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Role of TRPP2 in mouse airway smooth muscle tension and respiration

AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY 2019年第4期317卷 L466-L474页

作者： Sang, Dacheng Bai, suwen Yin, Sheng Jiang, Sen Ye, Li Hou, Wenxuan Yao, Yanheng Wang, Haoran Shen, Yonggang Shen, Bing du, Juan Anhui Med Univ Sch Basic Med Sci 81 Meishan Rd Hefei 230032 Anhui Peoples R China Capital Med Univ Beijing TianTan Hosp Dept Orthoped Surg Beijing Peoples R China Anhui Med Univ Anhui Prov Hosp Dept Neurosurg Hefei Anhui Peoples R China Anhui Hlth Coll Nursing Fac Chizhou Peoples R China

The transient receptor potential polycystin-2 (TRPP2) is encoded by the Pkd2 gene. and mutation of this gene can cause autosomal dominant polycystic kidney disease (ADPKD). Some patients with ADPKD experience extrarenal manifestations, including radiologic and clinical bronchiectasis. We hypothesized that TRPP2 may regulate airway smooth muscle (ASM) tension. Thus, we used smooth muscle-Pkd2 conditional knockout (Pkd2(SM-CKO)) mice to investigate whether TRPP2 regulated ASM tension and whether TRPP2 deficiency contributed to bronchiectasis associated with ADPKD. Compared with wild-type mice, Pkd2(SM-CKO) mice breathed more shallowly and faster, and their cross-sectional area ratio of bronchi to accompanying pulmonary arteries was higher, suggesting that TRPP2 may regulate ASM tension and contribute to the occurrence of bronchiectasis in ADPKD. In a bioassay examining isolated tracheal ring tension, no significant difference was found for highpotassium-induced depolarization of the ASM between the two groups, indicating that TRPP2 does not regulate depolarization-induced ASM contraction. By contrast, carbachol-induced contraction of the ASM derived from Pkd2(SM-CKO) mice was significantly reduced compared with that in wild-type mice. In addition, relaxation of the carbachol-precontracted ASM by isoprenaline, a beta-adrenergic receptor agonist that acts through the cAMP/adenylyl cyclase pathway. was also significantly attenuated in Pkd2(SM-CKO) mice compared with that in wild-type mice. Thus, TRPP2 deficiency suppressed both contraction and relaxation of the ASM. These results provide a potential target for regulating ASM tension and for developing therapeutic alternatives for some ADPKD complications of the respiratory system or for independent respiratory disease, especially bronchiectasis.

关键词： bronchial smooth muscle conditional knockout calcium respiration TRPP2

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双金属复合管件制造技术综述

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焊管 2023年第6期46卷 26-30,40页

作者：杜卫锋李华军张向迎苑稣文王磊杨军伟闫振欣刘振峰西安向阳航天材料股份有限公司西安710025

在总结了国内外双金属复合管件制造成型工艺的基础上,从制造工艺出发,分别介绍了双金属复合三通、双金属复合弯头、双金属复合异径接头和双金属复合法兰的制造工艺过程和工艺的优缺点,并对常用双金属复合管件制造工艺的优劣进行了排序... 详细信息

在总结了国内外双金属复合管件制造成型工艺的基础上,从制造工艺出发,分别介绍了双金属复合三通、双金属复合弯头、双金属复合异径接头和双金属复合法兰的制造工艺过程和工艺的优缺点,并对常用双金属复合管件制造工艺的优劣进行了排序。最后结合双金属复合管件直径和内衬材料两方面因素,给出了复合管件材料类型选择方案,以期为双金属复合管件的工程应用提供参考。

关键词：双金属复合管件复合三通复合弯头复合异径接头复合法兰

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碘普罗胺注射液外渗致严重皮下血肿和感染

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药物不良反应杂志 2020年第10期22卷 603-605页

作者：马素文孙峥邵越英杜祥颖卢洁首都医科大学宣武医院放射科北京100053 磁共振成像脑信息学北京市重点实验室北京100053 首都医科大学宣武医院教育处北京100053

1例69岁女性糖尿病患者因急性脑梗死行头部血管造影术。术前在高压注射器静脉注射碘普罗胺-370时发生右手注射部位造影剂外渗,造成严重皮下血肿、组织坏死和感染,外渗创面最大至6.0 cm×7.0 cm。给予50%硫酸镁+地塞米松冷局部湿敷,... 详细信息

1例69岁女性糖尿病患者因急性脑梗死行头部血管造影术。术前在高压注射器静脉注射碘普罗胺-370时发生右手注射部位造影剂外渗,造成严重皮下血肿、组织坏死和感染,外渗创面最大至6.0 cm×7.0 cm。给予50%硫酸镁+地塞米松冷局部湿敷,每日清创换药,外敷水凝胶、亲水纤维银、水胶体敷料等治疗,外渗后第14天创面坏死组织逐渐脱落,伤口开始愈合;外渗后第35天创面完全愈合。

关键词：造影剂诊断和治疗物质外渗血肿感染护理

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药理学研究生教学实践融合课程思政的路径探索

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中国继续医学教育 2023年第2期15卷 180-183页

作者：苗庆峰赵志英王娜祁金龙马翠卿赵金萍杜肖娜苏素文河北医科大学基础医学院药理学教研室河北石家庄050017 河北医科大学基础医学院免疫学教研室河北石家庄050017 河北医科大学社会科学部河北石家庄050017

立德树人是高等教育和医学教育的中心环节和根本任务,也是课程思政建设的核心目标。课程思政是一种全新的教学理理念和教学方式,其目的在于使专业课程与思想政治理论课同向同行,形成协同效应,充分发挥课程育人功能。当前,课程思政受到... 详细信息

立德树人是高等教育和医学教育的中心环节和根本任务,也是课程思政建设的核心目标。课程思政是一种全新的教学理理念和教学方式,其目的在于使专业课程与思想政治理论课同向同行,形成协同效应,充分发挥课程育人功能。当前,课程思政受到高校的广泛关注与重视,各高校教师在教学中努力探索课程思政融入教学的途径,把思想政治教育工作贯穿各专业课程教学过程中,实现中全过程育人、全方位育人。教学实践是研究生培养过程中的重要环节,该环节中研究生即是学生,又是教师,因此在研究生教学实践中开展课程思政,即影响研究生,又影响本科生,可以现实双重育人效应。文章探讨了河北医科大学药理学研究生教学实践中开展课程思政的经验,并期望为其他专业研究生教学实践融合课程思研究提供参考。

关键词：药理学研究生教学实践课程思政整合课程全程育人教育探索

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Randomized study to prove the quality of human ovarian tissue cryopreservation by xenotransplantation into mice

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JOURNAL OF OVARIAN RESEARCH 2019年第1期12卷 46-46页

作者： Ruan, Xiangyan Cui, Yamei du, Juan Jin, Jing Gu, Muqing Chen, suwen Mueck, Alfred O. Capital Med Univ Beijing Obstet & Gynecol Hosp Dept Gynecol Endocrinol 251 Yaojiayuan Rd Beijing 100026 Peoples R China Univ Womens Hosp Dept Womens Hlth Tubingen Germany Univ Tubingen Res Ctr Womens Hlth Tubingen Germany Capital Med Univ Beijing Obstet & Gynecol Hosp Dept Family Planning Beijing Peoples R China

PurposeTo study the quality of our human ovarian tissue cryopreservation technique as performed in the first official "International Fertility Protection Centre" in China in patients with certain cancer types using a mouse model, and to find the best site for tissue transplantation in the ***-six BALB/C female nude mice were randomly divided into 3 groups, group 1: control group;group 2: ovariectomized group;group 3: ovarian tissue transplantation group. Seventy-two pieces obtained from six ovarian tissue samples from each of three cancer patients were transplanted into the ovarian bursa cavity (OBC), the subcutaneous thigh (TS) and the subcutaneous neck (NS) and removed after 1.5 and 2.5 months, respectively. Follicular growth rate (FGR), total follicle surviving rate (TFSR), tissue recovery rate (TRR), antral follicles (AF), follicle stimulating hormone (FSH), estradiol (E2) and anti-Mullerian hormone (AMH) levels were *** significant differences in FGR, OBC, NS (p>0.05);TFSR was 100% in OBC, NS and TS. No significant differences in TRR (p>0.05);AF were found only in OBC;TFSR was 100% after transplantation;significantly higher FGR in the 2.5 months compared to the 1.5 months-group (p<0.05). AMH- and E2-level in group 1 and 3 were significantly higher than in group 2 (p<0.05);in contrast, FSH was significantly *** transplantation in the mice, the thawed ovarian tissue survived and follicles developed. The ovarian fossa site was the best site for transplantation. Our animal experiments can verify that our human ovarian tissue cryopreservation technique can preserve the quality of ovarian tissue. This is the essential precondition for successful re-transplantation into the patients after performing chemo/radiotherapy to protect ovarian function and fertility.

关键词： Human cryopreserved ovarian tissue quality Mouse model Follicular growth rate Follicular survival rate

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三九穴位贴敷治疗慢性稳定性劳力型心绞痛心肾阳虚证的疗效观察及对血管内皮功能和心功能指标的影响

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河北中医 2021年第5期43卷 817-821页

作者：王秀玲刘素文高明焕杜玉苗孙腊香王云凯河北省唐山市丰南区中医医院内科河北唐山063300 河北省唐山市丰南区中医医院药剂科河北唐山063300 河北省唐山市丰南区中医医院护理部河北唐山063300 河北省唐山市丰南区医院急诊科河北唐山063300

目的观察三九穴位贴敷治疗慢性稳定性劳力型心绞痛心肾阳虚证的临床疗效及对血管内皮功能和心功能指标的影响。方法将80例慢性稳定性劳力型心绞痛心肾阳虚证患者按照随机数字表法分为2组。对照组40例予西医常规治疗,治疗组40例在对照组... 详细信息

目的观察三九穴位贴敷治疗慢性稳定性劳力型心绞痛心肾阳虚证的临床疗效及对血管内皮功能和心功能指标的影响。方法将80例慢性稳定性劳力型心绞痛心肾阳虚证患者按照随机数字表法分为2组。对照组40例予西医常规治疗,治疗组40例在对照组治疗基础上行三九穴位贴敷治疗。2组均治疗4周。比较2组治疗前后心功能指标[左室射血分数(LVEF)、每搏输出量(SV)、心输出量(CO)、加速指数(ACI)]、血管内皮细胞功能指标[6-酮-前列腺素F 1α(6-keto-PGF 1α)、内皮素(ET)、血栓素B 2(TXB 2)],并统计2组临床疗效及心电图疗效。结果治疗组临床总有效率95.0%(38/40),对照组临床总有效率77.5%(31/40),治疗组临床疗效优于对照组(P<0.05)。治疗组心电图总有效率90.0%(36/40),对照组心电图总有效率70.0%(28/40),治疗组心电图疗效优于对照组(P<0.05)。治疗后2组LVEF、SV、CO、ACI均较本组治疗前升高(P<0.05),且治疗后治疗组均高于对照组(P<0.05)。治疗后2组6-keto-PGF 1α水平均较本组治疗前升高(P<0.05),ET、TXB 2水平均降低(P<0.05),且治疗后治疗组6-keto-PGF 1α水平高于对照组(P<0.05),ET、TXB 2水平均低于对照组(P<0.05)。结论三九穴位贴敷治疗慢性稳定性劳力型心绞痛心肾阳虚证,可改善患者血管内皮功能,并提升其心功能,其作用机制可能是通过调节ET、6-keto-PGF 1α和TXB 2表达水平,保护缺血心肌内皮细胞,抑制血小板聚集与血栓的形成。

关键词：冠心病心绞痛,稳定型穴位贴敷法

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ORAI3 EXACERBATES APOPTOSIS OF LENS EPITHELIAL CELLS BY DISRUPTING CALCIUM HOMEOSTASIS IN DIABETIC CATARACT

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TOXICON 2019年 158卷 S85-S85页

作者： Wang, Yong Bai, suwen du, Juan Xia, Lin Guo, Jizheng Dai, Fang Shen, Bing Anhui Med Univ Sch Basic Med Dept Physiol Hefei 230032 Anhui Peoples R China Anhui Med Univ Dept Ophthalmol Affiliated Hosp 1 Hefei 230022 Peoples R China Anhui Med Univ Dept Endocrinol Affiliated Hosp 1 Hefei 230022 Peoples R China

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关键词： Diabetic cataract Calcium homeostasis Store-operated calcium entry Oria3/STIM

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White mulberry fruit polysaccharides enhance endothelial nitric oxide production to relax arteries in vitro and reduce blood pressure in vivo

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BIOMEDICINE & PHARMACOTHERAPY 2019年 116卷 109022-000页

作者： Wang, Chuyan Cheng, Wenhui Bai, suwen Ye, Li du, Juan Zhong, Mingkui Liu, Jian Zhao, Ren Shen, Bing Hefei Univ Dept Biol & Environm Engn Hefei Anhui Peoples R China Anhui Med Univ Sch Basic Med Hefei Anhui Peoples R China Peking Univ Sch Basic Med Sci Dept Integrat Chinese & Western Med Beijing Peoples R China Anhui Med Univ Affiliated Hosp 1 Dept Cardiol Hefei Anhui Peoples R China Anhui Med Univ Affiliated Hosp 1 Anhui Prov Key Lab Reprod Hlth & Genet Hefei Anhui Peoples R China

Mulberry fruit polysaccharides have demonstrated excellent anti-inflammatory, antioxidant, hypolipidemic, and hypoglycemic properties. This study tested the effect of white mulberry fruit polysaccharides (WMFPs) on blood pressure. WMFPs induced endothelium-dependent relaxation in rat mesenteric arteries and NO production in endothelial cells, both of which were reversed by the NO synthase inhibitor N omega-nitro-L-arginine methyl ester hydrochloride, a phosphoinositide 3-kinase inhibitor LY294002, a cell-permeable Ca2+ chelator (1,2-bis (oaminophenoxy) ethane-N,N,N',N'-tetraacetic acid (acetoxymethyl ester)), and inhibitors of molecules downstream of NO, including the soluble guanylyl cyclase inhibitor 1H- [1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one, the potassium channel inhibitor tetraethylammonium chloride, the large conductance calcium-activated potassium channel-specific inhibitor iberiotoxin, and the K-ATP channel inhibitor glibenclamide. Intravenous injection of WMFPs reduced mean arterial blood pressure in both normotensive Sprague-Dawley and spontaneously hypertensive rats through enhanced endothelial NO production. This study demonstrated that WMFPs induce endothelium-dependent relaxation in rat mesenteric arteries to regulate blood pressure, suggesting that development of WMFPs as a novel antihypertensive agent is warranted.

关键词： Hypertension Nitric oxide Soluble guanylyl cyclase WMFPs Vessel relaxation

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Identification of susceptibility gene mutations associated with the pathogenesis of familial nonmedullary thyroid cancer

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MOLECULAR GENETICS & GENOMIC MEDICINE 2019年第12期7卷 e1015页

作者： Zhu, Junwei Wu, Kaile Lin, Zhangying Bai, suwen Wu, Jing Li, Peikun Xue, Haowei du, Juan Shen, Bing Wang, Huiyin Liu, Yehai Anhui Med Univ Dept Otorhinolaryngol Head & Neck Surg Affiliated Hosp 1 218 Jixi Rd Hefei 230022 Anhui Peoples R China Anhui Med Univ Sch Basic Med Sci Hefei Anhui Peoples R China Anhui Med Univ Dept Gen Surg Affiliated Hosp 2 Hefei Anhui Peoples R China Anhui Med Univ Departinent Orthoped Affiliated Hosp 1 Hefei Anhui Peoples R China Vanderbilt Univ Med Ctr Dept Pathol Microbiol & Immunol Vanderbilt Childrens Hosp Nashville TN USA

BackgroundFamilial nonmedullary thyroid cancer (FNMTC) accounts for approximately 3%-9% of all thyroid cancers;however, the mechanisms underlying FNMTC remain unclear. Environmental and genetic (especially genetic mutation) factors may play important roles in FNMTC etiology, development, and pathogenesis. MethodsThree affected members, including two first-degree relatives, and three healthy members of a family with FNMTC were studied. We performed whole-exome and targeted gene sequencing to identify gene mutations that may be associated with FNMTC pathogenesis. The results were analyzed using Exome Aggregation Consortium data and the Genome Aggregation Database and further validated using Sanger sequencing. ResultsOf 28 pivotal genes with rare nonsynonymous mutations found, 7 were identified as novel candidate FNMTC pathogenic genes (ANO7, CAV2, KANK1, PIK3CB, PKD1L1, PTPRF, and RHBDD2). Among them, three genes (PIK3CB, CAV2, and KANK1) are reportedly involved in tumorigenesis through the PI3K/Akt signaling pathway. ConclusionWe identified seven pathogenic genes in affected members of a family with FNMTC. The PI3K/Akt signaling pathway is thought to be closely related to the development of FNMTC, and three of the susceptibility genes identified herein are associated with this pathway. These findings expand our understanding of FNMTC pathogenesis and underscore PI3K/Akt pathology as a potential therapy target.

关键词： familial nonmedullary thyroid cancer genetic mutation Sanger sequencing targeted gene sequencing whole-exome sequencing

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阿奇霉素联合不同剂量氨溴索对小儿支原体肺炎的疗效观察

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疑难病杂志 2020年第6期19卷 587-590页

作者：赵维彩蔡杰飞徐素文武素娟盖冰杜博英赵允郝宗哲石家庄市第二医院儿科 050051 石家庄市第二医院小儿外科 050051

目的观察阿奇霉素联合不同剂量氨溴索对小儿支原体肺炎的疗效。方法选择2018年3月—2019年6月石家庄第二医院收治的支原体肺炎患儿146例作为研究对象,按双色球法随机分为2组,各73例,常规剂量组给予氨溴索7.5~15 mg/次联合阿奇霉素治疗,... 详细信息

目的观察阿奇霉素联合不同剂量氨溴索对小儿支原体肺炎的疗效。方法选择2018年3月—2019年6月石家庄第二医院收治的支原体肺炎患儿146例作为研究对象,按双色球法随机分为2组,各73例,常规剂量组给予氨溴索7.5~15 mg/次联合阿奇霉素治疗,大剂量组给予氨溴索15~30 mg/次联合阿奇霉素治疗。治疗7 d后观察2组患儿治疗后主要症状消失时间、治疗效果、炎性因子水平、肺功能变化、不良反应发生情况。结果常规剂量组治疗总有效率79.45%,低于大剂量组的95.89%(χ2=9.125,P=0.003);2组发热、肺部啰音消失时间比较差异无统计学意义(P>0.05),大剂量组咳嗽、喘息消失时间短于常规剂量组(t/P=11.571/<0.001、7.719/<0.001);治疗后大剂量组IL-2、IL-6、IL-10、TNF-α水平改善优于常规剂量组(t/P=-9.311/<0.001、11.820/<0.001、4.421/<0.001、9.645/<0.001);治疗后大剂量组FEV 1、FVC、PEF、MEF 50高于常规剂量组(t/P=-12.974/<0.001、-2.018/0.045、-11.917/<0.001、-3.048/0.003);2组治疗后不良反应比较差异无统计学意义(P>0.05)。结论与常规剂量比较,大剂量盐酸氨溴索与阿奇霉素联用于小儿支原体肺炎可以改善症状,减轻炎性反应,改善肺功能,疗效更好,且不增加不良反应。

关键词：支原体肺炎盐酸氨溴索阿奇霉素儿童

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