检索结果-内蒙古大学图书馆

Chiral Resolution of Transition Metal Polypyridyl Complexes via HPLC As a Gateway to Enantiopure DNA Targeting Probes

引用

EUROPEAN JOURNAL OF INORGANIC CHEMISTRY 2025年第11期28卷

作者： Smith, Simon N. Graczyk, Daniel Stitch, Mark Auville, Amelia stadler, victoria Quinn, Susan J. Univ Coll Dublin UCD Sch Chem Dublin D04 V1 W8 Ireland

The intrinsic structural and photophysical properties of octahedral tris-(bidentate) transition metal polypyridyl complexes make them attractive DNA probes whose binding affinity and specificity for DNA can be greatly influenced by the Delta- and Lambda-enantiomer forms. Strategies for chiral resolution include chiral precursors, fractional crystallisation with chiral salts as well as chromatographic methods. The present work details the optimisation of a chiral resolution process to facilitate the isolation of metal complex enantiomers via chiral stationary phase HPLC using a semi-preparative column. The scope of the study includes both Ru(II) and Os(II) polypyridyl enantiomers containing commonly encountered coordination environments as well as a range of more exotic ligand scaffolds that illustrate the generality of the method. Notably, this work also describes the ability to separate enantiomers of a mixture of two complexes prepared as a result of 'ligand-scrambling' during synthesis.

关键词： transition metal polypyridyl complex chirality chromatography HPLC

来源：评论

学校读者我要写书评

暂无评论

The use of hypoglycemic drugs in Parkinson's disease: An updated meta-analysis of randomized controlled trials

引用

PARKINSONISM & RELATED DISORDERS 2025年 130卷 107210-107210页

作者： Sobral, Milene Vitoria Sampaio Soares, Victor Goncalves Moreria, Joa Lucas de Magalhaes Leal Rodrigues, Livia Kneipp Rocha, Paula Bendaham, Lucas Cael Azevedo Ramos Goncalves, Ocilio Ribeiro Pirolla, Rafaela da Cunha Vilela, Lucas Veronezi de Abreu, victoria stadler Almeida, Kelson James Univ Western Sao Paulo Presidente Prudente Brazil Fed Univ Jequitinhonha & Mucuri Valleys Diamantina Brazil State Univ Feira De Santana Feira de Santana Brazil Univ Fed Minas Gerais Belo Horizonte Brazil Univ Miami Miami FL USA Univ Fed Roraima Boa Vista Brazil Univ Fed Piaui Teresina Brazil Med Sch Petropolis Rio De Janeiro Brazil

Introduction: Recent studies have demonstrated an association between hypoglycemic medications and neuroprotective action in neurodegenerative diseases, such as Parkinson's disease (PD). Therefore, in this metaanalysis, our objective was to evaluate the efficacy of these medications, compared to placebo, as diseasemodifying therapy in patients with PD. Methods: We systematically searched PubMed, Embase, and Cochrane for studies comparing the use of hypoglycemic drugs and placebo in patients with PD. Statistical analyses were performed using R Studio 4.3.2. Mean difference (MD) with 95 % confidence intervals (CI) were pooled across trials. Outcomes of interest were change in Movement Disorders Society - Unified Parkinson's Disease Rating Scale (MDS-UPDRS) parts I, II, III, IV, and Parkinson's Disease Questionnaire 39 (PDQ-39). Results: This meta-analysis included six randomized controlled trials (RCT) reporting data on 787 patients. Among them, 480 (61 %) received hypoglycemic drugs. Follow-up ranged from 36 to 61 weeks. At the end of follow-up, improvement in MDS-UPDRS part III score during OFF state occurred when subjects received any hypoglycemic agents at their lowest dose (MD -1.36;95 % IC -2.78 to -0.47;I2 = 38 %), as well as highest doses (MD -1.58;95 % IC -3.07 to -0.09;I2 = 50 %). Changes in MDS-UPDRS part III score in patients examined in the ON state who received any dose of any hypoglycemic agents (MD -3.32;95 % IC -5.28 to -1.36;I2 = 0 %) were significant. There was no significant difference between groups MDS-UPDRS parts I, II, IV, and PDQ-39. Conclusion: In patients with PD, the use of hypoglycemic agents showed efficacy on symptomatic PD treatment with an improvement in MDS-UPDRS part III.

关键词： Parkinson's disease Hypoglycemic drugs Meta-analysis

来源：评论

学校读者我要写书评

暂无评论

Pseudozyma spp. human infections: A systematic review

引用

MEDICAL MYCOLOGY 2020年第1期59卷 1-6页

作者： Telles, Joao Paulo Tasca Ribeiro, victoria stadler Kraft, Leticia Tuon, Felipe Francisco AC Camargo Canc Ctr Infect Dis Dept Sao Paulo SP Brazil Pontificia Univ Catolica Parana Lab Emerging Infect Dis Curitiba Parana Brazil

Pseudozyma spp. are described as environmental yeasts but have also been identified as rare human pathogens found in immunocompromised patients. This systematic review details the clinical manifestations, diagnosticmethodology, and empirical anti-fungal therapy for this rare yeast. PubMed, LILACS, Scielo, and Web of Science databases were searched for articles about Pseudozyma spp. infections from inception to June 2019. Inclusion criteria were any published studies that included patients with Pseudozyma spp. infection. Infections were identified using criteria set forth by the European Organization for Research and Treatment of Cancer, and were further classified according to clinical, laboratory, or radiologic findings, microbiologic confirmation, and response to therapy. Eleven articles were included with 15 patients. Oncological and/or hematological disorders were the most reported risk factors. Nontraditional microbiological methods correctly identified Pseudozyma spp., whereas traditional methods failed to identify fungal genus. Species were identified by sequencing, and most demonstrated a higher minimal inhibitory concentration (MIC) for fluconazole and echinocandins. MICs for itraconazole, voriconazole, and posaconazole varied by species. All isolates were susceptible to amphotericin B, which was the most used treatment. Pseudozyma spp. infections usually present with fever and are diagnosed by blood culture. Most species studied appeared to be resistant to fluconazole and echinocandin. Voriconazole, posaconazole, and amphotericin were effective in treating P. aphidis. However, more studies are needed to evaluate voriconazole and posaconazole in species other than P. aphidis.

关键词： Pseudozyma yeast amphotericin

来源：评论

学校读者我要写书评

暂无评论

Arboviral diseases and COVID-19 in Brazil: Concerns regarding climatic, sanitation, and endemic scenario

引用

JOURNAL OF MEDICAL VIROLOGY 2020年第11期92卷 2390-2391页

作者： Ribeiro, victoria stadler Tasca Telles, Joao Paulo Tuon, Felipe Francisco Pontificia Univ Catolica Parana Sch Med Lab Emerging Infect Dis R Imaculada Conceicao 1155 Prado Velho BR-80215901 Curitiba Parana Brazil AC Camargo Canc Ctr Infect Dis Dept Sao Paulo Brazil

Brazil is witnessing a massive increase of COVID-19 cases and may face some difficulties, not only regarding to other respiratory pathogens, but also to other relevant issues parallelly occurring, for instance, the beggining of autumn and winter seasons, which provides a longer period with high transmissibility of respiratory viroses. Additionally, Brazil is localized in a geographical tropical area with relevant arboviral diseases, where Dengue fever presented highest incidence during March-June, mainly at Southeast and Midwest regions, where probably it will occur overlapping curves of arboviruses and COVID-19, which will overload our public health system. The main affected áreas by COVID-19 in Brazil were the same that presented 66% of the Dengue fever cases in Brazil. Moreover, it is importante to highlight the difficulty found to distinguish Dengue fever and COVID-19 and its implications, which present similar laboratorial and clinical characteristics. Besides that, it has been pointed out false-positive results in serological tests for Dengue fever, which later were confirmed as COVID-19. These issues demand urgent attention,once they culminate in serious and devastating impacts in the Brazilian health system, public health, and social conditions. This article is protected by copyright. All rights reserved.

关键词： Coronavirus < Virus classification Dengue virus < Virus classification Endemic infection < Epidemiology Influenza virus < Virus classification Pandemics < Epidemiology Zoonoses < Epidemiology

来源：评论

学校读者我要写书评

暂无评论

Concerns about COVID-19 and tuberculosis in Brazil: Social and public health impacts

引用

ENFERMEDADES INFECCIOSAS Y MICROBIOLOGIA CLINICA 2021年第4期39卷 216-217页

作者： Tasca Ribeiro, victoria stadler Telles, Joao Paulo Tuon, Felipe Francisco Pontificia Univ Catolica Parana Sch Med Lab Emerging Infect Dis BR-80215901 Curitiba Parana Brazil AC Camargo Canc Ctr Dept Infect Dis Sao Paulo SP Brazil

来源：评论

学校读者我要写书评

暂无评论

Risk factors for plantar foot ulcer recurrence in patients with diabetes - A prospective pilot study

引用

JOURNAL OF TISSUE VIABILITY 2020年第2期29卷 135-137页

作者： Freitas, Franciele Winter, Marcos Cieslinski, Juliette Tasca Ribeiro, victoria stadler Tuon, Felipe Francisco Univ Fed Parana Posgrad Med Interna Curitiba PR Brazil Pontificia Univ Catolica Parana Sch Med Div Infect Dis Curitiba PR Brazil Pontificia Univ Catolica Parana Sch Med Lab Emerging Infect Dis R Imaculada Conceicao 1155 BR-80215901 Curitiba PR Brazil

Introduction: Diabetic foot ulcer (DFU) is a complication of diabetes mellitus (DM) with established recurrence risk factors evaluating patients from United States or Europe. There are scarce studies in developing countries about these risks. The aim of this study was to evaluate risk factors associated with DFU recurrence in a Brazilian prospective cohort. Materials and methods: A prospective cohort of patients with healed DFU followed from January 2014 to June 2017 in Curitiba, Brazil. Periodic home visits from a specialist nurse in DFU were performed during the period of the study to evaluate recurrence of ulcer. The presence of risk factors in the group of patients that developed an ulcer in the follow-up period was compared with the presence of these factors in the group of patients without recurrence. At enrollment, 35 subjects presented a previous ulcer distal with complete healing to follow-up. Results: From 35 patients, 15 were male (43%) and the mean age was of 65.8 +/- 10.9 years (48-85 year). Most patients were married with a low income ( < US$ 250/month). The mean BMI was 26.5 +/- 5.6 kg/cm(2) . Seventy-four percent (26/35) had another comorbidity. The mean duration of DM until ulcer was 14.6 +/- 5.2 years. The global mortality during the study (3 years) was 14%. The DFU recurred in 23 patients (65.7%). Both groups had similar findings, except by lower income ( < US$ 250/month) in the group of recurrent DFU. Conclusion: Recurrence of DFU is frequent and associated with low familiar income in a pilot Brazilian study.

关键词： Diabetic foot ulcer Ulcer Infection Diabetes mellitus Risk factors

来源：评论

学校读者我要写书评

暂无评论

Experimental procedures for decontamination and microbiological testing in cardiovascular tissue banks

引用

EXPERIMENTAL BIOLOGY AND MEDICINE 2018年第17-18期243卷 1286-1301页

作者： Suss, Paula Hansen Ribeiro, victoria stadler Tasca Cieslinski, Juliette Kraft, Leticia Tuon, Felipe Francisco Pontificia Univ Catolica Parana Lab Emerging Infect Dis Sch Med BR-80215901 Curitiba PR Brazil Pontificia Univ Catolica Parana Human Tissue Bank BR-80215901 Curitiba PR Brazil

Several methods for sampling, culturing, and decontaminating donor grafts are available for cardiovascular tissue banks. Most of these protocols are not standardized, leaving tissue banks to adapt their microbiological procedures to their tissue processing routines. Effective microbiological testing and decontamination procedures are essential to ensure tissue quality and safety for human application. This review presents the different procedures currently available for microbiological testing in cardiovascular tissue banks.

关键词： Biomedical experimental cardiovascular tissue banking cardiovascular allografts microbiological testing decontamination

来源：评论

学校读者我要写书评

暂无评论

Bioburden in transport solutions of human cardiovascular tissues: a comparative evaluation of direct inoculation and membrane filter technique

引用

CELL AND TISSUE BANKING 2018年第3期19卷 447-454页

作者： Kraft, Leticia Tasca Ribeiro, victoria stadler Wollmann, Luciana Cristina Suss, Paula Hansen Tuon, Felipe Francisco Pontificia Univ Catolica Parana Human Tissue Bank BR-80215901 Curitiba PR Brazil Pontificia Univ Catolica Parana Sch Med Div Infect Dis Rua Imaculada Conceicao 1155 BR-80215901 Curitiba PR Brazil

All cardiac allograft tissues are under potential contamination, requiring a validated terminal sterilization process or a minimal bioburden. The bioburden calculation is important to determine the bacterial burden and further decontamination and disinfection strategies for the valve processing. The aim of this study was to determine the bioburden from transport solution (TS) of heart valves obtained from non-heart-beating and heart-beating donors in different culture methods. The bioburden from TS was determined in 20 hearts donated for valve allograft tissue using membrane filter (MF) and direct inoculation. Tryptic soy agar and Sabouraud plates were incubated and colonies were counted. Ninety-five percent of samples from this study were obtained from heart-beating donors. The warm ischemic time period for heart was 1.06 +/- 0.74 h and the cold ischemic time period was 25.66 +/- 11.16 h. The mean TS volume was 232.68 +/- 96.67 mL (48.5-550 mL). From 20 samples directly inoculated on TSA agar plates, 2 (10%) were positive. However, when MF was used, from 20 samples in TSA, 13 (65%) were positive with a mean count of 1.36 +/- 4.04 CFU/mL. In Sabouraud plates, the direct inoculation was positive in 5 samples (25%) with a mean count of 0.24 +/- 0.56 CFU/mL. The use of MF increased the positivity to 50% (10 samples from a total of 20) with a mean of 0.28 +/- 0.68 CFU/mL. The positivity was superior using MF in comparison with direct inoculation (p < 0.05). The bioburden of TS is low and MF is the technique of choice due to higher positivity.

关键词： Bioburden Tissue bank Valve Bacteria Culture

来源：评论

学校读者我要写书评

暂无评论

Comparison of amphotericin B lipid complex, deoxycholate amphotericin B, fluconazole, and anidulafungin activity against Candida albicans biofilm isolated from breakthrough candidemia

引用

ENFERMEDADES INFECCIOSAS Y MICROBIOLOGIA CLINICA 2023年第10期41卷 596-603页

作者： Kraft, Leticia Ribeiro, victoria stadler Tasca Goncalves, Geiziane Aparecida Suss, Paula Hansen Tuon, Felipe Francisco Pontificia Univ Catolica Parana Sch Med Dept Hlth Sci Lab Emerging Infect Dis Curitiba Parana Brazil

Introduction: Biofilm formation causes virulence and resistance in Candida albicans. However, little is known about breakthrough candidemia isolates. We evaluated the antifungal activity of fluconazole, anidulafungin, deoxycholate amphotericin B (dAMB), and amphotericin B lipid complex (ABLC) against biofilms of C. albicans isolated from patients with breakthrough candidemia. Methods: The present study used strains of C. albicans isolated from breakthrough and non-breakthrough candidemia patients (control group). The susceptibility of planktonic cells to amphotericin B, anidulafungin, and fluconazole was determined by broth microdilution. Antifungal activity in sessile cells was evaluated using the minimum biofilm eradication concentration (MBEC), metabolic activity was estimated by reducing MTT, and biomass was estimated using crystal violet retention. Results: The planktonic strains were susceptible to amphotericin B, anidulafungin, and fluconazole, with minimum inhibitory concentrations of 1, <= 0.03, and 2 mg/L, respectively. However, fluconazole and anidulafungin did not exert an antifungal effect on biofilms. Additionally, dAMB and ABCL reduced the metabolic activity and biomass. However, eradication was only achieved using 16 mg/L dAMB. C. albicans isolates of breakthrough candidemia exhibited strong biofilm production, and the in vitro activity of available therapeutic options was poor. Conclusion: In the present study, only dAMB and ABCL exhibited antibiofilm effects against sessile breakthrough candidemia isolates. (c) 2022 Published by Elsevier Espan similar to a, S.L.U. on behalf of Sociedad Espan similar to ola de Enfermedades Infecciosas y Microbiologi ' a Cli ' nica.

关键词： Antifungals Candida Candidemia Breakthrough candidemia Biofilms

来源：评论

学校读者我要写书评

暂无评论

Invalid results of quantitative HIV and HCV NAT from living, heart beating and after circulatory death donors

引用

CELL AND TISSUE BANKING 2021年第4期22卷 631-633页

作者： Ribeiro, victoria stadler Tasca Pepes, Allana Kraft, Leticia Suss, Paula Hansen Tuon, Felipe Francisco Pontificia Univ Catolica Parana PUCPR Lab Emerging Infect Dis Sch Med Rua Imaculada Conceicao 1155 Curitiba Parana Brazil Pontificia Univ Catolica Parana PUCPR Human Tissue Bank Rua Imaculada Conceicao 1155 BR-80215901 Curitiba Parana Brazil

来源：评论

学校读者我要写书评

暂无评论

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

请选择保存的检索档案：

请选择收藏分类：

通借通还

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：