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中国免疫学杂志 2023年第6期39卷 1185-1188页

作者：董丹侯隽王竞州王素文宋瑞其陈雪玲石河子大学医学院免疫学教研室石河子832000

医学教育要强化医学生职业素养教育,加强医学伦理、科研诚信教育,发挥课程思政作用,着力培养医学生的救死扶伤精神。本文从思政元素挖掘、思政元素进教学文件、思政元素进教学设计、课程思政回头看4方面,介绍石河子大学医学院医学免疫... 详细信息

医学教育要强化医学生职业素养教育,加强医学伦理、科研诚信教育,发挥课程思政作用,着力培养医学生的救死扶伤精神。本文从思政元素挖掘、思政元素进教学文件、思政元素进教学设计、课程思政回头看4方面,介绍石河子大学医学院医学免疫学课程思政教学的实践过程。结课后,课程思政抽样调查结果显示:对课程整体教学设计评价好占93.3%;对线上教学讨论板块穿插人文思政教育的实践的总体评价好占96.7%;对前沿、热点或案例相关知识讨论、汇报的总体评价好占81.7%;对第二课堂、各类竞赛的总体评价好占95.0%。可见,在医学免疫学课程教学中课程思政的实践得到了学生的广泛认可。

关键词：医学免疫学课程思政实践与探索

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Preparation and properties of ZrPA doped CMPSU cross-linked PBI based high temperature and low humidity proton exchange membranes

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REACTIVE & FUNCTIONAL POLYMERS 2019年 137卷 57-70页

作者： Lv, Yanan Li, Zhongfang song, Mingfeng Sun, Peng Yin, Xiaoyan Wang, suwen Shandong Univ Technol Sch Chem & Chem Engn Zibo 255049 Peoples R China

Poly[4,4'-(diphenyl ether)-5,5'-bibenzimidazole] (oPBI) based high temperature proton exchange membranes are prepared by covalent cross-linking with chloromethylated polysulfone (CMPSU) and doping with zirconium phytate (ZrPA). ZrPA is synthesized as the proton conductor through a facile method from zirconyl chloride and phytic acid which is abundant and readily available. oPBI is cross-linked by CMPSU and that hydrogen bonds are formed between ZrPA and oPBI-CMPSU. The composite membranes are dense without through holes when doping with ZrPA. The composite membranes exhibit good thermal stability below 140 degrees C. Meanwhile, the composite membranes reveal good mechanical strength and methanol resistance. The oxidative stability is improved because of cross-linking and the doping of ZrPA. Conductivities of oPBI-CMPSU/ZrPA at different temperatures and relative humidity (RH) are investigated. At 100% RH, 50% RH and 0 RH, the conductivity of oPBI-CMPSU(20%)/ZrPA(30%) can reach 0.072 S/cm, 0.025 S/cm and 0.012 S/cm at 140 degrees C, respectively. Although the proton conductivity of the composite membrane was not particularly high at 100% RH, the composite membrane comparatively exhibited good proton conductivity at high temperature and at 50% RH and 0 RH.

关键词： High temperature proton exchange membrane Composite membrane Chloromethylated polysulfone ZrPA Covalent cross-linking

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Characterization of endoplasmic reticulum stress unveils ZNF703 as a promising target for colorectal cancer immunotherapy

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JOURNAL OF TRANSLATIONAL MEDICINE 2023年第1期21卷 713-713页

作者： Wang, Hufei Li, Zhi Tao, Yangbao Ou, suwen Ye, Jinhua Ran, songlin Luo, Kangjia Guan, Zilong Xiang, Jun Yan, Guoqing Wang, Yang Ma, Tianyi Yu, Shan song, Yanni Huang, Rui Harbin Med Univ Affiliated Hosp 2 Dept Colorectal Canc Surg Harbin 150080 Peoples R China Harbin Med Univ Affiliated Hosp 2 Dept Cardiol Harbin Peoples R China Harbin Med Univ Canc Hosp Dept Breast Surg Harbin Peoples R China Harbin Med Univ Affiliated Hosp 2 Dept Pathol Harbin 150080 Peoples R China

BackgroundColorectal cancer (CRC) is one of the most common malignant tumors globally, with high morbidity and mortality. Endoplasmic reticulum is a major organelle responsible for protein synthesis, processing, and transport. Endoplasmic reticulum stress (ERS) refers to the abnormal accumulation of unfolded and misfolded proteins in the endoplasmic reticulum, which are involved in tumorigenesis and cancer immunity. Nevertheless, the clinical significance of ERS remains largely unexplored in *** present study, we performed an unsupervised clustering to identify two types of ERS-related subtypes [ERS clusters, and ERS-related genes (ERSGs) clusters] in multiple large-scale CRC cohorts. Through the utilization of machine learning techniques, we have successfully developed an uncomplicated yet robust gene scoring system (ERSGs signature). Furthermore, a series of analyses, including GO, KEGG, Tumor Immune Dysfunction and Exclusion (TIDE), the Consensus Molecular Subtypes (CMS), were used to explore the underlying biological differences and clinical significance between these groups. And immunohistochemical and bioinformatics analyses were performed to explore ZNF703, a gene of ERSGs scoring *** observed significant differences in prognosis and tumor immune status between the ERS clusters as well as ERSGs clusters. And the ERSGs scoring system was an independent risk factor for overall survival;and exhibited distinct tumor immune status in multicenter CRC cohorts. Besides, analyses of TNM stages, CMS groups demonstrated that patients in advanced stage and CMS4 had higher ERSGs scores. In addition, the ERSGs scores inversely correlated with positive ICB response predictors (such as, CD8A, CD274 (PD-L1), and TIS), and directly correlated with negative ICB response predictors (such as, TIDE, T cell Exclusion, COX-IS). Notably, immunohistochemical staining and bioinformatics analyses revealed that ZNF70 correlated with CD3 + and CD8 + T cells infiltra

关键词： Endoplasmic reticulum stress Tumor immunity Colorectal cancer Prognosis ICB response biomarkers

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Photo-thermoelectric effect induced electricity in stretchable graphene-polymer nanocomposites for ultrasensitive strain sensing

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Nano Research 2019年第12期12卷 2982-2987页

作者： Ding Zhang Yiding song Lu Ping suwen Xu De Yang Yuanhao Wang Ya Yang CAS Center for Excellence in Nanoscience Beijing Key Laboratory of Micro-nano Energy and SensorBeijing Institute of Nanoenergy and NanosystemsChinese Academy of SciencesBeijing 100083China Department of Neurology Fuling Center Hospital of Chongqing CityChongqing 408000China Xinjiang Technical Institute of Physics&Chemistry Chinese Academy of SciencesUrumqi 830011China School of Nanoscience and Technology University of Chinese Academy of SciencesBeijing 100049China Center on Nanoenergy Research School of Physical Science and TechnologyGuangxi UniversityNanning 530004China

Stretchable strain sensors play an increasingly important role in artificial intelligent ***,high-performanee strain sensors havebeen slowly developed owing to the harsh requirement of self-powered function,long cycle life and high ***,we report aself-powered stretchable graphene-ecoflex composite strain sensor based on photo-thermoelectric(PTE)effect induced *** exhibits a high strain sensitivity of-0.056 In(nA)/%with strains ranged from 0%to 20%under 980 nm light illumination,where thestrain sensitivity can be found to in crease with in creasi ng light inte *** strain sensor maintains outstanding dyn amic stability un derperiodic strains ranged from 0 to 100%in 100 *** sensing resolution can be as high as 0.5%with both the response and recovery timeof less than 0.6 *** can precisely monitor human joint motions and stretchable strains by implanting the device in pork.

关键词： graphene-polymer nanocomposites photo-thermoelectric effect strain sensor stretchable implantable

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A widespread pathway for substitution of adenine by diaminopurine in phage genomes

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SCIENCE 2021年第6541期372卷 512-+页

作者： Zhou, Yan Xu, Xuexia Wei, Yifeng Cheng, Yu Guo, Yu Khudyakov, Ivan Liu, Fuli He, Ping song, Zhangyue Li, Zhi Gao, Yan Ang, Ee Lui Zhao, Huimin Zhang, Yan Zhao, suwen Tianjin Univ Tianjin Key Lab Modem Drug Delivery & High Effici Collaborat Innovat Ctr Chem Sci & Engn Sch Pharmaceut Sci & Technol Tianjin 300072 Peoples R China Tianjin Univ Frontiers Sci Ctr Synthet Biol Minist Educ Tianjin 300072 Peoples R China Shanghai Tech Univ iHuman Inst Shanghai 201210 Peoples R China Shanghai Tech Univ Sch Life Sci & Technol Shanghai 201210 Peoples R China Univ Chinese Acad Sci Beijing 100049 Peoples R China Chinese Acad Sci Shanghai Inst Nutr & Hlth Shanghai 200061 Peoples R China ASTAR Singapore Inst Food & Biotechnol Innovat Singapore Singapore All Russian Res Inst Agr Microbiol St Petersburg 196608 Russia Shanghai Jiao Tong Univ Dept Med Microbiol & Immunol Sch Med Shanghai 200025 Peoples R China Shanghai Tech Univ SIAIS Biomed Big Data Platform Shanghai 201210 Peoples R China Univ Illinois Dept Chem & Biomol Engn Urbana IL 61801 USA

DNA modifications vary in form and function but generally do not alter Watson-Crick base pairing. Diaminopurine (Z) is an exception because it completely replaces adenine and forms three hydrogen bonds with thymine in cyanophage S-2L genomic DNA. However, the biosynthesis, prevalence, and importance of Z genomes remain unexplored. Here, we report a multienzyme system that supports Z-genome synthesis. We identified dozens of globally widespread phages harboring such enzymes, and we further verified the Z genome in one of these phages, Acinetobacter phage SH-Ab 15497, by using liquid chromatography with ultraviolet and mass spectrometry. The Z genome endows phages with evolutionary advantages for evading the attack of host restriction enzymes, and the characterization of its biosynthetic pathway enables Z-DNA production on a large scale for a diverse range of applications.

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艾草/莫代尔/Aircell混纺针织纱的开发

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上海纺织科技 2022年第5期50卷 38-40页

作者：王静王秀君宋科新石梅于丹李苏文德州学院纺织服装学院山东德州253023

开发了一种具有较好抗菌保健功能,生产耗能低、环境友好的艾草/莫代尔/Aircell混纺针织纱。阐述了纱线规格和原料特性。根据原料特点制定纺纱工艺流程,选择纺纱设备;探讨了纺纱工艺原则和工艺配置方案,优化并确定了梳棉、并条、粗纱、... 详细信息

开发了一种具有较好抗菌保健功能,生产耗能低、环境友好的艾草/莫代尔/Aircell混纺针织纱。阐述了纱线规格和原料特性。根据原料特点制定纺纱工艺流程,选择纺纱设备;探讨了纺纱工艺原则和工艺配置方案,优化并确定了梳棉、并条、粗纱、细纱工序的工艺参数。经成纱质量指标及抗菌性能测试,开发的纱线成纱质量良好,并具有较好的抗菌性能。

关键词：艾草纤维 Aircell纤维莫代尔混纺纱针织纱工艺设计产品开发

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Fusobacterium nucleatum upregulates MMP7 to promote metastasis-related characteristics of colorectal cancer cell via activating MAPK(JNK)-AP1 axis

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JOURNAL OF TRANSLATIONAL MEDICINE 2023年第1期21卷 704-704页

作者： Ou, suwen Chen, Haipeng Wang, Hufei Ye, Jinhua Liu, Huidi Tao, Yangbao Ran, songlin Mu, Xiaoqin Liu, Fangzhou Zhu, Shuang Luo, Kangjia Guan, Zilong Jin, Yinghu Huang, Rui song, Yanni Liu, Shu-lin Harbin Med Univ Dept Colorectal Surg Affiliated Hosp 2 Harbin 150081 Peoples R China Chinese Acad Med Sci & Peking Union Med Coll Natl Clin Res Ctr Canc Natl Canc Ctr Dept Colorectal SurgCanc Hosp Beijing 100021 Peoples R China Harbin Med Univ Coll Pharm Genom Res Ctr Key Lab Gut Microbiota & Pharmacogen Heilongjiang Harbin 150081 Peoples R China Harbin Med Univ Univ Calgary Ctr Infect & Genom Cumming Sch Med Harbin 150081 Peoples R China Ningbo Univ Dept Gastrointestinal Surg Affiliated Hosp Med Sch Ningbo Peoples R China Harbin Med Univ Affiliated Hosp 4 Dept Gen Surg Harbin 150000 Peoples R China Harbin Med Univ Canc Hosp Dept Breast Surg Harbin 150081 Peoples R China Univ Calgary Dept Microbiol Immunol & Infect Dis Calgary AB T2N 4N1 Canada Harbin Med Univ Affiliated Hosp 1 Dept Pancreat & Biliary Surg Harbin 150001 Peoples R China

Background Colorectal cancer (CRC) is the third most common malignant tumor. Fusobacterium nucleatum (F. nucleatum) is overabundant in CRC and associated with metastasis, but the role of F. nucleatum in CRC cell migration and metastasis has not been fully *** Differential gene analysis, protein-protein interaction, robust rank aggregation analysis, functional enrichment analysis, and gene set variation analysis were used to figure out the potential vital genes and biological functions affected by F. nucleatum infection. The 16S rDNA sequencing and q-PCR were used to detect the abundance of F. nucleatum in tissues and stools. Then, we assessed the effect of F. nucleatum on CRC cell migration by wound healing and transwell assays, and confirmed the role of Matrix metalloproteinase 7 (MMP7) induced by F. nucleatum in cell migration. Furthermore, we dissected the mechanisms involved in F. nucleatum induced MMP7 expression. We also investigated the MMP7 expression in clinical samples and its correlation with prognosis in CRC patients. Finally, we screened out potential small molecular drugs that targeted MMP7 using the HERB database and molecular *** F. nucleatum infection altered the gene expression profile and affected immune response, inflammation, biosynthesis, metabolism, adhesion and motility related biological functions in CRC. F. nucleatum was enriched in CRC and promoted the migration of CRC cell by upregulating MMP7 in vitro. MMP7 expression induced by F. nucleatum infection was mediated by the MAPK(JNK)-AP1 axis. MMP7 was highly expressed in CRC and correlated with CMS4 and poor clinical prognosis. Small molecular drugs such as delta-tocotrienol, 3,4-benzopyrene, tea polyphenols, and gallic catechin served as potential targeted therapeutic drugs for F. nucleatum induced MMP7 in *** Our study showed that F. nucleatum promoted metastasis-related characteristics of CRC cell by upregulating MMP7 via MAPK(JNK)-AP1 axis. F. nuc

关键词： Colorectal cancer Fusobacterium nucleatum Matrix metalloproteinase 7 Migration

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Heat treatment to improve the wear resistance of PTFE/PMMA composites

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RSC ADVANCES 2019年第39期9卷 22289-22294页

作者： Gu, Dapeng Zhang, Longxiao Chen, suwen song, Kefeng Pan, Deng Yang, Bingchao Liu, Shouyao Yanshan Univ Sch Mech Engn Qinhuangdao 066004 Hebei Peoples R China Yanshan Univ Aviat Key Lab Sci & Technol Gener Technol Self Lu Qinhuangdao 066004 Hebei Peoples R China Yanshan Univ Dept Environm & Chem Engn Qinhuangdao 066004 Hebei Peoples R China Qufu Normal Univ Sch Phys & Phys Engn Qufu 273165 Peoples R China

Polytetrafluoroethylene/poly(methyl methacrylate) (PTFE/PMMA) composites were prepared by a self-curing method. The influence of heat treatment processes on the friction and wear behaviors of PTFE/PMMA composites against bearing steel balls were studied by a ball-on-disk tribometer. The thermal performance of PTFE/PMMA composites with heat treatment was analyzed by Thermogravimetric Analysis (TGA). The surface morphologies and element distribution of PTFE/PMMA composites in a PMMA matrix were detected by Field Emission Scanning Electron Microscopy (FE-SEM) and Energy Dispersive Spectroscopy (EDS). The results indicated that the wear rates of PTFE/PMMA composites with different heat treatments significantly declined compared with the unheated treatment composite. The wear rate of the PTFE/PMMA composite decreased firstly and then increased with molding temperature and time increasing, and reduced with the molding pressure increasing. The main wear mechanisms of PTFE/PMMA composites with different heat treatments were fatigue wear and abrasive wear.

关键词： Heat treatment

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DEVELOPING STANDARD WINDOW TO FLOOR RATIO(WFR)SYSTEM FOR GREEN RESIDENTIAL BUILDINGS IN SUBTROPICS

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Journal of Green Building 2021年第3期16卷 109-134页

作者： suwen Jiang Chen Wang Jeffrey Boon Hui Yap Heng Li Lincoln C.Wood Hong-song Hu Bin Xu Higher-educational Engineering Research Centre for Intelligence and Automation in Construction of Fujian Province College of Civil EngineeringHuaqiao University361021XiamenChina Director of Higher-educational Engineering Research Centre for Intelligence and Automation in Construction of Fujian Province College of Civil EngineeringHuaqiao University361021XiamenChina Department of Surveying Lee Kong Chian Faculty of Engineering and ScienceUniversiti Tunku Abdul Rahman(UTAR)43000 Department of Building and Real Estate The Hong Kong Polytechnic UniversityHong KongChina Department of Management University of OtagoNew Zealand and School of ManagementCurtin UniversityAustralia Engineering Research Centre for Intelligence and Automation in Construction of Fujian Province College of Civil EngineeringHuaqiao University361021XiamenChina Key Laboratory for Intelligent Infrastructure and Monitoring of Fujian Province College of Civil EngineeringHuaqiao University361021XiamenChina

The window system is generally regarded as the most vulnerable building system for the indoor energy performance of green *** systems are given sig-nificant attention by architects and engineers,especially in areas with long summer and high solar radiation such as the *** study aims to develop a standard window-to-floor ratio(WFR)system for green residential buildings in the *** Autodesk Revit as the interface,a real high-rise residential building was digitalized and imported into Ecotect for energy consumption *** analyses were conducted to determine the optimal WFR for building energy *** demonstrated 0.23 as the optimal WFR in Xiamen,one of the typical subtropical cities in ***,accompanied by a four-sidefins sunshade device and a double glass window(DGW)with clear“glass+air gap+reflective”glass,the building energy consumption was further reduced by 34.47%compared to the initial model,which successfully met the optimization target of 30%,set according to the green building *** results of this study are helpful to architects and building engineers when designing or retrofitting green buildings as we provide specific support for design features for energy performance.

关键词： building energy efficiency window-to-floor ratio BIM Ecotect

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线粒体分裂、线粒体自噬在烟草提取物诱导的支气管上皮细胞损伤模型中的作用

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安徽医科大学学报 2021年第9期56卷 1343-1349页

作者：王素文宋小敏李忱菲魏良煜张海李锋王炯安徽医科大学第一附属医院老年呼吸与危重症医学科合肥230022 上海市胸科医院(上海交通大学附属胸科医院)呼吸与危重医学科上海200030

目的探讨线粒体分裂、线粒体自噬在烟草提取物(CSE)诱导的支气管上皮细胞损伤模型中的作用。方法支气管上皮细胞与5%CSE共培养,使用线粒体分裂抑制剂Mdivi-1(Md)和线粒体自噬促进剂Urolithin A(UA)进行预处理,分别检测细胞增殖活力、氧... 详细信息

目的探讨线粒体分裂、线粒体自噬在烟草提取物(CSE)诱导的支气管上皮细胞损伤模型中的作用。方法支气管上皮细胞与5%CSE共培养,使用线粒体分裂抑制剂Mdivi-1(Md)和线粒体自噬促进剂Urolithin A(UA)进行预处理,分别检测细胞增殖活力、氧化应激、线粒体结构变化、炎症因子(IL-1β、IL-6、IL-18、CXCL1、CXCL8)mRNA水平、细胞程序性坏死组分(RIPK1、RIPK3、MLKL)mRNA水平、线粒体分裂蛋白(DRP1、MFF)和线粒体自噬蛋白(p62/SQSTM1、LC3B)的水平。结果5%CSE诱导氧化应激、炎症因子mRNA增加、线粒体网络结构破坏、线粒体分裂蛋白表达增加、线粒体自噬蛋白p62/SQSTM1蛋白表达增高、LC3BⅡ/Ⅰ蛋白表达下降、程序性坏死组分mRNA增加。Md/UA预处理可抑制氧化应激,抑制炎症因子、细胞程序性坏死组分mRNA表达,部分恢复线粒体网络结构,降低线粒体分裂蛋白水平。Md预处理增加线粒体自噬蛋白p62/SQSTM1蛋白水平,不影响LC3BⅡ/Ⅰ蛋白表达。UA预处理抑制线粒体自噬蛋白p62/SQSTM1蛋白水平,增加LC3BⅡ/Ⅰ蛋白表达。结论抑制线粒体分裂或促进线粒体自噬可抑制烟草暴露诱导的氧化应激和炎症反应,部分恢复线粒体结构,其机制可能与抑制线粒体分裂、抑制细胞程序性坏死组分mRNA表达有关。

关键词：线粒体分裂线粒体自噬烟草暴露炎症程序性坏死

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