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LPCAT1-mediated membrane phospholipid remodelling promotes ferroptosis evasion and tumour growth

NATURE CELL BIOLOGY 2024年第5期26卷 811-824页

作者： Li, Ziwen Hu, Yameng Zheng, Haiqing Li, Man Liu, Yuanji Feng, Rongni Li, Xincheng Zhang, Shuxia Tang, Miaoling Yang, Meisongzhu Yu, Ruyuan Xu, Yingru Liao, Xinyi Chen, suwen Qian, Wanying Zhang, Qiliang Tang, Daolin Li, Bo song, Libing Li, Jun Sun Yat Sen Univ Affiliated Hosp 3 Key Lab Liver Dis Guangdong Prov Guangzhou Peoples R China Sun Yat Sen Univ Zhongshan Sch Med Dept Biochem Guangzhou Peoples R China Guangzhou Med Univ Sch Basic Med Sci Guangzhou Municipal & Guangdong Prov Key Lab Prot Guangzhou Peoples R China UT Southwestern Med Ctr Dept Surg Dallas TX USA Southern Med Univ Canc Res Inst Sch Basic Med Sci Dept Biochem & Mol Biol Guangzhou Peoples R China Sun Yat Sen Univ Canc Ctr Collaborat Innovat Ctr Canc Med State Key Lab Oncol South China Guangzhou Peoples R China

The mechanisms underlying the dynamic remodelling of cellular membrane phospholipids to prevent phospholipid peroxidation-induced membrane damage and evade ferroptosis, a non-apoptotic form of cell death driven by iron-dependent lipid peroxidation, remain poorly understood. Here we show that lysophosphatidylcholine acyltransferase 1 (LPCAT1) plays a critical role in ferroptosis resistance by increasing membrane phospholipid saturation via the Lands cycle, thereby reducing membrane levels of polyunsaturated fatty acids, protecting cells from phospholipid peroxidation-induced membrane damage and inhibiting ferroptosis. Furthermore, the enhanced in vivo tumour-forming capability of tumour cells is closely associated with the upregulation of LPCAT1 and emergence of a ferroptosis-resistant state. Combining LPCAT1 inhibition with a ferroptosis inducer synergistically triggers ferroptosis and suppresses tumour growth. Therefore, our results unveil a plausible role for LPCAT1 in evading ferroptosis and suggest it as a promising target for clinical intervention in human cancer.

关键词： Cell death Phospholipids Targeted therapies

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Ground-Based MAX-DOAS Observation of Trace Gases from 2019 to 2021 in Huaibei, China

SSRN

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SSRN 2023年

作者： Mou, Fusheng Luo, Jing Zhang, Qijin Zhou, Chuang Wang, song Ye, Fan Li, suwen Sun, Youwen School of Physics and Electronic Information Huaibei Normal University Anhui Huaibei235000 China Anhui Province Key Laboratory of Pollutant Sensitive Materials and Environmental Remediation Huaibei235000 China Laboratory of Environmental Optics and Technology Anhui Institute of Optics and Fine Mechanics Hefei Institutes of Physical Science Chinese Academy of Sciences Hefei230031 China

With the spread of COVID-19 pandemic and the implementation of closure measures, population mobility and human activities have decreased, which has seriously impacts on atmospheric quality. In this study we investigated the impact of anthropogenic activities on air quality in Huaibei area. Tropospheric NO2, HCHO and SO2 columns were observed by ground-based Multiple AXis Differential Optical Absorption Spectrometer (MAX-DOAS) from December 2019 to May 2020 and from December 2020 to May 2021, and the concentrations of PM2.5, NO2, SO2 and O3 near the ground were obtained based on in-situ instruments. We divided the observation period into four phases, the pre-lockdown period, phase 1 lockdown, phase 2 lockdown and post-lockdown period. Ground-based MAX-DOAS results show that tropospheric NO2, HCHO and SO2 columns increased by 41%, 14% and 14%, respectively, during Phase 1 in 2021 vs. 2020. In-situ results show that NO2 and SO2 increased by 59% and 11%, respectively, during Phase 1 in 2021 vs. 2020, but PM2.5 and O3 decreased by 15% and 17%, respectively. In phase 2 period, due to the control measures were partially lifted, the concentration of pollutants did not change significantly. Ground-based MAX-DOAS observations show that the seasonal and monthly variation characteristics in Huaibei have not changed in 2020 and *** concentration of trace gases in winter was significantly higher than that in spring, and the monthly mean values of HCHO and SO2 decreased from December to April of the following year. The weekly MAX-DOAS results show that there is no obvious weekend effect of pollutants in Huaibei area, and NO2, HCHO and SO2 have obvious diurnal variation characteristics. The relationship between column densities and wind speed and direction in 2020 and 2021 was studied. The results show that in the absence of traffic control in 2021, elevated sources in the eastern part of the city emit a large amount of NO2, and sources of HCHO and SO2 emissions increase. The

关键词： COVID-19

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Prediction of velocity distribution in straight open-channel flow with partial vegetation by singular perturbation method

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Applied Mathematics and Mechanics(English Edition) 2016年第10期37卷 1315-1324页

作者： Wenxin HUAI suwen song Jie HAN Yuhong ZENG State Key Laboratory of Water Resources and Hydropower Engineering Science Wuhan University

A numerical analysis model based on two-dimensional shallow water differential equations is presented for straight open-channel flow with partial vegetation across the channel. Both the drag force acting on vegetation and the momentum exchange between the vegetation and non-vegetation zones are considered. The depth-averaged streamwise velocity is solved by the singular perturbation method, while the Reynolds stress is calculated based on the results of the streamwise velocity. Comparisons with the experimental data indicate that the accuracy of prediction is significantly improved by introducing a term for the secondary current in the model. A sensitivity analysis shows that a sound choice of the secondary current intensity coefficient is important for an accurate prediction of the depth-averaged streamwise velocity near the vegetation and non-vegetation interfaces, and the drag force coefficient is crucial for predictions in the vegetation zone.

关键词： depth-averaged velocity singular perturbation secondary flow

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LncRNA CTBP1-DT-encoded microprotein DDUP sustains DNA damage response signalling to trigger dual DNA repair mechanisms

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NUCLEIC ACIDS RESEARCH 2022年第14期50卷 8060-8079页

作者： Yu, Ruyuan Hu, Yameng Zhang, Shuxia Li, Xincheng Tang, Miaoling Yang, Meisongzhu Wu, Xingui Li, Ziwen Liao, Xinyi Xu, Yingru Li, Man Chen, suwen Qian, Wanying Gong, Li-Yun song, Libing Li, Jun Sun Yat Sen Univ Zhongshan sch med Affiliated Guangzhou Women & Childrens Hosp Program Canc Res Guangzhou Peoples R China Sun Yat sen Univ Zhongshan sch med Dept Biochem Guangzhou Peoples R China Shenzhen Univ Dept Biochem & Mol Biol Guangdong Prov Key Lab Genome Stabil & Dis Preven Sch Basic Med SciHlth Sci Ctr Shenzhen Peoples R China Sun Yat sen Univ Ctr Canc State Key Lab Oncol South China Collaborat Innovat Ctr Canc Med Shenzhen Peoples R China

Sustaining DNA damage response (DDR) signalling via retention of DDR factors at damaged sites is important for transmitting damage-sensing and repair signals. Herein, we found that DNA damage provoked the association of ribosomes with IRES region in lncRNA CTBP1-DT, which overcame the negative effect of upstream open reading frames (uORFs), and elicited the novel microprotein DNA damage-upregulated protein (DDUP) translation via a cap-independent translation mechanism. Activated ATR kinase-mediated phosphorylation of DDUP induced a drastic 'dense-to-loose' conformational change, which sustained the RAD18/RAD51C and RAD18/PCNA complex at damaged sites and initiated RAD51C-mediated homologous recombination and PCNA-mediated post-replication repair mechanisms. Importantly, treatment with ATR inhibitor abolished the effect of DDUP on chromatin retention of RAD51C and PCNA, thereby leading to hypersensitivity of cancer cells to DNA-damaging chemotherapeutics. Taken together, our results uncover a plausible mechanism underlying the DDR sustaining and might represent an attractive therapeutic strategy in improvement of DNA damage-based anticancer therapies.

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Transcriptomic and metabolmic approaches to counter the effect of Botrytis cinerea in grape berry with the application of nitric oxide

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SCIENTIA HORTICULTURAE 2022年 296卷 110901-110901页

作者： song, Zenglu Pang, Qianqian Lu, suwen Yu, Linhui Pervaiz, Tariq Fu, Weihong Jia, Haifeng Fang, Jinggui Nanjing Agr Univ Coll Hort Key Lab Genet & Fruit Dev 1st Weigang Rd Nanjing 210095 Peoples R China Nanjing Vocat Univ Ind Technol 1st Yangsanbei Rd Nanjing 210023 Peoples R China Beijing Forestry Univ Beijing Adv Innovat Ctr Tree Breeding Mol Design Beijing Peoples R China

The application of exogenous nitric oxide (NO) is convenient and safe approach to preserve fruits, though, the hidden genetic mechanism in treated grape berries is to be explored. In this study, the results depicted that the application of exogenous NO improved the shelf life of grape berries compared with the control group. The SNP treatment(400 mu M) significantly increased the antioxidant enzymes activities including: POD, SOD and CAT. NO inhibited the mycelial growth of Botrytis cinerea (B. cinerea) in the grape berry. RNA-Seq data showed that NO upregulated 2,226 and downregulated 1,249 DEGs, and 300 metabolomes were identified including: ***. NOC_pos annotated 202 metabolites, ***_neg annotated 98 metabolites. The RNA-Seq data is coherent with the metabolome that STSs and CHSs expression levels were significantly increased against disease resistance and antioxidant-associated stilbene synthase pathway, and the associated metabolites content were also signif-icantly increased. These changes led to an increase in the content of secondary metabolites such as resveratrol, which ultimately improved the shelf-life of the grapes.

关键词： Grapevine Nitric oxide RNA-Seq Metabolome Shelf-life Botrytis cinerea

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纳米填充硅橡胶超声干耦合特性

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应用声学 2023年第5期42卷 930-937页

作者：宋寿鹏张泽林樊素文魏明惠钮臣浩江苏大学机械工程学院镇江212013

针对工业超声无损检测领域干耦合材料种类匮乏且声能透射率低的问题,在室温硫化硅橡胶基底材料中添加不同成分和配比的纳米颗粒,制备了不同种类的干耦合材料,给出了干耦合条件下超声波的传输模型,得到了声学传输规律,对比分析了干耦合... 详细信息

针对工业超声无损检测领域干耦合材料种类匮乏且声能透射率低的问题,在室温硫化硅橡胶基底材料中添加不同成分和配比的纳米颗粒,制备了不同种类的干耦合材料,给出了干耦合条件下超声波的传输模型,得到了声学传输规律,对比分析了干耦合材料种类、厚度、硬度、超声中心频率及载荷因素对声能传输特性的影响。搭建了声学特性测试试验平台,分别对添加氧化铝、铁和二氧化硅纳米颗粒制备的干耦合材料进行了测定,试验结果表明填充二氧化硅质量分数为5%时,所形成的纳米填充硅橡胶的声阻抗提高了13.5%,使用200 kPa预载荷对试块测量时回波幅值提高了18.0%,具有良好的声耦合性能。可为实际超声检测时干耦合材料的制备及应用提供参考。

关键词：超声干耦合硅橡胶纳米颗粒传输特性

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基于5G技术的铁路综合视频监控系统方案设计

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铁路计算机应用 2024年第9期33卷 55-58页

作者：李苏雯李鹍宋明张俊凯中国铁道科学研究院集团有限公司标准计量研究所北京100081 中铁检验认证中心有限公司北京100081

随着我国铁路的快速发展,铁路视频监控业务的需求越来越多样化和复杂化,为此,提出基于5G移动通信(简称:5G)技术的铁路综合视频监控系统设计方案。通过增强型移动宽带、边缘计算、网络切片等技术的应用,可改进既有铁路综合视频监控系统... 详细信息

随着我国铁路的快速发展,铁路视频监控业务的需求越来越多样化和复杂化,为此,提出基于5G移动通信(简称:5G)技术的铁路综合视频监控系统设计方案。通过增强型移动宽带、边缘计算、网络切片等技术的应用,可改进既有铁路综合视频监控系统的性能,提高数据传输速率、优化业务,进一步保障铁路运输安全。

关键词：铁路运输安全视频监控 5G移动通信增强型移动宽带网络切片

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海洋生态系统服务价值及评估研究进展

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海洋预报 2022年第1期39卷 104-116页

作者：吴素文宋军张燕袁泽轶张跃大连海洋大学海洋科技与环境学院辽宁大连116023 大连海洋大学应用海洋学研究所辽宁大连116023 辽宁省近岸海洋环境科学与技术重点实验室辽宁大连116023 国家海洋信息中心天津300171

从服务产生的过程和学科两个角度对海洋生态系统服务概念进行了分析,以实际评估为出发点,讨论并优化了海洋生态系统服务的功能分类,并在此分类基础上,对各种功能进行分析,尤其是调节服务功能的评估方法及适用性,最后针对海洋生态系统服... 详细信息

从服务产生的过程和学科两个角度对海洋生态系统服务概念进行了分析,以实际评估为出发点,讨论并优化了海洋生态系统服务的功能分类,并在此分类基础上,对各种功能进行分析,尤其是调节服务功能的评估方法及适用性,最后针对海洋生态系统服务价值评估未来的研究趋势进行展望。

关键词：海洋生态系统服务功能分类价值评估研究进展

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A Reduced Complexity Decoding Algorithm for NB-LDPC Codes

A Reduced Complexity Decoding Algorithm for NB-LDPC Codes

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2017 17th IEEE International Conference on Communication Technology (ICCT 2017)

作者： suwen song Jun Lin Jing Tian Zhongfeng Wang School of Electronic Science and Engineering Nanjing University

Non-binary low-density parity-check（NB-LDPC） codes perform much better than their binary counterparts, when codeword length is moderate or high-order modulation is used. However, the implementation of a NB-LDPC decoder usually suffers from excessive hardware complexity and large memory requirement. Many new algorithms and decoding schedules have been introduced in recent literatures to reduce the decoding complexity in further. However, the complexity of current decoding algorithms for NB-LDPC codes is still high. In this paper, a two-extra-column trellis min-sum algorithm（TEC-TMSA） is proposed. The TEC-TMSA combines the twoextra-column method and the trellis min-sum algorithm in an intelligent way. Since only the minimum value of a row needs to be sorted out for configuration constructions, the computational complexity of the proposed TEC-TMSA is much lower than that of the TMSA. Furthermore, we develop a novel location-fixed selection scheme, which significantly decreases the number of required comparison operations in the TEC-TMSA with negligible performance loss.

关键词： Nonbinary low-density parity-check codes twoextra-column trellis min-sum location-fixed selection scheme low complexity

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Hydroxyl vacancies triggered high methanol oxidation activity of monolayered layered double hydroxides for energy-saving hydrogen production

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MATERIALS TODAY ENERGY 2022年 28卷

作者： Liu, Bin Wang, Xiao Wang, suwen Peng, Hui-Qing Xiao, Tongyao Liu, Guihao Bai, Sha Zhao, Yufei Zhang, Wenjun song, Yu-Fei Beijing Univ Chem Technol Coll Chem Beijing Adv Innovat Ctr Soft Matter Sci & Engn State Key Lab Chem Resource Engn Beijing 100029 Peoples R China City Univ Hong Kong Ctr Superdiamond & Adv Films COSDAF Dept Mat Sci & Engn Tat Chee Ave Hong Kong Peoples R China

Monolayered Ni-based layered double hydroxides (LDHs) enriched with hydroxyl vacancies are syn-thesized and first applied in the methanol-assisted energy-saving hydrogen production system including independent electrolysis and photovoltaic-electrolysis. The rich hydroxyl vacancies are revealed to endow monolayered LDHs with significantly superior performance in the aspects of the activity for methanol oxidation reaction and the boosting effect for cathodic hydrogen production compared to the bulk counterparts. The theoretical and experimental results confirm that the hydroxyl vacancies can increase density of states near Fermi level of LDH (i.e. elevate electrical conductivity to form favorable charge transportation during electrocatalysis), and promote its adsorption and further cleavage for methanol, thus leading to the enhanced methanol oxidation reaction performance.(c) 2022 Elsevier Ltd. All rights reserved.

关键词： Single -layer layered double hydroxides Defects Methanol electrooxidation Energy -efficient hydrogen generation Photovoltaic electrolysis

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