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International Conference on Signal Processing Proceedings (ICSP)

作者： Wang Tianzhen Li Zhou Chang suwen Wu Zhongyi du ping National Laboratory of Pattern Recognition Institute of Automation Chinese Academy and Sciences Beijing China Image Processing Laboratory Wuhan Automotive Polytechnic University Wuhan China

In this paper, a parallel coordinative visual model-the revised plate parallel retrieval model (Wang Tianzhen et al, 1994) is presented based on the analysis of the global effect of Chinese characters and the recent neurobiological research on the function of neuroglia in learning and memory. The theory assumes that visual neurons possess the function of memory and retrieval in addition to the commonly recognised function of signal transformation. It supposes all the pixels in the array of a Chinese character are encoded, stored and retrieved simultaneously and synchronously by each neuron separately. In the model, neuroglia cells play an important role in the integration of the visual signal. The model cannot only satisfactorily explain both the global effect and strokes effect, but can also explain the implicit memory of Chinese characters as well. We have experimented on an SIMD array processor to prove the viability of the PPR algorithm. The results are satisfactory. The model can be extended to general shape vision with some conditions.

关键词： Neurons Character recognition Image retrieval Image processing Frequency Visual system Information retrieval Centralized control Biomembranes Switches

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Parallel coordinative visual model - the Plate Parallel Retrieval Model (PPRM)

International Conference on Signal Processing Proceedings, I...

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International Conference on Signal Processing Proceedings, ICSP 1998年 2卷 1359-1363页

作者： Wang, Tianzhen Li, Zhou Chang, suwen Wu, Zhongyi du, Ping Wuhan Automotive Polytechnical Univ Wuhan China

In this paper, a parallel coordinative visual model - The revised Plate Parallel Retrieval Model is presented based on the analysis of the global effect of Chinese Characters and the recent neurobiological researches on the function of neuroglia in learning and memory. The theory assumes that visual neurons possess the function of memory and retrieval in addition to the commonly recognized function of signal transformation. It supposes all the pixels on the array of a Chinese character are encoded, stored and retrieved simultaneously and synchronously by each neuron separately. In the model, neuroglia cells play an important role in integration of visual signal. The model can not only satisfactorily explain both the global effect and strokes effect, but also explain implicit memory of Chinese characters well. We have experimented on a SIMD array processor to prove the possibility of PPR algorithm. The results are satisfactory. The model can be extended to general shape vision on some conditions.

关键词： Optical character recognition

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Multiomics characterization and verification of clear cell renal cell carcinoma molecular subtypes to guide precise chemotherapy and immunotherapy

IMETA

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IMETA 2023年第4期2卷 e147页

作者： Meng, Jialin Jiang, Aimin Lu, Xiaofan Gu, Di Ge, Qintao Bai, suwen Zhou, Yundong Zhou, Jun Hao, Zongyao Yan, Fangrong Wang, Linhui Wang, Haitao du, Juan Liang, Chaozhao Anhui Med Univ Anhui Prov Key Lab Genitourinary Dis Inst Urol Dept UrolAffiliated Hosp 1 Hefei Peoples R China Naval Med Univ Second Mil Med Univ Changhai Hosp Dept Urol Shanghai Peoples R China UNISTRA Inst Genet & Mol & Cellular Biol Dept Canc & Funct Genom CNRSINSERM Illkirch Graffenstaden France Chinese Univ Hong Kong Affiliated Hosp 2 Sch Med Shenzhen Peoples R China Longgang Dist Peoples Hosp Shenzhen Shenzhen Peoples R China Ningbo Univ Ningbo Med Ctr Dept Surg Lihuili Hosp Ningbo Zhejiang Peoples R China China Pharmaceut Univ Res Ctr Biostat & Computat Pharm Nanjing Peoples R China Univ Macau Fac Hlth Sci Canc Ctr Taipa Macau Peoples R China Ctr Canc Res Bethesda MD USA Anhui Med Univ Affiliated Hosp 1 Anhui Prov Key Lab Genitourinary Dis Inst UrolDept Urol Hefei 230022 Peoples R China Chinese Univ Hong Kong Affiliated Hosp 2 Sch Med Shenzhen 518172 Guangdong Peoples R China Longgang Dist Peoples Hosp Shenzhen Shenzhen 518172 Guangdong Peoples R China

Clear cell renal cell carcinoma (ccRCC) is a heterogeneous tumor with different genetic and molecular alterations. Schemes for ccRCC classification system based on multiomics are urgent, to promote further biological insights. Two hundred and fifty-five ccRCC patients with paired data of clinical information, transcriptome expression profiles, copy number alterations, DNA methylation, and somatic mutations were collected for identification. Bioinformatic analyses were performed based on our team's recently developed R package "MOVICS." With 10 state-of-the-art algorithms, we identified the multiomics subtypes (MoSs) for ccRCC patients. MoS1 is an immune exhausted subtype, presented the poorest prognosis, and might be caused by an exhausted immune microenvironment, activated hypoxia features, but can benefit from PI3K/AKT inhibitors. MoS2 is an immune "cold" subtype, which represented more mutation of VHL and PBRM1, favorable prognosis, and is more suitable for sunitinib therapy. MoS3 is the immune "hot" subtype, and can benefit from the anti-PD-1 immunotherapy. We successfully verified the different molecular features of the three MoSs in external cohorts GSE22541, GSE40435, and GSE53573. Patients that received Nivolumab therapy helped us to confirm that MoS3 is suitable for anti-PD-1 therapy. E-MTAB-3267 cohort also supported the fact that MoS2 patients can respond more to sunitinib treatment. We also confirm that SETD2 is a tumor suppressor in ccRCC, along with the decreased SETD2 protein level in advanced tumor stage, and knock-down of SETD2 leads to the promotion of cell proliferation, migration, and invasion. In summary, we provide novel insights into ccRCC molecular subtypes based on robust clustering algorithms via multiomics data, and encourage future precise treatment of ccRCC patients. We established a novel molecular classification for ccRCC via multiomics features, named multiomics subtype (MoS). MoS correlates with significantly different clinicopatholo

关键词： clear cell renal cell carcinoma immune activation molecular subtyping multiomics

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Role of tumour-derived exosomes in metastasis

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BIOMEDICINE & PHARMACOTHERAPY 2022年第0期147卷 112657-112657页

作者： Bai, suwen Wei, Yuan Liu, Rong Xu, Ruihuan Xiang, Li du, Juan Chinese Univ Hong Kong Longgang Dist Peoples Hosp Shenzhen Shenzhen 518172 Guangdong Peoples R China Chinese Univ Hong Kong Affiliated Hosp 2 Shenzhen 518172 Guangdong Peoples R China Anhui Med Univ Sch Basic Med Sci 81 Meishan Rd Hefei 230032 Anhui Peoples R China Chinese Univ Hong Kong Sch Med 2001 Longxiang Rd Shenzhen 518172 Guangdong Peoples R China

Tumour-derived exosomes (TDEs) are actively produced and released by tumour cells and carry messages from tumour cells to normal or abnormal cells residing at close or distant sites. TDEs participate in every process of tumour metastasis. However, the occurrence and development of tumours depend on the specific functions acquired by tumour cells on the primary and metastatic foci. In this review, we discussed that TDEs regulate the initial mechanism of metastasis, the formation of a pre-metastatic niche, immunosuppression and angiogenesis. In addition, we investigated the signalling pathways and effective components of TDEs and discussed that inhibition of exosomes can inhibit tumour progression. Finally, we discussed the application and future development of TDEs. An understanding of several molecular players and processes involved in metastasis can lead to the development of effective, targeted approaches to prevent metastasis and treat cancer.

关键词： Angiogenesis Extracellular matrix Epithelial -mesenchymal transition Immunosuppression Pre-metastatic niche Tumour-derived exosomes

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Exocyst controls exosome biogenesis via Rab11a

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MOLECULAR THERAPY NUCLEIC ACIDS 2022年第0期27卷 535-546页

作者： Bai, suwen Hou, Wenxuan Yao, Yanheng Meng, Jialin Wei, Yuan Hu, Fangfang Hu, Xianyu Wu, Jing Zhang, Ning Xu, Ruihuan Tian, Faqing Wang, Benguo Liao, Hailan du, Yinan Fang, Haoshu He, Wei Liu, Yehai Shen, Bing du, Juan Chinese Univ Hong Kong Longgang Dist Peoples Hosp Shenzhen Shenzhen 518172 Guangdong Peoples R China Chinese Univ Hong Kong Affiliated Hosp 2 Shenzhen 518172 Guangdong Peoples R China Anhui Med Univ Sch Basic Med Sci 81 Meishan Rd Hefei 230032 Anhui Peoples R China Anhui Med Univ Dept Urol Affiliated Hosp 1 Inst UrolAnhui Prov Key Lab Genitourinary Dis Hefei 230022 Peoples R China Anhui Med Univ Dept Gen Surg Affiliated Hosp 1 Hefei 230022 Anhui Peoples R China Anhui Med Univ Dept Otolaryngol Affiliated Hosp 1 Hefei 230022 Anhui Peoples R China Chinese Univ Hong Kong Sch Med 2001 Longxiang Rd Shenzhen 518172 Guangdong Peoples R China

Tumor cells actively release large quantities of exosomes, which pivotally participate in the regulation of cancer biology, including head and neck cancer (HNC). Exosome biogenesis and release are complex and elaborate processes that are considered to be similar to the process of exocyst-mediated vesicle delivery. By analyzing the expression of exocyst subunits and their role in patients with HNC, we aimed to identify exocyst and its functions in exosome biogenesis and investigate the molecular mechanisms underlying the regulation of exosome transport in HNC cells. We observed that exocysts were highly expressed in HNC cells and could promote exosome secretion in these cells. In addition, downregulation of exocyst expression inhibited HN4 cell proliferation by reducing exosome secretion. Interestingly, immunofluorescence and electron microscopy revealed the accumulation of multivesicular bodies (MVBs) after the knockdown of exocyst. Autophagy, the major pathway of exosome degradation, is not activated by this intracellular accumulation of MVBs, but these MVBs are consumed when autophagy is activated under the condition of cell starvation. Rab11a, a small GTPase that is involved in MVB fusion, also interacted with the exocyst. These findings suggest that the exocyst can regulate exosome biogenesis and participate in the malignant behavior of tumor cells.

关键词： exocyst exosome biogenesis head and neck cancer Rab11a multivesicular bodies intraluminal vesicles

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Orai3 exacerbates apoptosis of lens epithelial cells by disrupting Ca2+ homeostasis in diabetic cataract

Orai3 exacerbates apoptosis of lens epithelial cells by disr...

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第十一届全国钙信号和细胞功能研讨会

作者： Yong Wang suwen Bai Juan du Lin Xia Jizheng Guo Fang Dai Bing Shen Department of Ophthalmology the First Affiliated Hospital of Anhui Medical University Department of Physiology School of Basic Medicine Anhui Medical University Department of Endocrinology the First Affiliated Hospital of Anhui Medical University

Diabetic cataract is associated with increasing apoptosis of human lens epithelial cells and lacks for effective treatment except for surgery. However, the influence of Ca homeostasis/signaling on this enhanced apoptosis and its therapeutic potential remains unclear. Store-operated Ca entry（SOCE） is an important pathway mediating Ca influx in epithelial cells. Here we show that SOCE proteins Orai3/stromal-interacting molecule（STIM） induce abnormal cellular Ca homeostasis which enhances apoptosis of lens epithelial cells in diabetic cataract. We found that the expression levels of Orai3/STIM1 were markedly increased in lens epithelial cells of diabetic patients and in a human lens epithelial cell line（HLEpi C） cultured in high glucose conditions. SOCE evoked by ATP or thapsigargin was substantially increased in high glucosecultured HLEpi Cs and inhibited by Orai3-or STIM1-specific small interfering（si）RNAs. Additionally, high glucose conditions enhanced HLEpi C apoptosis via a mitochondrial pathway, which was also inhibited by Orai3-or STIM1-specific si RNAs. Thus, our data indicated that enhanced SOCE mediated by Orai3/STIM1 led to apoptosis of diabetic lens epithelial cells inducing cataract. This study provided both the first evidence for a pathological role of Orai3 in the development of diabetic cataract and a potential therapeutic target for diabetic cataract treatment besides surgery.

关键词： apoptosis Orai3 exacerbates apoptosis of lens epithelial cells by disrupting Ca homeostasis in diabetic cataract

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Multi-task unscented Kalman inversion (MUKI): a derivative-free joint inversion framework and its application to joint inversion of geophysical data

arXiv

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arXiv 2022年

作者： Wang, Longlong Chen, Yun Liu, Youshan du, Nanqiao Li, Wei suwen, Junliu State Key Laboratory of Lithospheric Evolution Institute of Geology and Geophysics Chinese Academy of Sciences China College of Earth and Planetary Sciences University of Chinese Academy of Sciences Beijing China CAS Center for Excellence in Deep Earth Science Guangzhou China Department of Earth Science University of Toronto Toronto Canada Hubei Subsurface Multi-Scale Imaging Key Laboratory Institute of Geophysics and Geomatics China University of Geosciences Wuhan China Key Laboratory of Earth and Planetary Physics Institute of Geology and Geophysics Chinese Academy of Sciences Beijing China

In the geophysical joint inversion, the gradient and Bayesian Markov Chain Monte Carlo (MCMC) sampling-based methods are widely used owing to their fast convergences or global optimality. However, these methods either require the computation of gradients and easily fall into local optimal solutions, or cost much time to carry out the millions of forward calculations in a huge sampling space. Different from these two methods, taking advantage of the recently developed unscented Kalman method in computational mathematics, we extend an iterative gradient-free Bayesian joint inversion framework, i.e., Multitask unscented Kalman inversion (MUKI). In this new framework, information from various observations is incorporated, the model is iteratively updated in a derivative-free way, and a Gaussian approximation to the posterior distribution of the model parameters is obtained. We apply the MUKI to the joint inversion of receiver functions and surface wave dispersion, which is well-established and widely used to construct the crustal and upper mantle structure of the earth. Based on synthesized and real data, the tests demonstrate that MUKI can recover the model more efficiently than the gradient-based method and the Markov Chain Monte Carlo method, and it would be a promising approach to resolve the geophysical joint inversion problems. Copyright © 2022, The Authors. All rights reserved.

关键词： Surface waves

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Randomized study to prove the quality of human ovarian tissue cryopreservation by xenotransplantation into mice

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JOURNAL OF OVARIAN RESEARCH 2019年第1期12卷 46-46页

作者： Ruan, Xiangyan Cui, Yamei du, Juan Jin, Jing Gu, Muqing Chen, suwen Mueck, Alfred O. Capital Med Univ Beijing Obstet & Gynecol Hosp Dept Gynecol Endocrinol 251 Yaojiayuan Rd Beijing 100026 Peoples R China Univ Womens Hosp Dept Womens Hlth Tubingen Germany Univ Tubingen Res Ctr Womens Hlth Tubingen Germany Capital Med Univ Beijing Obstet & Gynecol Hosp Dept Family Planning Beijing Peoples R China

PurposeTo study the quality of our human ovarian tissue cryopreservation technique as performed in the first official "International Fertility Protection Centre" in China in patients with certain cancer types using a mouse model, and to find the best site for tissue transplantation in the ***-six BALB/C female nude mice were randomly divided into 3 groups, group 1: control group;group 2: ovariectomized group;group 3: ovarian tissue transplantation group. Seventy-two pieces obtained from six ovarian tissue samples from each of three cancer patients were transplanted into the ovarian bursa cavity (OBC), the subcutaneous thigh (TS) and the subcutaneous neck (NS) and removed after 1.5 and 2.5 months, respectively. Follicular growth rate (FGR), total follicle surviving rate (TFSR), tissue recovery rate (TRR), antral follicles (AF), follicle stimulating hormone (FSH), estradiol (E2) and anti-Mullerian hormone (AMH) levels were *** significant differences in FGR, OBC, NS (p>0.05);TFSR was 100% in OBC, NS and TS. No significant differences in TRR (p>0.05);AF were found only in OBC;TFSR was 100% after transplantation;significantly higher FGR in the 2.5 months compared to the 1.5 months-group (p<0.05). AMH- and E2-level in group 1 and 3 were significantly higher than in group 2 (p<0.05);in contrast, FSH was significantly *** transplantation in the mice, the thawed ovarian tissue survived and follicles developed. The ovarian fossa site was the best site for transplantation. Our animal experiments can verify that our human ovarian tissue cryopreservation technique can preserve the quality of ovarian tissue. This is the essential precondition for successful re-transplantation into the patients after performing chemo/radiotherapy to protect ovarian function and fertility.

关键词： Human cryopreserved ovarian tissue quality Mouse model Follicular growth rate Follicular survival rate

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Molecular classification reveals the diverse genetic and prognostic features of gastric cancer: A multi-omics consensus ensemble clustering

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BIOMEDICINE & PHARMACOTHERAPY 2021年 144卷 112222-112222页

作者： Hu, Xianyu Wang, Zhenglin Wang, Qing Chen, Ke Han, Qijun Bai, suwen du, Juan Chen, Wei Anhui Med Univ Dept Gen Surg Affiliated Hosp 1 Hefei 230022 Anhui Peoples R China Shantou Univ Dept Biliary Pancreat Minimally Invas Surg Med Coll Affiliated Hosp 1 Shantou 515000 Guangdong Peoples R China Chinese Univ Hong Kong Longgang Dist Peoples Hosp Shenzhen 518172 Guangdong Peoples R China Chinese Univ Hong Kong Affiliated Hosp Provis 3 Shenzhen 518172 Guangdong Peoples R China Chinese Univ Hong Kong Sch Med Shenzhen 518172 Guangdong Peoples R China

Background: Globally, gastric cancer (GC) is the fifth most common tumor. It is necessary to identify novel molecular subtypes to guide patient selection for specific target therapeutic benefits. Methods: Multi-omics data, including transcriptomics RNA-sequencing (mRNA, LncRNA, miRNA), DNA methylation, and gene mutations in the TCGA-STAD cohort were used for the clustering. Ten classical clustering algorithms were executed to recognize patients with different molecular features using the "MOVICS" package in R. The activated signaling pathways were evaluated using the single-sample gene set enrichment analysis. The differential distribution of gene mutations, copy number alterations, and tumor mutation burden was compared, and potential responses to immunotherapy and chemotherapy were also assessed. Results: Two molecular subtypes (CS1 and CS2) were recognized by ten clustering algorithms with consensus ensembles. Patients in the CS1 group had a shorter average overall survival time (28.5 vs. 68.9 months, P = 0.016), and progression-free survival (19.0 vs. 63.9 months, P = 0.008) as compared to those in the CS2 group. Extracellular associated biological process activation was higher in the CS1 group, while the CS2 group displayed the enhanced activation of cell cycle-associated pathways. Significantly higher total mutation numbers and neoantigens were observed in the CS2 group, along with specific mutations in TTN, MUC16, and ARID1A. Higher infiltration of immunocytes was also observed in the CS2 group, reflective of the potential immunotherapeutic benefits. Moreover, the CS2 group could also respond to 5-fluorouracil, cisplatin, and paclitaxel. The similar diversity in clinical outcomes between CS1 and CS2 groups was successfully validated in the external cohorts, GSE62254, GSE26253, GSE15459, and GSE84437. Conclusion: The findings provided novel insights into the GC subtypes through integrative analysis of five -omics data by ten clustering algorithms. These could

关键词： Gastric cancer Molecular classification Multi-omics Overall survival Gene mutation

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Update on histone deacetylase inhibitors in peripheral T-cell lymphoma (PTCL)

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CLINICAL EPIGENETICS 2023年第1期15卷 124-124页

作者： Lu, Guang Jin, Shikai Lin, suwen Gong, Yuping Zhang, Liwen Yang, Jingwen Mou, Weiwei du, Jun Sichuan Univ West China Hosp Dept Hematol Chengdu 610041 Sichuan Peoples R China Shengli Oilfield Cent Hosp Dept Hematol Dongying 257034 Shandong Peoples R China Shanghai Jiao Tong Univ Sch Med Dept Clin Med Shanghai 200025 Peoples R China Shenzhen Peking Univ Hong Kong Univ Sci & Technol Clin Res Inst Med Ctr Shenzhen 518036 Guangdong Peoples R China Shengli Oilfield Cent Hosp Dept Pediat Dongying 257034 Shandong Peoples R China Shanghai Jiao Tong Univ Renji Hosp Sch Med Dept Hematol Shanghai 200127 Peoples R China

Peripheral T-cell lymphomas (PTCLs) are a group of highly aggressive malignancies with generally poor prognoses, and the first-line chemotherapy of PTCL has limited efficacy. Currently, several novel targeted agents, including histone deacetylase inhibitors (HDACis), have been investigated to improve the therapeutic outcome of PTCLs. Several HDACis, such as romidepsin, belinostat, and chidamide, have demonstrated favorable clinical efficacy and safety in PTCLs. More novel HDACis and new combination therapies are undergoing preclinical or clinical trials. Mutation analysis based on next-generation sequencing may advance our understanding of the correlation between epigenetic mutation profiles and relevant targeted therapies. Multitargeted HDACis and HDACi-based prodrugs hold promising futures and offer further directions for drug design.

关键词： Histone deacetylase HDACi PTCL Romidepsin Belinostat Chidamide

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