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Dietary bamboo vinegar powder improves growth performance, immunity, antioxidant capacity and lipid metabolism of largemouth bass (Micropterus salmoides)

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ANIMAL FEED SCIENCE AND TECHNOLOGY 2025年 321卷

作者： Lai, Weibin Xu, shuwen yu, Ran Li, Linyi Zuo, yuanyi Yang, Manqi Zhang, Liangliang Lu, Liming Xu, Yong Liu, Yiwen Wang, Hua Jiang, Jianchun Huaqiao Univ Coll Chem Engn Xiamen 361021 Peoples R China Huaqiao Univ Acad Adv Carbon Convers Technol Fujian Prov Key Lab Biomass Low Carbon Convers Xiamen 361021 Peoples R China Nanjing Forestry Univ Coll Chem Engn Nanjing 210000 Peoples R China Inst Chem Ind Forest Prod CAF Nanjing 210042 Peoples R China Wufeng Chicheng Biotech Co Ltd Yichang 443000 Peoples R China Huaqiao Univ Sch Clin Med Xiamen 361021 Peoples R China

Bamboo vinegar powder (BVP), a secondary product of bamboo charcoal production, contains multiple bioactive compounds. However, its effects on largemouth bass remain unclear. To investigate these effects, six experimental diets containing different BVP levels (0, 0.5, 1.0, 2.0, 4.0, and 8.0 g/kg) were designed, and a 56-day feeding experiment was conducted on largemouth bass (Micropterus salmoides, 7.00 +/- 0.02 g). Results demonstrated significant increase in the weight gain rate (P < 0.05) and specific growth rate (P < 0.05) and decrease in the feed conversion ratio (P < 0.05) with administration of diet containing 2.0 g/kg BVP. In addition, BVP (0.5-8.0 g/kg) significantly improved the levels of health indicators, such as aspartate aminotransferase, alanine transaminase, and alkaline phosphatase (P < 0.05) in the liver. In terms of antioxidative properties, BVP (1.0-2.0 g/kg) improved the levels of antioxidant enzymes, including total antioxidant capacity (P < 0.05) and catalase (P < 0.05), reduced the malondialdehyde content (P < 0.05), and upregulated the expression of nuclear factor erythroid 2-related factor 2 (P < 0.05). Regarding lipid metabolism, BVP (1.0-8.0 g/kg) decreased the triglyceride (P < 0.05) and total cholesterol (P < 0.05) levels in the liver and improved hepatic lipid metabolism by upregulating the expression of lipid transport (hormone-sensitive lipase and lipoprotein lipase) and lipid metabolism (fatty acid transport protein and microsomal triglyceride transfer protein) genes (P < 0.05). With regard to inflammation, BVP (0.5-4 g/kg) modulated the expression of inflammatory factors (interleukin-8, transforming growth factor-beta, and interleukin-10;P < 0.05) to improve the inflammatory response. Collectively, these results suggested that dietary BVP at a level of 2.0 g/kg can help improve growth performance, antioxidant capacity, and inflammatory response and reduce lipid deposition in the liver of largemouth bass.

关键词： Bamboo vinegar powder Largemouth bass Growth performance Antioxidant capacity Lipid metabolism

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Feasibility of the enhanced neuromuscular blockade recovery protocol with selective use of sugammadex in thyroid surgery with intraoperative neuromonitoring

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HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK 2024年第12期46卷 2917-2925页

作者： Yang, shuwen Sun, Zhirong Zhou, Changming Wei, Wenjun Qu, Ning Shi, Rongliang Ma, Ben Xu, Weibo Ji, Qinhai Zhang, Jun Wang, yu Fudan Univ Shanghai Canc Ctr Dept Head & Neck Surg Shanghai 200032 Peoples R China Fudan Univ Shanghai Med Coll Dept Oncol Shanghai Peoples R China Fudan Univ Shanghai Canc Ctr Canc Res Inst Shanghai 200032 Peoples R China Fudan Univ Shanghai Canc Ctr Dept Anesthesiol Shanghai 200032 Peoples R China Fudan Univ Shanghai Canc Ctr Dept Canc Prevent Shanghai Peoples R China

Background: To investigate feasibility of utilizing enhanced neuromuscular blocking agents with selective recovery protocol during thyroid surgery with intraoperative neuromonitoring (IONM). Methods: Two-hundred and ninety patients were randomized into two groups: group A 0.3 mg/kg rocuronium and group B 0.6 mg/kg. Sugammadex 2 mg/kg was injected if needed followed initial vagal stimulation (V0). Electromyography signals from vagus and recurrent laryngeal nerves before and after resection were recorded as V1, V2, R1, and R2. Results: In group B, 30 patients (20.7%) had V0 signals <100 mu V, compared to 9 (6.2%) in group A. After sugammadex administration, 144 patients (99.3%) in both groups achieved positive V1 signals. Group B demonstrated a shorter surgical time from rocuronium injection to V2 stimulation compared to group A, accompanied by a significantly lower incidence of intraoperative body movement (0 vs. 16 patients). Conclusions: 0.6 mg/kg rocuronium with selective use 2 mg/kg sugammadex for IONM in thyroid surgery can meet both anesthesia and surgery demands.

关键词： intraoperative neural monitoring neuromuscular blockade recurrent laryngeal nerve sugammadex thyroid surgery

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Effect of different free-range systems on the growth performance, carcass traits, and meat quality of Yangzhou geese

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ANIMAL BIOTECHNOLOGY 2023年第9期34卷 4301-4307页

作者： Chen, Jianzhou Weng, Kaiqi Liu, Jinlu Gu, Wang Luo, shuwen Zheng, Ming Cao, Zhengfeng Zhang, yu Zhang, Yang Chen, Guohong Xu, Qi Yangzhou Univ Coll Anim Sci & Technol Key Lab Anim Genet & Breeding & Mol Design Jiangsu Yangzhou Peoples R China Yangzhou Univ Joint Int Res Lab Agr & Agriprod Safety Minist Educ China Yangzhou Peoples R China Yangzhou Univ Key Lab Anim Genet & Breeding & Mol Design Jiangsu Yangzhou 225009 Peoples R China

This study was conducted to investigate the effects of different free-range systems on the growth performance, carcass traits, and meat quality of geese. Grass pasture zones in the study area were selected, and 28 d-old male Yangzhou geese with similar body weights (1.57 +/- 0.12 kg) were randomly allocated to one of three conditions: (A) free-range conditions in the apron area during 9:00 a.m.-4:00 p.m. (10-20 m from shed with grass pasture);(B) free-range conditions in the outer range from 9:00 a.m. to 4:00 p.m. (beyond 50 m from shed with grass pasture);and (C) barn system. Free range-reared geese had higher weight gain after 42 days of age than barn-reared geese, regardless of the range area. A lower feed conversion ratio was found in outer range-reared and apron area-reared geese from 28 to 63 days of age. In addition, the highest percentages of leg and breast muscle weights were observed in outer range-reared and apron area-reared geese, respectively. Finally, outer-range rearing resulted in a lower pH and lower moisture content. Therefore, these data suggest that the outer range system benefits growth performance and feed conversion ratio of geese and results in a higher percentage of leg muscle weight, lower pH, and lower moisture content.

关键词： Goose free range body weight carcass performance meat quality

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Poplar glutathione S-transferase PtrGSTF8 contributes to reactive oxygen species scavenging and salt tolerance

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PLANT PHYSIOLOGY AND BIOCHEMISTRY 2024年 212卷 108766页

作者： Song, yushuang yu, Keji Zhang, shuwen Li, Yi Xu, Changwen Qian, Hongping Guo, Yayu Zhang, Xi Li, Ruili Dixon, Richard A. Lin, Jinxing Beijing Forestry Univ Coll Biol Sci & Biotechnol Beijing 100083 Peoples R China Beijing Forestry Univ Inst Tree Dev & Genome Editing Beijing 100083 Peoples R China Univ North Texas BioDiscovery Inst Denton TX 76203 USA Univ North Texas Dept Biol Sci Denton TX 76203 USA

Glutathione S-transferases (GSTs) constitute a protein superfamily encoded by a large gene family and play a crucial role in plant growth and development. However, their precise functions in wood plant responses to abiotic stress are not fully understood. In this study, we isolated a Phi class glutathione S-transferase-encoding gene, PtrGSTF8, from poplar (Populus alba x P. glandulosa), which is significantly up-regulated under salt stress. Moreover, compared with wild-type (WT) plants, transgenic tobacco plants exhibited significant salt stress tolerance. Under salt stress, PtrGSTF8-overexpressing tobacco plants showed a significant increase in plant height and root length, and less accumulation of reactive oxygen species. In addition, these transgenic tobacco plants exhibited higher superoxide dismutase, peroxidase, and catalase activities and reduced malondialdehyde content compared with WT plants. Quantitative real-time PCR experiments showed that the overexpression of PtrGSTF8 increased the expression of numerous genes related to salt stress. Furthermore, PtrMYB108, a MYB transcription factor involved in salt resistance in poplar, was found to directly activate the promoter of PtrGSTF8, as demonstrated by yeast one-hybrid assays and luciferase complementation assays. Taken together, these findings suggest that poplar PtrGSTF8 contributes to enhanced salt tolerance and confers multiple growth advantages when overexpressed in tobacco.

关键词： Glutathione S-Transferase Poplar PtrGSTF8 PtrMYB108 Salt tolerance Transgenic tobacco

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Laser Powder Bed Fusion of 316L Stainless Steel: Effect of Laser Polishing on the Surface Morphology and Corrosion Behavior

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MICROMACHINES 2023年第4期14卷 850-850页

作者： Liu, Jun Ma, Haojun Meng, Lingjian Yang, Huan Yang, Can Ruan, Shuangchen Ouyang, Deqin Mei, shuwen Deng, Leimin Chen, Jie Cao, yu Wenzhou Univ Coll Mech & Elect Engn Zhejiang Prov Key Lab Laser Proc Robot Wenzhou 325035 Peoples R China Shenzhen Technol Univ Sino German Coll Intelligent Mfg Shenzhen 518118 Peoples R China Nantong Jinyuan Intelligent Technol Co Nantong 226007 Peoples R China Huazhong Univ Sci & Technol Wuhan Natl Res Ctr Optoelect Wuhan 430074 Peoples R China Wenzhou Univ Ruian Grad Coll Ruian 325207 Peoples R China

Recently, laser polishing, as an effective post-treatment technology for metal parts fabricated by laser powder bed fusion (LPBF), has received much attention. In this paper, LPBF-ed 316L stainless steel samples were polished by three different types of lasers. The effect of laser pulse width on surface morphology and corrosion resistance was investigated. The experimental results show that, compared to the nanosecond (NS) and femtosecond (FS) lasers, the surface material's sufficient remelting realized by the continuous wave (CW) laser results in a significant improvement in roughness. The surface hardness is increased and the corrosion resistance is the best. The microcracks on the NS laser-polished surface lead to a decrease in the microhardness and corrosion resistance. The FS laser does not significantly improve surface roughness. The ultrafast laser-induced micro-nanostructures increase the contact area of the electrochemical reaction, resulting in a decrease in corrosion resistance.

关键词： selective laser melting laser polishing 316L stainless steel surface morphology electrochemical corrosion

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Application of roadside air purifiers in urban street canyons: A pilot-scale study in Hong Kong

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SCIENCE OF THE TOTAL ENVIRONMENT 2024年 912卷 168671页

作者： Li, Xinwei Han, shuwen Wang, Pengge Mei, Han Ning, Zhi Dong, Fan Cui, Long Huang, yu Wang, Tao Leu, Shao-yuan Wang, Meng Lee, Shun-cheng Hong Kong Polytech Univ Dept Civil & Environm Engn Hong Kong Peoples R China Chinese Acad Sci Inst Earth Environm State Key Lab Loess & Quaternary Geol SKLLQG Xian Peoples R China Chinese Acad Sci Inst Earth Environm Key Lab Aerosol Chem & Phys Xian Peoples R China Hong Kong Univ Sci & Technol Div Environm & Sustainabil Clear Water Bay Hong Kong Peoples R China Univ Elect Sci & Technol China Inst Fundamental & Frontier Sci Res Ctr Carbon Neutral Environm & Energy Technol Chengdu Peoples R China Hong Kong Univ Sci & Technol Guangzhou Thrust Earth Ocean & Atmospher Sci Funct Hub Guangzhou Peoples R China

The implementation of roadside air purifiers has emerged as an effective active control measure to alleviate air pollution in urban street canyons. However, technical questions raised under real conditions remain challenging. In this study, we conducted a pilot-scale investigation involving seven units of self-designed roadside air purifiers in an urban street canyon in Hong Kong. The air cleaning effects were quantified with an air quality sensor network after rigorous quality control. The removal efficiencies of Nitrogen dioxide (NO2), Fine suspended particulates (PM2.5), Carbon monoxide (CO), and Nitric oxide (NO) were determined by comparing with simultaneously measured ambient concentrations, with hourly average efficiencies of 14.0 %-16.9 %, 3.5-10.0 %, 11.9 %-18.7 %, and 19.2 %-44.9 %, respectively. Generally, the purification effects presented variations depending on the ambient pollutants' levels. Higher ambient concentrations of NO2, PM2.5, CO correlated with increased purification effects, while NO presented the opposite trend. The influence of interval distance combined with spatial distribution indicated the operation of purifiers will induce local NO2 attenuation even at an interval distance of four meters. Statistical analysis delivered evidence the air cleaning ability exhibited optimal performance when relative humidity level is ranged from 70 % to 90 %, aligning with the prevailing conditions in Hong Kong. Additionally, improved purification effects were observed at the downwind direction, and their performance was enhanced when the wind speed exceeded 2.5 m/s. Moreover, we estimated the operational lifetime of the air purifiers to be approximately 130 days, offering crucial information regarding the filter replacement cycle. This work serves as a pioneering case study, showcasing the feasibility and deployment considerations of roadside air purifiers in effectively controlling air pollution in urban environments.

关键词： Roadside air purifiers Hong Kong roadside Urban air pollution Meteorological variables

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The casein-derived peptide YFYPEL alleviates intestinal epithelial cell dysfunction associated with NEC by regulating the PI3K/AKT signaling pathway

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FOOD & FUNCTION 2023年第8期14卷 3769-3778页

作者： Chen, Wenjuan Chen, Yanjie Qian, yun Zhang, Jun Hu, Xiaoshan Yan, Xiangyun Jiang, Chengyao Yao, shuwen yu, Qinlei Chen, Xiaohui Han, Shuping Nanjing Med Univ Nanjing Matern & Child Hlth Care Hosp Dept Pediat Womens Hosp Nanjing Jiangsu Peoples R China

Necrotizing enterocolitis (NEC) is a life-threatening risk to the health of neonates, but thus far, there is no very effective treatment. Although many studies have confirmed the therapeutic role of peptides in diseases, the effect of peptides in NEC remains poorly understood. This study investigated the role of casein-derived peptide YFYPEL in NEC cells and animal models. We synthesized YFYPEL and analysed its protective effects on NEC both in vitro and in vivo. YFYPEL integration in the intestine increased rat survival and clinical conditions, lowered the incidence of NEC, alleviated bowel inflammation, and enhanced intestinal cell migration. Furthermore, YFYPEL significantly decreased interleukin 6 expression and increased intestinal epithelial cell migration. Moreover, YFYPEL alleviated intestinal epithelial cell dysfunction through the PI3K/AKT pathway, as demonstrated by western blotting and bioinformatics analysis. A selective PI3K activator reversed the protective effect of YFYPEL on lipopolysaccharide-stimulated intestinal epithelial cells. Our study showed that YFYPEL reduced inflammatory cytokine expression and enhanced migration by regulating the PI3K/AKT pathway. The use of YFYPEL may thus develop into a novel modality in NEC treatment.

关键词： Peptides

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Blocking GP130 binding in interleukin-11 through site-specific PEGylation attenuates bleomycin-induced pulmonary fibrosis in mice

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INTERNATIONAL JOURNAL OF PHARMACEUTICS 2024年第Pt B期667卷 124916页

作者： Wang, Sa Wang, Pengyu Zhang, Minhui Song, Xiaotong Wei, Long Ma, Xinyuan Yao, Xin Zhang, shuwen Chen, Zijie Zheng, Yongxiang yu, Rong Zhang, Chun Sichuan Univ Key Lab Drug Targeting & Drug Delivery Syst Educ M Sichuan Engn Lab Plant Sourced Drug Chengdu 610041 Peoples R China Sichuan Univ Sichuan Res Ctr Drug Precis Ind Technol West China Sch Pharm Dept Biopharmaceut Chengdu 610041 Peoples R China

Recent insights have identified interleukin-11 (IL-11) as a pivotal profibrotic cytokine, with its signaling through IL-11R alpha and GP130 receptors emerging as a promising therapeutic target for fibrotic diseases. Herein, we developed receptor-biased IL-11 via site-specific PEGylation at the GP130 binding interface, aiming to explore its therapeutic potential for bleomycin-induced pulmonary fibrosis in mice. By conducting single site-directed cysteine mutagenesis at site II or site III of IL-11, we refined the conjugation site, demonstrating that mutation at site III exhibits heightened sensitivity to GP130 binding and signaling. Cysteine-based PEGylation substantially attenuated the ability of GP130 to bind to IL-11 W147C, while almost entirely preserving its IL-11R alpha binding ability. These PEGylated IL-11 W147C analogs showed potent inhibition of TF-1 cell proliferation and significant antagonism to TGF-(31-induced human lung fibroblasts (HLFs) differentiation into myofibroblasts. Moreover, PEGylation significantly prolonged the half-life of IL-11 W147C in healthy rats. Subcutaneous administration of PEGylated analogs, particularly PEG20/40 k-IL-11 W147C, effectively mitigated extracellular matrix deposition, preserved alveolar architecture, and attenuated the progression of pulmonary fibrosis in mice. The finding of this study not only underscores the therapeutic potential of IL-11 modulation, but also provides a general strategy for the design of cytokine-based biased antagonists and agonists targeting these multifaceted signaling pathways.

关键词： Interleukin-11 site-specific PEGylation IL-11 signaling inhibition Pulmonary fibrosis

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Optimization of bovine embryonic fibroblast feeder layer prepared by Mitomycin C

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CELL AND TISSUE BANKING 2023年第1期24卷 221-230页

作者： Zhao, Fang yu, Jianning Ding, Qiang Chen, Kunlin Xia, shuwen Qian, Yong Gao, yundong Lin, Zhiping Wang, Huili Zhong, Jifeng Jiangsu Acad Agr Sci Inst Anim SciState Key Lab Cultivat Base Jiangsu Key Lab Food Qual & SafetyMinist Sci & T Key Lab Crop & Anim Integrated FarmingMinist Agr Nanjing 210014 Jiangsu Peoples R China Shandong Ox Livestock Breeding Co Ltd Jinan 250100 Shandong Peoples R China Jiangsu Youyuan Dairy Res Inst Nanjing 211100 Jiangsu Peoples R China

Feeder cells play important roles in In-vitro culture of stem cells. However, the preparation protocol of feeder cells produced by bovine embryonic fibroblast cells (bEFs) is still lack. In this study, the preparation of bEF-feeder by Mitomycin C was optimized with different concentrations and treatment time. The cell viability of bEFs was detected by CCK8 and 5-Ethynyl-2 '-deoxyuridine. The growth of bESCs in each bEFs-feeder group was assessed by alkaline phosphatase staining and CCK8. Quantitative real time PCR was used to detect the mRNA expression of pluripotency-related genes of bESCs. Results showed that the proliferation of bEFs was significantly repressed while bEFs were treated with 14 ug/mL or 16 ug/mL Mitomycin C for 3 h, and the cell viability within 2-4 days after treatment was consistent with the 1st day. The numbers of bESCs clones in bEF-feeder treated with 14 mu g/mL Mitomycin C for 3 h or 16 mu g/mL Mitomycin C for 3 h were significantly higher than that in bEF-feeder treated with 8 mu g/mL Mitomycin C for 8 h or bEFs treated with 6 mu g/mL Mitomycin C for 9 h. The mRNA expression of pluripotency-related genes in bESCs cultured by bEF-feeder were higher than the MEF-feeder, the clone morphology of bESCs cultured in bEF-feeder was rounder and sharper than the MEF-feeder. In conclusion, the bEF-feeder prepared with 14 mu g/mL Mitomycin C for 3 h or 16 mu g/mL Mitomycin C for 3 h could effectively maintains the growth of bESCs, and bEF-feeder is more suitable for bESCs culture than the MEF-feeder.

关键词： Bovine embryonic fibroblasts Mitomycin C Cell proliferation Feeder cells Bovine pluripotent stem cell

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Structural connectivity from DTI to predict mild cognitive impairment in de novo Parkinson's disease

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NEUROIMAGE-CLINICAL 2024年 41卷 103548-103548页

作者： Huang, Xiaofei He, Qing Ruan, Xiuhang Li, yuting Kuang, Zhanyu Wang, Mengfan Guo, Riyu Bu, shuwen Wang, Zhaoxiu yu, Shaode Chen, Amei Wei, Xinhua South China Univ Technol Affiliated Hosp 2 Sch Med Dept Radiol Guangzhou Guangdong Peoples R China Southern Med Univ Affiliated Dongguan Hosp Dongguan Peoples Hosp Dongguan Guangdong Peoples R China Commun Univ China Sch Informat & Commun Engn Beijing Peoples R China

Background: Early detection of Parkinson's disease (PD) patients at high risk for mild cognitive impairment (MCI) can help with timely intervention. White matter structural connectivity is considered an early and sensitive indicator of neurodegenerative disease. Objectives: To investigate whether baseline white matter structural connectivity features from diffusion tensor imaging (DTI) of de novo PD patients can help predict PD-MCI conversion at an individual level using machine learning ***: We included 90 de novo PD patients who underwent DTI and 3D T1-weighted imaging. Elastic net based feature consensus ranking (ENFCR) was used with 1000 random training sets to select clinical and structural connectivity features. Linear discrimination analysis (LDA), support vector machine (SVM), K-nearest neighbor (KNN) and naive Bayes (NB) classifiers were trained based on features selected more than 500 times. The area under the ROC curve (AUC), accuracy (ACC), sensitivity (SEN) and specificity (SPE) were used to evaluate model ***: A total of 57 PD patients were classified as PD-MCI nonconverters, and 33 PD patients were classified as PD-MCI converters. The models trained with clinical data showed moderate performance (AUC range: 0.62-0.68;ACC range: 0.63-0.77;SEN range: 0.45-0.66;SPE range: 0.64-0.84). Models trained with structural connectivity (AUC range, 0.81-0.84;ACC range, 0.75-0.86;SEN range, 0.77-0.91;SPE range, 0.71-0.88) performed similar to models that were trained with both clinical and structural connectivity data (AUC range, 0.81-0.85;ACC range, 0.74-0.85;SEN range, 0.79-0.91;SPE range, 0.70-0.89).Conclusions: Baseline white matter structural connectivity from DTI is helpful in predicting future MCI conversion in de novo PD patients.

关键词： Parkinson's disease Mild cognitive impairment Structural connectivity Diffusion tensor imaging Machine learning

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