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In vivo Photoacoustic Molecular Imaging with Simultaneous Multiple Selective Targeting Using Antibody-Conjugated Gold Nanorods

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OPTICS EXPRESS 2008年第23期16卷 18605-18615页

作者： Li, Pai-Chi Wang, Churng-ren Chris Shieh, Dar-Bin Wei, Chen-Wei Liao, Chao-Kang Poe, Carolina Jhan, suwen Ding, Ann-Ann Wu, Ya-Na Natl Taiwan Univ Grad Inst Biomed Elect & Bioinformat Taipei 106 Taiwan Natl Taiwan Univ Dept Elect Engn Taipei 106 Taiwan Natl Chung Cheng Univ Dept Chem & Biochem Chiayi 621 Taiwan Natl Cheng Kung Univ Inst Mol Med Tainan 701 Taiwan Natl Cheng Kung Univ Inst Oral Med Tainan 701 Taiwan

The use of gold nanorods for photoacoustic molecular imaging with simultaneous multiple targeting is reported. Multiple targeting is done by utilizing the tunable optical absorption property of gold nanorods. This technique allows multiple molecular signatures to be obtained by simply switching laser wavelength. HER2 and EGFR were chosen as the primary target molecules for examining two cancer cells, OECM1 and Cal27. Both in vitro and in vivo mouse model imaging experiments were performed, with contrast enhancement of up to 10dB and 3.5dB, respectively. The potential in improving cancer diagnosis is demonstrated. (c) 2008 Optical Society of America

关键词： Imaging techniques Laser irradiation Molecular imaging Molecular probes Photoacoustic imaging Small animal imaging

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Synthesis and luminescence properties of Pyromellitic acid-functionalized LaF3 nanoparticles doped with Eu3+ions

Synthesis and luminescence properties of Pyromellitic acid-f...

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第四届全国掺杂纳米材料发光性质学术会议

作者： suwen Li Dehui Sun Huijuan ren College of Science Changchun Institute of TechnologyChangchun 130021P.R. China

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Fabrication and photoluminescent properties of Gd₂O₃ : Eu³⁺ nanowires in AAO template

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JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY 2007年第2期7卷 474-480页

作者： Li, suwen Song, Hongwei Yu, Lixin Liu, Zhongxin Pan, Guohui Yu, Hongquan Dai, QiLin Fan, Libo Lei, Yanqiang Wang, Tie ren, Xinguang Lu, Shaozhe Zhao, Haifeng Chinese Acad Sci Changchun Inst Opt Fine Mech & Phys Key Lab Excited State Phys Changchun 130033 Peoples R China Chinese Acad Sci Grad Sch Beijing 100039 Peoples R China

Uniform Gd2O3 : Eu3+ nanowires were fabricated by using anodic aluminum oxide template (AAO). The spectral measurements indicate that with the increasing annealing temperature the excitation band of Eu3+ in Gd2O3 : Eu3+ nanowires/AAO shifted blue, the intensity ratio of D-5(0)-F-7(2) to D-5(0)-F-7(1) decreased, and the lifetime became longer. In the sample annealed at 1000 C two spectral components, the sharper and broader lines were identified, corresponding to two different local environments, the Eu3+ ions in cubic phase and in amorphous phase, respectively. The D-5(0)-F-7(1), transitions of Eu3+ ions in cubic phase had longer lifetime than that in amorphous phase. In contrast to the lifetime of the D-5(0)-F-7(J) transitions in the bulk, that in Gd2O3 : Eu3+/AAO composite films increased due to influence of the surrounding media (AAO).

关键词： nanowires AAO template annealing local environments photoluminescence characteristics

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防振条对蒸汽发生器传热管完整性的影响分析

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核动力工程 2016年第6期37卷 109-112页

作者：崔素文朱勇任红兵深圳中广核工程设计有限公司广东深圳518172

以二代加压水堆核电厂蒸汽发生器(SG)为例,分析了防振条组件对SG传热管完整性可能产生的影响。分析表明:发现防振条自身扭转、防振条与传热管之间的间隙、防振条的下插深度等对传热管的完整性影响较大。为提高传热管在役运行的可靠性,... 详细信息

以二代加压水堆核电厂蒸汽发生器(SG)为例,分析了防振条组件对SG传热管完整性可能产生的影响。分析表明:发现防振条自身扭转、防振条与传热管之间的间隙、防振条的下插深度等对传热管的完整性影响较大。为提高传热管在役运行的可靠性,防振条的设计中对防振条组件(AVB)与SG传热管之间的设计间隙应作充分的考虑,避免在装配时对管束和AVB施加异常外力并确保同组AVB的下插深度一致。

关键词：防振条扭转间隙下插深度

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蒸汽发生器设计中ALARA原则的考虑

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核动力工程 2015年第4期36卷 107-110页

作者：崔素文任红兵高希培深圳中广核工程设计有限公司广东深圳518172

合理可行尽量低(ALARA)原则是核电厂辐射防护的基本原则。蒸汽发生器作为一回路最重要的设备之一,其设计应考虑ALARA原则,以限制并减少核电站人员的辐照剂量。通过对影响辐照剂量的重要设计过程进行分析后得出结论:通过优化选材、快速... 详细信息

合理可行尽量低(ALARA)原则是核电厂辐射防护的基本原则。蒸汽发生器作为一回路最重要的设备之一,其设计应考虑ALARA原则,以限制并减少核电站人员的辐照剂量。通过对影响辐照剂量的重要设计过程进行分析后得出结论:通过优化选材、快速疏导一回路冷却剂、改善在役检查、加强屏蔽、优化水化学等举措,可使蒸汽发生器的设计更加满足ALARA原则。最后,根据上述研究结论,对二代加核电站蒸汽发生器的设计提出改进建议。

关键词：蒸汽发生器设计合理可行尽量低(ALARA) 电解抛光疏水水化学

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Solvothermal synthesis and photoluminescent properties of ZnS/cyclohexylamine: Inorganic-organic hybrid semiconductor nanowires

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JOURNAL OF PHYSICAL CHEMISTRY B 2006年第26期110卷 12948-12953页

作者： Fan, Libo Song, Hongwei Zhao, Haifeng Pan, Guohui Yu, Hongquan Bai, Xue Li, suwen Lei, Yanqiang Dai, Qilin Qin, Ruifei Wang, Tie Dong, Biao Zheng, Zhuhong ren, Xinguang Chinese Acad Sci Changchun Inst Opt Fine Mech & Phys Key Lab Excited State Phys Changchun 1330033 Peoples R China Chinese Acad Sci Grad Sch Beijing 100039 Peoples R China

An inorganic-organic hybrid semiconductor, ZnS/CHA (CHA = cyclohexylamine) nanocomposites was successfully synthesized via a solvothermal method using CHA as solvent, which yielded uniform and ultralong nanowires with widths of 100-1000 nm and lengths of 5-20 mu m. Changing the reaction conditions could alter the morphology and optical properties of the nanocomposites. The periodic layer subnanometer structures were identified by high-resolution transmission electron microscopy (HR-TEM) images, with thickness of similar to 2 nm. The composites exhibited a very large blue-shift in their optical absorption edge as well as an exciton excitation band due to a strong quantum confinement effect caused by the internal subnanometer-scale structures. The pure hexagonal wurtzite ZnS nanowires were also obtained by extracting the ZnS/CHA nanocomposites with dimethyl formamide (DMF). In addition, the luminescent properties of exciton and defect-related transitions in different samples of ZnS/CHA were discussed in detail.

关键词： NANOSTRUCTURED materials NANOWIRES ELECTRON microscopy TRANSMISSION electron microscopy

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Preparation, Characterization and Photoluminescence Properties of Ternary Europium Complexes Eu(DBM)₃bath Encapsulated into Aluminosilicate Zeolites

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JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY 2008年第8期8卷 3959-3966页

作者： Liu, Huihui Song, Hongwei Li, suwen ren, Xinguang Lu, Shaozhe Yu, Hongquan Pan, Guohui Zhang, Hui Hu, Lanying Dai, Qilin Qin, Ruifei Yu, Jihong Wang, Guangmei Jiang, Jiuxing Chinese Acad Sci Changchun Inst Opt Fine Mech & Phys Key Lab Excited State Phys Changchun 130033 Peoples R China Chinese Acad Sci Grad Sch Changchun 130033 Peoples R China Jilin Univ Coll Chem State Key Lab Inorgan Synth & Preparat Chem Changchun 130012 Peoples R China

To modify the photoluminescence properties the Eu(DBM)(3)bath complexes were encapsulated into the sub-nanometer pores of aluminosilicates zeolites L and Y and characterized by X-ray diffraction (XRD), transmission electron micrographs (TEM), Fourier transform infrared spectroscopy (FTIR) and ultraviolet-visible (UV-vis) absorption spectra. The luminescent properties of the encapsulated composites (Eu-L and Eu-Y) were systematically studied. The results indicate that in both the two composites the crystal-field symmetry becomes lower, as a consequence, the D-5(0)-F-7(2) electronic-dipole transition relative to the ID.-IF, magnetic-dipole transition of Eu3+ increases in contrast to the pure complexes. The outer quantum efficiency of the Eu3+ emission and the photostability of Eu3+ are both improved considerably. The adsorption of water in the composites has influence on the thermostability and decay dynamics of the Eu3+ emission. In the composite Eu-L, which contains less water the thermostability of luminescence is improved considerably and the lifetime becomes longer in comparison to the pure complexes. Overall, zeolite L is a more ideal host material for modification of lanthanide complexes.

关键词： Eu(DBM)(3)bath Aluminosilicate Zeolites Composites Photoluminescence

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Multi-service QoS guaranteed based downlink cross-layer resource block allocation algorithm in LTE systems

Multi-service QoS guaranteed based downlink cross-layer reso...

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International Conference on Wireless Communications and Signal Processing (WCSP)

作者： Yunzhi Qian Canjun ren suwen Tang Ming Chen National Mobile Communications Research Laboratory South-East University Nanjing China

A sub-optimal multi-service quality-of-service (QoS) guaranteed resource block allocation algorithm for downlink LTE system is proposed in this paper. Its key features are that all users are classified into three categories according to their channel state information in physical layer and queue state information in data-link layer. Then proposed scheduler assigns resource blocks to predefined three user categories in turns. Numerical results demonstrate that the proposed algorithm reduces the data loss rate considerably and improves the resource exploitation rate meanwhile user QoS requirement is ensured. For a densely populated system, the proposed scheme shows a graceful degradation, possibly leading to a high average user satisfaction.

关键词： Downlink Resource management Scheduling algorithm Round robin Physical layer Delay effects Mobile communication Laboratories Channel state information OFDM

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A Jitter Attenuating Timing Chain

A Jitter Attenuating Timing Chain

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International Symposium on Advanced Research in Asynchronous Circuits and Systems

作者： suwen Yang Mark R. Greenstreet Jihong ren Canada Intel

A long chain of inverters and wire segments will amplify clock jitter and drop timing pulses due to intersymbol interference. We present a jitter attenuating buffer based on surfing techniques. Our buffer circuit consists of a few inverters with variable output strength that implement a simple, low-gain DLL. Chains of these surfing buffers attenuate jitter making them well suited for source-synchronous interfaces. Furthermore, our chains can be used to reliably transmit handshaking signals and support sliding-window protocols to improve the throughput of asynchronous communication.

关键词： Timing jitter Wire Clocks Pulse amplifiers Pulse inverters Intersymbol interference Circuits Protocols Throughput Asynchronous communication

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Molecular Basis for the Final Oxidative Rearrangement Steps in Chartreusin Biosynthesis

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JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 2018年第34期140卷 10909-10914页

作者： Wang, Yi Shuang Zhang, Bo Zhu, Jiapeng Yang, Cheng Long Guo, Yu Liu, Cheng Li Liu, Fang Huang, Huiqin Zhao, suwen Liang, Yong Jiao, Rui Hua Tan, ren Xiang Ge, Hui Ming Nanjing Univ Inst Funct Biomol Sch Life Sci State Key Lab Pharmaceut Biotechnol Nanjing 210023 Jiangsu Peoples R China Nanjing Univ Chinese Med Sch Med & Life Sci State Key Lab Cultivat Base TCM Qual & Efficacy Nanjing 210023 Jiangsu Peoples R China Shanghai Tech Univ iHuman Inst Shanghai 201210 Peoples R China Chinese Acad Trop Agr Sci Minist Agr Key Lab Biol & Genet Resources Trop Crops Inst Trop Biosci & Biotechnol Haikou 571101 Hainan Peoples R China Nanjing Univ Sch Chem & Chem Engn Jiangsu Key Lab Adv Organ Mat State Key Lab Coordinat Chem Nanjing 210023 Jiangsu Peoples R China

Oxidative rearrangements play key roles in introducing structural complexity and biological activities of natural products biosynthesized by type II polyketide synthases (PKSs). Chartreusin (1) is a potent antitumor polyketide that contains a unique rearranged pentacyclic aromatic bilactone aglycone derived from a type II PKS. Herein, we report an unprecedented dioxygenase, ChaP, that catalyzes the final a-pyrone ring formation in 1 biosynthesis using flavin-activated oxygen as an oxidant. The X-ray crystal structures of ChaP and two homologues, docking studies, and site-directed mutagenesis provided insights into the molecular basis of the oxidative rearrangement that involves two successive C-C bond cleavage steps followed by lactonization. ChaP is the first example of a dioxygenase that requires a flavin-activated oxygen as a substrate despite lacking flavin binding sites, and represents a new class in the vicinal oxygen chelate enzyme superfamily.

关键词： Peptides and proteins Monomers Biosynthesis Aromatic compounds Rearrangement

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