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IEEE 17th International Conference on Communication Technology (ICCT)

作者： song, suwen Lin, Jun Tian, Jing Wang, Zhongfeng Nanjing Univ Sch Elect Sci & Engn Nanjing Jiangsu Peoples R China

ISBN: (纸本)9781509039449

Non-binary low-density parity-check (NB-LDPC) codes perform much better than their binary counterparts, when codeword length is moderate or high-order modulation is used. However, the implementation of a NB-LDPC decoder usually suffers from excessive hardware complexity and large memory requirement. Many new algorithms and decoding schedules have been introduced in recent literatures to reduce the decoding complexity in further. However, the complexity of current decoding algorithms for NB-LDPC codes is still high. In this paper, a two-extra-column trellis min-sum algorithm (TEC-TMSA) is proposed. The TEC-TMSA combines the two-extra-column method and the trellis min-sum algorithm in an intelligent way. Since only the minimum value of a row needs to be sorted out for configuration constructions, the computational complexity of the proposed TEC-TMSA is much lower than that of the TMSA. Furthermore, we develop a novel location-fixed selection scheme, which significantly decreases the number of required comparison operations in the TEC-TMSA with negligible performance loss.

关键词： Nonbinary low-density parity-check codes two-extra-colonm trellis min-sum location-fixed selection scheme low complexity

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Role of glutaminyl-peptide cyclotransferase in breast cancer doxorubicin sensitivity

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CANCER BIOLOGY & THERAPY 2024年第1期25卷 2321767页

作者： Xu, Bin Yang, Liu Yang, Lixian Al-Maamari, Ahmed Zhang, Jingyu song, Heng Wang, Meiqi Su, suwen song, Zhenchuan Hebei Med Univ Dept Breast Ctr Hosp 4 Shijiazhuang Hebei Peoples R China Xingtai Peoples Hosp Dept Breast Surg Xingtai Hebei Peoples R China Hebei Med Univ Dept Pharmacol Key Lab Neural & Vasc Biol Key Lab New Drug Pharmacol & ToxicolMinist Educ Shijiazhuang Hebei Peoples R China Hebei Med Univ Dept Radiotherapy Hosp 4 Shijiazhuang Hebei Peoples R China Hebei Med Univ Dept Breast Ctr Key Lab Breast Canc Mol Med Hebei Prov Hosp 4 169 Tianshan St Shijiazhuang 050035 Hebei Peoples R China Hebei Med Univ Dept Pharmacol Key Lab Neural & Vasc Biol Key Lab New Drug Pharmacol & ToxicolMinist Educ 361 Zhongshan East Rd Shijiazhuang 050000 Hebei Peoples R China

Doxorubicin (DOX) is one of the most effective and widely used chemotherapeutic drugs. However, DOX resistance is a critical risk problem for breast cancer treatment. Previous studies have demonstrated that metadherin (MTDH) involves in DOX resistance in breast cancer, but the exact mechanism remains unclear. In this study, we found that glutaminyl-peptide cyclotransferase (QPCT) was a MTDH DOX resistance-related downstream gene in breast cancer. Elevated expression of QPCT was found in the GEPIA database, breast cancer tissue, and breast cancer cells. Clinical data showed that QPCT expression was positively associated with poor prognosis in DOX-treated patients. Overexpression of QPCT could promote the proliferation, invasion and migration, and reduce DOX sensitivity in MCF-7 and MDA-MB-231 cells. Mechanistically, MTDH positively regulates the expressions of NF-kappa B (p65) and QPCT, and NF-kappa B (p65) directly regulates the expression of QPCT. Therefore, MTDH/NF-kappa B (p65)/QPCT signal axis was proposed. Collectively, our findings delineate the mechanism by which the MTDH/NF-kappa B (p65) axis regulate QPCT signaling and suggest that this complex may play an essential role in breast cancer progression and affect DOX sensitivity.

关键词： Breast cancer QPCT MTDH/NF-kappa B axis doxorubicin sensitivity

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Dynamic structural remodeling of LINC01956 enhances temozolomide resistance in MGMT-methylated glioblastoma

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SCIENCE TRANSLATIONAL MEDICINE 2024年第767期16卷 1页

作者： Liao, Xinyi Zhang, Shuxia Li, Xincheng Qian, Wanying Li, Man Chen, suwen Wu, Xingui Yu, Xuexin Li, Ziwen Tang, Miaoling Xu, Yingru Yu, Ruyuan Zhang, Qiliang Wu, Geyan Zhang, Nu song, Libing Li, Jun Sun Yat Sen Univ Canc Ctr Collaborat Innovat Ctr Canc Med State Key Lab Oncol South China Guangzhou 510060 Guangdong Peoples R China Sun Yat Sen Univ Zhongshan Sch Med Dept Biochem Guangzhou 510080 Guangdong Peoples R China Sun Yat Sen Univ Affiliated Hosp 1 Dept Neurosurg Guangzhou 510080 Guangdong Peoples R China

The mechanisms underlying stimuli-induced dynamic structural remodeling of RNAs for the maintenance of cellular physiological function and survival remain unclear. Here, we showed that in MGMT promoter-methylated glioblastoma (GBM), the RNA helicase DEAD-box helicase 46 (DDX46) is phosphorylated by temozolomide (TMZ)-activated checkpoint kinase 1 (CHK1), resulting in a dense-to-loose conformational change and an increase in DDX46 helicase activity. DDX46-mediated tertiary structural remodeling of LINC01956 exposes the binding motifs of LINC01956 to the 3 ' untranslated region of O-6-methylguanine DNA methyltransferase (MGMT). This accelerates recruitment of MGMT mRNA to the RNA export machinery and transportation of MGMT mRNA from the nucleus to the cytoplasm, leading to increased MGMT abundance and TMZ resistance. Using patient-derived xenograft (PDX) and tumor organoid models, we found that treatment with the CHK1 inhibitor SRA737abolishes TMZ-induced structural remodeling of LINC01956 and subsequent MGMT up-regulation, resensitizing TMZ-resistant MGMT promoter-methylated GBM to TMZ. In conclusion, these findings highlight a mechanism underlying temozolomide-induced RNA structural remodeling and may represent a potential therapeutic strategy for patients with TMZ-resistant MGMT promoter-methylated GBM.

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Ground-Based MAX-DOAS Observation of Trace Gases from 2019 to 2021 in Huaibei, China

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ATMOSPHERE 2023年第4期14卷 739-739页

作者： Mou, Fusheng Luo, Jing Zhang, Qijin Zhou, Chuang Wang, song Ye, Fan Li, suwen Sun, Youwen Huaibei Normal Univ Sch Phys & Elect Informat Huaibei 235000 Peoples R China Anhui Prov Key Lab Pollutant Sensit Mat & Environm Huaibei 235000 Peoples R China Chinese Acad Sci Anhui Inst Opt & Fine Mech Hefei Inst Phys Sci Lab Environm Opt & Technol Hefei 230031 Peoples R China

With the spread of the COVID-19 pandemic and the implementation of closure measures in 2020, population mobility and human activities have decreased, which has seriously impacted atmospheric quality. Huaibei City is an important coal and chemical production base in East China, which faces increasing environmental problems. The impact of anthropogenic activities on air quality in this area was investigated by comparing the COVID-19 lockdown in 2020 with the normal situation in 2021. Tropospheric NO2, HCHO and SO2 column densities were observed by ground-based multiple axis differential optical absorption spectroscopy (MAX-DOAS). In situ measurements for PM2.5, NO2, SO2 and O-3 were also taken. The observation period was divided into four phases, the pre-lockdown period, phase 1 lockdown, phase 2 lockdown and the post-lockdown period. Ground-based MAX-DOAS results showed that tropospheric NO2, HCHO and SO2 column densities increased by 41, 14 and 14%, respectively, during phase 1 in 2021 vs. 2020. In situ results showed that NO2 and SO2 increased by 59 and 11%, respectively, during phase 1 in 2021 vs. 2020, but PM2.5 and O-3 decreased by 15 and 17%, respectively. In the phase 2 period, due to the partial lifting of control measures, the concentration of pollutants did not significantly change. The weekly MAX-DOAS results showed that there was no obvious weekend effect of pollutants in the Huaibei area, and NO2, HCHO and SO2 had obvious diurnal variation characteristics. In addition, the relationship between the column densities and wind speed and direction in 2020 and 2021 was studied. The results showed that, in the absence of traffic control in 2021, elevated sources in the Eastern part of the city emitted large amounts of NO2. The observed ratios of HCHO to NO2 suggested that tropospheric ozone production involved NOX-limited scenarios. The correlation analysis between HCHO and different gases showed that HCHO mainly originated from primary emission sources related

关键词： MAX-DOAS remote sensing NO2 SO2 HCHO lockdown diurnal variation COVID-19

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Housefly Phormicin inhibits Staphylococcus aureus and MRSA by disrupting biofilm formation and altering gene expression in vitro and in vivo

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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES 2021年第0期167卷 1424-1434页

作者： Wang, Bing Yao, Yang Wei, PengWei song, ChaoRong Wan, Shan Yang, suwen Zhu, Gui Ming Liu, Hong Mei Guizhou Med Univ Engn Res Ctr Med Biotechnol Guiyang 550025 Guizhou Peoples R China Guizhou Med Univ Key Lab Biol & Med Engn Guiyang 550025 Guizhou Peoples R China Guizhou Med Univ Sch Biol & Engn Guiyang 550025 Guizhou Peoples R China Guizhou Med Univ Affiliated Hosp 1 Dept Microbial Immunol Guiyang 550025 Guizhou Peoples R China Guizhou Med Univ China Minist Educ Key Lab Environm Pollut Monitoring & Dis Control Guiyang 550025 Guizhou Peoples R China

The increasing drug resistance of pathogenic bacteria is a crisis that threatens public health. Antimicrobial peptides (AMPs) have been suggested to be potentially effective alternatives to solve this problem. Here, we tested housefly Phormicin-derived peptides for effects on Staphylococcus aureus and methicillin-resistant Staphylococcus aureus (MRSA) infections in vitro and in vivo. A decreased bacterial load of MRSA was observed in the mouse scald model after treatment with Phormicin and in the positive control group (vancomycin). A mouse scrape model indicated that Phormicin helps the host fight drug-resistant MRSA infections. The protective effect of Phormicin on MRSA was confirmed in the Hermetia illucens larvae model. Phormicin also disrupted the formation of S. aureus and MRSA biofilms. Furthermore, this effect coincided with the downregulation of biofilm formation-related gene expression (agrC, sigB, RNAIII, altA, rbf, hla, hld, geh and psm?). Notably, virulence genes and several regulatory factors were also altered by Phormicin treatment. Based on these findings, housefly Phormicin helps the host inhibit MRSA infection through effects on biofilm formation and related gene networks. Therefore, housefly Phormicin potential represents a candidate agent for clinical MRSA chemotherapy. (C) 2018 Elsevier B.V. All rights reserved.

关键词： Musca domestica Phormicin Antimicrobial peptide Biofilm formation

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Interfacial Polarization Triggered by Covalent-Bonded MXene and Black Phosphorus for Enhanced Electrochemical Nitrate to Ammonia Conversion

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ADVANCED ENERGY MATERIALS 2023年第31期13卷 2301136-2301136页

作者： Wang, suwen song, Chengfang Cai, Yanjiang Li, Yongfu Jiang, Peikun Li, Hui Yu, Bing Ma, Tianyi Zhejiang A&F Univ State Key Lab Subtrop Silviculture Hangzhou 311300 Peoples R China Zhejiang A&F Univ Sch Environm & Resources Hangzhou 311300 Peoples R China RMIT Univ Sch Sci Melbourne Vic 3000 Australia

MXenes have recently emerged as a new class of electrocatalysts for diverse energy conversion reactions, but they are generally considered to be catalytically inert. Herein, a strategy of interfacial polarization is put forward to improve the catalytic activity of MXenes, with the construction of an interfacial structure consisting of black phosphorus (BP) nanoflakes and Nb2C MXene nanosheets for electrochemical nitrate reduction to ammonia as a proof of concept. The experimental and computational results reveal that a strong interfacial polarization is built between BP nanoflakes and Nb2C nanosheets in the prepared BP/Nb2C composite. The polarization of Nb centers by adjacent BP sites gives rise to the formation of positively centered Nb atoms and BP-polarized Nb atoms, which synergistically catalyze the cleavage of N-O bonds in HNO2* to form NO*. In addition, the stabilization of monatomic *N by the BP/Nb2C composite is also enhanced compared with BP nanoflakes and Nb2C nanosheets. As a result, both the ammonia yield rate and Faraday efficiency of the BP/Nb2C composite are much higher than that of BP nanoflakes and Nb2C nanosheets. Overall, this work shows the great potential for constructing a strong interfacial polarization to improve the catalytic performance of MXenes-based electrocatalysts.

关键词： ammonia synthesis electrocatalysis interfacial polarization nitrate reduction

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Investigation of Retrieval Method for Aerosol and Water Vapor Profiles Based on Max-Doas Technology

SSRN

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SSRN 2024年

作者： Zhou, Chuang Li, suwen Mou, Fusheng Luo, Jing Wang, song Ye, Fan Wang, Zhiduo Tang, Yujie Anhui Province Key Laboratory of Pollutant Sensitive Materials and Environmental Remediation Huaibei Normal University Anhui Huaibei235000 China

Simultaneously obtaining the vertical distribution and profile of aerosol and water vapor is of great significance for in-depth understanding of the Earth's radiation balance, regional water cycle, and the causes of frequent haze weather in China. In this study, a system and inversion method were developed based on the multi-axis differential optical absorption spectroscopy (MAX-DOAS) technique for the simultaneous retrieval of tropospheric aerosol and water vapor profiles. The absorption of dioxy (O4) was obtained by multi-elevation measurement using the developed ground-based MAX-DOAS system. This involved minimizing a cost function through the combination of an atmospheric radiative transfer model to first invert aerosol extinction profiles and subsequently invert water vapor profiles. During the inversion of profiles, parameter selection in the look-up table method was optimized, reducing dependence on prior profile information and enabling more accurate retrieval of pollutant distributions. In the monitoring period in Huaibei region, aerosols were predominantly concentrated below 1.5 km, while water vapor was mainly concentrated below 1 km, with concentrations gradually decreasing with increasing altitude. Comparisons of the water vapor vertical column densities (VCDs) retrieved through the look-up table method with the European Centre for Medium-Range Weather Forecasts (ECMWF) ERA5 model and geometric approximation showed good agreement in trends, with correlation coefficients of 0.93 and 0.98, respectively. To understand the sources of water vapor at different vertical layers, a 24-hour backward trajectory clustering analysis was conducted using the HYSPLIT model based on observed wind fields during the monitoring period. Results indicated that at 500 meters altitude, water vapor primarily originated from the southeast direction, while at 1 km and 2 km altitude, the dominant source of water vapor was from the southwest direction. The study demonstrates the su

关键词： Cost functions

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Passivating Oxygen Evolution Activity of NiFe-LDH through Heterostructure Engineering to Realize High-Efficiency Electrocatalytic Formate and Hydrogen Co-Production

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SMALL 2023年第27期19卷 2208027-2208027页

作者： Jiang, Shuai Xiao, Tongyao Xu, Cui Wang, suwen Peng, Hui-Qing Zhang, Wenjun Liu, Bin song, Yu-Fei Beijing Univ Chem Technol Coll Chem Beijing Adv Innovat Ctr Soft Matter Sci & Engn State Key Lab Chem Resource Engn Beijing 100029 Peoples R China City Univ Hong Kong Ctr Superdiamond & Adv Films COSDAF Tat Chee Ave Hong Kong Peoples R China City Univ Hong Kong Dept Mat Sci & Engn Tat Chee Ave Hong Kong Peoples R China Guangdong Prov Key Lab Fuel Cell Technol Guangzhou 510640 Peoples R China

An electrocatalytic methanol oxidation reaction (MOR) is proposed to replace oxygen evolution reaction (OER) in water electrolysis owing to the favorable thermodynamics of MOR than OER. However, there is still a competition between the MOR and the OER when the applied potential is in the conventional OER zone. How to inhibit OER while maintaining efficient MOR is an open and challenging question, and there are few reports focusing on this thus far. Herein, by taking NiFe layered double hydroxide (LDH) as a model catalyst due to its intrinsically high catalytic activity for the OER, the perspective of inhibiting OER is shown and thus promoting MOR through a heterogenous engineering of NiFe-LDH. The engineered heterostructure comprising NiFe-LDH and in situ formed NiFe-hexylaminobenzene (NiFe-HAB) coordination polymer exhibits outstanding electrocatalytic capability for methanol oxidation to formic acid (e.g., the Faradaic efficiencies (FEs) of formate product are close to 100% at various current densities, all of which are much larger than those (53-65%) on unmodified NiFe-LDH). Mechanism studies unlock the modification of NiFe-HAB passivates the OER activity of NiFe-LDH through tailoring the free energies for element reaction steps of the OER and increasing the free energy of the rate-determining step, consequently leading to efficient MOR.

关键词： heterogenous engineering inhibition of oxygen evolution in situ semi-transformation methanol oxidation to formic acid NiFe-LDHs

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Tribological Performance of Si3N4-PTFE Composites Prepared by High-Pressure Compression Molding

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TRIBOLOGY TRANSACTIONS 2020年第4期63卷 756-769页

作者： Gu, Dapeng Liu, Shouyao Chen, suwen song, Kefeng Yang, Bingchao Pan, Deng Yanshan Univ Sch Mech Engn Qinhuangdao Hebei Peoples R China Yanshan Univ Aviat Key Lab Sci & Technol Gener Technol Self Lu Qinhuangdao Hebei Peoples R China Yanshan Univ Dept Environm & Chem Engn Qinhuangdao Hebei Peoples R China Qufu Normal Univ Sch Phys & Phys Engn Qufu Shandong Peoples R China

The tribological performance of ceramic-polymer composites prepared by high-pressure (3 GPa) compression molding of silicon nitride (Si3N4) and polytetrafluoroethylene (PTFE) with epoxy resin (EP) binder was investigated under dry friction conditions. Fourier transform infrared (FTIR) spectroscopy, field emission scanning electron microscopy, and energy-dispersive spectroscopy (EDS) were utilized to characterize Si3N4-PTFE-EP composites. The Vickers hardness and shore hardness were tested and the thermal stability was evaluated by thermogravimetric analysis (TGA). The results indicate that the lowest wear rate reaches 10(-7) mm(3) (Nm)(-1) and the lowest friction coefficient is about 0.06. With an increase in the PTFE mass fraction, the main wear form gradually changes from abrasive wear to adhesive wear, but fatigue wear always exists.

关键词： Ceramic-polymer composites tribology high-pressure compression molding transfer film

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Adaptive inverse backlash boundary vibration control design for an Euler-Bernoulli beam system

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JOURNAL OF THE FRANKLIN INSTITUTE-ENGINEERING AND APPLIED MATHEMATICS 2020年第6期357卷 3434-3450页

作者： He, Xiuyu song, Yuhua Han, Zhiji Zhang, Shuang Jing, Peng Qi, suwen Univ Sci & Technol Beijing Sch Automat & Elect Engn Beijing 100083 Peoples R China Univ Sci & Technol Beijing Inst Artificial Intelligence Beijing 100083 Peoples R China Univ Sci & Technol Beijing Key Lab Knowledge Automat Ind Proc Minist Educ Beijing 100083 Peoples R China Shenzhen Univ Sch Med Dept Biomed Engn Shenzhen 518060 Peoples R China

In this paper, we address the vibration suppression problem of an Euler-Bernoulli beam structure suffering from the input backlash nonlinearity and the unknown disturbance. Considering the nonlinearity and discontinuity of the backlash with the uncertain parameter, an adaptive inverse backlash dynamics is proposed to handle the nonlinear characteristic and correct the mismatch of the backlash parameter. Further, an adaptive vibration control law is developed to improve the system performance via combining with the proposed inverse backlash dynamics. Meanwhile, a disturbance observer is designed to reject the external boundary disturbance, and we bring a logarithmic barrier function in control design to ensure the end-point displacement of this system be constrained in the desired limitation. At last, we analyze the stability of this flexible system and the effectiveness of the proposed control method with simulation experiments. (C) 2020 The Franklin Institute. Published by Elsevier Ltd. All rights reserved.

关键词： Vibration control

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