synthesis and defect engineering of molybdenum oxides and their SERS applications

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NANOSCALE 2021年第11期13卷 5620-5651页

作者： Gu, Chenjie Li, Delong Zeng, shuwen Jiang, Tao Shen, xiang Zhang, Han Ningbo Univ Inst Photon 818 Feng Hua Rd Ningbo 315211 Peoples R China Shenzhen Univ Collaborat Innovat Ctr Optoelect Sci & Technol Inst Microscale OptoelectMinist Educ Int Collaborat Lab 2D Mat Optoelect Sci & Technol Shenzhen 518060 Peoples R China Univ Limoges XLIM Res Inst CNRS UMR 7252 Ave Albert Thomas F-87060 Limoges France

Surface-enhanced Raman scattering (SERS) spectroscopy has been developed into a cross-disciplinary analytical technology through exploring various materials' Raman vibrational modes with ultra-high sensitivity and specificity. Although conventional noble-metal based SERS substrates have achieved great success, oxide-semiconductor-based SERS substrates are attracting researchers' intensive interest due to their merits of facile fabrication, high uniformity and tunable SERS characteristics. Among all the SERS active oxide semiconductors, molybdenum oxides (MoOx) possess exceptional advantages of high Raman enhancement factor, environmental stability, recyclable detection, etc. More interestingly, the SERS effect of the MoOx SERS substrates may involve both the electromagnetic enhancement mechanism and the chemical enhancement mechanism, which is determined by the stoichiometry and morphology of the material. Therefore, the focus of this review will be on two critical points: (1) synthesis and material engineering methods of the functional MoOx material and (2) MoOx SERS mechanism and performance evaluation. First, we review recent works on the MoOx preparation and material property tuning approaches. Second, the SERS mechanism and performance of various MoOx substrates are surveyed. In particular, the performance uniformity, enhancement factor and recyclability are evaluated. In the end, we discuss several challenges and open questions related to further promoting the MoOx as the SERS substrate for monitoring extremely low trace molecules and the theory for better understanding of the SERS enhancement mechanism.

关键词： Molybdenum oxide

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Advances in bacteria-based drug delivery systems for anti-tumor therapy

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CLINICAL & TRANSLATIONAL IMMUNOLOGY 2024年第7期13卷 e1518页

作者： shuwen, Han Yifei, Song Xinyue, Wu Zhanbo, Qu xiang, Yu Xi, Yang Huzhou Univ Huzhou Cent Hosp Affiliated Cent Hosp 1558 Sanhuan North Rd Huzhou 313000 Zhejiang Peoples R China Zhejiang Chinese Med Univ Huzhou Cent Hosp Affiliated Clin Med Coll 5 Huzhou Zhejiang Peoples R China Key Lab Multiom Res & Clin Transformat Digest Canc Huzhou Zhejiang Peoples R China

In recent years, bacteria have gained considerable attention as a promising drug carrier that is critical in improving the effectiveness and reducing the side effects of anti-tumor drugs. Drug carriers can be utilised in various forms, including magnetotactic bacteria, bacterial biohybrids, minicells, bacterial ghosts and bacterial spores. Additionally, functionalised and engineered bacteria obtained through gene engineering and surface modification could provide enhanced capabilities for drug delivery. This review summarises the current studies on bacteria-based drug delivery systems for anti-tumor therapy and discusses the prospects and challenges of bacteria as drug carriers. Furthermore, our findings aim to provide new directions and guidance for the research on bacteria-based drug systems. In this study, we discuss the application of bacteria or bacterial secretions, including magnetotactic bacteria, bacterial biohybrids, minicells, bacterial ghosts, and bacterial outer membrane vesicles, as drug carriers in the delivery of anti-tumor drugs. Synthetic biology, chemistry and nanotechnology are widely used in bacteria-based drug delivery systems to enhance tumor-targeting ability and therapeutic efficacy. However, achieving clinical translation of bacteria-based drug delivery systems for anti-tumor therapy is challenging because of biosafety concerns, regulatory hurdles and ethical concerns. image

关键词： anti-tumor bacteria drug delivery system synthetic biology

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Design of Sub wavelength-Grating-Coupled Fano Resonance Sensor in Mid-infrared

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PLASMONICS 2021年第2期16卷 463-469页

作者： Wang, Yuhan Wang, Dianhong Zhang, xiangli Huang, Tianye Zhao, xiang Zeng, shuwen China Univ Geosci Wuhan Sch Mech Engn & Elect Informat Wuhan 430074 Hubei Peoples R China Univ Limoges XLIM Res Inst F-87032 Limoges France

By introducing the sub-wavelength grating (SWG) waveguide in the long-range surface phonon resonance (LRSPhR) device, a mid-infrared Fano resonance is formed due to the coupling between surface phonon polariton and Bloch mode. By taking advantage of strong light-matter interaction in the SWG, such Fano resonance is expected to offer improved sensing performance. Based on the rigorous coupled-wave analysis (RCWA) method, the index sensitivity and figure of merit of such a sensor reach 7496 RIU-1 and 46,432, respectively, which is 6 times compared with the conventional waveguide-coupled LRSPhR. The proposed SWG-coupled Fano resonance can be a promising platform for mid-infrared biochemical sensing.

关键词： Fano resonance Mid-infrared Long-range surface phonon resonance Sub-wavelength grating

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Synthetical improvement of dynamic mechanical property and toughness for precast concrete element based on optimization design of composition and curing regime

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JOURNAL OF BUILDING ENGINEERING 2024年 95卷

作者： xiang, Yu Lai, Wenjie Lan, shuwen Zhang, Shengqi Wang, Jilin Xiao, Qiyuan Zeng, Xiaohui Cent South Univ Sch Civil Engn Changsha 410075 Hunan Peoples R China Cent South Univ Dundee Int Inst Changsha 410075 Hunan Peoples R China Cent South Univ Sch Comp Sci & Engn Changsha 410075 Hunan Peoples R China Hainan Univ Coll Civil Engn & Architecture Haikou 570228 Hainan Peoples R China

The brittleness and toughening measures of steam-cured concrete are currently less researched aspects. This study focuses on exploring the improvement in the toughness of steam-cured concrete and evaluating its influence on dynamic mechanical properties through a series of macroscopic performance tests. These tests include four-point bending tests, three-point bending fracture tests, uniaxial compression tests, and drop hammer impact tests, all conducted from the perspective of optimizing composition materials and steam curing regimes. The experimental results indicate that, under a relatively short heating time and a prolonged constant temperature curing period, the pure cement steam-cured concrete (S1 group), compared to the S2 group which used 20 % FA and 10 % GGBS to replace cement while also increasing the aggregate content with a modified steam curing regime, exhibited higher strength and elastic modulus but also showed greater brittleness. For example, the damping ratio increased to 0.6-0.7, the flexural-to- compressive strength ratio exceeded 6, and the number of specimens damaged by drop hammer impact significantly decreased, and the notch specimen exhibits lower peak load and displacement during fracture, with generally lower fracture parameter values. The fracture energy of the S2 group is 100-130 N center dot m-1-1 higher than that of the S1 group, reaching approximately 670 N center dot m-1,-1 , and the ductility index increased by 0.3-0.4. This research can provide technical support for the high-quality preparation of precast components using steam-cured concrete and offer a theoretical basis for reducing the brittleness of steam-cured concrete.

关键词： Steam-cured concrete Elastic modulus Damping ratio Fracture Impact damage

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Design and Discovery of New Collagen V-Derived FGF2-Blocking Natural Peptides Inhibiting Lung Squamous Cell Carcinoma In Vitro and In Vi vo

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JOURNAL OF MEDICINAL CHEMISTRY 2024年第15期67卷 12660-12675页

作者： Kuang, Keli Chen, xiang Wang, Maolin Han, Weijing Qiu, Xue Jin, Taoli Xu, Rong Yuan, Bing Qian, Meiqi Li, Chunyan xiang, Run Li, Fei Zhang, shuwen Yang, Zi Du, Junrong Li, Dapeng Zhang, Chun Wang, Qiantao Jia, Tao Sichuan Univ Sichuan Engn Lab Plant Sourced Drug Key Lab Drug Targeting & Drug Delivery Syst West China Sch PharmEduc Minist & Sichuan Prov Chengdu 610041 Peoples R China Sichuan Univ Sichuan Res Ctr Drug Precis Ind Technol West China Sch Pharm Chengdu 610041 Peoples R China Songshan Lake Mat Lab Dongguan 523808 Guangdong Peoples R China Ocean Univ China Sch Med & Pharm Key Lab Marine Drugs Minist Educ Qingdao 266003 Peoples R China Ocean Univ China Lab Marine Drugs & Bioprod Qingdao Natl Lab Marine Sci & Technol Qingdao 266237 Peoples R China Univ Elect Sci & Technol China Sichuan Canc Hosp & Inst Sichuan Clin Res Ctr Canc Dept Thorac SurgAffiliated Canc HospSichuan Canc Chengdu 610041 Peoples R China

Aberrant FGF2/FGFR signaling is implicated in lung squamous cell carcinoma (LSCC), posing treatment challenges due to the lack of targeted therapeutic options. Designing drugs that block FGF2 signaling presents a promising strategy different from traditional kinase inhibitors. We previously reported a ColV alpha 1-derived fragment, HEPV (127AA), that inhibits FGF2-induced angiogenesis. However, its large size may limit therapeutic application. This study combines rational peptide design, molecular dynamics simulations, knowledge-based prediction, and GUV and FRET assays to identify smaller peptides with FGF2-blocking properties. We synthesized two novel peptides, HBS-P1 (45AA) and HBS-P2 (66AA), that retained the heparin-binding site. Both peptides demonstrated anti-LSCC and antiangiogenesis properties in cell viability and microvessel network induction assays. In two LSCC subcutaneous models, HBS-P1, with its affinity for FGF2 and enhanced penetration ability, demonstrated substantial therapeutic potential without apparent toxicities. Our study provides the first evidence supporting the development of collagen V-derived natural peptides as FGF2-blocking agents for LSCC treatment.

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Some further results on the stability of Ky Fan's points

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JOURNAL OF INEQUALITIES AND APPLICATIONS 2017年第1期2017卷 1页

作者： xiang, shuwen He, Jihao Liu, Chengwei Jia, Wensheng Yang, Yanlong Guizhou Univ Coll Comp Sci & Technol Guiyang 550025 Guizhou Peoples R China Guizhou Univ Sch Math & Stat Guiyang 550025 Guizhou Peoples R China

In this paper, some further results on the stability of Ky Fan's points are proposed by introducing a type of stronger perturbation of section mappings defined by a semi- metric called the maximum Hausdorff semi-metric, and the existence of the essential components of the set of Ky Fan's points to this perturbation is proved. As an application, the existence of the essential component of the Nash equilibrium is presented using the proposed method, and strong robustness to payoff function perturbation is achieved.

关键词： Ky Fan's points section mappings maximum Hausdorff semi-metric essential component Nash equilibrium

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Measuring cohesive energy of van der Waals heterostructures by nanoparticle intercalation method

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MECHANICS OF MATERIALS 2022年 166卷 104243-104243页

作者： Lou, Liqun Chen, Peijian xiang, Chunping Peng, Juan Zhang, shuwen China Univ Min & Technol Sch Mech & Civil Engn State Key Lab Geomech & Deep Underground Engn Xuzhou 221116 Jiangsu Peoples R China Nanjing Univ Aeronaut & Astronaut State Key Lab Mech & Control Mech Struct Nanjing 210016 Jiangsu Peoples R China Chinese Acad Sci Lanzhou Inst Chem Phys State Key Lab Solid Lubricat Lanzhou 730000 Peoples R China Ocean Univ China Coll Engn Qingdao 266100 Shandong Peoples R China Harvard Univ John A Paulson Sch Engn & Appl Sci Cambridge MA 02138 USA

To assemble new heterojunctions and fulfill promising applications of two-dimensional materials, it is crucial to understand the interfaces properties of various heterostructures. Significant challenges exist in accurately measuring cohesive energies of van der Waals heterostructures, largely due to the difficulty and complexity in proceeding testing methods such as peeling, nanoindentation, etc. Herein, we propose a facile and effective method, i.e., nanoparticle intercalation method to accurately evaluate cohesive energy of heterostructures through theoretical analysis and molecular dynamics simulation. It is found that the shape of nanoparticles has negligible impact on the measured cohesive energy. The nanoparticle measurement method with multiple nanoparticles can be well employed to obtain the cohesive energy in a single test. The results should be helpful for the experimental design of van der Waals heterostructures in a wide range of applications, including tunneling transistors, flexible electronics, as well as photovoltaic devices.

关键词： Molecular dynamics simulation Nanoparticle Cohesive energy Bilayer heterostructure

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Improvement of hydrogen production performance by in situ doping of carbon nanotubes into TiO2 materials

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JOURNAL OF NANOPARTICLE RESEARCH 2022年第3期24卷 61-61页

作者： Bai, Chunmei xiang, Jin Zhao, Zilong Luo, shuwen Li, Liang Sun Yat Sen Univ Sch Civil Engn Zhuhai 519082 Peoples R China Jinzhong Univ Dept Mech Jinzhong 030600 Shanxi Peoples R China Sun Yat Sen Univ Sch Chem Engn & Technol Zhuhai 519082 Peoples R China Univ Hertfordshire Sch Phys Engn & Comp Sci Hatfield AL10 9AB Herts England

In order to prepare highly efficient and stable photocatalytic hydrogen production catalyst, spot-coated carbon nanotube (CNT) composites were prepared by in situ growth of TiO2 on the surface of CNT by adding CNT in four butyl titanate and then sol-gel method under ultrasonic irradiation. Compared with the nanocomposites doped with dopamine, the prepared nanocomposites obviously had lower agglomerated degree and showed excellent hydrogen evolution performance. The optimal hydrogen production performance was 0.0337 mg/ml for the prepared nanocomposites, which had a stable photocatalytic efficiency.

关键词： TiO2 Carbon nanotubes Nanocomposite Photocatalyst Hydrogen production

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