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Highly efficient prevention of radiation dermatitis using a PEGylated superoxide dismutase dissolving microneedle patch

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EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS 2024年 201卷 114347页

作者： Ma, Zhenchao Chen, Yingrong Tang, Kaixian Yang, Hongxia Tian, Mengli Xi, Xiaoyuan Han, shuwen Yang, Shuixin Ru, Lixin yu, Xiang Zhejiang Chinese Med Univ Huzhou Cent Hosp Sch Clin Med 5 Huzhou 313000 Zhejiang Peoples R China Huzhou Univ Affiliated Cent Hosp Huzhou Cent Hosp Huzhou 313000 Zhejiang Peoples R China Huzhou Inst Food & Drug Control Huzhou 313002 Zhejiang Peoples R China

PEGylated superoxide dismutase (PEG-SOD) is commonly used as a cytoprotective agent in radiotherapy. However, its effectiveness in preventing radiation dermatitis is limited owing to its poor skin permeability. To address this issue, a PEG-SOD-loaded dissolving microneedle (PSMN) patch was developed to effectively prevent radiation dermatitis. Initially, PSMN patches were fabricated using a template mold method with polyvinylpyrrolidone K90 as the matrix material. PSMNs exhibited a conical shape with adequate mechanical strength to penetrate the stratum corneum. More than 90 % of PEG-SOD was released from the PSMN patches within 30 min. Notably, the PSMN patches showed a significantly higher drug skin permeation than the PEG-SOD solutions, with a 500-fold increase. In silico simulations and experiments on skin pharmacokinetics confirmed that PSMN patches enhanced drug permeation and skin absorption, in contrast to PEG-SOD solutions. More importantly, PSMN patches efficiently mitigated ionizing radiation-induced skin damage, accelerated the healing process of radiation-affected skin tissues, and exhibited highly effective radioprotective activity for DNA in the skin tissue. Therefore, PSMN patches are promising topical remedy for the prevention of radiation dermatitis.

关键词： Radiation dermatitis Microneedles Transdermal delivery PEGylated superoxide dismutase Ionizing radiation

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Risk assessment and spatial analysis of paralytic shellfish toxin (PST) concentrations and acute dietary exposure of commercially available shellfish in coastal areas in China

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FOOD CONTROL 2024年 160卷

作者： Li, shuwen He, Jiao Sun, Jinfang Pan, Feng Zhou, Pingping Zhang, Lei Yang, Xin Cao, Chengbin yu, Xiaojin Cao, Pei Southeast Univ Sch Publ Hlth Dept Epidemiol & Biostat Nanjing 210009 Peoples R China China Natl Ctr Food Safety Risk Assessment Beijing 100022 Peoples R China

Paralytic shellfish toxins (PSTs) are produced by marine dinoflagellates and can be accumulated in filter feeding shellfish. In this study, we assessed acute dietary exposure to PSTs among residents of Chinese coastal provinces and cities, utilizing point and probabilistic estimates. Additionally, we performed global and local spatial autocorrelation analyses to evaluate PSTs contamination and dietary exposure levels in the coastal regions of China. The point estimate revealed that Hebei province exhibited the highest level of PSTs dietary exposure, measuring 39.57 mu g STX eq./kg bw. In all regions, except for Guangxi, Jiangsu, Shandong, and Shanghai, the ratio between acute dietary exposure and the acute reference dose (ARfD) exceeded 1. Probabilistic estimates indicated that P99.9 exceeded the ARfD value exclusively in Guangdong, Hainan, and Liaoning. In comparison, the point estimate was significantly higher than the P99.9 value of the probabilistic estimate. The spatial analysis results showed "low-high" aggregation of PSTs concentration and point estimate dietary exposure levels in Liaoning and Shandong, while probabilistic estimate dietary exposure level exhibited "low-high" aggregation in Guangxi. This implied the presence of regional variations in PSTs contamination and dietary exposure within the coastal regions of China, along with specific localized clustering features. Therefore, it is advisable to develop regionalized precision monitoring and dietary interventions to ensure the safety of shellfish consumption, particularly in response to the regional distribution characteristics of PSTs contamination and dietary exposure.

关键词： Paralytic shellfish poisoning Spatial analysis Spatial autocorrelation analysis Shellfish consumption Dietary exposure Risk assessment

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A sulfonated polyimide containing flexible aliphatic segments with high chemical stability for vanadium redox flow battery application

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JOURNAL OF POWER SOURCES 2024年 589卷

作者： Li, Xuesong Wang, Gang Zhang, shuwen Wei, Shiguo yu, Yan Li, Gang Chen, Jijun Zhou, yufeng Zhang, Jie Chen, Jinwei Wang, Ruilin Sichuan Univ Coll Mat Sci & Engn Chengdu 610065 Peoples R China Sichuan Weilide Energy Co Ltd Leshan 614000 Peoples R China

To improve sulfonated polyimide (SPI) chemical stability, the SPI containing flexible aliphatic segments is successfully designed and synthesized. The highest occupied molecular orbital (HOMO) energy, lowest unoccupied molecular orbital (LUMO) energy and their energy gaps (HOMO-LUMO gap (Delta E)) can quantitatively compare the molecular reactivity, which are calculated and used to compare firstly in the SPIs for vanadium redox flow battery (VRFB) application. Furthermore, the natural bond orbital (NBO) charge of SPIs is also used to calculate and compare, respectively. Theoretical calculation shows SPI(DAD) has higher chemical stability. Obtained by experimental results that the retention time in water of SPI(DAD)-60 membrane is 23.58 h at 80 degrees C, which is nearly four times than conventional SPI under the same conditions. The SPI(DAD)-60 membrane at a current density of 100 mA cm-2 shows higher columbic efficiency (CE: 96.83%), and energy efficiency (EE: 79.47%) than that of N212 membrane (CE: 93.14%, EE: 74.13%). Besides, the SPI(DAD)-60 membrane has 479.1 mA h more charging capacity after 100 cycles compared to N212 membrane. The theoretical calculation of the LUMO energy, HOMO-LUMO gap may be a potential tool that is used to analyze and evaluate the chemical stability of membranes for VRFB application.

关键词： All vanadium redox flow batteries Sulfonated polyimide Chemical stability Flexible aliphatic segments HOMO-LUMO gap

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Linking Bacterial Growth Responses to Soil Salinity with Cd Availability

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BULLETIN OF ENVIRONMENTAL CONTAMINATION AND TOXICOLOGY 2022年第2期109卷 286-297页

作者： Wang, Lifu Qin, Luyao Sun, Xiaoyi Zhao, shuwen yu, Lei Wang, Meng Chen, Shibao Chinese Acad Agr Sci Inst Agr Resources & Reg Planning Key Lab Plant Nutr & Fertilizer Minist Agr & Rural Affairs 12 Zhongguancun South St Beijing 100081 Peoples R China

This study investigated the effects of different types of saline stress on the availability of cadmium (Cd) and bacterial growth. Changes in soil physicochemical properties and DTPA-Cd content as well as microbial responses after the addition of salts were measured. The addition of 18 g kg(-1) of salts with NaCl and Na2SO4 increased the available Cd content by up to 17.80%-29.79%. Respiration rate, biomass, and relative bacterial growth decreased with increasing salt concentrations. Estimated salinity tolerance of bacterial communities based on pollution-induced community tolerance. The salinity tolerance index EC50 of the bacterial community was estimated by logistic equation and ranged from 4.32-12.63 g kg(-1). Structural equation modeling showed that soil salinity stress significantly affected Cd availability and bacterial community, while bacterial growth characteristics also contributed to reducing available Cd. We conclude that saline stress can alter soil Cd availability in soils by affecting the growth characteristics of soil bacterial communities.

关键词： Salinity stress Cd availability Soil properties Bacterial growth SEM

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Trends of ischemic heart disease mortality attributable to household air pollution during 1990-2019 in China and India: an age-period-cohort analysis

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ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH 2022年第58期29卷 87478-87489页

作者： Wang, Tong Ma, yudiyang Li, Ruiqing Sun, Jinyi Huang, Lihong Wang, shuwen yu, Chuanhua Wuhan Univ Sch Publ Hlth Dept Epidemiol & Biostat Wuhan 430071 Peoples R China Wuhan Univ Global Hlth Inst Wuhan 430071 Peoples R China

Cardiovascular diseases (CVD) caused by household air pollution (HAP) have sparked widespread concern globally in the recent decade. Meanwhile, increased ischemic heart disease (IHD) mortality has been the leading cause of worldwide CVD deaths. Both China and India experienced a high IHD burden and high exposure to HAP. The present study aimed to estimate and compare the long-term trends of HAP-attributable IHD mortality in the two countries. The data of this study were extracted from the Global Burden of Diseases (GBD) Study 2019. The age-period-cohort (APC) analysis was utilized to estimate the independent trends of the age, period, and cohort effects from 1990 to 2019. The age-standardized mortality rates (ASMRs) of HAP-attributable IHD have fallen faster in China than in India for both sexes. The local drift and net drift values were < 0 for all age groups in both countries. The age effects in both countries and sexes increased with time, suggesting age is a risk factor for IHD;conversely, period and cohort effects in China demonstrated a faster decline in both genders than in India. It indicated that China has been more successful than India in decreasing HAP-attributable IHD mortality.

关键词： Ischemic heart disease Household air pollution Age-period-cohort analysis China India

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Soil bacterial community responses to cadmium and lead stabilization during ecological restoration of an abandoned mine

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SOIL USE AND MANAGEMENT 2022年第3期38卷 1459-1469页

作者： Zhao, shuwen Qin, Luyao Wang, Lifu Sun, Xiaoyi yu, Lei Wang, Meng Chen, Shibao Chinese Acad Agr Sci Inst Agr Resources & Reg Planning Minist Agr & Rural Affairs Key Lab Plant Nutr & Fertilizer Beijing 100081 Peoples R China

Ecological restoration refers to the gradual recovery of damaged ecosystems by utilizing their self-recovery capacity and artificial measures. It is considered as an effective technique to alleviate heavy metal pollution in open-pit mining soils. However, little is known about the stability of heavy metals and soil bacterial responses in artificially restored soil-plant systems. In this study, different vegetation restoration strategies were established in the Dabaoshan mining area, China, and the accumulation and transfer of Cd/Pb in the soil-plant system and the responses of the soil bacterial community were investigated. Results showed that ecological restoration with a combination of trees, shrubs and grasses/herbs could increase soil cation-exchange capacity and organic matter content, but not soil pH. The mixture of trees, shrubs and grasses/herbs was most effective for reducing the available Pb content to 33.7% of the content in the control, and the mixture of trees and grasses/herbs was beneficial in reducing Cd to 60.4% of the content in the control. Data showed that ecological restoration could change the quantity, composition and community structure of soil microorganisms. The soils in which a mixture of trees, shrubs and grasses/herbs were grown had the greatest abundance and diversity of bacteria;the abundances of Proteobacteria increased by 12% and Actinobacteria by 5% from those of the control. Plant coverage, soil available Cd content, and organic matter emerged as major determinants of bacterial community composition. This study demonstrates a promising remediation strategy for limiting Cd/Pb mobility in mining areas.

关键词： an abandoned mine heavy metals microbes stabilization trees shrubs and grasses/herbs

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The Pink Zone Pattern (PP) sign: A novel simple marker for early gastric cancer

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DIGESTIVE AND LIVER DISEASE 2023年第8期55卷 1100-1104页

作者： Ruan, Rongwei Zhang, Hui yu, Jiangping Chen, Shengsen Tao, Yali Zhu, shuwen Li, Yandong Wang, Shi Chinese Acad Sci Univ Chinese Acad Sci Canc Hosp Inst Canc & Basic Med IBMCDept EndoscopyZhejian Hangzhou Peoples R China Banshan Rd 1 Hangzhou 310022 Peoples R China

Background: We previously found a pink-colored change in early gastric cancer (EGC) lesions under magnifying endoscopy with narrow-band imaging (ME-NBI) and named it the "Pink Zoon Pattern" (PP) sign, which appeared independent of microvascular and microstructural changes. The aim of this study was to further investigate the characteristics of the PP sign in ***: The consecutive patients with suspicious gastric lesions detected by ME-NBI and confirmed by pathology at Zhejiang Cancer Hospital between November 2020 and December 2021 were enrolled in the study. The suspicious lesions were observed and assessed by the "VS" system and the PP sign ***: We found that in the PP-positive group, 238 lesions (96.0%) were diagnosed as malignant. The overall accuracy, sensitivity, and specificity were 84.7%, 85.3%, and 81.8%. Among 164 EGC lesions diagnosed with low confidence (Grades 2, 3, and 4) using the VS system, the overall accuracy of PP to discriminate tumor from normal was 82.3%. The sensitivity and specificity were 82.7% and 81.5% ***: The PP sign could be a new simple sign for the diagnosis of EGC and as an effective supplement to VS system when using ME-NBI.& COPY;2023 Editrice Gastroenterologica Italiana S.r.l. Published by Elsevier Ltd. All rights reserved.

关键词： Pink zoon pattern sign Early gastric cancer Magnifying endoscopy Diagnosis

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Whey Protein-Based High Internal Phase Emulsion Gel Characterization and Its Effect on the Textural and Melting Properties of Processed Cheese

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FOOD AND BIOPROCESS TECHNOLOGY 2024年第7期17卷 2061-2075页

作者： Li, Hongjuan Zhang, Leilei Cao, Hongyu Liu, Tingting Xi, Ziyu Li, Hongbo Chen, Xiaohong Zou, Yang Zhang, shuwen Pang, Xiaoyang yu, Jinghua Tianjin Univ Sci & Technol Coll Food Sci & Engn State Key Lab Food Nutr & Safety Key Lab Food Nutr & SafetyMinist Educ 29 13 AveTEDA Tianjin 300457 Peoples R China Chinese Acad Agr Sci Inst Food Sci & Technol Beijing 100193 Peoples R China Tianjin Haihe Dairy Prod Co Ltd Tianjin 300308 Peoples R China

Some undesirable physical characteristics of processed cheese due to insufficient fat emulsification have prompted extra ingredients to be added to compensate. Whey proteins offer promising nutritional and emulsifying properties. In this study, whey protein and corn oil were applied to high internal phase emulsion gels with enhanced texture of processed cheese while offering additional functional ingredients. Emulsion gels were prepared after pre-emulsification of different levels of corn oil and milk fat and used in cheese. The gel strength, water holding capacity (WHC), rheology, and thermal stability properties of gel, as well as the texture and melting properties of cheese, were characterized. Corn oil could be pre-emulsified by heat-denatured whey protein forming a stable hexagonal arrangement structure at higher oil content, and the emulsion gels exhibited good viscoelasticity, WHC, and thermal stability. In contrast, the high crystallinity of milk fat conferred hardness to gel at higher oil content but was detrimental to the network structure of gel, with large gel particles and a rough network. The cheese made from high internal phase emulsion gels had a soft texture, and corn oil was more effective than milk fat in reducing the hardness of cheese, giving springness and cohesiveness to cheese, with a significant reduction in oil separation.

关键词： Whey protein emulsion gel High internal phase Corn oil Processed cheese Texture Melting properties

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Emerging platinum(0) nanotherapeutics for efficient cancer therapy

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JOURNAL OF CONTROLLED RELEASE 2022年 352卷 276-287页

作者： Qiao, Han Chen, Zhichao Fu, shuwen yu, Xiang Sun, Mengchi Zhai, Yinglei Sun, Jin Shenyang Pharmaceut Univ Sch Pharm Shenyang 110016 Peoples R China Shenyang Pharmaceut Univ Wuya Coll Innovat Dept Pharmaceut Shenyang 110016 Liaoning Peoples R China Shenyang Pharmaceut Univ Sch Med Devices Shenyang 110016 Liaoning Peoples R China Zhejiang Univ Affiliated Cent Hosp Huzhou Cent Hosp Affiliated Huzhou HospSch MedHuzhou Univ Huzhou Peoples R China Shenyang Pharmaceut Univ Wuya Coll Innovat Dept Pharmaceut 103 Wenhua Rd Shenyang 110016 Liaoning Peoples R China Shenyang Pharmaceut Univ Sch Med Devices Dept Biomed Engn Shenyang 110016 Liaoning Peoples R China

Platinum (Pt)-based chemotherapy has been necessary for clinical cancer treatment. However, traditional bivalent drugs are hindered by poor physicochemical properties, severe toxic side effects, and drug resistance. Currently, elemental Pt(0) nanotherapeutics (NTs) have emerged to tackle the dilemma. The inherent acid -responsiveness of Pt(0) NTs could help to improve tumor selectivity and alleviate toxic effects. Moreover, the metal nature of Pt facilitates the great combination of Pt(0) NTs with photothermal and photodynamic therapy and imaging-guided diagnosis. Based on recent important researches, this review provides an updated intro-duction to Pt(0) NTs. First, the challenges of traditional Pt-based chemotherapy have been outlined. Then, Pt(0) NTs with multiple applications of tumor theranostics have been overviewed. Furthermore, the combinations of Pt (0) NTs with other therapeutical modalities are introduced. Last but not least, we envision the possible challenges and prospects associated with Pt(0) NTs.

关键词： Pt(0) nanotherapeutics Acid-responsiveness Metal nature Tumor theranostics Therapeutical modalities

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Pest Control in Agriculture Using LED Light Technology Based on High Spectral Imaging 24

Pest Control in Agriculture Using LED Light Technology Based...

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2nd International Conference on Artificial Intelligence, Systems and Network Security, AISNS 2024

作者： Xu, Weiwei yu, Shiwen Wang, yufei Qin, Tingting Yin, Ziqiang Zhu, Minghui Zhu, shuwen School of Electrical and Information Engineering Jilin Engineering Normal University Jilin Changchun China

ISBN: (纸本)9798400711237

Hyperspectral imaging technology is a comprehensive technology that combines optical spectroscopy and imaging technology. Its application in agriculture is increasingly extensive, and its unique advantages make it play an important role in crop monitoring, pest diagnosis and so on. This time, by using hyperspectral imaging technology and the principle that the LED visible light source does not contain ultraviolet light, is not attractive to insects and can emit specific wavelengths of light, STM32 microcontroller and software circuit are used to design and develop an environment for agricultural pests that can detect the surrounding light intensity, temperature, humidity and so on. And it can automatically control the adjustment of LED light source through digital image processing technology, carry out light control technology of precise insect repellent, and successfully apply it in actual production. © 2024 Copyright held by the owner/author(s).

关键词： Hyperspectral imaging

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