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Design and Discovery of New Collagen V-Derived FGF2-Blocking Natural Peptides Inhibiting Lung Squamous Cell Carcinoma In Vitro and In Vi vo

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JOURNAL OF MEDICINAL CHEMISTRY 2024年第15期67卷 12660-12675页

作者： Kuang, Keli Chen, xiang Wang, Maolin Han, Weijing Qiu, Xue Jin, Taoli Xu, Rong Yuan, Bing Qian, Meiqi Li, Chunyan xiang, Run Li, Fei Zhang, shuwen Yang, Zi Du, Junrong Li, Dapeng Zhang, Chun Wang, Qiantao Jia, Tao Sichuan Univ Sichuan Engn Lab Plant Sourced Drug Key Lab Drug Targeting & Drug Delivery Syst West China Sch PharmEduc Minist & Sichuan Prov Chengdu 610041 Peoples R China Sichuan Univ Sichuan Res Ctr Drug Precis Ind Technol West China Sch Pharm Chengdu 610041 Peoples R China Songshan Lake Mat Lab Dongguan 523808 Guangdong Peoples R China Ocean Univ China Sch Med & Pharm Key Lab Marine Drugs Minist Educ Qingdao 266003 Peoples R China Ocean Univ China Lab Marine Drugs & Bioprod Qingdao Natl Lab Marine Sci & Technol Qingdao 266237 Peoples R China Univ Elect Sci & Technol China Sichuan Canc Hosp & Inst Sichuan Clin Res Ctr Canc Dept Thorac SurgAffiliated Canc HospSichuan Canc Chengdu 610041 Peoples R China

Aberrant FGF2/FGFR signaling is implicated in lung squamous cell carcinoma (LSCC), posing treatment challenges due to the lack of targeted therapeutic options. Designing drugs that block FGF2 signaling presents a promising strategy different from traditional kinase inhibitors. We previously reported a ColV alpha 1-derived fragment, HEPV (127AA), that inhibits FGF2-induced angiogenesis. However, its large size may limit therapeutic application. This study combines rational peptide design, molecular dynamics simulations, knowledge-based prediction, and GUV and FRET assays to identify smaller peptides with FGF2-blocking properties. We synthesized two novel peptides, HBS-P1 (45AA) and HBS-P2 (66AA), that retained the heparin-binding site. Both peptides demonstrated anti-LSCC and antiangiogenesis properties in cell viability and microvessel network induction assays. In two LSCC subcutaneous models, HBS-P1, with its affinity for FGF2 and enhanced penetration ability, demonstrated substantial therapeutic potential without apparent toxicities. Our study provides the first evidence supporting the development of collagen V-derived natural peptides as FGF2-blocking agents for LSCC treatment.

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Design of Sub wavelength-Grating-Coupled Fano Resonance Sensor in Mid-infrared

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PLASMONICS 2021年第2期16卷 463-469页

作者： Wang, Yuhan Wang, Dianhong Zhang, xiangli Huang, Tianye Zhao, xiang Zeng, shuwen China Univ Geosci Wuhan Sch Mech Engn & Elect Informat Wuhan 430074 Hubei Peoples R China Univ Limoges XLIM Res Inst F-87032 Limoges France

By introducing the sub-wavelength grating (SWG) waveguide in the long-range surface phonon resonance (LRSPhR) device, a mid-infrared Fano resonance is formed due to the coupling between surface phonon polariton and Bloch mode. By taking advantage of strong light-matter interaction in the SWG, such Fano resonance is expected to offer improved sensing performance. Based on the rigorous coupled-wave analysis (RCWA) method, the index sensitivity and figure of merit of such a sensor reach 7496 RIU-1 and 46,432, respectively, which is 6 times compared with the conventional waveguide-coupled LRSPhR. The proposed SWG-coupled Fano resonance can be a promising platform for mid-infrared biochemical sensing.

关键词： Fano resonance Mid-infrared Long-range surface phonon resonance Sub-wavelength grating

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Some further results on the stability of Ky Fan's points

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JOURNAL OF INEQUALITIES AND APPLICATIONS 2017年第1期2017卷 1-12页

作者： xiang, shuwen He, Jihao Liu, Chengwei Jia, Wensheng Yang, Yanlong Guizhou Univ Coll Comp Sci & Technol Guiyang 550025 Guizhou Peoples R China Guizhou Univ Sch Math & Stat Guiyang 550025 Guizhou Peoples R China

In this paper, some further results on the stability of Ky Fan's points are proposed by introducing a type of stronger perturbation of section mappings defined by a semi- metric called the maximum Hausdorff semi-metric, and the existence of the essential components of the set of Ky Fan's points to this perturbation is proved. As an application, the existence of the essential component of the Nash equilibrium is presented using the proposed method, and strong robustness to payoff function perturbation is achieved.

关键词： Ky Fan's points section mappings maximum Hausdorff semi-metric essential component Nash equilibrium

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Measuring cohesive energy of van der Waals heterostructures by nanoparticle intercalation method

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MECHANICS OF MATERIALS 2022年 166卷

作者： Lou, Liqun Chen, Peijian xiang, Chunping Peng, Juan Zhang, shuwen China Univ Min & Technol Sch Mech & Civil Engn State Key Lab Geomech & Deep Underground Engn Xuzhou 221116 Jiangsu Peoples R China Nanjing Univ Aeronaut & Astronaut State Key Lab Mech & Control Mech Struct Nanjing 210016 Jiangsu Peoples R China Chinese Acad Sci Lanzhou Inst Chem Phys State Key Lab Solid Lubricat Lanzhou 730000 Peoples R China Ocean Univ China Coll Engn Qingdao 266100 Shandong Peoples R China Harvard Univ John A Paulson Sch Engn & Appl Sci Cambridge MA 02138 USA

To assemble new heterojunctions and fulfill promising applications of two-dimensional materials, it is crucial to understand the interfaces properties of various heterostructures. Significant challenges exist in accurately measuring cohesive energies of van der Waals heterostructures, largely due to the difficulty and complexity in proceeding testing methods such as peeling, nanoindentation, etc. Herein, we propose a facile and effective method, i.e., nanoparticle intercalation method to accurately evaluate cohesive energy of heterostructures through theoretical analysis and molecular dynamics simulation. It is found that the shape of nanoparticles has negligible impact on the measured cohesive energy. The nanoparticle measurement method with multiple nanoparticles can be well employed to obtain the cohesive energy in a single test. The results should be helpful for the experimental design of van der Waals heterostructures in a wide range of applications, including tunneling transistors, flexible electronics, as well as photovoltaic devices.

关键词： Molecular dynamics simulation Nanoparticle Cohesive energy Bilayer heterostructure

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Molybdenum Oxide/Tungsten Oxide Nano-heterojunction with Improved Surface-Enhanced Raman Scattering Performance

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ACS APPLIED MATERIALS & INTERFACES 2021年第28期13卷 33345-33353页

作者： Xie, Songyang Chen, Dong Gu, Chenjie Jiang, Tao Zeng, shuwen Wang, Ying Ying Ni, Zhenhua Shen, xiang Zhou, Jun Ningbo Univ Photon Res Inst Ningbo 315211 Peoples R China Harbin Inst Technol Weihai Dept Optoelect Sci Weihai 264209 Peoples R China Southeast Univ Sch Phys Nanjing 211189 Peoples R China Univ Limoges XLIM Res Inst CNRS F-87060 Limoges France

By virtue of their high uniformity and stability, metal oxide-based surface-enhanced Raman spectroscopy (SERS) substrates have attracted enormous attention for molecular trace detection. However, strategies for further enhancing the SERS sensitivity are still desired. Herein, MoOx/WOx nano-heterojunctions are constructed by mixing MoOx and WOx together (MoOx/WOx hybrid) with diverse weight ratios. Using a 532 nm laser as the excitation source and R6G as the Raman reporter, it is shown that the Raman signal intensity (for the peak @ 1360 cm(-1)) obtained on the optimal MoOx/WOx hybrid (MoOx/WOx = 1:1/3) is twice that observed on a pure MoOx or WOx substrate. Moreover, a limit of detection of 10(-8) M and an enhancement factor of 10(8) are achieved. In the SERS enhancement mechanism investigation, it is revealed that MoOx and WOx form a staggered band structure. During the SERS measurement, electron-hole pairs are generated in the nano-heterojunction using the incident laser. They are then separated by the built-in potential with the electrons moving toward WOx. The accumulated electrons on WOx are further transferred to the R6G molecules through the coupling of orbitals. Consequently, the molecular polarizability is amplified, and SERS performance is enhanced. The abovementioned explanation is supported by the evidence that the contribution of the chemical enhancement mechanism in the optimal MoOx/WOx hybrid substrate is about 2.5 times or 5.9 times that in the pure WOx or MoOx substrate.

关键词： SERS molybdenum oxides tungsten oxides nano-heterojunction charge transfer

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SIRT1 single-nucleotide polymorphisms are associated with corticosteroid sensitivity in primary immune thrombocytopenia patients

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ANNALS OF HEMATOLOGY 2021年第10期100卷 2453-2462页

作者： Wang, shuwen Zhang, Xiaoyu Leng, Shaoqiu Zhang, Yanqi Li, Ju Peng, Jun Zhou, Zeping Feng, Qi Hu, xiang Shandong Univ Qilu Hosp Cheeloo Coll Med Dept Hematol Jinan Peoples R China Shandong Univ Qilu Hosp Cheeloo Coll Med Shandong Prov Key Lab Immunohematol Jinan Peoples R China Chinese Acad Med Sci & Peking Union Med Coll State Key Lab Expt Hematol Inst Hematol Tianjin Peoples R China Chinese Acad Med Sci & Peking Union Med Coll Blood Dis Hosp Tianjin Peoples R China Kunming Med Univ Affiliated Hosp 2 Dept Hematol Kunming Yunnan Peoples R China

Background Primary immune thrombocytopenia (ITP) is an autoimmune disorder characterized by decreased platelet count. While corticosteroids are a useful first-line therapy for ITP patients, their long-term effectiveness is limited, and the determinants of corticosteroid sensitivity in ITP patients remain largely unknown. Sirtuin 1 (SIRT1), a member of the mammalian sirtuin family, is related to the anti-inflammatory effects of corticosteroids. Here, we investigate the contribution of the SIRT1 single-nucleotide polymorphisms (SNPs) rs12778366 and rs4746720 to ITP susceptibility. Methods We recruited 330 ITP patients and 309 healthy controls from Han population, and performed genotyping of SIRT1 rs12778366 and rs4746720 using a MassARRAY system. The results were validated in another 55 ITP patients from ethnic minorities. Results Using clinical data of patients and controls from Han polulation, including corticosteroid sensitivity, susceptibility, refractoriness, and severity, our results revealed that the CC/TC genotypes of SIRT1 rs12778366 were associated with a 2.034-fold increased risk of corticosteroid resistance compared to the homozygous major TT genotype (dominant, CC/TC vs. TT, OR = 2.034, 95% CI = 1.039-3.984, p = 0.038). In contrast, the CC/CT genotype of SIRT1 rs4746720 showed a 0.560-fold decreased risk of corticosteroid resistance (dominant, 95% CI = 0.321-0.976, OR = 0.560, p = 0.041). The C allele substitute in SIRT1 rs12778366 was significantly associated with the corticosteroid sensitivity of ITP patients (p = 0.021). The similar results were obtained in minority ITP patients. Conclusion This study indicates that SIRT1 rs12778366 and rs4746720 may be genetic factors related to corticosteroid sensitivity in ITP patients.

关键词： Primary immune thrombocytopenia SIRT1 Single-nucleotide polymorphism Corticosteroid sensitivity

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Antitumor potential of Hedyotis diffusa Willd: A systematic review of bioactive constituents and underlying molecular mechanisms

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BIOMEDICINE & PHARMACOTHERAPY 2020年 130卷 110735-110735页

作者： Han, Xinru Zhang, xiang Wang, Qian Wang, Lu Yu, shuwen Shandong First Med Univ Dept Pharm Cent Hosp Jinan 250013 Shandong Peoples R China

Cancer is a major cause of death in the world. Chemotherapy can extend the life of cancer patients to some extent, but the quality of life is reduced. Therefore, the quest for more efficient and less toxic medication strategies is still at the forefront of current research. Hedyotis diffusa Willd (HDW), a Chinese herb medicine, has received great attention in the past two decades and has been well documented in clinics for antitumor activity in a variety of human cancers. This review discussed a total of 58 different kinds of active antitumor components isolated from HDW, including iridoids, flavonoids, flavonol glycosides, anthraquinones, phenolic acids, and their derivatives, sterols, and volatile oils. Their antitumor activities include inhibition of tumor cell proliferation, induction of tumor cell apoptosis and tumor angiogenesis, regulation of the host immune response, anti-inflammatory and antioxidant, and protective autophagy. Besides, we provide up-to-date and systematic evidence for HDW antitumor activities and the possible underlying molecular mechanisms and reference for further development of novel drugs and dosage formulation in control of human cancers.

关键词： Hedyotis diffusa Willd Antitumor activity Apoptosis Proliferation Cell cycle termination Anti-inflammation

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Electrical Tuning of MoOx/Ag Hybrids and Investigation of their Surface-Enhanced Raman Scattering Performance

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PHYSICA STATUS SOLIDI-RAPID RESEARCH LETTERS 2021年第2期15卷

作者： Xu, Yinghao Lai, Kui Gu, Chenjie Jiang, Tao Shen, xiang Zeng, shuwen Ho, Aaron Ho-Pui Ang, Diing Shenp Zhou, Jun Ningbo Univ Inst Photon 818 Fenghua Rd Ningbo 315211 Peoples R China Univ Limoges XLIM Res Inst CNRS Ave Albert Thomas F-87060 Limoges France Chinese Univ Hong Kong Dept Elect Engn Shatin Hong Kong Peoples R China Nanyang Technol Univ Sch Elect & Elect Engn 50 Nanyang Ave Singapore 639798 Singapore

Surface-enhanced Raman scattering (SERS) technology is a cutting-edge analytical tool for molecule detection. Attractive SERS performance has been achieved on noble metal nanostructures;however these substrates usually suffer from difficulties of direct adjusting of the physical structures to achieve tunable SERS performance. Studies on semiconductor oxides have revealed that attractive SERS performance can be obtained on them, but strategies of engineering material properties for SERS performance improvement still pose a challenge. Here, an electrically programmable SERS substrate is prepared by depositing hydrothermally synthesized MoOx/Ag hybrids within electrodes as the SERS active region. In the experiment, an electrical field is applied on the electrodes to regulate Ag+ ion migration and redeposition in the MoOx solid electrolyte. Through adjusting the leakage current level, the size of the Ag nanoparticles in the MoOx/Ag hybrids is electrically controlled. The SERS performance of the substrate is evaluated using rhodamine 6G as the Raman reporter. The results evidence that Raman enhancement factors of 1.13 x 10(5), 4.75 x 10(5), and 1.04 x 10(6) can be obtained by programming the leakage current level to 10(-7), 10(-5), and 10(-3) A, respectively. A maximum detection limit of 10(-8) m is achieved on the 10(-3) A substrate.

关键词： electrical programming electromagnetic enhancement molybdenum oxide Ag nanoparticle hybrids surface-enhanced Raman scattering

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基于有限理性的信息集广义多目标博弈

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深圳大学学报（理工版） 2018年第1期35卷 105-109页

作者：何基好向淑文贾文生邓喜才贵州大学计算机科学与技术学院贵州贵阳550025 贵州大学数学与统计学院贵州贵阳550025 贵州师范学院数学与计算机系贵州贵阳550018

研究基于有限理性的信息集广义多目标博弈的弱Pareto-Nash平衡问题的稳定性.在信息集广义多目标博弈的弱Pareto-Nash平衡问题的度量空间是完备度量空间的结论下,运用博弈论语言描述的有限理性模型建立此问题的有限理性模型,通过验证一... 详细信息

研究基于有限理性的信息集广义多目标博弈的弱Pareto-Nash平衡问题的稳定性.在信息集广义多目标博弈的弱Pareto-Nash平衡问题的度量空间是完备度量空间的结论下,运用博弈论语言描述的有限理性模型建立此问题的有限理性模型,通过验证一些假设得到,弱Pareto-Nash平衡问题是结构稳定的,对ε-平衡是鲁棒的.

关键词：运筹学博弈论信息集广义多目标博弈弱Pareto-Nash平衡点有限理性稳定性

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Effect of Centipeda Herba Volatile Oil on Allergic Rhinitis by Nasal Sniffing

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Medicinal Plant 2024年第6期15卷 79-82页

作者： xiang QIN Xiaoni PAN Yuan PAN Yanfeng MO shuwen LI Tingting XIE Shiyou ZHOU Jiancheng LIANG Lixiang LU Suoyi HUANG School of Clinical Medicine Youjiang Medical University for NationalitiesBaise 533000China School of Public Health and Management Youjiang Medical University for NationalitiesBaise 533000China Key Laboratory of Research on Characteristic Ethnic Medicine in the Youjiang River Basin of Guangxi Colleges and Universities Baise 533000China

[Objectives] To explore the efficacy of different concentrations of Centipeda Herba volatile oil in the treatment of allergic rhinitis (AR) by nasal sniffing and the optimal drug concentration.[Methods] Forty-eight mice were randomly divided into control group, blank group, alcohol treatment group, low concentration group, medium concentration group and high concentration group, with 8 mice in each group. Except for the blank group, each mouse in the other groups was intraperitoneally injected with 1 mL of a mixture of 50 μgOVA+5 mg [Al(OH)_(3)] +1 mL of normal saline for 14 d. The allergic rhinitis mouse model was successfully established by intranasal instillation of 5% OVA solution on both sides (20 μL per side, once a day) from the 15 th day after stimulation for 7 d. The blank group was treated with the same amount of saline as above. The volatile oil of Centipeda Herba was obtained by steam distillation and petroleum ether extraction, and then was made into 1.25%, 2.5% and 5% volatile oil of Centipeda Herba with 75% alcohol. The control group was stimulated once every other day with reagent 2 after 7 d of stimulation (maintenance) until the end of treatment. The blank group was treated with 5 mL saline by nasal sniffing for 30 d, twice in the morning and evening, 30 min each time. The alcohol treatment group was treated with 5 mL of 75% alcohol, and the low concentration group, the medium concentration group and the high concentration group were treated with 5 mL of 1.25%, 2.5% and 5% Centipeda Herba volatile oil, respectively. The treatment time was the same as that of the blank group, and the treatment process was carried out in their respective closed contamination boxes. Before and after the treatment, the frequency of sneezing, the frequency of scratching nose, the amount of nasal discharge, activity and other general characteristics of the mice were observed, and the allergic behavior score was carried out. Besides, the IgE content in the serum of the mi

关键词： Allergic rhinitis Volatile oil of Centipeda Herba Nasal sniffing therapy IgE Eosinophil

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