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Macrophages and monocytes mediated activation of oxidative phosphorylation implicated the prognosis and clinical therapeutic strategy of Wilms tumour

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COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL 2022年 20卷 3399-3408页

作者： Meng, Jialin Chen, Yonghao Lu, Xiaofan Ge, Qintao Yang, Feixiang Bai, suwen Liang, Chaozhao du, Juan Anhui Med Univ Affiliated Hosp 1 Dept Urol Hefei 230022 Anhui Peoples R China Anhui Med Univ Inst Urol Hefei 230022 Anhui Peoples R China Anhui Med Univ Anhui Prov Key Lab Genitourinary Dis Hefei 230022 Anhui Peoples R China Sichuan Univ Dept Gastroenterol West China Hosp Chengdu 610041 Sichuan Peoples R China China Pharmaceut Univ Res Ctr Biostat & Computat Pharm State Key Lab Nat Med Nanjing 211198 Peoples R China UNISTRA Dept Canc & Funct Genom INSERM CNRSInst Genet & Mol & Cellular Biol F-67400 Strasbourg France Chinese Univ Hong Kong Affiliated Hosp 2 Sch Med Shenzhen 518172 Guangdong Peoples R China

Wilms tumour is the fourth leading cause of paediatric malignancy, but the detailed relationship between the tumour microenvironment and prognosis remains largely unclear. In this research, gene expression profile and clinical information from TARGET and the First Affiliated Hospital of Anhui Medical University were collected. After comparing the prognostic value of the associated immune cells, we established a nomogram to predict the prognosis of Wilms tumour based on monocyte infiltration, macrophage infiltration, stage, and sex. Further results showed that the most significant relationship between matrix metallopeptidase 9 and prognosis or macrophage infiltration. Meanwhile, by gene set enrichment or variation analyses and immunohistochemistry staining, we demonstrated that the most highly enriched hub genes were closely related to the activated oxidative phosphorylation pathway. Finally, through tumour immune dysfunction and an exclusion algorithm, the satisfactory discriminative performance of our nomogram was revealed for predicting the response to clinical therapy. Anti-PD1 therapy is more suitable for Wilms tumour patients with high nomogram points, and chemotherapies are more effective for patients with low nomogram score.(c) 2022 The Authors. Published by Elsevier B.V. on behalf of Research Network of Computational and Structural Biotechnology. This is an open access article under the CC BY-NC-ND license (http://***/licenses/by-nc-nd/4.0/).

关键词： Nomogram Tumor-infiltratingimmunecells Prognosis Wilmstumor Macrophages

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Preparation and performance of amidoximated silver-silica core-shell nanoparticles for uranium extraction from seawater

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JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY 2022年第11期331卷 4541-4552页

作者： Mo, Huilian Sun, Ruopei Qu, Chang Jiang, Chao du, Ziyao Wang, Jing Wang, Ziyang Meng, Xiangjian Chen, suwen Lanzhou Univ Frontiers Sci Ctr Rare Isotopes Lanzhou 730000 Gansu Peoples R China Lanzhou Univ Sch Nucl Sci & Technol Lanzhou 730000 Gansu Peoples R China Lanzhou Univ Sch Stomatol Lanzhou 730000 Gansu Peoples R China

Biofouling caused by marine microorganisms could remarkably decrease the adsorption capacity of adsorbents towards uranium extraction from seawater since the materials usually have to be immersed in marine environment for several months owing to the extremely low content of uranium. In order to avoid the interference of microbial adhesion, this work designed and fabricated a new antibacterial material named amidoximated silver-silica core-shell nanoparticle (Ag@SiO2-AO) as a potential adsorbent for uranium extraction from seawater. Experimental results demonstrated that in uranium-spiked seawater, the maximal uranium uptake of Ag@SiO2-AO reached 47.42 mg/g, and the silver released by the material was effective to inhibit Escherichia coli and Staphylococcus aureus by interrupting cell respiration, resulting in lipid peroxidation and ultimately the death of cell.

关键词： Uranium extraction from seawater Biofouling Core-shell nanoparticles Amidoximated adsorbents

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MiR-200c-3p increased HDMEC proliferation through the notch signaling pathway

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EXPERIMENTAL BIOLOGY AND MEDICINE 2021年第8期246卷 897-905页

作者： Hu, Xianyu Bai, suwen Li, Lingyi Tian, Pengfei Wang, Sun Zhang, Ning Shen, Bing du, Juan Liu, Shengxiu Anhui Med Univ Affiliated Hosp 1 Dept Gen Surg Hefei 230022 Anhui Peoples R China Anhui Med Univ Sch Basic Med Sci Hefei 230032 Anhui Peoples R China Anhui Med Univ Affiliated Hosp 1 Dept Dermatol Hefei 230022 Anhui Peoples R China Chinese Univ Hong Kong Longgang Dist Peoples Hosp Shenzhen Shenzhen 518172 Guangdong Peoples R China Chinese Univ Hong Kong Affiliated Hosp Prov 3 Shenzhen 518172 Guangdong Peoples R China

Excessive proliferation of vascular endothelial cells can cause hemangioma. Although typically benign, hemangiomas can become life-threatening. The microRNA miR-200c-3p is abnormally expressed in some types of tumors, but its expression, biological role, and mechanism of action in infantile hemangioma remain to be fully elucidated. The expression levels of miR-200c-3p in hemangioma tissue were compared with those in adjacent healthy tissue by using bioinformatics analyses and TargetScan. Western blot, enzyme-linked immunosorbent assay, and Cell Counting Kit 8 analyses were used to determine the biological function and site of action of miR-200c-3p in human dermal microvascular endothelial cells (HDMECs). MiR-200c-3p was one of the top 10 differentially expressed genes between healthy tissue, and hemangiomas tissues, having markedly decreased expression in hemangioma tissue. Reduction of miR-200c-3p expression in HDMECs through the transfection of a miR-200c-3p inhibitor significantly increased HDMEC proliferation. The addition of the Notch signaling pathway inhibitor DAPT to HDMECs transfected with the miR-200c-3p inhibitor eliminated the inhibitor-induced enhancement of proliferation in HDMECs. These findings indicate that miR-200c-3p targets the Notch signaling pathway to promote the proliferation of vascular endothelial cells, suggesting that miR-200c-3p plays an important role in the pathogenesis of hemangioma.

关键词： Infantile hemangioma miR-200c-3p notch signaling pathway cell proliferation

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Zinc loaded amidoxime polyacrylonitrile porous resin microcapsules for uranium extraction from seawater

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JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY 2023年第4期332卷 1225-1235页

作者： Wang, Ziyang Meng, Xiangjian du, Ziyao Wang, Siyi Qu, Chang Mo, Huilian Jiang, Chao Wang, Jing Zang, Yu Chen, suwen Lanzhou Univ Frontiers Sci Ctr Rare Isotopes Lanzhou 730000 Gansu Peoples R China Lanzhou Univ Sch Nucl Sci & Technol Lanzhou 730000 Gansu Peoples R China Lanzhou Univ Sch Stomatol Lanzhou 730000 Gansu Peoples R China

In this study, a microcapsule resin grafted with amidoxime group was prepared by phase transformation method, and the microcapsule resin was loaded with zinc as an antibacterial agent. The final preparation of Zn@AO-PAN PMR enhanced the antibacterial ability of Zn@AO-PAN PMR in real seawater based on its good uranium adsorption performance. The theoretical maximum adsorption capacity of Zn@AO-PAN PMR in real seawater could reach 50.30 mg/g. At the same time, the loading of Zn don't lose the adsorption capacity of the resin for U(VI). The antibacterial mechanism of Zn@AO-PAN PMR was explored using MAD.

关键词： Microcapsule resin Antibacterial ability Uranium Seawater

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LncRNA PART1 promotes malignant biological behaviours associated with head and neck cancer cells via synergistic action with FUT6

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CANCER CELL INTERNATIONAL 2024年第1期24卷 185页

作者： Yao, Yanheng Zhang, Yuxin Shi, Jiyuan Xu, Xiling Gao, Yunran Bai, suwen Hu, Qin Wu, Jing du, Juan Anhui Med Univ Sch Basic Med Sci 81 Meishan Rd Hefei 230032 Anhui Peoples R China Chinese Univ Hong Kong Affiliated Hosp 2 Shenzhen & Longgang Dist Peoples Hosp Shenzhen Gua Sch Med Shenzhen 518172 Peoples R China Chinese Univ Hong Kong Ciechanover Inst Precis & Regenerat Med Sch Med Shenzhen 518172 Guangdong Peoples R China Anhui Med Univ Affiliated Hosp 1 218 JiXi Ave Hefei 230022 Anhui Peoples R China

The aim of this study was to determine the role of lncRNA PART1 and downstream FUT6 in tumorigenesis and progression of head and neck cancer (HNC). Bioinformatics analysis and qRT-PCR revealed that lncRNA PART1 was expressed at low levels in HNC patients. The proliferation, apoptosis, migration and flow cytometry results showed that low expression of lncRNA PART1 inhibited apoptosis and promoted HNC cell migration and proliferation. In addition, animal experiments have also shown that low expression of lncRNA PART1 can promote tumor growth. LncRNA PART1 overexpression promoted apoptosis and inhibited HNC cell migration and proliferation. Through bioinformatics analysis, FUT6 was found to be expressed at low levels in HNC and to be correlated with patient survival. Immunohistochemical and qRT-PCR results revealed that FUT6 was underexpressed in tumour tissues and HNC cells. Cell and animal experiments showed that overexpression of FUT6 could inhibit tumour proliferation and migration. Bioinformatics analysis revealed that lncRNA PART1 was positively correlated with FUT6. By qRT-PCR and western blot, we observed that after knockdown of lncRNA PART1, both the mRNA and protein expression levels of FUT6 were reduced. The above results indicated that lncRNA PART1 and FUT6 play an important role in HNC, and that lncRNA PART1 affected the development of tumor by downstream FUT6.

关键词： Head and neck cancer LncRNA PART1 FUT6 Apoptosis Proliferation

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Preparation of porous amidoximated nanofibers with antibacterial properties, and experiments on uranium extraction from seawater

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JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY 2023年第3期332卷 669-682页

作者： du, Ziyao Qu, Chang Meng, Xiangjian Wang, Ziyang Mo, Huilian Jiang, Chao Sun, Ruopei Wang, Jing Gong, Tianle Chen, suwen Lanzhou Univ Frontiers Sci Ctr Rare Isotopes Lanzhou 730000 Gansu Peoples R China Lanzhou Univ Sch Nucl Sci & Technol Lanzhou 730000 Gansu Peoples R China Lanzhou Univ Sch Stomatol Lanzhou 730000 Gansu Peoples R China

A novel porous adsorbent, named silver-loaded amidoximated polyacrylonitrile porous nanofibers (Ag@AO-PAN PNF), with both adsorption and antibacterial properties, was designed and synthesized by using polyvinylpyrrolidone (PVP) as porogen, amidoxime group as uranium adsorption group, and nano-silver as antibacterial agent. Results of adsorption experiments in uranium-spiked natural seawater showed that the nanofibers had good adsorption capacity for uranium (the maximum uranium uptake was 34.7 mg/g). On the other hand, Ag@AO-PAN PNF also exhibited excellent antibacterial activity against both E. coli and S. aureus, which could effectively inhibit adhesion of these bacteria to the surface of the adsorbent. The adsorption experiments carried out in bacteria-containing environment also demonstrated that the presence of nano-silver effectively inproved the adsorption capacity of the material towards uranium.

关键词： Uranium extraction from sea water Anti-biofouling Electrospinning

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Endothelial progenitor cell-derived exosomes ameliorate endothelial dysfunction in a mouse model of diabetes

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BIOMEDICINE & PHARMACOTHERAPY 2020年 131卷 110756-110756页

作者： Bai, suwen Yin, Qianqian Dong, Tao Dai, Fang Qin, Ying Ye, Li du, Juan Zhang, Qiu Chen, Hongbo Shen, Bing Anhui Med Univ Sch Basic Med Sci Hefei 230032 Anhui Peoples R China Anhui Med Univ Maternal & Child Hlth Hosp Dept Obstet & Gynecol 15 Yimin Rd Hefei 230000 Anhui Peoples R China Anhui Med Univ Affiliated Hosp 1 Dept Endocrinol Hefei 230022 Anhui Peoples R China Anhui Med Univ Affiliated Hosp 2 Dept Endocrinol Hefei 230022 Anhui Peoples R China Anhui Med Univ Affiliated Hosp 1 Dept Neurol Hefei 230032 Anhui Peoples R China

Atherosclerosis is a serious cardiovascular complication of diabetes characterized by inflammation and endothelial damage. Indeed, dysfunction of the endothelium is considered an early marker of atherosclerosis. Endothelial progenitor cells (EPCs) are prerequisites for blood vessels lined with endothelial cells (ECs), which produce many factors to regulate blood vessel function. Importantly, EPCs also repair some dysfunctions in ECs. Exosomes have been associated with the occurrence and development of disease. Here, we analyzed the microRNAs (miRNAs) contained in exosomes derived from EPCs by using next-generation sequencing. We found that most of the top 10 highest expressed miRNAs in these exosomes were related to atherosclerosis. In a mouse model of atherosclerotic diabetes, treatment with EPC-derived exosomes significantly reduced the production of diabetic atherosclerotic plaques and inflammatory factors. In an in vitro assay examining the contractility of the thoracic aorta from these mice, the addition of EPC-derived exosomes significantly ameliorated the observed endothelium-dependent contractile dysfunction. Taken together, these results indicated that EPC-derived exosomes ameliorated atherosclerotic endothelial dysfunction in a mouse model of atherosclerotic diabetes. Thus, the present study provides a potential therapeutic application of EPC-derived exosomes in cardiovascular disease.

关键词： endothelial progenitor cell exosomes endothelium diabetes microRNAs next-generation sequencing

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miRNA-221-3p in Endothelial Progenitor Cell-Derived Exosomes Accelerates Skin Wound Healing in Diabetic Mice

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DIABETES METABOLIC SYNDROME AND OBESITY-TARGETS AND THERAPY 2020年 13卷 1259-1270页

作者： Xu, Juan Bai, suwen Cao, Yadi Liu, Lei Fang, Yang du, Juan Luo, Li Chen, Mingwei Shen, Bing Zhang, Qiu Anhui Med Univ Affiliated Hosp 1 Dept Endocrinol 218 Jixi Rd Hefei 230022 Anhui Peoples R China Anhui Med Univ Sch Basic Med Sci Hefei 230032 Anhui Peoples R China

Background: Patients with diabetic cutaneous ulcers experience financial burden and a lower quality of life and life expectancy. Endothelial progenitor cell (EPC)-derived exosomes facilitate skin wound healing by positively modulating vascular endothelial cell function. Exosomes play their important regulatory role through microRNA (miRNA). We explored the potential role and molecular mechanisms of miRNA in EPC-derived exosome healing of diabetic skin wounds. Methods: Exosomes were isolated from the media of EPCs derived from mice bone marrow. High-throughput sequencing was used to detect the expression of exosome miRNA, and miRNA target genes were predicted using online databases. A diabetic mouse skin wound model was established, and wounds were treated with exosomes, miRNA-221-3p, or phosphate-buffered saline. Results: Exosomes from EPCs accelerated skin wound healing in both control and diabetic mice. High-throughput sequencing showed that miRNA-221-3p was highly expressed in EPC-derived exosomes. Skin wound healing in control and diabetic mice was significantly enhanced by EPC-derived exosomes and miRNA-221-3p administration Immunohistochemical analyses showed that EPC-derived exosomes and miRNA-221-3p increased protein expression levels of the angiogenesis-related factors VEGF, CD31 and cell proliferation marker Ki67. Bioinformatics analyses indicated that miRNA-221-3p may be involved in the AGE-RAGE signaling pathway in diabetic complications, cell cycle, and the p53 signaling pathway. Conclusion: We concluded that miRNA-221-3p is one of the high-expressed miRNAs in EPC-derived exosomes and promoted skin wound healing in diabetic mice. The finding uncovers the molecular mechanism of EPC-derived exosomes and provides a potential novel approach to the clinical treatment of diabetic skin wounds.

关键词： endothelial progenitor cells exosome diabetes miRNA-221-3p wound healing

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Role of TRPP2 in mouse airway smooth muscle tension and respiration

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AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY 2019年第4期317卷 L466-L474页

作者： Sang, Dacheng Bai, suwen Yin, Sheng Jiang, Sen Ye, Li Hou, Wenxuan Yao, Yanheng Wang, Haoran Shen, Yonggang Shen, Bing du, Juan Anhui Med Univ Sch Basic Med Sci 81 Meishan Rd Hefei 230032 Anhui Peoples R China Capital Med Univ Beijing TianTan Hosp Dept Orthoped Surg Beijing Peoples R China Anhui Med Univ Anhui Prov Hosp Dept Neurosurg Hefei Anhui Peoples R China Anhui Hlth Coll Nursing Fac Chizhou Peoples R China

The transient receptor potential polycystin-2 (TRPP2) is encoded by the Pkd2 gene. and mutation of this gene can cause autosomal dominant polycystic kidney disease (ADPKD). Some patients with ADPKD experience extrarenal manifestations, including radiologic and clinical bronchiectasis. We hypothesized that TRPP2 may regulate airway smooth muscle (ASM) tension. Thus, we used smooth muscle-Pkd2 conditional knockout (Pkd2(SM-CKO)) mice to investigate whether TRPP2 regulated ASM tension and whether TRPP2 deficiency contributed to bronchiectasis associated with ADPKD. Compared with wild-type mice, Pkd2(SM-CKO) mice breathed more shallowly and faster, and their cross-sectional area ratio of bronchi to accompanying pulmonary arteries was higher, suggesting that TRPP2 may regulate ASM tension and contribute to the occurrence of bronchiectasis in ADPKD. In a bioassay examining isolated tracheal ring tension, no significant difference was found for highpotassium-induced depolarization of the ASM between the two groups, indicating that TRPP2 does not regulate depolarization-induced ASM contraction. By contrast, carbachol-induced contraction of the ASM derived from Pkd2(SM-CKO) mice was significantly reduced compared with that in wild-type mice. In addition, relaxation of the carbachol-precontracted ASM by isoprenaline, a beta-adrenergic receptor agonist that acts through the cAMP/adenylyl cyclase pathway. was also significantly attenuated in Pkd2(SM-CKO) mice compared with that in wild-type mice. Thus, TRPP2 deficiency suppressed both contraction and relaxation of the ASM. These results provide a potential target for regulating ASM tension and for developing therapeutic alternatives for some ADPKD complications of the respiratory system or for independent respiratory disease, especially bronchiectasis.

关键词： bronchial smooth muscle conditional knockout calcium respiration TRPP2

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A PARALLEL COORDINATIVE VISUAL MODEL—THE PLATE PARALLEL RETRIEVAL MODEL(PPRM)

A PARALLEL COORDINATIVE VISUAL MODEL—THE PLATE PARALLEL RET...

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1998 Fourth International Conference Signal Processing

作者： Wang Tianzhen Li Zhou Chang suwen Wu Zhongyi du ping Image Processing Lab.Wuhan Automative Polytechnical University National lab.of Pattern Recognition Institute of Automation Chinese Academy of Sciences Station Education Commission Laboratory for Image Processing and Intelligent Control China

In this paper,a parallel coordinative visual model—The revised Plate Parallel Retrieval Model(Wang 1994) [1]is presented based on the analysis of the global effect of Chinese Characters and the recent neurobiological researches on the function of neuroglia in learning and *** theory assumes that visual neurons possess the function of memory and retrieval in addition to the commonly recognised function of signal *** supposes all the pixels on the array of a Chinese character are encoded,stored and relieved simultaneously and sychronously by each neuron separately.

关键词： A PARALLEL COORDINATIVE VISUAL MODEL THE PLATE PARALLEL RETRIEVAL MODEL

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