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ORAI3 EXACERBATES APOPTOSIS OF LENS EPITHELIAL CELLS BY DISRUPTING CALCIUM HOMEOSTASIS IN DIABETIC CATARACT

TOXICON 2019年 158卷 S85-S85页

作者： Wang, Yong Bai, suwen du, Juan Xia, Lin Guo, Jizheng Dai, Fang Shen, Bing Anhui Med Univ Sch Basic Med Dept Physiol Hefei 230032 Anhui Peoples R China Anhui Med Univ Dept Ophthalmol Affiliated Hosp 1 Hefei 230022 Peoples R China Anhui Med Univ Dept Endocrinol Affiliated Hosp 1 Hefei 230022 Peoples R China

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关键词： Diabetic cataract Calcium homeostasis Store-operated calcium entry Oria3/STIM

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White mulberry fruit polysaccharides enhance endothelial nitric oxide production to relax arteries in vitro and reduce blood pressure in vivo

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BIOMEDICINE & PHARMACOTHERAPY 2019年 116卷 109022-000页

作者： Wang, Chuyan Cheng, Wenhui Bai, suwen Ye, Li du, Juan Zhong, Mingkui Liu, Jian Zhao, Ren Shen, Bing Hefei Univ Dept Biol & Environm Engn Hefei Anhui Peoples R China Anhui Med Univ Sch Basic Med Hefei Anhui Peoples R China Peking Univ Sch Basic Med Sci Dept Integrat Chinese & Western Med Beijing Peoples R China Anhui Med Univ Affiliated Hosp 1 Dept Cardiol Hefei Anhui Peoples R China Anhui Med Univ Affiliated Hosp 1 Anhui Prov Key Lab Reprod Hlth & Genet Hefei Anhui Peoples R China

Mulberry fruit polysaccharides have demonstrated excellent anti-inflammatory, antioxidant, hypolipidemic, and hypoglycemic properties. This study tested the effect of white mulberry fruit polysaccharides (WMFPs) on blood pressure. WMFPs induced endothelium-dependent relaxation in rat mesenteric arteries and NO production in endothelial cells, both of which were reversed by the NO synthase inhibitor N omega-nitro-L-arginine methyl ester hydrochloride, a phosphoinositide 3-kinase inhibitor LY294002, a cell-permeable Ca2+ chelator (1,2-bis (oaminophenoxy) ethane-N,N,N',N'-tetraacetic acid (acetoxymethyl ester)), and inhibitors of molecules downstream of NO, including the soluble guanylyl cyclase inhibitor 1H- [1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one, the potassium channel inhibitor tetraethylammonium chloride, the large conductance calcium-activated potassium channel-specific inhibitor iberiotoxin, and the K-ATP channel inhibitor glibenclamide. Intravenous injection of WMFPs reduced mean arterial blood pressure in both normotensive Sprague-Dawley and spontaneously hypertensive rats through enhanced endothelial NO production. This study demonstrated that WMFPs induce endothelium-dependent relaxation in rat mesenteric arteries to regulate blood pressure, suggesting that development of WMFPs as a novel antihypertensive agent is warranted.

关键词： Hypertension Nitric oxide Soluble guanylyl cyclase WMFPs Vessel relaxation

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基于FPGA的SPI接口Flash控制器设计及其在存储配置数据中的应用

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吉林大学学报（理学版） 2014年第5期52卷 1022-1026页

作者：赵庆平李素文杜伟宁姜恩华淮北师范大学物理与电子信息学院安徽淮北235000 空军航空大学飞行训练基地长春130062

针对现场可编程门阵列(FPGA)丰富的逻辑资源及产生精确时序的能力,给出一种基于FPGA的SPI控制器的设计方法.可方便地对SPI flash进行读写、擦除等操作,从而能快速、准确地存储数据.在SPI控制器设计过程中使用Modelsim进行仿真验证,并用V... 详细信息

针对现场可编程门阵列(FPGA)丰富的逻辑资源及产生精确时序的能力,给出一种基于FPGA的SPI控制器的设计方法.可方便地对SPI flash进行读写、擦除等操作,从而能快速、准确地存储数据.在SPI控制器设计过程中使用Modelsim进行仿真验证,并用VHDL硬件描述语言进行编程,下载到FPGA开发板上进行测试,对SPI接口flash进行操作,证明了系统设计方法的正确性和可靠性,该方法对flash存储控制系统的设计具有普遍适用性,实现了对以FPGA为控制核心的系统数据长时间存储.

关键词：串行外设接口控制器现场可编程门阵列 VHDL设计 Modelsim仿真

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The role of transient receptor potential channels in metastasis

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BIOMEDICINE & PHARMACOTHERAPY 2023年 158卷 114074-114074页

作者： Bai, suwen Wei, Yuan Liu, Rong Chen, Yuhua Ma, Wanling Wang, Minghua Chen, Li Luo, Yumei du, Juan Chinese Univ Hong Kong Longgang Dist Peoples Hosp Shenzhen Shenzhen Guangdong Peoples R China Chinese Univ Hong Kong Affiliated Hosp 2 Sch Med Shenzhen Guangdong Peoples R China Anhui Med Univ Sch Basic Med Sci 81 Meishan Rd Hefei 230032 Anhui Peoples R China Sun Yat sen Univ Affiliated Hosp 7 Dept Obstet & gynecol Zhenyuan Rd Shenzhen 518107 Guangdong Peoples R China Chinese Univ Hong Kong Ciechanover Inst Precis & Regenerat Med Sch Med Shenzhen 518172 Guangdong Peoples R China Chinese Univ Hong Kong Longgang Dist Peoples Hosp Shenzhen Shenzhen 518172 Guangdong Peoples R China Chinese Univ Hong Kong Affiliated Hosp 2 Sch Med Shenzhen 518172 Guangdong Peoples R China Chinese Univ Hong Kong Sch Med 2001 Longxiang Rd Shenzhen 518172 Guangdong Peoples R China

Metastasis is the hallmark of failed tumor treatment and is typically associated with death due to cancer. Transient receptor potential (TRP) channels affect changes in intracellular calcium concentrations and participate at every stage of metastasis. Further, they increase the migratory ability of tumor cells, promote angiogenesis, regulate immune function, and promote the growth of tumor cells through changes in gene expression and function. In this review, we explore the potential mechanisms of action of TRP channels, summarize their role in tumor metastasis, compile inhibitors of TRP channels relevant in tumors, and discuss current challenges in research on TRP channels involved in tumor metastasis.

关键词： Transient Receptor Potential Channels Metastasis Epithelial-mesenchymal transition Angiogenesis Immune Modulation

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Physical interaction of tropomyosin 3 and STIM1 regulates vascular smooth muscle contractility and contributes to hypertension

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BIOMEDICINE & PHARMACOTHERAPY 2021年 134卷 111126-111126页

作者： Xu, Fangfang Zhu, Jinhang Chen, Ye He, Ke Guo, Jizheng Bai, suwen Zhao, Ren du, Juan Shen, Bing Anhui Med Univ Sch Basic Med Sci 81 Mei Shan Rd Hefei 230032 Anhui Peoples R China Anhui Med Univ Affiliated Hosp 1 Dept Cardiol Hefei 230032 Anhui Peoples R China

Scope: Tropomyosin (TPM), an actin-binding protein widely expressed across different cell types, is primarily involved in cellular contractile processes. We investigated whether TPM3 physically and functionally interacts with stromal interaction molecule 1 (STIM1) to contribute to vascular smooth muscle cell (VSMC) contraction, store-operated calcium entry (SOCE), and high-salt intake-induced hypertension in rats. Methods and results: Analysis of a rat RNA-seq data set of 80 samples showed that the STIM1 and Tpm3 transcriptome expression pattern is highly correlated, and co-immunoprecipitation results indicated that TPM3 and STIM1 proteins physically interacted in rat VSMCs. Immunohistochemical data displayed obvious co-localization of TPM3 and STIM1 in rat VSMCs. Knockdown of TPM3 or STIM1 in VSMCs with specific small interfering RNA significantly suppressed contractions in tension measurement assays and decreased SOCE in calcium assays. Rats fed a high-salt diet for 4 weeks had significantly higher systolic blood pressure than controls, with significantly increased contractility and markedly increased TPM3 and STIM1 expression levels in the mesenteric resistance artery (shown by tension measurements and immunoblotting, respectively). Additionally, high salt environment in vitro induced significant enhancement of TPM3 and STIM1 expression levels in VSMCs. Conclusions: We showed for the first time that TPM3 and STIM1 physically and functionally interact to contribute to VSMC contraction, SOCE, and high-salt intake-induced hypertension. Our findings provide mechanistic insights and offer a potential therapeutic target for high-salt intake-induced hypertension.

关键词： TPM3 STIM1 High-salt intake Vascular smooth muscle cell Store-operated calcium entry Vasoconstriction

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Orai3 exacerbates apoptosis of lens epithelial cells by disrupting Ca²⁺ homeostasis in diabetic cataract

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CLINICAL AND TRANSLATIONAL MEDICINE 2021年第3期11卷 e327页

作者： Wang, Yong Bai, suwen Zhang, Ru Xia, Lin Chen, Linghui Guo, Jizheng Dai, Fang du, Juan Shen, Bing Anhui Med Univ Affiliated Hosp 1 Dept Ophthalmol Hefei Peoples R China Anhui Med Univ Sch Basic Med Dept Physiol 81 Meishan Rd Hefei 230032 Anhui Peoples R China Anhui Med Univ Affiliated Hosp 1 Dept Endocrinol Hefei Peoples R China

HLEpiCs were cultured with normal glucose (5.5 mM) or high glucose (25.6 mM) for 1, 3, 7, and 14 days and found that compared with the cells in normal glucose, the Ca2+ influx via SOCE was significantly increased in the high glucose group after either thapsigargin (TG) or ATP treatment, and the increase in SOCE was greater when the high glucose treatment lasted longer (Figure 1). [...]compared with those in the cells in normal glucose, the expression levels of Orai3 and STIM1 proteins were significantly enhanced in the cells in high glucose on each day (Figure S2A, B, and E). The fasting blood glucose levels were significantly higher both in streptozotocin-injected Orai3–/– and wild-type rats compared to control Orai3–/– and wild-type rats (Figure 2D–G). [...]the lens turbidity levels were markedly higher both in diabetic Orai3–/– and wild-type rats compared to control Orai3–/– and wild-type rats (Figure 2H–I), but interestingly, the lens turbidity levels were significantly lower in Orai3–/– diabetic rats compared with wild-type diabetic rats (Figure 2H–I). [...]the results in animal models strongly suggest that Orai3 may be importantly involved in the development of DC. In our study, we provided evidence that a high glucose environment increased the apoptotic ratio of the lens epithelial cells, which would contribute to lens opacities.

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碘普罗胺注射液外渗致严重皮下血肿和感染

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药物不良反应杂志 2020年第10期22卷 603-605页

作者：马素文孙峥邵越英杜祥颖卢洁首都医科大学宣武医院放射科北京100053 磁共振成像脑信息学北京市重点实验室北京100053 首都医科大学宣武医院教育处北京100053

1例69岁女性糖尿病患者因急性脑梗死行头部血管造影术。术前在高压注射器静脉注射碘普罗胺-370时发生右手注射部位造影剂外渗,造成严重皮下血肿、组织坏死和感染,外渗创面最大至6.0 cm×7.0 cm。给予50%硫酸镁+地塞米松冷局部湿敷,... 详细信息

1例69岁女性糖尿病患者因急性脑梗死行头部血管造影术。术前在高压注射器静脉注射碘普罗胺-370时发生右手注射部位造影剂外渗,造成严重皮下血肿、组织坏死和感染,外渗创面最大至6.0 cm×7.0 cm。给予50%硫酸镁+地塞米松冷局部湿敷,每日清创换药,外敷水凝胶、亲水纤维银、水胶体敷料等治疗,外渗后第14天创面坏死组织逐渐脱落,伤口开始愈合;外渗后第35天创面完全愈合。

关键词：造影剂诊断和治疗物质外渗血肿感染护理

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Identification of susceptibility gene mutations associated with the pathogenesis of familial nonmedullary thyroid cancer

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MOLECULAR GENETICS & GENOMIC MEDICINE 2019年第12期7卷 e1015页

作者： Zhu, Junwei Wu, Kaile Lin, Zhangying Bai, suwen Wu, Jing Li, Peikun Xue, Haowei du, Juan Shen, Bing Wang, Huiyin Liu, Yehai Anhui Med Univ Dept Otorhinolaryngol Head & Neck Surg Affiliated Hosp 1 218 Jixi Rd Hefei 230022 Anhui Peoples R China Anhui Med Univ Sch Basic Med Sci Hefei Anhui Peoples R China Anhui Med Univ Dept Gen Surg Affiliated Hosp 2 Hefei Anhui Peoples R China Anhui Med Univ Departinent Orthoped Affiliated Hosp 1 Hefei Anhui Peoples R China Vanderbilt Univ Med Ctr Dept Pathol Microbiol & Immunol Vanderbilt Childrens Hosp Nashville TN USA

BackgroundFamilial nonmedullary thyroid cancer (FNMTC) accounts for approximately 3%-9% of all thyroid cancers;however, the mechanisms underlying FNMTC remain unclear. Environmental and genetic (especially genetic mutation) factors may play important roles in FNMTC etiology, development, and pathogenesis. MethodsThree affected members, including two first-degree relatives, and three healthy members of a family with FNMTC were studied. We performed whole-exome and targeted gene sequencing to identify gene mutations that may be associated with FNMTC pathogenesis. The results were analyzed using Exome Aggregation Consortium data and the Genome Aggregation Database and further validated using Sanger sequencing. ResultsOf 28 pivotal genes with rare nonsynonymous mutations found, 7 were identified as novel candidate FNMTC pathogenic genes (ANO7, CAV2, KANK1, PIK3CB, PKD1L1, PTPRF, and RHBDD2). Among them, three genes (PIK3CB, CAV2, and KANK1) are reportedly involved in tumorigenesis through the PI3K/Akt signaling pathway. ConclusionWe identified seven pathogenic genes in affected members of a family with FNMTC. The PI3K/Akt signaling pathway is thought to be closely related to the development of FNMTC, and three of the susceptibility genes identified herein are associated with this pathway. These findings expand our understanding of FNMTC pathogenesis and underscore PI3K/Akt pathology as a potential therapy target.

关键词： familial nonmedullary thyroid cancer genetic mutation Sanger sequencing targeted gene sequencing whole-exome sequencing

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基于Kinect的无标记手部姿态估计系统

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南京大学学报（自然科学版） 2015年第2期51卷 297-303页

作者：周文猛杨一品周余于耀金苏文都思丹南京大学电子科学与工程学院南京210023 上海协同科技上海200063

随着计算机技术的发展,人机交互的方式越来越多样化,声音、手势、肢体动作等都可以用来向计算机传递信息.本文实现的手部姿态估计系统,使用Kinect作为输入设备,在无标记的情况下对人体手部的姿态进行估计、跟踪,恢复出人体手部的姿态信... 详细信息

随着计算机技术的发展,人机交互的方式越来越多样化,声音、手势、肢体动作等都可以用来向计算机传递信息.本文实现的手部姿态估计系统,使用Kinect作为输入设备,在无标记的情况下对人体手部的姿态进行估计、跟踪,恢复出人体手部的姿态信息.采用参数化的手部三维模型,提出了有效的评价函数衡量三维模型投影结果与真实观测值之间的差异,使用改进的粒子群寻优算法求解该评价函数的最优解,进而得到手部姿态信息.针对手部运动帧间的连续性,使用前一帧的优化信息初始化当前帧粒子群,提高了粒子群优化算法的收敛速度.此外,还利用了粒子群算法的内在并行特性,使用GPU并行加速,并针对手部图像处理这一具体任务加以优化,达到了20Hz的处理速度.

关键词： Kinect 手的姿态估计无标记粒子群优化算法 GPU加速

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推进江苏省新型职业农民培育的对策研究

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农业经济与管理 2015年第1期 26-32页

作者：杜华章刘仪影钱素文魏圣林江苏省泰州市姜堰区农业委员会江苏泰州225500 河海大学公共管理学院南京210098

培养高素质的新型职业农民是加快推进江苏由传统农业向现代农业转变的核心问题。从现代农业发展的客观要求、农民就业结构的重大变化、农民收入结构非农化趋势等三个方面阐明江苏省培育新型职业农民的现实需求。以农业专业大户、家庭农... 详细信息

培养高素质的新型职业农民是加快推进江苏由传统农业向现代农业转变的核心问题。从现代农业发展的客观要求、农民就业结构的重大变化、农民收入结构非农化趋势等三个方面阐明江苏省培育新型职业农民的现实需求。以农业专业大户、家庭农场、农民专业合作社、农业龙头企业和农业社会化服务组织五类新型农业经营主体为代表,分析江苏新型职业农民队伍发展现状,并在此基础上,提出江苏加快培育新型职业农民的对策建议,主要是:加强新型职业农民培育的顶层设计,构建配套的顶层制度体系;加大土地流转力度,推进适度规模经营;加快培育职业农民,扩大新型职业农民队伍;构建新型农业社会化服务体系,培育社会服务型职业农民;加大扶持力度,营造优良的政策环境等。

关键词：新型职业农民现实需求发展现状对策建议江苏省

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