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Study on the dual-Fano resonance generation and its potential for self-calibrated sensing

OPTICS EXPRESS 2020年第16期28卷 23703-23716页

作者： Zhao, xiang Cheng, Zhuo Zhu, Ming Huang, Tianye Zeng, shuwen Pan, Jianxing Song, Chaolong Wang, Yuhan Shum, Perry Ping China Univ Geosci Sch Mech Engn & Elect Informat Wuhan 430074 Peoples R China Huazhong Univ Sci & Technol Sch Elect Informat & Commun Wuhan 430074 Peoples R China Wuhan Natl Lab Optoelect Wuhan 430074 Peoples R China Univ Limoges CNRS UMR 7252 XLIM Res Inst 123 Ave Albert Thomas F-87060 Limoges France

Sensors based on Fano resonance (FR) have become a promising platform for various biological and chemical applications. However, most investigations on FR are limited to the generation of individual resonance. In this paper, based on the coupling between surface plasmon polariton (SPP) and two photonic waveguide modes, a dual-FR system is designed and analyzed. To explain the coupling mechanism, an extended temporal coupled-mode model is established to provide the physical insight. The spectral response obtained from the model matches well with the numerical one. Due to the decoupled nature of the FRs, a self-calibrated or dual-parameter sensing scheme for refractive index and temperature is proposed. The refractive index sensitivity up to 765 nm/RIU and temperature sensitivity up to 0.087 nm/degrees C are obtained by wavelength interrogation with figure-of-merit (FOM) up to 33260.9 RIU-1 and 3.78 degrees C-1 respectively. The proposed sensor provides great potential in fields of the multi-parameter sensing. (C) 2020 Optical Society of America under the terms of the OSA Open Access Publishing Agreement

关键词： Attenuated total reflectance Effective refractive index Fano resonance Refractive index Total internal reflection Waveguide modes

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Simultaneous Mid-Infrared Gas Sensing and Upconversion Based on Third Harmonic Generation in Cascaded Waveguides

IEEE PHOTONICS JOURNAL

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IEEE PHOTONICS JOURNAL 2020年第2期12卷 1-12页

作者： Pan, Jianxing Chen, Zhenxing Huang, Tianye Zeng, shuwen Cheng, Zhuo Huang, Pan Zhao, xiang Shum, Perry Ping Brambilla, Gilberto China Univ Geosci Wuhan Sch Mech Engn & Elect Informat Wuhan 430074 Peoples R China Wuhan Natl Lab Optoelect Wuhan 430074 Peoples R China Univ Limoges UMR 7252 CNRS XLIM Res Inst F-87060 Limoges France Nanyang Technol Univ Ctr Fiber Technol Sch Elect & Elect Engn Singapore 637553 Singapore Univ Southampton Optoelect Res Ctr Univ Rd Southampton SO17 1BJ Hants England

The performance of conventional gas sensors based on light absorption in the mid-infrared are limited by the high-cost and low efficiency of photon detection at these wavelengths. In this paper, cascaded suspended waveguides are proposed and analyzed for mid-infrared gas sensing with enhanced detection limit. The cascaded structure contains two sections in which the first part is optimized for light absorption and the other one is tailored to satisfy the phase matching condition for third harmonic generation toward near-infrared wavelengths. In this configuration, the input mid-infrared light firstly experiences "fingerprint" frequency absorption in the on-chip gas chamber. Consequently, the residuary light produces third harmonic radiation in the second section. Benefiting from the nonlinear relation between pump and harmonic power, the sensitivity of the sensor is significantly improved. Moreover, the signal is up converted from mid-infrared to near-infrared and thus it can be easily detected by efficient near-infrared detectors. The results show that the detection limit can reach the order of nmol/L and the absorption lengths can be reduced to three times shorter comparing to direct mid-infrared detection. The proposed configuration has great potential for high performance on-chip gas sensing.

关键词： Photonic sensor cascaded devices suspended waveguides third harmonic generation

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基于司外揣内从六经辨证探讨肿瘤“症-经-证”辨治模式

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中华中医药杂志 2023年第12期38卷 5888-5891页

作者：李燕黄文博周舒雯陈想祝捷由凤鸣付西成都中医药大学附属医院成都610072 成都中医药大学肿瘤研究所成都610075

肿瘤症状纷繁复杂,亟待一定的辨治模式用以指导中医临证。司外揣内提供由外症判断内证的基本思路,而实现从症到证的抽象转化须赖于逻辑严谨的辨证思维,以症归六经、六经分证为思维模式的六经辨证不失为连接症-证的逻辑桥梁。文章结合司... 详细信息

肿瘤症状纷繁复杂,亟待一定的辨治模式用以指导中医临证。司外揣内提供由外症判断内证的基本思路,而实现从症到证的抽象转化须赖于逻辑严谨的辨证思维,以症归六经、六经分证为思维模式的六经辨证不失为连接症-证的逻辑桥梁。文章结合司外揣内与六经辨证创建肿瘤“症-经-证”三位一体辨治模式,据症归经、依经判证、由证论治为具体步骤,通过探讨此辨治模式在肺癌、胃癌、乳腺癌三大恶性肿瘤的临证应用,为类推于诸多肿瘤的治疗提供了参考。创建中医肿瘤辨治模式,可以拓展中医肿瘤临床诊疗思路,达到提升临床疗效的目的。

关键词：司外揣内六经辨证症-经-证肿瘤辨治模式

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Emodin improves alveolar hypercoagulation and inhibits pulmonary inflammation in LPS-provoked ARDS in mice via NF-κB inactivation

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INTERNATIONAL IMMUNOPHARMACOLOGY 2020年 88卷 107020-107020页

作者： Liu, Bo Cheng, Yumei Wu, Yanqi Zheng, Xinghao Li, xiang Yang, Guixia He, Tianhui Li, shuwen Shen, Feng Guizhou Med Univ Dept Intens Care Unit Affiliated Hosp Guiyang 550001 Peoples R China Guizhou Med Univ Guiyang 550001 Peoples R China

Background: Alveolar hypercoagulation and pulmonary inflammation are important characteristics and they regulate each other in acute respiratory distress syndrome (ARDS). NF-kappa B pathway has been confirmed to be involved in regulation of this crosstalk. Emodin, a traditional Chinese herb, shows potent inhibitory effect on NF-kappa B pathway, but whether it is effective in alveolar hypercoagulation and pulmonary inflammation in ARDS remains to be elucidated. Purpose: The aim of this experiment was to evaluate the efficacy of emodin on LPS-provoked alveolar hypercoagulation and excessive pulmonary inflammation in ARDS, and its potential mechanism. Methods: Mice ARDS was set up through LPS (40 mu l, 4 mg/ml) inhalation. Male mice were randomly received with BPS, LPS only, LPS + emodin (5 mg/kg, 10 mg/kg, 20 mg/kg, respectively) and BAY65-1942, an inhibitor of IKK beta. After 48 h of LPS stimulation, pulmonary pathological injury, expressions of Tissue factor (TF), plasminogen activator inhibitor (PAI)-1, activated protein C (APC), collagen I, collagen III, interleukin (IL) 8, IL-1 beta and tumor necrosis factor (TNF)-alpha in lung tissues, as well as concentrations of antithrombin III (AT III), procollagen peptide type III (PIIIP), soluble thrombomodulin (sTM), thrombin antithrombin complex (TAT), myeloperoxidase (MPO) and the percentage of inflammatory cells in bronchoalveolar lavage fluid (BALF) were all determined. NF-kappa B pathway activation as well as NF-kappa B DNA binding activity in pulmonary tissue were simultaneously checked. Results: LPS stimulation resulted in obvious lung injury, excessive inflammatory cells infiltration, which all were dose-dependently ameliorated by emodin. Expressions of TF, PAI-1, collagen I and collagen III as well as IL-8, IL-1 beta and TNF-alpha in pulmonary tissue were all elevated while APC decreased under LPS provocation, which were all reversed by emodin treatment in dose-dependent manner. LPS promoted the secretions of PII

关键词： Emodin Acute respiratory distress syndrome NF-kappa B pathway Alvolar hypercoagulation and fibrinolytic inhibition Pulmonary inflammation

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Dietary supplementation with protein hydrolysates from the shell of red swamp crayfish (Procambarus clarkii) affects growth, muscle antioxidant capacity and circadian clock genes expression of zebrafish (Danio rerio)

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AQUACULTURE REPORTS 2022年 27卷

作者： Li, Honghui Isaac, Niyokwizera He, shuwen Ou, Xiaohui xiang, Jing Tian, Xing Zhu, Haojie Liu, Li Wen, Li Chu, Wuying Changsha Univ Sci & Technol Sch Food Sci & Bioengn Changsha 410114 Peoples R China Changsha Univ Coll Biol & Environm Engn Hunan Prov Key Lab Nutr & Qual Control Aquat Anim Changsha 410022 Peoples R China Hunan Fisheries Sci Inst Changsha 410153 Peoples R China Changsha Univ Coll Biol & Environm Engn Changsha 410022 Hunan Peoples R China

Protein hydrolysates are rich in amino acids and bioactive peptides, beneficial for the organism health. This study analyzed not only the effects of dietary supplementation with P. clarkii shell protein hydrolysates (PCSPHs) on the growth performance, muscle biochemical indices and histological characteristics of zebrafish, but also the changes of muscle antioxidant capacity and circadian clock genes expression were also evaluated. After feeding, the final body weight, weight gain rate and specific growth rate of zebrafish fed with PCSPHs supplementation were significantly higher than normal diet, and reduced contents of muscle triglyceride and aspartate amino-transferase. Meanwhile, dietary supplementation with PCSPHs improved total amino acid contents and myofiber structure of zebrafish. Antioxidant enzyme activities of total superoxide dismutase (T-SOD), catalase (CAT), glutathione peroxidase (GPx) and glutathione (GSH) content, and the expression of antioxidant related genes increased with PCSPHs supplementation. Furthermore, the expression of Nrf2 protein showed a significantly up -regulated trend with the increasing of dietary PCSPHs levels. However, it was interesting that the expression of circadian rhythm related genes was also affected by dietary PCSPHs levels, and showed a significant up-regulated and down-regulated trend. The above results showed that dietary supplementation with PCSPHs could promote the growth performance, muscle amino acid contents and myofiber structure of zebrafish, but also enhance the muscle antioxidant capacity and regulates the expression of circadian clock genes. It is hypothesized that this may be related to the expression of antioxidant signaling pathway Nrf2/Keap1. Our study will provide a theo-retical basis for improving the muscle quality and health of aquatic animals.

关键词： Procambarus clarkii shell Protein hydrolysates Muscle Antioxidant capacity Circadian clock genes

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小规模限制性在线课程在放射科住培生临床教学中的研究进展

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影像研究与医学应用 2025年第7期9卷 8-10页

作者：董淑雯崔园园樊荣荣王祥徐少春萧毅海军军医大学第二附属医院放射诊断科上海200003

随着医学教育的变革,小规模限制性在线课程(SPOC)这种新兴教学模式在医学领域逐渐兴起。放射科因其学科特性,需充分掌握专业技能,方可获得更为精准的检查结果,以辅助临床各类疾病的诊疗,故对住院医师规范化培训的教学质量要求颇高。SPO... 详细信息

随着医学教育的变革,小规模限制性在线课程(SPOC)这种新兴教学模式在医学领域逐渐兴起。放射科因其学科特性,需充分掌握专业技能,方可获得更为精准的检查结果,以辅助临床各类疾病的诊疗,故对住院医师规范化培训的教学质量要求颇高。SPOC教学具有小规模、限制性及在线教学等特点,带教老师能精准关注学生个体,限制性保证学生基础和能力相近,在线教学则提供丰富且灵活的学习资源。近年来,SPOC在医学领域的多学科教学中广泛应用,并取得一定的成效,本文综述了其在放射科住培生临床教学中的应用进展。

关键词：小规模限制性在线课程放射科住培生临床教学临床技能虚拟影像系统

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Highly Sensitive Polarimetric Sensor Based on Fano Resonance for DNA Hybridization Detection

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PLASMONICS 2020年第3期15卷 769-781页

作者： Zhao, xiang Huang, Tianye Zeng, shuwen Son, Chaolong Cheng, Zhuo Wu, Xu Huang, Pan Pan, Jianxing Wu, Yiheng Shum, Perry Ping China Univ Geosci Wuhan Sch Mech Engn & Elect Informat Wuhan 430074 Peoples R China Univ Limoges UMR 7252 CNRS XLIM Res Inst 123 Ave Albert Thomas F-87060 Limoges France Nanyang Technol Univ Ctr Fiber Technol Elect & Elect Engn Singapore Singapore

Surface plasmon resonance (SPR) sensor based on reflectivity measurement has been widely studied for its convenient detection, high sensitivity, and real-time functions. However, the resonance curves of SPR reflectivity spectrum are broad that lead to a low detection limit (DL) and low detection resolution. In this work, Fano resonance (FR), which has an asymmetrical sharp and narrow resonance peak, is demonstrated here to improve the DL and resolution of the plasmonic sensor. More importantly, a three-point method is employed here to analyzed and extract the polarization information of the reflected light by replacing the conventional intensity interrogation method. The sharp signal change of the Fano resonance realized by the designed configuration together with the three-point method led to a significantly enhancement on the DL and the resolution of the FR-based sensor up to one order of magnitude comparing to conventional scheme commonly used with the commercial products. Thus, the proposed sensor is of great potential for biochemical sensing such as DNA detection in terms of measuring the refractive index change at the sensing interface.

关键词： Fano resonance Three-point method Detection limit Biochemical sensing

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基于虚拟现实的人工智能技术在放射科临床教学中的应用现状及展望

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影像研究与医学应用 2024年第22期8卷 1-3页

作者：王祥徐少春孙红标董淑雯段广闻范丽海军军医大学长征医院放射诊断科上海200002

放射科作为一门临床辅助诊断的学科,不仅具有较强的专业性,而且具有较高的实践性,因此,具有综合素质强的放射科专业人才非常重要。现阶段,在放射科的临床教学工作中,还存在各种各样的不足之处,如学生的学习积极性低,缺乏学习兴趣,师生... 详细信息

放射科作为一门临床辅助诊断的学科,不仅具有较强的专业性,而且具有较高的实践性,因此,具有综合素质强的放射科专业人才非常重要。现阶段,在放射科的临床教学工作中,还存在各种各样的不足之处,如学生的学习积极性低,缺乏学习兴趣,师生之间缺乏有效的交流互动,教学效率不高,教学理念落后等。人工智能在医学影像诊断中的应用已经逐渐成熟,在医学教育领域中,将人工智能技术与虚拟现实相结合,可提供更直观、更立体的影像,帮助医师更准确地进行病变诊断和分析。本文对基于虚拟现实的人工智能技术在放射科临床教学中的应用现状进行综述,以期提升其普及率,进而提升放射科临床教学工作的质量及效率。

关键词：虚拟现实人工智能技术放射科临床教学

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Piezo1 deficiency alleviates acute liver failure by inhibiting CpG-ODN induced inflammatory responses

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INTERNATIONAL IMMUNOPHARMACOLOGY 2025年 159卷 114879页

作者： Zhao, Ruxia Zhang, Xiaoyu Liu, Xinyue Wang, shuwen Leng, Shaoqiu Peng, Jun Hu, xiang Shandong Univ Qilu Hosp Dept Hematol Jinan Peoples R China Shandong Univ Qilu Hosp Shandong Key Lab Hematol Dis & Immune Microenviron Jinan Peoples R China Chinese Acad Med Sci & Peking Union Med Coll Inst Hematol Natl Clin Res Ctr Blood Dis State Key Lab Expt Hematol Tianjin Peoples R China Chinese Acad Med Sci & Peking Union Med Coll Blood Dis Hosp Tianjin Peoples R China Shandong Univ State Key Lab Innovat & Transformat Luobing Theory Jinan Peoples R China Shandong Univ Key Lab Cardiovasc Remodeling & Funct Res MOE NHC CAMS & Shandong Prov Jinan Peoples R China Shandong Univ Qilu Hosp Dept Cardiol Jinan Peoples R China

Macrophages play a critical role in the progression of acute liver failure (ALF), a life-threatening clinical syndrome characterized by the rapid onset of liver injury. Recent research suggests that mechanosensation signaling may be pivotal in modulating acute inflammation. However, its involvement in ALF pathogenesis remains poorly understood. In this study, we found that Piezo1 was highly expressed in liver macrophages during liver injury in both humans and mice. Mice with macrophage-specific Piezo1 depletion were resistant to CpG-ODN/D-GalNinduced ALF, whereas mice pretreated with Yoda1 showed increased susceptibility. Furthermore, Piezo1deficient macrophages exhibited reduced secretion of inflammatory cytokines upon CpG-ODN stimulation in vitro, while Yoda1 treatment enhanced cytokine secretion. Mechanistically, Piezo1 activation promotes the phosphorylation of CaMKII, which further enhances CpG-ODN-induced NF-kappa B activation. Additionally, Piezo1 activation promotes the endosomal translocation of TLR9 through the cytoskeleton remodeling. These findings suggest that Piezo1-mediated mechanosensation contributes to the development of CpG-ODN/D-GalN-induced ALF and may serve as a potential therapeutic target.

关键词： Piezo1 Liver failure Inflammation TLR9 Cytoskeleton

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Hydraulics and Mixing of the Deep Overflow in the Lifamatola Passage of the Indonesian Seas

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JOURNAL OF PHYSICAL OCEANOGRAPHY 2020年第9期50卷 2797-2814页

作者： Tan, shuwen Pratt, Larry J. Yuan, Dongliang Li, xiang Wang, Zheng Li, Yao Corvianawatie, Corry Surinati, Dewi Budiman, Asep S. Bayhaqi, Ahmad Chinese Acad Sci Inst Oceanol Key Lab Ocean Circulat & Waves Qingdao Peoples R China Qingdao Natl Lab Marine Sci & Technol Qingdao Peoples R China Chinese Acad Sci Ctr Ocean Megasci Qingdao Peoples R China Univ Chinese Acad Sci Beijing Peoples R China Woods Hole Oceanog Inst Dept Phys Oceanog Woods Hole MA USA Indonesian Inst Sci Res Ctr Oceanog Jakarta Indonesia

Hydrographic measurements recently acquired along the thalweg of the Lifamatola Passage combined with historical moored velocity measurements immediately downstream of the sill are used to study the hydraulics, transport, mixing, and entrainment in the dense overflow. The observations suggest that the mean overflow is nearly critical at the mooring site, suggesting that a weir formula may be appropriate for estimating the overflow transport. Our assessment suggests that the weir formulas corresponding to a rectangular, triangular, or parabolic cross section all result in transports very close to the observation, suggesting their potential usage in long-term monitoring of the overflow transport or parameterizing the transport in numerical models. Analyses also suggest that deep signals within the overflow layer are blocked by the shear flow from propagating upstream, whereas the shallow wave modes of the full-depth continuously stratified flow are able to propagate upstream from the Banda Sea into the Maluku Sea. Strong mixing is found immediately downstream of the sill crest, with Thorpe-scale-based estimates of the mean dissipation rate within the overflow up to 1.1 x 10(-7) W kg(-1) and the region-averaged diapycnal diffusivity within the downstream overflow in the range of 2.3 x 10(-3) to 10.1 x 10(-3) m(2) s(-1). Mixing in the Lifamatola Passage results in 0.6-1.2-Sv (1 Sv = 10(6) m(3) s(-1)) entrainment transport added to the overflow, enhancing the deep-water renewal in the Banda Sea. A bulk diffusivity coefficient estimated in the deep Banda Sea yields 1.6 x 10(-3) +/- 5 x 10(-4) m(2) s(-1), with an associated downward turbulent heat flux of 9 W m(-2).

关键词： Diapycnal mixing Entrainment Internal waves Topographic effects In situ oceanic observations

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