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Hypophosphatemia is an independent risk factor for AKI among hospitalized patients with COVID-19 infection

RENAL FAILURE 2021年第1期43卷 1329-1337页

作者： Chen, Zijin Gao, Chenni yu, Haijin Lu, Lin Liu, Jialin Chen, Wei Xiang, Xiaogang Hussain, Hafiz Muhammad Jafar Lee, Benjamin J. Li, Chuanlei Wei, Wenjie Huang, yuhan Li, Xiang Fang, Zhengying yu, shuwen Weng, Qinjie Ouyang, Yan Hu, Xiaofan Tong, Jun Liu, Jian Lin, Li Liu, Mingyu Xu, Xiaoman Liu, Dan Song, yuan Lv, Xifeng Zha, Yixin Ye, Zhiyin Jiang, Tingting Jia, Jieshuang Chen, Xiaonong Bi, yufang Xue, Jun Chen, Nan Hu, Weiguo He, Cijiang John Wang, Huiming Liu, Jun Xie, Jingyuan Shanghai Jiao Tong Univ Inst Nephrol Sch Med Ruijin HospDept Nephrol 197 Ruijin Er Rd Shanghai 200025 Peoples R China Fudan Univ North Huashan Hosp Dept Nephrol Shanghai Peoples R China Shanghai Jiao Tong Univ Sch Med Ruijin Hosp Dept Crit Care Med Shanghai Peoples R China Shanghai Jiao Tong Univ Inst Resp Dis Sch Med Ruijin HospDept Pulm & Critical Care Med Shanghai Peoples R China Shanghai Jiao Tong Univ Sch Med Ruijin Hosp Dept Infect Dis Shanghai Peoples R China Houston Kidney Consultants Houston TX USA Houston Methodist Inst Acad Med Houston TX USA Shanghai Jiao Tong Univ Shanghai Gen Hosp Dept Nephrol 85 Wujin Rd Shanghai 200080 Peoples R China Wuhan Ninth Hosp Wuhan Peoples R China Wuhan Ninth Hosp Renal Dept Wuhan Hubei Peoples R China Wuhan Univ Renmin Hosp Radiol Dept Wuhan Hubei Peoples R China Wuhan Univ Renmin Hosp Renal Dept Jiefang Rd 238 Wuhan 430060 Hubei Peoples R China Shanghai Jiao Tong Univ Shanghai Gen Hosp Clin Res Ctr Shanghai Peoples R China Shanghai Jiao Tong Univ Sch Med Ruijin Hosp Dept Endocrinol & Metab Dis Shanghai Peoples R China Fudan Univ Huashan Hosp Dept Nephrol Shanghai Peoples R China Shanghai Jiao Tong Univ Ruijin Hosp Sch Med Dept Surg Shanghai Peoples R China Mt Sinai Sch Med Div Nephrol New York NY USA

Background This study sought to investigate incidence and risk factors for acute kidney injury (AKI) in hospitalized COVID-19. Methods In this retrospective study, we enrolled 823 COVID-19 patients with at least two evaluations of renal function during hospitalization from four hospitals in Wuhan, China between February 2020 and April 2020. Clinical and laboratory parameters at the time of admission and follow-up data were recorded. Systemic renal tubular dysfunction was evaluated via 24-h urine collections in a subgroup of 55 patients. Results In total, 823 patients were enrolled (50.5% male) with a mean age of 60.9 +/- 14.9 years. AKI occurred in 38 (40.9%) ICU cases but only 6 (0.8%) non-ICU cases. Using forward stepwise Cox regression analysis, we found eight independent risk factors for AKI including decreased platelet level, lower albumin level, lower phosphorus level, higher level of lactate dehydrogenase (LDH), procalcitonin, C-reactive protein (CRP), urea, and prothrombin time (PT) on admission. For every 0.1 mmol/L decreases in serum phosphorus level, patients had a 1.34-fold (95% CI 1.14-1.58) increased risk of AKI. Patients with hypophosphatemia were likely to be older and with lower lymphocyte count, lower serum albumin level, lower uric acid, higher LDH, and higher CRP. Furthermore, serum phosphorus level was positively correlated with phosphate tubular maximum per volume of filtrate (TmP/GFR) (Pearson r = 0.66, p < .001) in subgroup analysis, indicating renal phosphate loss via proximal renal tubular dysfunction. Conclusion The AKI incidence was very low in non-ICU patients as compared to ICU patients. Hypophosphatemia is an independent risk factor for AKI in patients hospitalized for COVID-19 infection.

关键词： COVID-19 proximal tubule acute kidney injury risk factors hypophosphate

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Noncooperative multiagent game model for the electricity market on the basis of the renewable energy portfolio standard

ENGINEERING REPORTS

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ENGINEERING REPORTS 2022年第10期4卷

作者： Zhao, Wenhui Fan, shuwen Hou, Jiansheng yu, Jinlong Shanghai Univ Elect Power Coll Econ & Management Shanghai 200090 Peoples R China Jin Hua Elect Power Design Inst Co LTD Jinhua Zhejiang Peoples R China State Grid Huang Shan Power Supply Co Huangshan Peoples R China

In China, after the revision of the renewable energy policy, transactions among the main parties involved in the electricity market are becoming increasingly complicated. Nevertheless, the impact of the Renewable Energy Portfolio Standard (RPS) on market equilibrium has not been studied so far. Hence, in this study, a noncooperative multiagent game model for the electricity market was developed on the basis of the recently released RPS and by considering various factors, such as green certificate transactions and the changing of the selling entities. The improved firefly algorithm was used to solve the model, and problematic gaming was analyzed empirically. Once the new RPS is implemented, the price of bound electricity will become higher than that of nonbound electricity, and the trading volume of bound electricity will increase. Because fossil energy producers will no longer be responsible for the electricity quotas, their electricity trading volumes will now be more related to the market demand than they were earlier. Renewable energy companies will increase their revenues by reducing their bound electricity sales. If the RPS increases the electricity quota ratios, the costs incurred by electricity sales companies and large power users will also increase, leading the electricity sales companies to reduce their electricity trading volumes. The study findings will help analyze the impacts of implementing the RPS and provide a basis and a reference for policymakers to make improvements to the standard in the future.

关键词： electricity market noncooperative multiagent game model renewable energy development RPS

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Simulation and Experimental Investigation of Fe-based Alloy Powder Production by Gas Atomization

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JOURNAL OF MATERIALS ENGINEERING AND PERFORMANCE 2024年 1-16页

作者： Guan, shuwen Gan, Bin Liu, Shichang Chen, Fucai Tan, Bo Liu, Zhen Xiao, Guanfei yu, Bo CAM Shenyang Res Inst Foundry Co Ltd Natl Key Lab Adv Casting Technol Shenyang 110022 Peoples R China Nucl Power Inst China Sci & Technol Reactor Syst Design Technol Lab Chengdu 610213 Peoples R China

The gas atomization is commonly utilized to produce metal powder in additive manufacturing. Based on experimental data, this paper used computational fluid dynamics to simulate the flow field and analyze the gas-melt two-phase mechanism in two-stage atomization. The study investigated the impact of atomization parameters and nozzle structure on aspiration pressure, gas flow field, and particle size distribution. The results indicated that a delivery tube protrusion length of 3 mm achieves a stable atomization process. Furthermore, the particle size of the powder decreased initially and then increased with an increase in injection angle. The VOF (Volume of Fluid) model and DPM (Discrete Phase Model) could effectively simulate the gas atomization process, with the simulated particle size distribution closely aligning with the experimental results. The experimental Fe-based alloy powder exhibited good sphericity with minimal satellites, making it suitable for laser additive manufacturing with metallic materials.

关键词： atomization parameters gas atomization metal powder nozzle structure numerical simulation

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SAP30 promotes clear cell renal cell carcinoma proliferation and inhibits apoptosis through the MT1G axis

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EUROPEAN JOURNAL OF MEDICAL RESEARCH 2025年第1期30卷 1-15页

作者： Guo, Wei Wang, shuwen Yang, Zitong Dong, yu Xia, Zhinan Xue, Wei Zhang, Cheng Zhejiang Univ Ctr Oncol Med Sch Med Affiliated Hosp 4Dept Urol Yiwu 322000 Peoples R China Zhejiang Univ Int Inst Med Int Sch Med Yiwu 322000 Peoples R China China Med Univ Dept Urol Shengjing Hosp Shenyang 110004 Peoples R China

Sin3A-associated protein 30 (SAP30) is a crucial component of the SIN/HDAC histone deacetylase complex and acts as a scaffold that facilitates target gene binding. SAP30 is highly expressed in various tumours;however, its role in renal cell carcinoma (RCC) remains unclear. In our study, we observed the upregulation of SAP30 in clear cell renal cell carcinoma (ccRCC) tissues, and its elevated expression was correlated with a poor prognosis. Previous research has suggested that SAP30 may influence the growth, proliferation, and apoptosis of RCC cells. Gene Ontology (GO) analysis of the downstream regulatory targets of SAP30 revealed that SAP30 suppressed the expression of MT1G, a protein that binds to p53. Mechanistically, SAP30 inhibited MT1G transcription, thereby impairing the function of MT1G in delivering zinc ions to p53, which diminished p53 activity. Moreover, reduced MT1G levels attenuated the inhibitory effect of MT1G on MDM2, further destabilizing p53. Consequently, this cascade promoted RCC progression. In conclusion, our findings indicate that SAP30 inhibits the p53 pathway through MT1G suppression, suggesting that SAP30 and MT1G are potential prognostic markers and therapeutic targets for RCC.

关键词： Transcription factor p53 SAP30 MT1G ccRCC

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Emulsion Stabilized by Biocompatible and Stimuli-Responsive Poly(N-vinylcaprolactam)-Based Microgels: Effects of Electrostatic Repulsion and Deformability on Emulsion Stability

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LANGMUIR 2024年第32期40卷 16946-16958页

作者： Tan, shuwen Xu, Xiaojia Zhang, Ting Li, Min Liu, Xiaoyan Claesson, Per M. Fang, yu Shaanxi Normal Univ Sch Chem & Chem Engn Key Lab Appl Surface & Colloid Chem Minist Educ Xian 710119 Peoples R China KTH Royal Inst Technol Dept Chem Div Surface & Corros Sci SE-10044 Stockholm Sweden

Microgels have been widely used for stabilizing emulsions due to their softness and stimulus responsiveness. Although ultrastable emulsions have been prepared by microgel nanoparticles, the role of electrostatic interactions on emulsion stability is still a controversial topic and further investigation of the effect of microgel deformability is required. In the present study, neutral poly(N-vinylcaprolactam) (PVCL) and charged poly(N-vinylcaprolactam)-co-methacrylic acid (P(VCL-co-MAA)) microgels were synthesized and further used as emulsifiers to stabilizing emulsion. The P(VCL-co-MAA) microgel has a swelling ratio larger than that of the PVCL microgel in water. The nanomechanical properties of the microgels in water were characterized by atomic force microscopy with using the tip of different radii. The result reveals that the P(VCL-co-MAA) microgel is more deformable than the PVCL counterpart. Stability tests of the emulsions showed that below the volume phase transition temperature (VPTT) of the microgels, both microgel types can stabilize the emulsions under various conditions. Unexpectedly, most of the emulsions still remain stable above the VPTT. Further increasing the temperature to 60 degrees C, P(VCL-co-MAA) microgel emulsions remained stable at a pH value above the pK(a) of MAA while the emulsion was unstable below the pK(a). However, phase separation occurs in PVCL microgel-stabilized emulsions at 60 degrees C. These results demonstrate that electrostatic repulsion and deformability of the microgels can enhance the emulsion stability, providing insights into the rational design and preparation of ultrastable Pickering emulsions.

关键词： Biocompatibility

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Inspecting Traffic in Residential Networks with Opportunistically Outsourced Middleboxes 36

Inspecting Traffic in Residential Networks with Opportunisti...

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36th IEEE/IFIP Network Operations and Management Symposium, NOMS 2023

作者： Liu, shuwen Liu, yu Shue, Craig A. Worcester Polytechnic Institute United States

ISBN: (纸本)9781665477161

Home networks lack the powerful security tools and trained personnel available in enterprise networks. This complicates efforts to address security risks in residential settings. While prior efforts explore outsourcing network traffic to cloud or cloudlet services, such an approach exposes that network traffic to a third party, which introduces privacy risks, particularly where traffic is decrypted (e.g., using Transport Layer Security Inspection (TLSI)). To enable security screening locally, home networks could introduce new physical hardware, but the capital and deployment costs may impede deployment. In this work, we explore a system to leverage existing available devices, such as smartphones, tablets and laptops, already inside a home network to create a platform for traffic inspection. This software-based solution avoids new hardware deployment and allows decryption of traffic without risk of new third parties. Our investigation compares on-router inspection of traffic with an approach using that same router to direct traffic through smartphones in the local network. Our performance evaluation shows that smartphone middleboxes can substantially increase the throughput of communication from around 10 Mbps in the on-router case to around 90 Mbps when smartphones are used. This approach increases CPU usage at the router by around 15%, with a 20% CPU usage increase on a smartphone (with single core processing). The network packet latency increases by about 120 milliseconds. © 2023 IEEE.

关键词： Smartphones

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Effects of different processed tomatoes on carotenoid release and microbiota composition during in vitro gastrointestinal digestion and colonic fermentation

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FOOD & FUNCTION 2023年第22期14卷 10177-10187页

作者： Wu, Xinyi Zhu, Changan Zhang, Min Wang, shuwen yu, Jingquan Tian, Jinhu Hu, Zhangjian Zhejiang Univ Dept Hort Hangzhou 310058 Peoples R China Zhejiang Univ Coll Biosyst Engn & Food Sci Hangzhou 310058 Peoples R China Zhejiang Univ Hainan Inst Sanya 572000 Peoples R China

Carotenoids in tomatoes confer significant health benefits to humans but with the disadvantage of the carotenoids from raw tomatoes not being easily absorbed for utilization. Thus, this study aimed to investigate the effects of different cooking processes on carotenoid release and human gut microbiota composition during in vitro simulated gastrointestinal digestion of tomatoes. The results showed that stir-frying significantly increased the release of lycopene and beta-carotene during gastrointestinal digestion, with boiling being the second most effective treatment. The boiling-treated tomatoes enhanced the carotenoid release during in vitro fermentation. Gut microbiota analysis revealed that the digestion of the raw and boiled tomatoes promoted the growth of potentially beneficial microbiota while reducing the ratio of Firmicutes/Bacteroides, which potentially helps prevent obesity. Boiling treatment significantly reduced the growth of Peptostreptococcus and was negatively correlated with carotenoid release. Overall, the boiling-treated tomatoes were more effective than the raw or stir-fried tomatoes in terms of both colon health benefits and carotenoid release.

关键词： Carotenoids

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Performance Enhancement of Ternary Polymer Solar Cells Induced by Tetrafluorotetracyanoquinodimethane Doping

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CHEMISTRY OF MATERIALS 2019年第18期31卷 7650-7656页

作者： yu, shuwen Yang, Qing yu, Wei Zhang, Jing Liu, Junxue Jin, Shengye Guo, Xin Li, Can Chinese Acad Sci Dalian Natl Lab Clean Energy Dalian Inst Chem Phys State Key Lab Catalysis Dalian 116023 Peoples R China Univ Chinese Acad Sci Beijing 100049 Peoples R China

Molecular electrical doping has been proved as an effective strategy to improve the performance of traditional binary polymer solar cells (PSCs). However, its effectiveness is not demonstrated yet in ternary PSCs which have recently emerged as a promising technique for organic photovoltaics. In this report, we investigate tetrafluorotetracyanoquinodimethane doping of a ternary PSC composed of one donor polymer and dual acceptors. It is found that an ion pair forms between the dopant and donor polymer, leading to the increase in conductivity, hole density, and hole mobility. By employing a low doping concentration of 0.1%, the power conversion efficiency of the ternary PSC is improved, mainly contributed by enhancements of the short-circuit current density (J(sc)) and fill factor (FF). Investigation of charge transport processes and kinetics reveals that J(sc) and FF improvements are ascribed to more efficient charge extraction, restrained nongeminate charge recombination, and optimized microstructure in doped ternary PSCs.

关键词： Carrier dynamics Mobility Electrical conductivity Doping Polymers

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Correlation between biochemical and clinical hyperandrogenism parameter in polycystic ovary syndrome in relation to age

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BMC ENDOCRINE DISORDERS 2023年第1期23卷 89-89页

作者： Guo, Zaixin Jin, Fengjun Chen, shuwen Hu, Pan Hao, Yanfang yu, Qi Chinese Acad Med Sci & Peking Union Med Coll Peking Union Med Coll Hosp Dept Obstet & Gynecol Beijing Peoples R China

BackgroundTo assess the correlation between clinical and biochemical hyperandrogenism parameters in polycystic ovary syndrome (PCOS) according to *** prospective study included 256 PCOS patients diagnosed according to the Rotterdam criteria in a university-based hospital. Androgen levels were measured using liquid chromatography-tandem mass spectrometry. Hirsutism, acne, and alopecia were assessed using the modified Ferriman-Gallwey (mF-G) score, Comprehensive Acne Severity Scale (CASS), and the Ludwig scale, respectively. The correlation between biochemical and clinical hyperandrogenism parameters was assessed in younger and older women with *** 256 PCOS patients were classified by age into two groups: age 18-29 years (n = 151) and age 30-40 years (n = 84). In women with PCOS, mF-G was significantly positively correlated with the free androgen index (FAI), dehydroepiandrosterone (DHEA), and DHEA sulfate (DHEA-S). CASS had a significant positive correlation with DHEA. mF-G was positively correlated with FAI in those aged 18-29 years, but the correlations were not significant in those aged 30-40 years. The positive correlation between specific body regions of clinical hyperandrogenism, especially mF-G of chin, lower abdomen, and thighs, and testosterone, as well as with FAI, was highest in those aged 18-29 years. In those aged 30-40 years clinical hyperandrogenism was mainly affected by DHEA, DHEA-S, and *** correlation between biochemical and clinical hyperandrogenism parameters varied with age in our East Asian population. Clinical hyperandrogenism was positively correlated with FAI in younger women with PCOS. The correlation between biochemical and clinical hyperandrogenism was not significant in older women with PCOS.

关键词： Age Dehydroepiandrosterone Hyperandrogenism Polycystic ovary syndrome

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The binding effect and photooxidation on oxytetracycline with algal extracellular polymeric substances and natural organic matter

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CHEMOSPHERE 2022年第Part2期307卷 135826页

作者： Wang, yu Gong, Xinye Huang, Deying Yan, shuwen Zhang, Jibiao Fudan Univ Dept Environm Sci & Engn Shanghai 200433 Peoples R China Fudan Univ Dept Chem Shanghai 200433 Peoples R China

Surface water contains a large amount of dissolved organic matter (DOM). Interactions between DOM and micropollutants have a significant impact on micropollutant degradation. In this study, algal extracellular polymeric substances (EPS) and natural organic matter (NOM) were selected as two DOM sources and oxytetracycline (OTC) as a representative micropollutant. EPS was mainly composed of tryptophan and protein-like organics, while NOM was mainly composed of fulvic acid-like, humic acid-like, and hydrophobic acid components. In addition, OTC degradation significantly decreased when bound with EPS and the C=O and C-H bonds of CH2 or CH3 groups may be involved in binding EPS and OTC, respectively, while -COOH may be involved in the binding of NOM and OTC. Furthermore, triplet intermediates were found to play a major role in OTC photodegradation in both EPS and NOM, with the contribution calculated as 49.96% and 44.61%, respectively. Steady-state concentrations of (EPS)-E-3* in EPS and (NOM)-N-3* in NOM were 3.59 x 10(-14) mol L-1 and 5.54 x 10(-15) mol L-1, respectively. These results provide new insights into the degradation of antibiotic-containing wastewater in the natural environment or engineering applications.

关键词： Algal extracellular polymeric substances Natural organic matter Binding interaction Photooxidation Oxytetracycline

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