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Advanced glycation end product-modified low-density lipoprotein promotes pro-osteogenic reprogramming via RAGE/NF-κB pathway and exaggerates aortic valve calcification in hamsters

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MOLECULAR MEDICINE 2024年第1期30卷 76-76页

作者： Yang, Xi Zeng, Jingxin Xie, Kaiji su, shuwen Guo, Yuyang Zhang, Hao Chen, Jun Ma, Zhuang Xiao, Zezhou Zhu, Peng Zheng, Shaoyi Xu, Dingli Zeng, Qingchun Southern Med Univ Nanfang Hosp Dept Cardiol State Key Lab Organ Failure Res 1838 Northern Guangzhou Ave Guangzhou 510515 Peoples R China Southern Med Univ Guangdong Prov Key Lab Shock & Microcirculat Guangzhou 510515 Peoples R China Guangzhou Regenerat Med & Hlth Guangdong Lab Bioland Lab Guangzhou 510005 Peoples R China Southern Med Univ Nanfang Hosp Dept Cardiovasc Surg Guangzhou 510515 Peoples R China

Background Advanced glycation end product-modified low-density lipoprotein (AGE-LDL) is related to inflammation and the development of atherosclerosis. Additionally, it has been demonstrated that receptor for advanced glycation end products (RAGE) has a role in the condition known as calcific aortic valve disease (CAVD). Here, we hypothesized that the AGE-LDL/RAGE axis could also be involved in the pathophysiological mechanism of *** Human aortic valve interstitial cells (HAVICs) were stimulated with AGE-LDL following pre-treatment with or without interleukin 37 (IL-37). Low-density lipoprotein receptor deletion (Ldlr -/- ) hamsters were randomly allocated to chow diet (CD) group and high carbohydrate and high fat diet (HCHFD) *** AGE-LDL levels were significantly elevated in patients with CAVD and in a hamster model of aortic valve calcification. Our in vitro data further demonstrated that AGE-LDL augmented the expression of intercellular cell adhesion molecule-1 (ICAM-1), interleukin-6 (IL-6) and alkaline phosphatase (ALP) in a dose-dependent manner through NF-kappa B activation, which was attenuated by nuclear factor kappa-B (NF-kappa B) inhibitor Bay11-7082. The expression of RAGE was augmented in calcified aortic valves, and knockdown of RAGE in HAVICs attenuated the AGE-LDL-induced inflammatory and osteogenic responses as well as NF-kappa B activation. IL-37 suppressed inflammatory and osteogenic responses and NF-kappa B activation in HAVICs. The vivo experiment also demonstrate that supplementation with IL-37 inhibited valvular inflammatory response and thereby suppressed valvular osteogenic *** AGE-LDL promoted inflammatory responses and osteogenic differentiation through RAGE/NF-kappa B pathway in vitro and aortic valve lesions in vivo. IL-37 suppressed the AGE-LDL-induced inflammatory and osteogenic responses in vitro and attenuated aortic valve lesions in a hamster model of CAVD.

关键词： AGE-LDL CAVD Inflammatory Osteogenic Hamsters IL-37

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Activation of Piezo1 promotes osteogenic differentiation of aortic valve interstitial cell through YAP-dependent glutaminolysis

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SCIENCE ADVANCES 2023年第22期9卷 eadg0478页

作者： Zhong, Guoheng su, shuwen Li, Juncong Zhao, Hengli Hu, Dongtu Chen, Jun Li, Shichao Lin, Yingwen Wen, Liming Lin, Xiangjie Xian, Gaopeng Xu, Dingli Zeng, Qingchun Southern Med Univ Nanfang Hosp Dept Cardiol State Key Lab Organ Failure Res Guangzhou 510515 Peoples R China Southern Med Univ Guangdong Prov Key Lab Shock & Microcirculat Guangzhou 510515 Peoples R China Bioland Lab Guangzhou Regenerat Med & Hlth Guangdo Guangzhou Peoples R China

Hemodynamic overload and dysregulation of cellular metabolism are involved in development of calcific aortic valve disease (CAVD). However, how mechanical stress relates to metabolic changes in CAVD remains unclear. Here, we show that Piezo1, a mechanosensitive ion channel, regulated glutaminase 1 (GLS1)-mediated gluta-minolysis to promote osteogenic differentiation of valve interstitial cells (VICs). In vivo, two models of aortic valve stenosis were constructed by ascending aortic constriction (AAC) and direct wire injury (DWI). Inhibition of Piezo1 and GLS1 in these models respectively mitigated aortic valve lesion. In vitro, Piezo1 activation induced by Yoda1 and oscillatory stress triggered osteogenic responses in VICs, which were prevented by Piezo1 inhi-bition or knockdown. Mechanistically, Piezo1 activation promoted calcium-dependent Yes-associated protein (YAP) activation. YAP modulated GLS1-mediated glutaminolysis, which enhanced osteogenic differentiation through histone acetylation of runt-related transcription factor 2 (RUNX2) promoters. Together, our work pro-vided a cross-talk between mechanotransduction and metabolism in the context of CAVD.

关键词： Chemical activation

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Efficacy and safety of antithrombotic therapy with non-vitamin K antagonist oral anticoagulants after transcatheter aortic valve replacement: a systematic review and meta-analysis

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THERAPEUTIC ADVANCES IN CHRONIC DISEASE 2021年 12卷 20406223211056730页

作者： An, Qing su, shuwen Tu, Yan Gao, Lingfeng Xian, Gaopeng Bai, Yujia Zhan, Qiong Xu, Xingbo Xu, Dingli Zeng, Qingchun Southern Med Univ Clin Med Coll 1 State Key Lab Organ Failure Res Dept CardiolNanfang Hosp 1838 Northern Guangzhou Ave Guangzhou 510515 Peoples R China Southern Med Univ Guangdong Prov Key Lab Shock & Microcirculat Guangzhou Peoples R China Guangzhou Regenerat Med & Hlth Guangdong Lab Bioland Lab Guangzhou Peoples R China Georg August Univ Univ Med Ctr Gottingen Dept Cardiol & Pneumol Gottingen Germany

Objective: A meta-analysis was performed to compare the efficacy and safety of antithrombotic therapy with non-vitamin K antagonist oral anticoagulants (NOACs) versus standard care in patients after successful transcatheter aortic valve replacement (TAVR). Methods: A systematic search of PubMed, Cochrane Central Register of Controlled Trials, and EMBASE databases and website (through 21 October 2020) was performed. Risk ratios (RRs) with 95% confidence intervals (CIs) for all outcomes were calculated using random-effects models. Results: Twelve studies (two studies were randomized controlled trials) comprising 6943 patients were included (5299 had indications for oral anticoagulation (OAC) and 1644 had none). No significant differences were found between NOACs and the standard care in the incidences of all stroke, a composite endpoint, and major/life-threatening bleeding. NOACs were associated with lower all-cause mortality than vitamin K antagonists (VKAs) in post-TAVR patients with indications for OAC after more than 1 year of follow-up [RR = 0.64;95% CI, (0.42, 0.96);p = 0.03], whereas NOACs exhibited poor outcomes than antiplatelet therapy (APT) in patients without indications for OAC [RR = 1.66;95% CI, (1.12, 2.45);p = 0.01]. In the prevention of valve thrombosis, NOACs and VKAs were not significantly different in patients with indications for OAC [RR = 0.66;95% CI, (0.24, 1.84);p = 0.43], whereas NOACs were better than APT in patients without indications for OAC [RR = 0.19;95% CI, (0.04, 0.83);p = 0.03]. Conclusions: In patients with indications for OAC, post-TAVR antithrombotic therapy with NOACs was more favorable due to its lower all-cause mortality after more than 1 year of follow-up. In those without indications for OAC, NOACs presented poorer outcomes due to its higher all-cause mortality.

关键词： APT meta-analysis NOACs TAVR VKAs

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佛山市青少年口腔健康相关生活质量及影响因素分析

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中国学校卫生 2021年第4期42卷 560-564页

作者：苏淑文张建明邓瑞冰王伟萍崔添强苏育武李霞佛山科学技术学院附属口腔医院/佛山市口腔医院广东528225 佛山科学技术学院口腔医学院

目的调查佛山市12~15岁青少年口腔健康相关生活质量,并探索其影响因素,为青少年的口腔健康促进提供对策建议。方法采用多阶段分层等容量随机抽样的方式招募佛山市3840名12~15岁青少年,对青少年口腔健康进行横断面研究。采用口腔临床检... 详细信息

目的调查佛山市12~15岁青少年口腔健康相关生活质量,并探索其影响因素,为青少年的口腔健康促进提供对策建议。方法采用多阶段分层等容量随机抽样的方式招募佛山市3840名12~15岁青少年,对青少年口腔健康进行横断面研究。采用口腔临床检查和口腔健康问卷调查收集信息,并利用描述性分析、非参数检验和等级Logistic回归分析法对青少年口腔健康相关生活质量及相关影响因素进行分析。结果口腔问题对佛山地区青少年生活质量的中等至严重程度影响主要反映在进食方面(27.1%)。等级Logistic回归分析结果显示,低糖摄入频率、牙龈出血牙数较少,无过去12个月内牙疼及牙齿碰伤或摔伤史、居住地(南海、顺德)等因素与口腔健康相关生活质量呈正相关(OR=0.6~0.8,P值均<0.05)。结论佛山地区青少年口腔健康相关生活质量略优于全国总体平均水平。建议根据细分区域的综合情况精准制定实施口腔公共卫生措施,联合多方力量加强青少年人群饮食限糖,预防牙龈出血,及时缓解并治疗牙痛,重点关注有牙外伤史的青少年人群,并且改变青少年自身、家长和教师有关口腔检查的就医观念,帮助其养成定期进行口腔检查的习惯。

关键词：口腔卫生生活质量健康促进回归分析青少年

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Ultrahigh triethylamine sensitivity of WO3-MoO3 n-n heterojunction sensor operating at low-temperature

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CHEMICAL ENGINEERING JOURNAL 2025年 507卷

作者： Zhu, shuwen Fan, Huiqing su, Yao Fan, Yongbo Wang, Weijia Northwestern Polytech Univ Sch Mat Sci & Engn State Key Lab Solidificat Proc Xian 710072 Peoples R China Hong Kong Polytech Univ Dept Appl Phys Hung Hom Hong Kong 100872 Peoples R China

Real-time monitoring of triethylamine (TEA) is essential for environmental safety and various applications in daily life. However, TEA gas sensors still encounter specific technical challenges, such as high operating temperatures and insufficient sensitivity. In this study, in order to reduce the operating temperature and improve sensitivity, WO3-MoO3 (WMo) n-n heterojunctions were synthesized via calcination and subsequent solvothermal method, in which WO3 tightly bound to the MoO3 nanobelt surface. The resulting heterojunction demonstrated excellent TEA sensing performance. The optimized gas sensor achieved a high response of 627.28 to 20 ppm TEA at a low operating temperature (100 degrees C). In addition, the device exhibited strong selectivity and stability. These improvements in gas sensing performance were attributed to the formation of n-n heterojunction between MoO3 and WO3, as well as the surface gas sensing reaction of oxygen species facilitated by oxygen vacancies at the heterojunction interface. This study can be applied to the design of novel n-n type metal oxide heterojunction materials for the application of low-temperature high-sensitivity TEA sensors.

关键词： Semiconducting metal oxide Triethylamine sensor Heterojunctions WO3-MoO3

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佛山市高校本科生牙齿矫正需求现状及影响因素研究

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中国校医 2024年第3期38卷 211-214,229页

作者：周云连谭柯源董梓燕乡雨婷许锡秋苏淑文佛山科学技术学院医学院广东佛山528000 佛山科学技术学院附属口腔医院广东佛山528000

目的了解高校本科生对牙齿矫正的需求及相关影响因素。方法采用方便抽样的方法,通过问卷星平台,利用自编问卷对广东省佛山市某公立高等学校的在校本科生开展调查。结果收集有效问卷1020份。结果显示,有牙齿矫正需求的人数为394人,占总... 详细信息

目的了解高校本科生对牙齿矫正的需求及相关影响因素。方法采用方便抽样的方法,通过问卷星平台,利用自编问卷对广东省佛山市某公立高等学校的在校本科生开展调查。结果收集有效问卷1020份。结果显示,有牙齿矫正需求的人数为394人,占总调查人数的38.6%。男性中,169人(32.9%)有牙齿矫正需求;女性中,225人(44.4%)有牙齿矫正需求。医学类学生中,184人(43.2%)有牙齿矫正需求;非医学类学生中,210人(34.5%)有牙齿矫正需求;860人(84.3%)表示,亲戚朋友的建议会驱使其产生寻求牙齿矫正服务的动机;443人(43.4%)表示对牙齿矫正价格的接受能力低于5000元“;非常了解牙齿矫正”的人占18.2%,“对牙齿矫正略有耳闻”的占73.4%,表示“完全不知道牙齿矫正”的占8.3%。二元logistic回归分析结果显示,性别(OR=1.476,P=0.009)、专业(OR=1.623,P=0.002)、价格接受能力(OR=1.387~3.640,P均<0.05)、口腔健康评价指数(OR=0.915,P<0.001)是影响大学生牙齿矫正需求的显著因素。结论该大学本科生中有牙齿矫正需求的比例接近四成,在寻求牙齿矫正的动机方面受亲戚朋友影响较大,该人群对牙齿矫正的知晓率不高,女性、医学专业、牙齿矫正价格的接受能力较强,口腔健康相关生活质量低等是使该人群产生牙齿矫正需求的显著影响因素。

关键词：牙齿矫正需求影响因素大学生

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Research on dependent evidence combination based on principal component analysis

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MATHEMATICAL BIOSCIENCES AND ENGINEERING 2024年第4期21卷 4853-4873页

作者： su, Xiaoyan Shang, shuwen Xiong, Leihui Hong, Ziying Zhong, Jian Shanghai Univ Elect Power Sch Automat Engn Shanghai 200090 Peoples R China State Grid Nanchang Elect Power Supply Co Nanchang 330069 Peoples R China

Dempster -Shafer evidence theory, as a generalization of probability theory, is a powerful tool for dealing with a variety of uncertainties, such as incompleteness, ambiguity, and conflict. Be- cause of its advantages in information fusion compared with traditional probability theory, it is widely used in various fields. However, the classic Dempster's combination rule assumes that evidences are independent of each other, which is difficult to satisfy in real life. Ignoring the dependence among the evidences will lead to unreasonable fusion results, and even wrong conclusions. Considering the lim- itations of D -S evidence theory, this paper proposed a new evidence fusion model based on principal component analysis (PCA) to deal with the dependence among evidences. First, the approximate inde- pendent principal components of each information source were obtained based on principal component analysis. Second, the principal component data set was used as a new information source for evidence theory. Third, the basic belief assignments (BBAs) were constructed. As the fundamental construct of evidence theory, a BBA is a probabilistic function corresponding to each hypothesis, quantifying the belief assigned based on the evidence at hand. This function facilitates the synthesis of disparate evi- dence sources into a mathematically coherent and unified belief structure. After constructing the BBAs, the BBAs were fused and a conclusion was drawn. The case study verified that the proposed method is more robust than several traditional methods and can deal with redundant information effectively to obtain more stable results.

关键词： information fusion evidence theory dependence basic belief assignment principal component analysis

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Thermal Runaway Gas Generation of Lithium Iron Phosphate Batteries Triggered by Various Abusive Conditions

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JOURNAL OF ENERGY ENGINEERING 2024年第4期150卷 04024017-04024017页

作者： su, Lei Yang, Fan Hu, Wei Chen, shuwen Lyu, Nawei State Grid Hubei Elect Power Res Inst Wuhan 430074 Peoples R China Zhengzhou Univ Sch Elect & Informat Engn Zhengzhou 450001 Henan Peoples R China

Lithium iron phosphate (LFP) batteries are widely utilized in energy storage systems due to their numerous advantages. However, their further development is impeded by the issue of thermal runaway. This paper offers a comparative analysis of gas generation in thermal runaway incidents resulting from two abuse scenarios: thermal abuse and electrical abuse. The study initially focuses on 13-Ah lithium iron phosphate single-cell batteries. Experiments were conducted to induce thermal runaway through both forms of abuse, analyzing the production and dispersion of H2 and CO gases in each case. It was observed that thermal abuse-induced thermal runaway resulted in higher gas concentrations and more pronounced fluctuations, whereas electrical abuse-induced thermal runaway exhibited lower gas concentrations and lower fluctuations. subsequently, key materials and temperature variations at the positive and negative electrodes were investigated under both types of thermal runaway, revealing distinct differences that are identified as the primary reasons for the significant disparities in H2 and CO gas generation during the two thermal runaway conditions. The conclusions drawn in this paper advance the understanding of the mechanisms underlying H2 and CO gas concentration generation in thermal runaway scenarios.

关键词： Lithium compounds

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Assessment of Dependent Performance Shaping Factors in SPAR-H Based on Pearson Correlation Coefficient

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Computer Modeling in Engineering & Sciences 2024年第2期138卷 1813-1826页

作者： Xiaoyan su shuwen Shang Zhihui Xu Hong Qian Xiaolei Pan School of Automation Engineering Shanghai University of Electric PowerShanghai 200090China State Key Laboratory of Nuclear Power Safety Monitoring Technology and Equipment Shenzhen518172China

With the improvement of equipment reliability,human factors have become the most uncertain part in the *** standardized Plant Analysis of Risk-Human Reliability Analysis(SPAR-H)method is a reliable method in the field of human reliability analysis(HRA)to evaluate human reliability and assess risk in large complex ***,the classical SPAR-H method does not consider the dependencies among performance shaping factors(PSFs),whichmay cause overestimation or underestimation of the risk of the actual *** address this issue,this paper proposes a new method to deal with the dependencies among PSFs in SPAR-H based on the Pearson correlation ***,the dependence between every two PSFs is measured by the Pearson correlation ***,the weights of the PSFs are obtained by considering the total dependence ***,PSFs’multipliers are modified based on the weights of corresponding PSFs,and then used in the calculating of human error probability(HEP).A case study is used to illustrate the procedure and effectiveness of the proposed method.

关键词： Reliability evaluation human reliability analysis SPAR-H performance shaping factors dependence pearson correlation analysis

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Using Epistemic Network Analysis to Explore Primary School Students’ Computational Thinking in Pair Programming Learning

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Journal of Educational Computing Research 2024年第2期62卷 559-593页

作者： su, Yu-Sheng Wang, shuwen Liu, Xiaohong National Chung Cheng University Taiwan Nanjing Normal University China

Pair programming (PP) can help improve students’ computational thinking (CT), but the trajectory of CT skills and the differences between high-scoring and low-scoring students in PP are unknown and need further exploration. In this study, a total of 32 fifth graders worked on Scratch tasks in 16 pairs. The group discourse of three learning topics (comprising 9 projects) was collected. After the audio files were transcribed, 1,303 conversations were obtained. They were analyzed via Epistemic Network Analysis (ENA) Webkit, which can reveal the trajectory of students’ CT development via analyzing codes of discourse related to CT in PP. Three Scratch learning topics were assessed based on the Dr. Scratch platform to acquire the level of students’ CT and to determine the low- and high-scoring groups. Results indicated that CT concepts and CT practices were always closely related in PP and CT practices, and CT perspectives could be gradually and closely related after a long period of CT training. A significant difference between the two groups’ CT structures was found. The high-scoring group had more fragments of CT practice and connecting of CT perspectives, while the low-scoring group showed more fragments of CT concepts and expressing of CT perspectives. This research provides insights into cultivating primary school students’ CT using Scratch in the context of PP. The findings can provide suggestions for instructors to design instructional interventions to facilitate students’ CT skills via PP learning. Instructors can improve CT skills by guiding students to constantly ask questions, and specifying the role swap between driver and navigator in PP. Besides, instructors could give more consideration to the development of CT perspectives, and especially the ability to question. © The Author(s) 2023.

关键词： computational thinking epistemic network analysis pair programming primary school scratch

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