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A Novel Sulfonated Polyimide Composite Membrane Containing a Sulfonated Porous Material for All-Vanadium Redox Flow Batteries

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ACS APPLIED MATERIALS & INTERFACES 2024年第40期16卷 54529-54538页

作者： Li, Xuesong Wang, Gang Zhang, shuwen Wei, Shiguo yu, Yan Wang, Bing Jing, Yangtian Chen, Jijun Zhang, Jie Zhou, yufeng Chen, Jinwei Wang, Ruilin Sichuan Univ Coll Mat Sci & Engn Chengdu 610065 Peoples R China Sichuan Weilide Energy Co Ltd Leshan 614000 Peoples R China

To improve the battery efficiency and cycling stability of sulfonated polyimide (SPI), a polyphosphazene with built-in -SO3H moieties (PP-SO3H), which is a porous covalent organic framework (COF) material, is facilely synthesized by the polymeric combination of hexachlorocyclotriphosphazene (HCCP) and p-diaminobenzenesulfonic acid. Due to its tunable pore size and flexible molecular design, the COF material can address the trade-off between the conductivity and the ion permeability of ion exchange membranes well, thereby improving the ion selectivity of membranes. The experimental results show that the SPI/PP-SO3H composite membrane has an excellent conductivity (up to 114.8 mS cm-1);the ion selectivity of the SPI/2% PP-SO3H membrane is 11.69 x 104 S min cm-3, which is 2.18 times higher than that of the SPI base membrane. PP-SO3H also improves the SPI membrane's mechanical strength, and the effect of PP-SO3H on SPI intermolecular interactions is analyzed by surface electrostatic potential (ESP) theoretical calculations. The Coulombic efficiency (CE) of the SPI/2% PP-SO3H membrane is 98.92%, the energy efficiency (EE) is 84.1% at a current density of 100 mA cm-2, and the self-discharge time of the SPI/2% PP-SO3H membrane is 3.5 times compared with the SPI base membrane. To measure the cycling stability of the composite membrane, the SPI/2% PP-SO3H membrane is cycled in the VRFB for more than 400 cycles, which is more stable than that of the SPI base membrane. These results show that SPI/2% PP-SO3H composite membranes are viable for VRFB applications.

关键词： all-vanadium redox flow battery ion selectivity covalent organic frameworks sulfonated porous material mechanical stability

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A dihydromyricetin-loaded phellinus igniarius polysaccharide/L-arginine modified chitosan-based hydrogel for promoting wound recovery in diabetic mice via JNK and TGF-β/Smad signaling pathway

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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES 2024年第Part1期259卷 129124页

作者： Yang, Jiali Zhang, Lifeng Sun, shuwen Zhang, Shuai Ding, Qiteng Chai, Guodong yu, Weimin Zhao, Ting Shen, Liqian Gao, Yang Liu, Wencong Ding, Chuanbo Jilin Agr Univ Coll Tradit Chinese Med Changchun 130118 Peoples R China Coll Tradit Chinese Med Jilin Agr Sci & Technol Coll Jilin 132101 Peoples R China Jilin Prov Jianwei Nat Biotechnol Co Ltd Baishan 134600 Peoples R China Wuzhou Univ Sch Food & Pharmaceut Engn Wuzhou 543002 Peoples R China

The wound of diabetes has long-term excessive inflammation leading to wound fibrosis and scar formation. In the process of diabetic wound healing, good wound dressing is required for intervention. In this study, we designed a dihydromyricetin-loaded hydrogel (PCD) based on phellinus igniarius polysaccharide and l-arginine modified chitosan as an alternative material to promote diabetes wound healing. PCD had a uniform porous structure, good thermal stability, excellent mechanical properties, high water absorption, excellent antioxidant and anti-inflammatory activities and good biocompatibility and biodegradability. In addition, in the full-thickness skin trauma model of diabetes, PCD significantly inhibited the JNK signaling pathway to reduce inflammatory response, and significantly down-regulated the expression of TGF-beta 1, Smad2, Smad3 and Smad4 to directly inhibit the TGF-beta/Smad signaling pathway to accelerate wound healing and slow down scar formation in diabetes mice. Therefore, PCD has a broad application prospect in promoting diabetes wound healing.

关键词： Diabetic wound healing Hydrogel Dihydromyricetin JNK TGF-beta/Smad Scar

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Toxicologic effect and transcriptome analysis for sub-chronic exposure to carbendazim, prochloraz, and their combination on the liver of mice

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ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH 2024年第4期31卷 5500-5512页

作者： Zhang, shuwen Luo, Ting Weng, You Wang, Dou Sun, Li yu, Zheping Zhao, Yao Liang, Senmiao Ren, Haiying Zheng, Xiliang Jin, yuanxiang Qi, Xingjiang Zhejiang Acad Agr Sci Inst Hort Hangzhou 310021 Peoples R China State Key Lab Managing Biot & Chem Threats Qual & Hangzhou 310021 Peoples R China Zhejiang Acad Agr Sci Inst Agroprod Safety & Nutr Minist Agr Lab Hangzhou Risk Assessment Agr Prod Hangzhou 310021 Peoples R China Zhejiang Univ Technol Coll Biotechnol & Bioengn Hangzhou 310032 Peoples R China Xianghu Lab Hangzhou 311231 Peoples R China

Carbendazim (CBZ) and prochloraz (PCZ) are broad-spectrum fungicides used in agricultural peat control. Both fungicides leave large amounts of residues in fruits and are toxic to non-target organisms. However, the combined toxicity of the fungicides to non-target organisms is still unknown. Therefore, we characterized the toxic effects of dietary supplementation with CBZ, PCZ, and their combination for 90 days in 6-week-old male Institute of Cancer Research (ICR) mice. CBZ-H (100 mg/kg day), PCZ-H (10 mg/kg day), and their combination treatments increased the relative liver weights and caused liver injury. The serum total cholesterol (TC), triglyceride (TG), glucose (Glu), pyruvate (PYR), low-density lipoprotein cholesterol (LDL-C), and high-density lipoprotein cholesterol (HDL-C) levels were reduced, and synergistic toxicity was observed. Hepatic transcriptome revealed that 326 differentially expressed genes (DEGs) of liver were observed in the CBZ treatment group, 149 DEGs in the PCZ treatment group, and 272 DEGs in the combination treatment group. According to KEGG enrichment analysis, the fungicides and their combination affected lipid metabolism, amino acid metabolism, and ferroptosis. In addition, the relative mRNA levels of key genes involved in lipid metabolism were also examined. Compared with individual exposure, combined exposure to CBZ and PCZ caused a more obvious decrease in the expression of some genes related to glycolipid metabolism. Furthermore, the relative mRNA levels of some key genes in the combination treatment group were lower than those in the CBZ and PCZ treated groups. In summary, CBZ, PCZ, and their combination generally caused hepatotoxicity and glycolipid metabolism disorders, which could provide new insights for investigating the combined toxicity of multiple fungicides to animals.

关键词： Transcriptome Carbendazim Prochloraz Hepatotoxicity Mice

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CAS FGOALS-f3-L Model Datasets for CMIP6 DCPP Experiment

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Advances in Atmospheric Sciences 2023年第10期40卷 1911-1922页

作者： Shuai HU Bo WU Yiming WANG Tianjun ZHOU Yongqiang yu Bian HE Pengfei LIN Qing BAO Hailong LIU Kangjun CHEN shuwen ZHAO State Key Laboratory of Numerical Modeling for Atmospheric Sciences and Geophysical Fluid Dynamics Institute of Atmospheric PhysicsChinese Academy of SciencesBeijing 100029China University of the Chinese Academy of Sciences Beijing 100864China

The outputs of the Chinese Academy of Sciences(CAS)Flexible Global Ocean-Atmosphere-Land System(FGOALSf3-L)model for the decadal climate prediction project(DCPP)of the Coupled Model Intercomparison Project Phase 6(CMIP6)are described in this *** FGOALS-f3-L was initialized through the upgraded,weakly coupled data assimilation scheme,referred to as EnOI-IAU,which assimilates observational anomalies of sea surface temperature(SST)and upper-level(0–1000-m)ocean temperature and salinity profiles into the coupled ***,nine ensemble members of 10-year hindcast/forecast experiments were conducted for each initial year over the period of 1960–2021,based on initial conditions produced by three initialization *** hindcast and forecast experiments follow the experiment designs of the Component-A and Component-B of the DCPP,*** decadal prediction output datasets contain a total of 44 monthly mean atmospheric and oceanic *** preliminary evaluation indicates that the hindcast experiments show significant predictive skill for the interannual variations of SST in the north Pacific and multi-year variations of SST in the subtropical Pacific and the southern Indian Ocean.

关键词： CMIP6 DCPP FGOALS-f3-L decadal prediction model initialization

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Position-Responsive SEI Layer in Bicomponent-Bidirectional Gradient Current Collector Induces Homogenized Ion Flux for Highly Reversible Li Metal Anode

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ADVANCED FUNCTIONAL MATERIALS 2024年第9期34卷 2310358-2310358页

作者： Yin, Xiangkai Zhu, Runxi Hu, Xiaofei Zhao, Hongyang Li, Xinyang Liu, Limin Niu, shuwen Wang, Jiazheng Meng, Yi Su, Yaqiong Ding, Shujiang yu, Wei Xi An Jiao Tong Univ Univ Shaanxi Prov Engn Res Ctr Energy Storage Mat & Chem Engn Res Ctr Energy Storage Mat & DevicesSch Chem Xian 710049 Peoples R China Xiamen Univ Coll Chem & Chem Engn Xiamen 361005 Peoples R China

A gradient current collector (GCC) can encourage preferential Li metal deposition on the more lithiophilic/conductive bottom of 3D anodes, enhancing the reversibility of the battery. However, as the deposition proceeds, the reduction of lithophilicity/conductivity easily causes the disturbance of Li+ flux. Herein, a brand-new bicomponent-bidirectional gradient current collector (BGCC) is proposed. The BGCC constructs slow-release additives with reverse gradient distribution (SA gradient) based on GCC, allowing it to build a position-responsive solid electrolyte interface layer. Additionally, as the deposition amount increases, the slow-release additives will release more and present a stronger ability to regulate Li+ flux, ensuring the anodereversibility under large deposition amounts conditions. Consequently, asymmetric cells can exhibit high reversibility with an average coulomb efficiency (CE) of 97.8% and sustain over 200 cycles using carbonate-based electrolytes. The Li@BGCC||LiFePO4 full cells hold a capacity retention of 94.8% over 400 cycles with thin Li. Notably, even at low temperatures, the Li@BGCC anodes can exhibit a CE as high as 98.46% and excellent capacity retention of 97.8% after 100 cycles paired with NCM811 cathodes. This strategy opens up a new direction for the development of 3D current collectors. The gradient current collector (GCC) loses the effect of uniform Li metal deposition in some areas with poor lithophilicity/conductivity. To solve the problem, this work constructs a novel bicomponent-bidirectional gradient current collector by introducing a gradient-distributed slow-release additive into GCC. Due to the synergistic effect of the additive and GCC, Li metal can be uniformly deposited at any ***

关键词： 3D current collectors gradient current collector Li metal anode position-responsive SEI layers slow-release additives

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Follicular fluid-derived exosomal HMOX1 promotes granulosa cell ferroptosis involved in follicular atresia in geese (Anser cygnoides)

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POULTRY SCIENCE 2024年第8期103卷 103912页

作者： Zhang, yu Jiang, Youluan Dong, Xiaoqian Luo, shuwen Jiao, Guoyu Weng, Kaiqi Bao, Qiang Zhang, Yang Vongsangnak, Wanwipa Chen, Guohong Xu, Qi Yangzhou Univ Key Lab Evaluat & Utilizat Poultry Genet Resources Minist Agr & Rural Affairs Yangzhou 225009 Jiangsu Peoples R China Yangzhou Univ Joint Int Res Lab Agr & Agriprod Safety Minist Educ Yangzhou 225009 Jiangsu Peoples R China Kasetsart Univ Fac Sci Dept Zool Bangkok 10900 Thailand

The proliferation and death of granulosa cells (GCs) in poultry play a decisive role in follicular fate and egg production. The follicular fluid (FF) contains a variety of nutrients and genetic substances to ensure the communication between follicular cells. Exosomes, as a new intercellular communication, could carry and transport the proteins, RNA, and lipids to react on GCs, which had been found in FF of various domestic animals. Whether exosomes of FF in poultry play a similar role is unclear. In this study, geese, a poultry with low egg production, were chosen, and the effect of FF exosomes on the proliferation and death of GCs was investigated. Firstly, there were not only a large number of healthy small yellow follicles (HSYFs) but also some atresia small yellow follicles (ASYFs) in the egg-laying stage. Also, the GC layers of ASYFs became loose interconnections, inward detachment, and diminished survival rate than that of HSYFs. Besides, compared to HSYFs, the contents of E2, P4, and the mRNA expression levels of ferroptosis-related genes GPX4, FPN1, and FTH1 were significantly decreased, while COX2, NCOA4, VDAC3 mRNA were significantly increased, and the structure of mitochondrial cristae disappeared and the outer membrane broke in the GC layers of ASYFs. Moreover, the ROS, MDA, and oxidation levels in the GC layers of ASYFs were significantly higher than those of HSYFs. All these hinted that ferroptosis might result in a large number of GCs death and involvement in follicle atresia. Secondly, FF exosomes were isolated from HSYFs and ASYFs, respectively, and identified by TEM, NTA, and detection of exosome marker proteins. Also, we found the exosomes were phagocytic by GCs by tracking CM-Dil. Moreover, the addition of ASYF-FF exosomes significantly elevated the MDA content, Fe2+ levels, and the mitochondrial membrane potential (MMP) in GCs, thus significantly inhibiting the proliferation of GCs, which was restored by the ferroptosis inhibitor ferrostatin-1.

关键词： exosome HMOX1 follicular granulosa cell ferroptosis follicular atresia

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SQT: Debiased Visual Question Answering via Shuffling Question Types

SQT: Debiased Visual Question Answering via Shuffling Questi...

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IEEE International Conference on Multimedia and Expo (ICME)

作者： Huai, Tianyu Yang, shuwen Zhang, Junhang Wang, Guoan yu, Xinru Ma, Tianlong He, Liang East China Normal Univ Shanghai Peoples R China

ISBN: (纸本)9781665468916

Visual Question Answering (VQA) aims to obtain answers through image-question pairs. Nowadays, the VQA model tends to get answers only through questions, ignoring the information in the images. This phenomenon is caused by bias. As indicated by previous studies, the bias in VQA mainly comes from text modality. Our analysis of bias suggests that the question type is a crucial factor in bias formation. To interrupt the shortcut from question type to answer for de-biasing, we propose a self-supervised method for Shuffling Question Types (SQT) to reduce bias from text modality, which overcomes the prior language problem by mitigating the question-to-answer bias without introducing external annotations. Moreover, we propose a new objective function for negative samples. Experimental results show that our approach can achieve 61.76% accuracy on the VQA-CP v2 dataset, which outperforms the state-of-the-art in both self-supervised and supervised methods.

关键词： Visual question answering De-biasing Self-supervised

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In silico-guided metabolic engineering of Bacillus subtilis for efficient biosynthesis of purine nucleosides by blocking the key backflow nodes

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BIOTECHNOLOGY FOR BIOFUELS AND BIOPRODUCTS 2022年第1期15卷 1-18页

作者： Deng, Aihua Qiu, Qidi Sun, Qinyun Chen, Zhenxiang Wang, Junyue Zhang, yu Liu, shuwen Wen, Tingyi Chinese Acad Sci Inst Microbiol CAS Key Lab Pathogen Microbiol & Immunol Beijing 100101 Peoples R China Univ Chinese Acad Sci Coll Life Sci Beijing 100049 Peoples R China Univ Chinese Acad Sci Savaid Med Sch Beijing 100049 Peoples R China Chinese Acad Sci China Innovat Acad Green Manufacture Beijing 100049 Peoples R China

Background Purine nucleosides play essential roles in cellular physiological processes and have a wide range of applications in the fields of antitumor/antiviral drugs and food. However, microbial overproduction of purine nucleosides by de novo metabolic engineering remains a great challenge due to their strict and complex regulatory machinery involved in biosynthetic pathways. Results In this study, we designed an in silico-guided strategy for overproducing purine nucleosides based on a genome-scale metabolic network model in Bacillus subtilis. The metabolic flux was analyzed to predict two key backflow nodes, Drm (purine nucleotides toward PPP) and YwjH (PPP-EMP), to resolve the competitive relationship between biomass and purine nucleotide synthesis. In terms of the purine synthesis pathway, the first backflow node Drm was inactivated to block the degradation of purine nucleotides, which greatly increased the inosine production to 13.98-14.47 g/L without affecting cell growth. Furthermore, releasing feedback inhibition of the purine operon by promoter replacement enhanced the accumulation of purine nucleotides. In terms of the central carbon metabolic pathways, the deletion of the second backflow node YwjH and overexpression of Zwf were combined to increase inosine production to 22.01 +/- 1.18 g/L by enhancing the metabolic flow of PPP. By switching on the flux node of the glucose-6-phosphate to PPP or EMP, the final inosine engineered strain produced up to 25.81 +/- 1.23 g/L inosine by a pgi-based metabolic switch with a yield of 0.126 mol/mol glucose, a productivity of 0.358 g/L/h and a synthesis rate of 0.088 mmol/gDW/h, representing the highest yield in de novo engineered inosine bacteria. Under the guidance of this in silico-designed strategy, a general chassis bacterium was generated, for the first time, to efficiently synthesize inosine, adenosine, guanosine, IMP and GMP, which provides sufficient precursors for the synthesis of various purine intermediate

关键词： Bacillus subtilis Genome-scale metabolic network model Metabolic engineering Backflow node Purine nucleosides Chassis bacterium

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Hydrophobic chitosan/salicylic acid blends film with excellent tensile properties for degradable food packaging plastic materials

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JOURNAL OF APPLIED POLYMER SCIENCE 2022年第43期139卷 e53042-e53042页

作者： Liu, Jin Wang, Tianhao Hu, Canmin Lei, Li Liang, yu Gao, Zideng Ren, Xueqin Hu, shuwen China Agr Univ Coll Resources & Environm Sci Beijing 100193 Peoples R China China Agr Univ Beijing Key Lab Farmland Soil Pollut Prevent & Re Beijing Peoples R China Minist Land & Resources China Key Lab Agr Land Qual Beijing Peoples R China

Degradable plastic materials made from biopolymer Chitosan (CS) present one of the alternatives to plastic bags for food packaging, but the stability and durability limits its application. Herein, we demonstrated a facile method of producing hydrophobic CS/salicylic acid (SA) film in organic phase for the first time. SA, which can destruct hydrogen bonds of CS was initially blended with CS in N, N-dimethylacetamide using a catalyst. On this basis, CS/SA blend was crosslinked via isocyanate to the hydrophobic CS-SA film. The derivatives structures were characterized using SEM, FTIR, UV-Vis, and fluorescence spectrum. The film-forming ability of CS was maintained, while the hydrophobicity, mechanical strength, and thermal stability of films were improved. These dramatic improvements occurred with the blending effects of CS and SA and the crosslinking effects of organic isocyanate cross linker. The permeabilities to water vapor and water-soluble substances of film were promoted, which are conducive to the application of the film as food packaging. The demonstration of bacteriostatic and grape preservation properties featured the super performance of the synthetic CS/SA film. Our work provides novel food preservation materials, which can replace the commonly used packaging materials and promote the development of the degradable food packaging plastic bags field.

关键词： degradation films hydrophobicity mechanical properties packaging

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Hierarchical Self-Assembly of Polyethylene Midblock Copolymers in Hot Steam: Key Role of Crystalline and Topological Structure

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MACROMOLECULAR CHEMISTRY AND PHYSICS 2021年第7期222卷

作者： Cheng, shuwen Hu, yu Wu, Xuanhong Li, Wei Mu, Jingshan Ningbo Univ Ningbo Key Lab Specialty Polymers Sch Mat Sci & Chem Engn Ningbo 315211 Peoples R China

A series of linear-shaped, H-shaped, and dumbbell-shaped semi-crystalline triblock copolymers (E-1, E-2 and E-3) is prepared, which contains polyethylene (PE) midblock and poly(methyl methacrylate) (PMMA) endblocks. The molecular design in this study is focused on the variation of the length and number of PMMA chains, with a fixed PE midblock (M-n = 16 000 g mol(-1)) and approximate composition (wt(PE)%:wt(PMMA) approximate to 1:1), upon which the hierarchical self-assembly behavior in solvent vapor annealing (SVA) process is investigated. The dumbbell-shaped E-3, which contains the most and shortest PMMA chains, shows a drastic reduction of the T-m and crystallinity of PE midblock. It is attributed to the plasticization effects by the dumbbell architecture, which disturbed the chain folding of PE block. The variation of the topological structure of copolymers not only accelerates the transformation of morphologies from spherical to network, but also leads to the formation of new morphologies. After repeated annealing, both E-1 and E-2 form crossed network, columnar and flower-like morphologies by higher-level assembly from preassembled vermicular micelles. By comparison, the dumbbell-shaped E-3 assembled into lamellar or stacks of "lamellar" morphologies. The hierarchical self-assembly can be governed by the combination of the driving forces of PE crystallization and the topologies structure.

关键词： block copolymers crystallization self‐ assembly solvent vapor annealing topological structures

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