Metastasis is the leading cause of high ovarian-cancer-related mortality worldwide. Three major processes constitute the whole metastatic cascade: invasion, intravasation, and extravasation. Tumor cells often reprogra...
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Metastasis is the leading cause of high ovarian-cancer-related mortality worldwide. Three major processes constitute the whole metastatic cascade: invasion, intravasation, and extravasation. Tumor cells often reprogram their metabolism to gain advantages in proliferation and survival. However, whether and how those metabolic alterations contribute to the invasiveness of tumor cells has yet to be fully understood. Here we performed a genome-wide CRISPR-Cas9 screening to identify genes participating in tumor cell dissemination and revealed that PTGES3 acts as an invasion suppressor in ovarian cancer. Mechanistically, PTGES3 binds to phosphofructokinase, liver type (PFKL) and generates a local source of prostaglandin E2 (PGE2) to allosterically inhibit the enzymatic activity of PFKL. Repressed PFKL leads to downgraded glycolysis and the subsequent TCA cycle for glucose metabolism. However, ovarian cancer suppresses the expression of PTGES3 and disrupts the PTGES3-PGE2-PFKL inhibitory axis, leading to hyperactivation of glucose oxidation, eventually facilitating ovarian cancer cell motility and invasiveness.
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ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
目的探讨并行采集技术在术中磁共振成像(Intraoperative Magnetic Resonance Imaging,iMRI)系统的应用价值。方法基于3.0 T iMRI系统,对20例正常被试进行T1轴位、T2轴位、T2反转恢复序列轴位、T2矢状位四个序列的常规采集和并行采集,计...
详细信息
目的探讨并行采集技术在术中磁共振成像(Intraoperative Magnetic Resonance Imaging,iMRI)系统的应用价值。方法基于3.0 T iMRI系统,对20例正常被试进行T1轴位、T2轴位、T2反转恢复序列轴位、T2矢状位四个序列的常规采集和并行采集,计算并比较常规和并行采集的成像时间、图像的不均匀性指标(Non-Uniformity Index,NUI)和主观评分。结果相较于常规采集,采用并行采集技术的总扫描时长缩短了41.9%。并行采集技术下图像的NUI和主观评分相较于常规采集无显著差异(P>0.05)。结论并行采集技术在iMRI系统的应用有效缩短了扫描时长,且对术中成像质量无影响,可以为提高手术效率、保证患者安全提供技术支持。
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