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中西医结合心脑血管病杂志 2018年第23期16卷 3431-3433页

作者：孙丽霞姬延平苏军牛红梅宋秀芝张素文张振国邯郸市第七医院河北邯郸056001 邯郸市中医院

目的探讨芪参益气滴丸对心肌缺血再灌注大鼠炎症反应和细胞凋亡的影响。方法收集120只正常大鼠建立缺血/再灌注损伤模型,随机分为对照组、缺血/再灌注组(生理盐水)、试验组(5 g芪参益气滴丸),每组40只。造模成功24 h后迅速断头取心脏,采... 详细信息

目的探讨芪参益气滴丸对心肌缺血再灌注大鼠炎症反应和细胞凋亡的影响。方法收集120只正常大鼠建立缺血/再灌注损伤模型,随机分为对照组、缺血/再灌注组(生理盐水)、试验组(5 g芪参益气滴丸),每组40只。造模成功24 h后迅速断头取心脏,采用MTT法检测细胞增殖能力;采用TUNEL测定法检测细胞凋亡率;采用放射免疫法检测白介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)的表达。结果与对照组比较,缺血/再灌注模型组和试验组细胞增殖能力明显降低,细胞凋亡率明显增加,具有统计学意义(P <0.05)。与缺血/再灌注模型组比较,试验组细胞增殖能力明显增加,细胞凋亡率能力明显降低,具有统计学意义(P <0.05)。与对照组比较,缺血/再灌注模型组IL-6水平表达明显升高,TNF-α表达明显下降,具有统计学意义(P <0.05);与缺血/再灌注模型组比较,试验组IL-6表达明显降低,TNF-α表达明显升高,具有统计学意义(P <0.05)。结论芪参益气滴丸可减轻缺血再灌注心肌细胞损伤,其作用机制可能是通过抗炎和抗细胞凋亡来实现保护作用的。

关键词：芪参益气滴丸缺血/再灌注心肌细胞炎症细胞凋亡白介素-6 肿瘤坏死因子-α 细胞增殖能力

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Human GLP-1 receptor transmembrane domain structure in complex with allosteric modulators

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NATURE 2017年第7657期546卷 312-+页

作者： song, Gaojie Yang, Dehua Wang, Yuxia de Graaf, Chris Zhou, Qingtong Jiang, Shanshan Liu, Kaiwen Cai, Xiaoqing Dai, Antao Lin, Guangyao Liu, Dongsheng Wu, Fan Wu, Yiran Zhao, suwen Ye, Li Han, Gye Won Lau, Jesper Wu, Beili Hanson, Michael A. Liu, Zhi-Jie Wang, Ming-Wei Stevens, Raymond C. ShanghaiTech Univ iHuman Inst 393 Middle Huaxia Rd Shanghai 201210 Peoples R China Chinese Acad Sci Shanghai Inst Mat Med Natl Ctr Drug Screening 189 Guo Shou Jing Rd Shanghai 201203 Peoples R China Chinese Acad Sci Shanghai Inst Mat Med CAS Key Lab Receptor Res 189 Guo Shou Jing Rd Shanghai 201203 Peoples R China Vrije Univ Amsterdam Fac Sci Div Med Chem AIMMS De Boelelaan 1108 NL-1081 HZ Amsterdam Netherlands Fudan Univ Sch Pharm 826 Zhang Heng Rd Shanghai 201203 Peoples R China ShanghaiTech Univ Sch Life Sci & Technol 393 Middle Huaxia Rd Shanghai 201210 Peoples R China Univ Chinese Acad Sci 19A Yuquan Rd Beijing 100049 Peoples R China Univ Southern Calif Bridge Inst Dept Chem 3430 S Vermont Ave Los Angeles CA 90089 USA Novo Nordisk DK-2760 Malov Denmark Chinese Acad Sci Shanghai Inst Mat Med CAS Key Lab Receptor Res 555 Zuchongzhi Rd Shanghai 201203 Peoples R China GPCR Consortium San Marcos CA 92078 USA Kunming Med Univ Inst Mol & Clin Med Kunming 650500 Peoples R China

The glucagon-like peptide-1 receptor (GLP-1R) and the glucagon receptor (GCGR) are members of the secretin-like class B family of G-protein-coupled receptors (GPCRs) and have opposing physiological roles in insulin release and glucose homeostasis(1). The treatment of type 2 diabetes requires positive modulation of GLP-1R to inhibit glucagon secretion and stimulate insulin secretion in a glucose-dependent manner(2). Here we report crystal structures of the human GLP-1R transmembrane domain in complex with two different negative allosteric modulators, PF-06372222 and NNC0640, at 2.7 and 3.0 angstrom resolution, respectively. The structures reveal a common binding pocket for negative allosteric modulators, present in both GLP-1R and GCGR(3) and located outside helices V-VII near the intracellular half of the receptor. The receptor is in an inactive conformation with compounds that restrict movement of the intracellular tip of helix VI, a movement that is generally associated with activation mechanisms in class A GPCRs(4-6). Molecular modelling and mutagenesis studies indicate that agonist positive allosteric modulators target the same general region, but in a distinct sub-pocket at the interface between helices V and VI, which may facilitate the formation of an intracellular binding site that enhances G-protein coupling.

关键词： Nanocrystallography Drug discovery

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Structural Basis for Apelin Control of the Human Apelin Receptor

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STRUCTURE 2017年第6期25卷 858-+页

作者： Ma, Yingli Yue, Yang Ma, Yanbin Zhang, Qing Zhou, Qingtong song, Yunpeng Shen, Yuqing Li, Xun Ma, Xiaochuan Li, Chao Hanson, Michael A. Han, Gye Won Sickmier, E. Allen Swaminath, Gayathri Zhao, suwen Stevens, Raymond C. Hu, Liaoyuan A. Zhong, Wenge Zhang, Mingqiang Xu, Fei Amgen Biopharmaceut R&D Shanghai Co Ltd Amgen Asia R&D Ctr Shanghai 201210 Peoples R China ShanghaiTech Univ iHuman Inst 2F Bldg 699 Haike Rd Shanghai 201210 Peoples R China ShanghaiTech Univ Sch Life Sci & Technol Shanghai 201210 Peoples R China Chinese Acad Sci Shanghai Inst Biol Sci Inst Biochem & Cell Biol Shanghai 200031 Peoples R China Univ Chinese Acad Sci Beijing 100049 Peoples R China GPCR Consortium San Marcos CA 92078 USA Univ Southern Calif Dept Chem Bridge Inst Los Angeles CA 90089 USA Amgen Inc Dept Mol Engn Therapeut Discovery 360 BinneySt Cambridge MA 02142 USA Amgen Inc Cardiovasc Disorders 1120 Vet Blvd San Francisco CA 94080 USA

Apelin receptor (APJR) is a key regulator of human cardiovascular function and is activated by two different endogenous peptide ligands, apelin and Elabela, each with different isoforms diversified by length and amino acid sequence. Here we report the 2.6-A resolution crystal structure of human APJR in complex with a designed 17-amino-acid apelin mimetic peptide agonist. The structure reveals that the peptide agonist adopts a lactam constrained curved two-site ligand binding mode. Combined with mutation analysis and molecular dynamics simulations with apelin-13 binding to the wild-type APJR, this structure provides a mechanistic understanding of apelin recognition and binding specificity. Comparison of this structure with that of other peptide receptors suggests that endogenous peptide ligands with a high degree of conformational flexibility may bind and modulate the receptors via a similar two site binding mechanism.

关键词： human apelin receptor designed agonist peptide mimic apelin recognition and binding specificity cardiovascular drug target

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青海玉树勒巴沟古秀泽玛佛教摩崖造像调查简报

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藏学学刊 2017年第1期16卷 63-94,316页

作者：青海省文物考古研究所四川大学中国藏学研究所卢素文张长虹乔虹宋耀春四川大学中国藏学研究所青海省文物考古研究所

古秀泽玛摩崖造像位于青海省玉树藏族自治州玉树县,造像由两铺阴线刻图像组成,分别为“礼佛图”和“说法图”。“礼佛图”中的佛为释迦牟尼佛,旁边的男供养人头戴高桶状冠帽,身穿翻领左衽长袍,是典型的吐蕃时期的服饰,通过与吐蕃时期赞... 详细信息

古秀泽玛摩崖造像位于青海省玉树藏族自治州玉树县,造像由两铺阴线刻图像组成,分别为“礼佛图”和“说法图”。“礼佛图”中的佛为释迦牟尼佛,旁边的男供养人头戴高桶状冠帽,身穿翻领左衽长袍,是典型的吐蕃时期的服饰,通过与吐蕃时期赞普形象的对比,结合藏东地区发现的吐蕃时期的题记,推测该供养人为吐蕃赞普。说法图的主尊亦为释迦牟尼佛,其背屏样式、双狮垂帘座等的原型可以追溯到印度,是迄今藏区发现的较早的样式;但面部特征、圆形身光和桃尖形头光等与敦煌、藏东等地的造像有相似之处,具有明显的汉藏融合的特点。这两处造像的年代大约为8世纪下半叶至9世纪。

关键词：造像吐蕃供养人藏东赞普

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Surface modification to improve the sorption property of U(VI) on mesoporous silica

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JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY 2014年第3期299卷 1589-1595页

作者： song, Lijuan Wang, Yulong Zhu, Lu Guo, Bolong Chen, suwen Wu, Wangsuo Lanzhou Univ Sch Nucl Sci & Technol Lab Radiochem & Nucl Environm Lanzhou 730000 Peoples R China

Polyoxometalates K-7[alpha-PW11O39] center dot 14H(2)O(PW11) modified mesoporous silica (MCM-48) with cubic structure, was prepared by impregnation and calcination methods. The modified mesoporous silica sorbent (PW11/MCM-48) was studied as a potential adsorbent for U(VI) from aqueous solutions. MCM-48 and PW11/MCM-48 were confirmed by X-ray diffraction and nitrogen physisorption techniques. The results indicate the original keggin structure of PW11 and mesoporous structure of MCM-48 are maintained after supporting PW11 on mesoporous silica MCM-48. The effects of contact time, solid-to-liquid ratio (m/V), solution pH and ionic strength on U(VI) sorption behaviors of the pure and modified mesoporous silicas were also studied. Typical sorption isotherms such as Langmuir and Freundlich isotherms were determined for sorption process. The results suggest that the sorption of U(VI) on MCM-48 or PW11/MCM-48 are strongly dependent on pH values but independent of ionic strength. The sorption capacity of PW11/MCM-48 for U(VI) is about ten times more than that of MCM-48.

关键词： Mesoporous silica Modify Polyoxometalates Sorption U(VI)

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稀土离子掺杂Eu(TTA)_3/PMMA温敏漆的制备与表征

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弹性体 2015年第6期25卷 15-19页

作者：朱鹏孙晶宋亚娇刘素文苑红丹长春理工大学化学与环境工程学院吉林长春130022 内蒙古赤峰市疾病预防控制中心内蒙古赤峰024000 内蒙古赤峰工业职业技术学院轻工化工系内蒙古赤峰024000

以稀土氯化物、噻吩甲酰基三氟丙酮（TTA）为原料分别合成了稀土离子Ln3＋（La3＋、Gd3＋、Y3＋）掺杂Eu（TTA）。探针分子；将探针分子与甲基丙烯酸甲酯（MMA）混合后聚合，获得Ln3＋掺杂Eu（TTA）。／PMMA温敏漆。采用红外光谱、紫外... 详细信息

以稀土氯化物、噻吩甲酰基三氟丙酮（TTA）为原料分别合成了稀土离子Ln3＋（La3＋、Gd3＋、Y3＋）掺杂Eu（TTA）。探针分子；将探针分子与甲基丙烯酸甲酯（MMA）混合后聚合，获得Ln3＋掺杂Eu（TTA）。／PMMA温敏漆。采用红外光谱、紫外吸收光谱、激发发射光谱对探针分子结构及温敏漆荧光特性进行表征。红外光谱表明，Ln3＋与TTA配位成键，Ln3＋的掺入未改变Eu（TTA）。结构。紫外吸收光谱显示，探针分子的最佳吸收波段位于290～376nm。340nm激发下，发现温敏漆在614nm处具有最强荧光发射峰，且Ln3＋的掺入对Eu（TTA）。发光具有增益作用。不同温度下发射光谱表明，随着温度的升高，温敏漆的最强荧光发射峰强度逐渐减弱，说明温敏漆具有良好的温度猝灭特性，且Ln3＋的掺入能够提高温敏漆的测温灵敏度，其中Gd抖掺杂Eu（TTA）。／PMMA温敏漆测温灵敏度最高。

关键词：温敏漆温度猝灭发光探针分子稀土

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新型甘薯薯渣粉制备工艺优化研究

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中国粮油学报 2014年第10期29卷 100-105页

作者：杨晓宽梁建兰孟军刘素稳宋鑫常学东河北科技师范学院食品科技学院秦皇岛066004

为改善甘薯薯渣粉的品质,以甘薯薯渣为原料,采用四元二次正交旋转设计研究甘薯薯渣粉碎细度、Na_2S_2O_4浓度、干燥温度、洞道干燥装置载量4个因素对甘薯薯渣粉白度及含水率综合评分的影响,用DPS 7.05软件分析得到回归方程。研究结果表... 详细信息

为改善甘薯薯渣粉的品质,以甘薯薯渣为原料,采用四元二次正交旋转设计研究甘薯薯渣粉碎细度、Na_2S_2O_4浓度、干燥温度、洞道干燥装置载量4个因素对甘薯薯渣粉白度及含水率综合评分的影响,用DPS 7.05软件分析得到回归方程。研究结果表明,新型甘薯薯渣粉最佳工艺条件为:粉碎细度60目、Na_2S_2O_4浓度0.9%、干燥温度80℃、载量64.5%。在此工艺条件下,新型甘薯薯渣粉的白度为75.10%,含水率为2.027%,综合评分达到99.84,持水力为35.60 g/g,持油力为7.77 g/g,溶胀力达119.00 mL/g,优化甘薯薯渣粉部分理化和功能性品质特性得到提高,其白度和持油力性能显著改善,适合应用到油炸食品、松饼、面包制品等食品领域。

关键词：甘薯薯渣粉正交旋转设计白度含水率制备优化

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Effect of electropulsing treatment on the mechanical properties of Q235 steel strip

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Steel in Translation 2013年第6期43卷 344-347页

作者： Chen, suwen Tang, Guoyi song, Shenhua song, Guolin Gromov, V.E. Advanced Materials Institute Graduate School at Shenzhen Tsinghua University Shenzhen China Department of Materials Science and Engineering Shenzhen Graduate School Harbin Institute of Technology Harbin China Siberian State University of Industry Novokuznetsk Russia

The elctropulsing treatment (EPT) has been successfully applied to the processing of a low carbon Q235 steel strip. Comparing with the conventional heat treatment (CHT), a proper EPT is capable of achieving the similar or even better effect on the mechanical properties of the steel strip. It was found that the optimum combination of the EPT parameters are 180 V in voltage and 500 Hz in frequency (180 V-500 Hz) leading to a combination of tensile strength-elongation of 371 MPa-47.5%. Optical microscopy analyses indicates that the EPT/180 V-500 Hz for Q235 steel strip can accelerate the formation of the completely recrystallized microstructure in which the grain size become relatively finer and more uniform compared to the elongated one formed in the cold-rolled sample. Such phenomenon is consistent with the improvement of the mechanical performance of the Q235 steel sample under the EPT. However, the EPT with inadequate frequency can only result in partial recrystallization of the grains, while the one with an exceed frequency may lead to the apparent grain growth within the sample. Both cases can not produce satisfactory combination of strength and ductility for the steel samples. © 2013 Allerton Press, Inc.

关键词： Grain growth

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壳聚糖/羟基磷灰石对Zn(Ⅱ)的吸附动力学及热力学研究

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河北大学学报（自然科学版） 2014年第3期34卷 267-272页

作者：马志广刘梦超宋怡楠刘素文李江红河北大学化学与环境科学学院、药物化学与分子诊断教育部重点实验室河北保定071002

采用原位复合法制备了壳聚糖/羟基磷灰石复合吸附剂(CS/HA),研究了该吸附剂对水溶液中Zn(Ⅱ)的吸附热力学及动力学.动力学研究表明:在实验条件下吸附量与时间的关系符合伪二级动力学方程,求出了吸附活化能.热力学研究表明:在实验条件下,... 详细信息

采用原位复合法制备了壳聚糖/羟基磷灰石复合吸附剂(CS/HA),研究了该吸附剂对水溶液中Zn(Ⅱ)的吸附热力学及动力学.动力学研究表明:在实验条件下吸附量与时间的关系符合伪二级动力学方程,求出了吸附活化能.热力学研究表明:在实验条件下,CS/HA对Zn(Ⅱ)的吸附符合Langmuir等温吸附方程,得到了ΔHθ,ΔSθ,ΔGθ等一些热力学参数.

关键词：壳聚糖羟基磷灰石吸附动力学热力学

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Controllable Synthesis of Bi₂WO₆ Nanofibrous Mat by Electrospinning and Enhanced Visible Photocatalytic Degradation Performances

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INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH 2012年第31期51卷 10307-10312页

作者： Zhao, Gang Liu, suwen Lu, Qifang song, Lingjun Shandong Polytech Univ Key Lab Proc & Testing Technol Glass & Funct Cera Jinan 250353 Peoples R China

Bi2WO6 nanofibrous mat has been successfully synthesized by a simple electrospinning process. TG-DTA, FT-IR, XRD, SEM, and UV-visible diffuse reflectance spectra were used to characterize the mat. The results indicated that the mat was composed of one-dimensional nanofibers, whose diameter was about 300 nm. The one-dimensional nanofibers consisted of Bi2WO6 nanoparticles with diameter 112 nm. Also, the Bi2WO6 nanofibrous mat exhibited excellent visible photocatalytic property in the photodegradation of methylene blue. Meanwhile, the photocatalyst synthesized by electrospinning is helpful for separation and recycling. What's more, the preparation method is suitable for large-scale commercial production. So, the work has great application value in the future.

关键词： BISMUTH compounds -- Synthesis ELECTROSPINNING PHOTOCATALYSIS PERFORMANCE evaluation X-ray diffraction FOURIER transform infrared spectroscopy NANOPARTICLES METHYLENE blue

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