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中华流行病学杂志 2018年第9期39卷 1287-1290页

作者：冯岚宋彬臧照芳孙乃玲王建书刘芳雷苏文中国疾病预防控制中心标准处北京102206 苏州市疾病预防控制中心 215004

标准的实施作为标准化活动中最为重要的环节，是标准化活动的目的所在。疾病预防与控制机构是我国疾病防控的主体，而公共卫生标准的实施为疾病预防与控制机构开展疾病监测与防控工作提供了技术依据。本文基于现场座谈和问卷调查对公共... 详细信息

标准的实施作为标准化活动中最为重要的环节，是标准化活动的目的所在。疾病预防与控制机构是我国疾病防控的主体，而公共卫生标准的实施为疾病预防与控制机构开展疾病监测与防控工作提供了技术依据。本文基于现场座谈和问卷调查对公共卫生标准在疾病预防与控制机构业务工作中的实施情况进行调查。结果显示，疾病预防与控制机构通过网络方式获知标准，参加和开展培训的部门分别占50．00％（25／50）和34．00％（17／50）；国家强制规定实施相关标准仍然是各部门应用标准的主要原因；政府推动、工作需求促进标准实施，对标准的熟悉程度影响标准的实施。原因可能是省级及以下卫生标准协调管理部门的缺失、获取标准的途径相对匮乏、标准组织培训工作有待加强等，应强化公共卫生标准的实施。

关键词：公共卫生标准疾病预防与控制机构实施

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High-throughput identification of G protein-coupled receptor modulators through affinity mass spectrometry screening

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CHEMICAL SCIENCE 2018年第12期9卷 3192-3199页

作者： Qin, Shanshan Meng, Mengmeng Yang, Dehua Bai, Wenwen Lu, Yan Peng, Yao song, Gaojie Wu, Yiran Zhou, Qingtong Zhao, suwen Huang, Xiping McCorvy, John D. Cai, Xiaoqing Dai, Antao Roth, Bryan L. Hanson, Michael A. Liu, Zhi-Jie Wang, Ming-Wei Stevens, Raymond C. Shui, Wenqing ShanghaiTech Univ iHuman Inst Shanghai 201210 Peoples R China Nankai Univ Coll Pharm Tianjin 300071 Peoples R China Chinese Acad Sci Natl Ctr Drug Screening CAS Key Lab Receptor Res Shanghai Inst Mat Med Shanghai 201203 Peoples R China ShanghaiTech Univ Sch Life Sci & Technol Shanghai 201202 Peoples R China Univ N Carolina Chapel Hill Sch Med Dept Pharmacol Chapel Hill NC 27599 USA GPCR Consortium San Marcos CA 92078 USA Fudan Univ Sch Pharm Shanghai 201203 Peoples R China

G protein-coupled receptors (GPCRs) represent the largest class of cell surface proteins and thus constitute an important family of therapeutic targets. Therefore, significant effort has been put towards the identification of novel ligands that can modulate the activity of a GPCR target with high efficacy and selectivity. However, due to limitations inherent to the most common techniques for GPCR ligand discovery, there is a pressing need for more efficient and effective ligand screening methods especially for the identification of potential allosteric modulators. Here we present a high-throughput, label-free and unbiased screening approach for the identification of small molecule ligands towards GPCR targets based on affinity mass spectrometry. This new approach features the usage of target-expressing cell membranes rather than purified proteins for ligand screening and allows the detection of both orthosteric and allosteric ligands targeting specific GPCRs. Screening a small compound library with this approach led to the rapid discovery of an antagonist for the 5-HT receptor and four positive allosteric modulators for GLP-1 receptor that were not previously reported.

关键词： Mass spectrometry

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Mesoporous silica (KIT-6) derivatized with hydroxyquinoline functionalities as a selective adsorbent of uranium(VI)

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JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY 2016年第2期308卷 381-392页

作者： Zhu, Lu Shi, Xiangchen song, Lijuan Sun, Yalou Chen, suwen Wu, Wangsuo Lanzhou Univ Sch Nucl Sci & Technol Lanzhou 730000 Peoples R China

Two modified mesoporous silica (KIT-6) materials for absorbing uranium(VI) were prepared respectively via post-grafting of 8-hydroxyquinoline and 8-hydroxyquinoline onto surface of KIT-6, which were characterized by FT-IR, NMR, TEM, and sorption/desorption analysis. Effect of pH values, contact time, ionic strength, solid-liquid ratio, temperature, and coexisting ions on sorption behavior of the modified KIT-6 were also investigated. Typical sorption isotherms (Langmuir and Freundlich) were used to determine the sorption process and the maximum U(VI) sorption capacity. The results indicate that the two modified KIT-6 exhibit better selective sorption of U(VI) as compared to the original KIT-6.

关键词： Mesoporous silica Surface modification Sorption Uranium(VI)

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我国公共卫生领域卫生标准不协调之初探

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中华流行病学杂志 2019年第5期40卷 601-604页

作者：冯岚宋彬李卫国臧照芳孙乃玲姚玅洁程义斌孙波佟颖李静朱秋鸿刘拓魏红联董彬杨海兵卢金星雷苏文中国疾病预防控制中心传染病预防控制所北京102206 苏州市疾病预防控制中心 215004 苏州市吴江区疾病预防控制中心 215200 中国疾病预防控制中心北京102206 中国疾病预防控制中心环境所北京100021 北京市疾病预防控制中心 100013 中国疾病预防控制中心职业卫生所北京100027 中国疾病预防控制中心地方病控制中心哈尔滨150081 北京大学儿少卫生研究所 100191

标准的交叉、重复、矛盾等不协调问题已成为当前我国标准化工作现状存在的主要问题之一。减少标准的交叉、重复、矛盾,增强标准的统一性和权威性,已成为我国深化标准化改革的重要目标。本文通过资料检索和专题调研等方法,检索公共卫生... 详细信息

标准的交叉、重复、矛盾等不协调问题已成为当前我国标准化工作现状存在的主要问题之一。减少标准的交叉、重复、矛盾,增强标准的统一性和权威性,已成为我国深化标准化改革的重要目标。本文通过资料检索和专题调研等方法,检索公共卫生领域具体标准案例,从部分卫生标准之间、与跨部门相同专业领域标准之间以及与行政规范性文件、学(协)会指南及技术规范之间等多个角度进行比较,初步探讨我国公共卫生领域卫生标准交叉、重复、矛盾等不协调问题,并对产生的主要原因进行分析,针对性地提出相关策略建议。

关键词：公共卫生卫生标准不协调

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Selective activation of TWIK-related acid-sensitive K⁺ 3 subunit-containing channels is analgesic in rodent models

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SCIENCE TRANSLATIONAL MEDICINE 2019年第519期11卷 eaaw8434页

作者： Liao, Ping Qiu, Yunguang Mo, Yiqing Fu, Jie song, Zhenpeng Huang, Lu Bai, suwen Wang, Yang Zhu, Jia-Jie Tian, Fuyun Chen, Zhuo Pan, Nanfang Sun, Er-Yi Yang, Linghui Lan, Xi Chen, Yinbin Huang, Dongping Sun, Peihua Zhao, Lifen Yang, Dehua Lu, Weiqiang Yang, Tingting Xiao, Junjie Li, Wei-Guang Gao, Zhaobing Shen, Bing Zhang, Qiansen Liu, Jin Jiang, Hualiang Jiang, Ruotian Yang, Huaiyu Sichuan Univ Natl Local Joint Engn Res Ctr Translat Med Anesth Lab Anesthesia & Crit Care Med West China HospDept Anesthesiol Chengdu 610000 Sichuan Peoples R China Chinese Acad Sci Shanghai Inst Materia Med State Key Lab Drug Res Shanghai 201203 Peoples R China Chinese Acad Sci Shanghai Inst Materia Med CAS Key Lab Receptor Res Shanghai 201203 Peoples R China Univ Chinese Acad Sci Beijing 100049 Peoples R China East China Normal Univ Sch Life Sci Inst Biomed Sci Shanghai Key Lab Regulatory Biol Shanghai 200241 Peoples R China Anhui Med Univ Dept Physiol Hefei 230032 Anhui Peoples R China Shanghai Jiao Tong Univ Sch Med Collaborat Innovat Ctr Brain Sci Dept Anat & Physiol Shanghai 200025 Peoples R China Soochow Univ Jiangsu Key Lab Neuropsychiat Dis Suzhou 215123 Jiangsu Peoples R China Soochow Univ Coll Pharmaceut Sci Suzhou 215123 Jiangsu Peoples R China Shanghai Univ Sch Life Sci Cardiac Regenerat & Ageing Lab Shanghai 200444 Peoples R China

The paucity of selective agonists for TWIK-related acid-sensitive K+ 3 (TASK-3) channel, a member of two-pore domain K+ (K2P) channels, has contributed to our limited understanding of its biological functions. By targeting a druggable transmembrane cavity using a structure-based drug design approach, we discovered a biguanide compound, CHET3, as a highly selective allosteric activator for TASK-3-containing K2P channels, including TASK-3 homomers and TASK-3/TASK-1 heteromers. CHET3 displayed potent analgesic effects in vivo in a variety of acute and chronic pain models in rodents that could be abolished pharmacologically or by genetic ablation of TASK-3. We further found that TASK-3-containing channels anatomically define a unique population of small-sized, transient receptor potential cation channel subfamily M member 8 (TRPM8)-, transient receptor potential cation channel subfamily V member 1 (TRPV1)-, or tyrosine hydroxylase (TH)-positive nociceptive sensory neurons and functionally regulate their membrane excitability, supporting CHET3 analgesic effects in thermal hyperalgesia and mechanical allodynia under chronic pain. Overall, our proof-of-concept study reveals TASK-3-containing K2P channels as a druggable target for treating pain.

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Chicory inulin ameliorates type 2 diabetes mellitus and suppresses JNK and MAPK pathways in vivo and in vitro

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MOLECULAR NUTRITION & FOOD RESEARCH 2017年第8期61卷 2017 Aug;61(8)页

作者： Ning, Chong Wang, Xiyao Gao, song Mu, Jingjing Wang, Yuehua Liu, suwen Zhu, Jinyan Meng, Xianjun Shenyang Agr Univ Coll Food Sci Shenyang Liaoning Peoples R China Liaoning Inst Sci & Technol Sch Biomed & Chem Engn Benxi Peoples R China Hebei Normal Univ Sci & Technol Coll Food Sci & Technol Qinhuangdao Peoples R China Food Inspect Monitoring Ctr Zhuanghe Dalian Peoples R China

Scope: Chicory inulin is a naturally occurring fructan that is conducive to glucose and lipid metabolism in patients with diabetes mellitus. This study aims to investigate the mechanism by which chicory inulin improves glucolipid metabolism in diabetic conditions. Methods and results: Rats were injected with streptozotocin and fed with high fat diet to induce diabetes, and then administrated with different doses of chicory inulin for 8 weeks. The glycometabolism and lipid metabolism parameters were determined, the activity of insulin receptor substrate (IRS) andmitogen-activated protein kinase (MAPK) pathways were examined by western blot. The effect of chicory inulin on glucose uptake ofmyoblast and hepatocyte were also measured in vitro. Data were analyzed by student's t-test or one-way analysis of variance followed by the Bonferroni post-hoc testing. The results showed that chicory inulin improved glucolipid metabolism, and it activated IRS but suppressed the MAPK pathways in vivo and in vitro. Conclusion: Our study demonstrates that chicory inulin, as a nutritional supplement, may be beneficial for the patients with type 2 diabetes mellitus, and the metabolism-modulatory effect seems to be related with the inhibition of JNK and P38 MAPK pathways.

关键词： Chicory inulin Diabetes Glycometabolism Lipid metabolism Mitogen-activated protein kinase

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疾病预防控制机构工作人员应用公共卫生标准情况调查

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中国卫生标准管理 2018年第15期9卷 1-3页

作者：臧照芳王建书宋彬冯岚孙乃玲雷苏文中国疾病预防控制中心卫生标准处北京102206 苏州市疾病预防控制中心环境卫生科江苏苏州215004 苏州市疾病预防控制中心职业卫生科江苏苏州215004

公共卫生领域的相关标准是疾病预控控制机构卫生检测和疾病防治工作开展的依据,对规范性开展工作发挥重要作用。文章采用问卷调查的方法对疾病预防控制机构中的工作人员应用公共卫生标准情况进行了调查,分析探讨了在标准使用过程中存在... 详细信息

公共卫生领域的相关标准是疾病预控控制机构卫生检测和疾病防治工作开展的依据,对规范性开展工作发挥重要作用。文章采用问卷调查的方法对疾病预防控制机构中的工作人员应用公共卫生标准情况进行了调查,分析探讨了在标准使用过程中存在的问题,最后对促进疾病预防控制机构公共卫生标准的实施提出了建议。

关键词：公共卫生标准疾病预防控制机构标准实施标准制修订标准宣贯问卷调查

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The mitochondrial genome of Pomacea maculata (Gastropoda: Ampullariidae) (Publication with Expression of Concern. See vol. 30, pg. 474, 2019)

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MITOCHONDRIAL DNA PART A 2016年第4期27卷 2895-2896页

作者： Yang, Qianqian Liu, suwen song, Fan Li, Hu Liu, Jinpeng Liu, Guangfu Yu, Xiaoping China Jiliang Univ Coll Life Sci Zhejiang Prov Key Lab Biometrol & Inspect & Quara Hangzhou 310018 Zhejiang Peoples R China China Agr Univ Dept Entomol Beijing 100094 Peoples R China Univ Kentucky Lucille P Markey Canc Ctr Lexington KY USA

The golden apple snail, Pomacea maculata Perry, 1810 (Gastropoda: Ampullariidae) is one of the most serious invasive alien species from the native range of South America. The mitochondrial genome of P. maculata (15 516 bp) consists of 37 genes (13 protein/coding genes, two rRNAs, and 22 tRNAs) and a non-coding region with a 16 bp repeat unit. Most mitochondrial genes of P. maculata are distributed on the H-strand, except eight tRNA genes, which are encoded on the L-strand. A phylogenetic analysis showed that there was a close relationship between P. maculata and another invasive golden apple snail species, Pomacea canaliculata (Lamarck, 1822).

关键词： Golden apple snails mitogenome Pomacea maculata

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Organic silicon electroluminescent display device

Organic silicon electroluminescent display device

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作者： Zheng Yan Guo suwen Bian Jingyu Chen Lei Jiang Yun Zhang Ruijun song Changbo Quan Lihua Wang Lu Lu Hongmei

标准号: US10147768(B2)

An organic silicon electroluminescent display device includes a protective layer, a transparent conductive layer, an organic silicon electroluminescent layer and a basic conductive layer, which are combined to prepare a flat flaky or continuous wire or matrix point electroluminescent device. The basic conductive layer is made from a conductive material with good electroconductibility;the organic silicon electroluminescent layer is prepared through mixing an electroluminescent material with a resin or rubber material containing organic silicon;the transparent conductive layer is made from a conductive material with good electroconductibility;the organic silicon electroluminescent layer is located between the transparent conductive layer and the basic conductive layer;when an electric field is applied to both the transparent conductive layer and the basic conductive layer, the organic silicon electroluminescent layer with elasticity is bent, folded and pressed, and stretched to produce light with high brightness.

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芪参益气滴丸对心肌缺血再灌注大鼠炎症反应和细胞凋亡的影响

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中西医结合心脑血管病杂志 2018年第23期16卷 3431-3433页

作者：孙丽霞姬延平苏军牛红梅宋秀芝张素文张振国邯郸市第七医院河北邯郸056001 邯郸市中医院

目的探讨芪参益气滴丸对心肌缺血再灌注大鼠炎症反应和细胞凋亡的影响。方法收集120只正常大鼠建立缺血/再灌注损伤模型,随机分为对照组、缺血/再灌注组(生理盐水)、试验组(5 g芪参益气滴丸),每组40只。造模成功24 h后迅速断头取心脏,采... 详细信息

目的探讨芪参益气滴丸对心肌缺血再灌注大鼠炎症反应和细胞凋亡的影响。方法收集120只正常大鼠建立缺血/再灌注损伤模型,随机分为对照组、缺血/再灌注组(生理盐水)、试验组(5 g芪参益气滴丸),每组40只。造模成功24 h后迅速断头取心脏,采用MTT法检测细胞增殖能力;采用TUNEL测定法检测细胞凋亡率;采用放射免疫法检测白介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)的表达。结果与对照组比较,缺血/再灌注模型组和试验组细胞增殖能力明显降低,细胞凋亡率明显增加,具有统计学意义(P <0.05)。与缺血/再灌注模型组比较,试验组细胞增殖能力明显增加,细胞凋亡率能力明显降低,具有统计学意义(P <0.05)。与对照组比较,缺血/再灌注模型组IL-6水平表达明显升高,TNF-α表达明显下降,具有统计学意义(P <0.05);与缺血/再灌注模型组比较,试验组IL-6表达明显降低,TNF-α表达明显升高,具有统计学意义(P <0.05)。结论芪参益气滴丸可减轻缺血再灌注心肌细胞损伤,其作用机制可能是通过抗炎和抗细胞凋亡来实现保护作用的。

关键词：芪参益气滴丸缺血/再灌注心肌细胞炎症细胞凋亡白介素-6 肿瘤坏死因子-α 细胞增殖能力

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