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RETRACTED: The Influence of ICAM1 3′UTR Gene Polymorphism on the Occurrence and Metastasis of Primary Liver Cancer (Retracted Article)

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BIOMED RESEARCH INTERNATIONAL 2021年第1期2021卷

作者： He, Li wang, suwen Ma, Xusheng Xinjiang Med Univ Houbo Coll 12 Shengli Rd Karamay Xinjiang Peoples R China Shihezi Univ Sch Med Beier Rd Shihezi Xinjiang Peoples R China

Objective. In this study, we explored the influence of single nucleotide polymorphism (SNP) in the noncoding region of intercellular adhesion molecule 1 (ICAM1) gene on the occurrence and metastasis of primary hepatocellular carcinoma (PHC). Methods. Sanger sequencing was used to analyze the genotypes of rs3093032, rs923366, and rs281437 locus in the 3' untranslated region (UTR) of the ICAM1 gene. The level of plasma ICAM1 was analyzed by enzyme-linked immunosorbent assay (ELISA). Results. After adjusting for risk factors such as BMI, smoking, drinking, family history of tumors, and hepatitis B virus test results, the CT genotype at rs3093032 of the ICAM1 gene (OR = 0.19, 95% CI: 0.08-0.44, P < 0.01), dominance model (OR = 0:23, 95% CI: 0.11-0.48, P < 0.01), and T allele (OR = 0:27, 95% CI: 0.14-0.53, P < 0:01) were related to the reduced risk of PHC susceptibility. rs923366 locus CT genotype (OR = 0:63, 95% CI: 0.44-0.90, P = 0.01), TT genotype (OR = 0.23, 95% CI: 0.10-0.53, P < 0.01), dominant model (OR = 0:55, 95% CI: 0.39-0.77, P < 0.01), recessive model (OR = 0:28, 95% CI: 0.12-0.62, P < 0:01), and T allele (OR = 0.55, 95% CI: 0.42-0.73, P < 0.01) were related to a reduction in the risk of PHC susceptibility. rs281437 locus CT genotype (OR = 2:08, 95% CI: 1.40-3.09, P < 0: 01), TT genotype (OR = 5.20, 95% CI: 2.22-12.17, P < 0.01), dominant model (OR = 2:45, 95% CI: 1.69-3.54, P < 0.01), recessive model (OR = 4.32, 95% CI: 1.86-10.06, P < 0.01), and T allele (OR = 2.46, 95% CI: 1.79-3.38, P < 0.01) were significantly related to the increased risk of PHC susceptibility. SNPs at rs3093032, rs923366, and rs281437 of the ICAM1 gene were significantly correlated with TNM stage and tumor metastasis of PHC patients (P < 0:05). Conclusion. SNPs at rs3093032, rs923366, and rs281437 in the 3' UTR region of the ICAM1 gene are related to the occurrence and metastasis of PHC.

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Multiwalled Carbon Nanotubes/Polypyrrole/Graphene/Nonwoven Fabric Composites Used as Electrodes of Electrochemical Capacitor

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JOURNAL OF APPLIED POLYMER SCIENCE 2014年第21期131卷

作者： Liu, Feifei wang, suwen Han, Gaoyi Liu, Ruiqin Chang, Yunzhen Xiao, Yaoming Shanxi Univ Inst Mol Sci Key Lab Chem Biol & Mol Engn Educ Minist Taiyuan 030006 Peoples R China

The reduced graphene oxide/nonwoven fabric (rGO/NWF) composites have been fabricated through heating the NWF coated with the mixture of GO and HONH2 center dot HCl at 130 degrees C, during which the GO is chemically reduced to rGO. Then the composites of polypyrrole (PPy)/rGO/NWF have been prepared through chemically polymerizing pyrrole vapor by using the FeCl3 center dot 6H(2)O adsorbed on rGO/NWF substrate as oxidant. Finally, multiwalled carbon nanotubes (MWCNTs) are used as conductive enhancer to modify PPy/rGO/NWF through dip-dry process to obtain MWCNTs/PPy/rGO/NWF. The prepared composites have been characterized and their capacitive properties have been evaluated in 1.0M KCl electrolyte by using two-electrode symmetric capacitor test. The results reveal that MWCNTs/PPy/rGO/NWF possesses a maximum specific capacitance (C-sc) of about 319 F g(-1) while PPy/rGO/NWF has a C-sc of about 277.8 F g(-1) at the scan rate of 1 mV s(-1) and that optimum MWCNTs/PPy/rGO/NWF retains 94.5% of initial C-sc after 1000 cycles at scan rate of 80 mV s(-1) which is higher than PPy/rGO/NWF (83.4%). Further analysis reveals that the addition of MWCNTs can increase the charger accumulation at the outer and inner of the composites, which is favorable to improve the stability and the rapid charge-discharge capacity. (C) 2014 Wiley Periodicals, Inc.

关键词： carbon nanotubes composites conducting polymers electrochemical capacitors

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面向工业需要的英国工程博士及其培养特色

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高等工程教育研究 2005年第2期53卷 76-79页

作者：王素文顾建民浙江大学高等教育研究所

1992年英国开始设立工程博士学位。工程博士计划面向英国工业需要 ,兼取美国博士生教育重视课程学习和德国工程博士培养重视工程实践的长处 ,同时强调管理知识的学习和相关能力的培养 ,独具特色。英国工程博士不仅在学位要求上与哲学博... 详细信息

1992年英国开始设立工程博士学位。工程博士计划面向英国工业需要 ,兼取美国博士生教育重视课程学习和德国工程博士培养重视工程实践的长处 ,同时强调管理知识的学习和相关能力的培养 ,独具特色。英国工程博士不仅在学位要求上与哲学博士各有侧重 ,而且在组织形式和培养模式上也是独具匠心。

关键词：培养模式博士生教育特色课程学习英国博士学位能力工程工业组织形式

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Alleviation effect of macrophage depletion on hepatotoxicity of triptolide: A new insight based on metabolomics and proteomics

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JOURNAL OF ETHNOPHARMACOLOGY 2025年 343卷 119485页

作者： Zhang, Xiaoguang Zhang, Jia Xun, Ge Gao, Yanhua Zhao, Jie Fu, Yan Su, suwen Kong, Dezhi wang, Qiao wang, Xu Hebei Med Univ Core Facil & Ctr Shijiazhuang Hebei Peoples R China Hebei Med Univ Sch Pharm Shijiazhuang Hebei Peoples R China China Acad Chinese Med Sci Inst Chinese Mat Med Beijing Peoples R China Henan Univ Chinese Med Acad Chinese Med Sci Zhengzhou Henan Peoples R China Hebei Med Univ Dept Pharmacol Key Lab Neural & Vasc Biol Key Lab New Drug Pharmacol & ToxicolMinist Educ Shijiazhuang Hebei Peoples R China Hebei Med Univ Inst Chinese Integrat Med Shijiazhuang Hebei Peoples R China

Ethnopharmacological relevance: Triptolide (TP) is an abietane-type diterpenoid isolated from the traditional Chinese herb Tripterygium wilfordii Hook. F, which is used to relieve rheumatism, alleviate joint pain and swelling, and promote blood circulation for more than 600 years in China. The most common preparations containing TP from Tripterygium wilfordii Hook F, which are Tripterygium tablets and Tripterygium glycoside tablets, are widely used in clinical for treating rheumatoid arthritis and other autoimmune diseases at present. However, the clinical application is hindered by severe systemic toxicity induced by TP, especially hepatotoxicity. It is crucial to discover potent and specific detoxification strategy for TP. Aim of study: According to our previous study, TP-induced hepatotoxicity is primarily related to macrophages. This study aimed to investigate the alleviation effects of macrophage depletion on the TP-induced liver injury in mice and to explore the related mechanisms by integration of metabolomics and proteomics. Materials and methods: Mice were treated with clodronate liposomes to deplete macrophage before administration of triptolide. The alleviation effects were evaluated by biochemical analysis of serum and histopathology observation of the hepatic tissues. Metabolomics and proteomics were carried out to explore the mechanism of macrophage depletion on triptolide-induced liver injury. The levels of mRNA and protein of TLR4- MyD88-NF-kappa B axis were further detected. Results: The altered levels of biochemistry indicators, including aminotransferase (ALT) and aspartate aminotransferase (AST), albumin (ALB), and gamma-glutamyltranspeptidase (GGT) were significantly recovered, and histopathological liver injury also showed restoring tendency in mice with macrophage depletion compared to mice with TP-treatment. The inflammation indicator interleukin-6 (IL-6) and interleukin-1 beta (IL-1 beta) were recovered significantly after depletion of macro

关键词： Macrophages Triptolide Hepatotoxicity Multi-omics

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Establishment of CFD-ANN-NSGA-II model for stirred reactor design

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CHEMICAL ENGINEERING SCIENCE 2025年 311卷

作者： Jiang, Zhou Chen, Jiajun Xie, suwen Li, Xingyan Liu, Huazong wang, Luyao Hong, Chen Li, Ganlu Li, Hui Chen, Kequan Nanjing Tech Univ Coll Biotechnol & Pharmaceut Engn State Key Lab Mat Oriented Chem Engn Nanjing 211816 Peoples R China Jiangxi Vocat Coll Appl Technol Ganzhou 342800 Peoples R China

Herein, the multiobjective optimization method based on the CFD-ANN-NSGA-II model is proposed to efficiently optimize the structural parameters of the stirred reactor, thereby improving its gas-liquid mass transfer efficiency and reducing its energy consumption. Coupling CFD simulations with the ANN-NSGA-II model enabled accurate performance predictions. The R2 values of the parameters epsilon, kLa, t, and P/V were 0.940, 0.989, 0.956, and 0.970, respectively, and their mean square error values were 0.0010, 0.0224, 0.0218, and 0.0521, respectively. The optimal reactor structural parameters were H/D = 2.16, d/D = 0.38, w/d = 0.50, and C1/D = 0.30. The epsilon and kLa values of the structure increased with optimization to 13.5 % and 0.171 s-1, respectively, while the t and P/V values decreased. The study describes an efficient and reliable theoretical method for the multiobjective optimization of chemical equipment, verifying the potential of adopting artificial intelligence in complex fluid system optimization, with important value for engineering applications.

关键词： Stirred reactor Computational fluid dynamics simulation Artificial neural network Genetic algorithm Volumetric mass transfer coefficient

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Enhancing CO2 capture efficiency: CFD investigation of gas-liquid self-suction reactor configurations

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SEPARATION AND PURIFICATION TECHNOLOGY 2025年 360卷

作者： Li, Xingyan Xie, suwen Liu, Huazong Gan, Jian Jiang, Zhou wang, Luyao Zhu, Hongyu Li, Ganlu Li, Hui Chen, Kequan Nanjing Tech Univ Coll Biotechnol & Pharmaceut Engn State Key Lab Mat Oriented Chem Engn Nanjing 211816 Peoples R China Jiangxi Coll Appl Technol Ganzhou 341000 Peoples R China

The separation and removal of industrial waste gases (such as CO2) has broad prospects. Efficient gas separation and removal equipment is the key to the purification of industrial waste gases. In this study, a new type of gas separation and purification reaction equipment was designed that can effectively improve the capture of CO2. The Propeller self-suction impeller coupled with the dynamic membrane-aeration impeller (Propeller + DMAI, also SDMSR) is the best impeller combination, achieving a gas holdup (epsilon G) of up to 11.4 % and a volume mass transfer coefficient (kLa) of up to 0.061 s- 1. Compared with other combinations, epsilon G and kLa are significantly improved. Additionally, compared with the dynamic membrane-stirred reactor (DMSR) and self-suction stirred reactor (SSR), SDMSR enhances CO2 mass transfer and gas recovery, with a CaCO3 nucleation rate constant of 1.37 s-1, which is 11.38 % and 52.22 % higher than DMSR and SSR, respectively. In summary, this study provides a reference for the separation and purification of special gases.

关键词： Self-suction reactor Dynamic membrane Fine bubble Gas recovery Gas-liquid mass transfer

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The application of Nanorod MnO2 adsorbed with MWCNTs for magnesium-air fuel cells

The application of Nanorod MnO2 adsorbed with MWCNTs for mag...

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第一届全国储能科学与技术大会

作者： YUE Panfeng LI Zhongfang wang suwen wang Yuxin School of Chemical Engineering Shandong University of Technology State Key Laboratory of Chemical Engineering School of Chemical EngineeringTianjin University

*** Manganese oxide,which characteristically possesses lower price and ease of preparation,has commonly become a subject for development But its lower activity is *** black is a common supporter for improve the activi... 详细信息

关键词： MWCNTs The application of Nanorod MnO2 adsorbed with MWCNTs for magnesium-air fuel cells MnO

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Fatty acid binding protein 4 regulates doxorubicin-induced renal injury via mediating lipid metabolism and apoptosis

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CHEMICO-BIOLOGICAL INTERACTIONS 2025年 408卷 111419页

作者： wang, Chuchu Zhang, Tao Guan, Yufeng Han, Boye Wu, Shang wang, Xu Yu, Jing Zhang, Junxia Zhang, Guoqiang Miao, Qingfeng Su, suwen Hebei Med Univ Dept Pharmacol Key Lab Pharmacol & Toxicol New Drugs Key Lab Neural & Vasc BiolMinist Educ Shijiazhuang Peoples R China Hebei Med Univ Dept Intens Care Unit ICU Hosp 4 Shijiazhuang Hebei Peoples R China Hebei Med Univ Breast Ctr Hosp 4 Shijiazhuang Hebei Peoples R China Hebei Med Univ Sch Pharm Shijiazhuang 050017 Peoples R China Hebei Med Univ Dept Pharm Hosp 1 Shijiazhuang Peoples R China Hebei Hosp Tradit Chinese Med Dept Nephrol Shijiazhuang Hebei Peoples R China Hebei Med Univ Dept Dermatol Hosp 1 Shijiazhuang Hebei Peoples R China

Doxorubicin(DOX) is an anthracycline chemotherapeutic drug used in the treatment of a wide range of tumors. However, the nephrotoxicity has limited the clinical application of DOX. Fatty acid-binding protein 4 (FABP4), a key adipokine mainly expressed in adipocytes, is strongly associated with kidney dysfunction and kidney disease. This study aims to investigate the role of FABP4 in DOX-induced nephrotoxicity. In vivo experiments, the mice were divided into 4 groups randomly: CON group, DOX group, 4T1 group, and 4T1 + DOX group respectively. DOX was given by intraperitoneal injection at a dose of 15 mg/kg. The kidney function indicators, the morphology and lipid deposition in renal tissues and the preliminary mechanism were assessed. In vitro experiment, HK-2 cell was used to detect DOX-induced kidney cell injury with or without BMS309403. DOX caused renal dysfunction in both DOX group and 4T1 + DOX group, with a more severe kidney injury in DOX group. DOX also induced kidney lipid deposition, glycerophospholipids metabolism dysfunction, apoptosis accompanied by increased FABP4 and decreased Peroxisome Proliferator Activated Receptor- gamma (PPAR-gamma) levels in the kidney tissues. The decreased cell viability, increased apoptotic ratio, elevated protein levels of apoptosis and the lipid deposition caused by DOX were all alleviated by BMS309403. FABP4 mediated DOX induced kidney damage in normal mice and tumor-bearing mice by lipid metabolism disorders and cell apoptosis. This study may enhance the clinical management of DOX-induced kidney injury and provide new therapeutic targets and preventive strategies for the clinical application of DOX.

关键词： Doxorubicin Kidney damage FABP4 Lipid metabolisim Apoptosis Tumor-bearing animal

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Durability of Polytetraphenylporphyrin Cobalt Adsorbed on Carbon Black as an Electrocatalyst for Oxygen Reduction

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JOURNAL OF THE ELECTROCHEMICAL SOCIETY 2011年第2期158卷 B139-B142页

作者： Ji, Yanfeng Li, Zhongfang wang, suwen Xu, Guofeng Li, Degang Yu, Xianjin Shandong Univ Technol Sch Chem Engn Zibo 255049 Peoples R China

Polytetraphenylporphyrin Co(II) (PTPPCo) is obtained by heat-treating 5,10,15,20-tetra(4-carboxyphenyl)-porphyrin Co(II) at 400 degrees C in an argon atmosphere. Thermogravimetric analysis is used to evaluate the thermal stability of PTPPCo. Oxidation resistance of PTPPCo is measured by refluxing in Fentons reagent for 72 h. The ultraviolet-visible spectra indicate that PTPPCo is not decomposed and cobalt ion is not exfoliated. Polytetraphenylporphyrin Co/C (PTPPCo/C) is obtained by the heat-treatment of PTPPCo, which is adsorbed on Vulcan XC-72 with 6 wt % Co-N-4 loading, at 600 degrees C in an Ar atmosphere. Cyclic voltammetry, linear sweep voltammetry, and chronoamperometry tests are performed in order to observe the catalyst durability in different conditions. Almost no performance deficiency is observed after 10,000 continuous voltammetric cycles, 200 potentiometric cycles, and 60 h of chronoamperometry test. PTPPCo/C catalysts display significant chemical stability and electrocatalytic durability. These catalysts may be useful for polymer electrolyte membrane fuel cells. (C) 2010 The Electrochemical Society. [DOI: 10.1149/1.3521317] All rights reserved.

关键词： Electrolytic reduction

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Hesperitin prevents non-alcoholic steatohepatitis by modulating mitochondrial dynamics and mitophagy via the AMPKα-Drp1/ PINK1-Parkin signaling pathway

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BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS 2025年第1期1870卷 159570页

作者： Chen, suwen Lu, Haifei Yin, Guoliang Zhang, Xin Meng, Decheng Yu, Wenfei wang, Linya Liu, Hongshuai Zhang, Fengxia Shandong Univ Tradit Chinese Med Jinan 250013 Peoples R China China Acad Chinese Med Sci Guanganmen Hosp Dept Cardiol Beijing 100032 Peoples R China Hubei Univ Chinese Med Huanggang Hosp Chinese Med Huanggang 438000 Peoples R China Shandong Univ Tradit Chinese Med Affiliated Hosp Dept Neurol Jinan 250013 Peoples R China

Non-alcoholic fatty liver disease (NAFLD) is becoming a global public health burden, yet effective therapeutic strategies are notably lacking. NAFLD development may be mediated by mitochondrial dysfunction, according to new research. Producing mitochondrial regulators from plant-based substances to treat mitochondrial dysfunction is an appealing approach to treating NAFLD. Hesperetin (HES) is a flavonoid that is found naturally and is a member of the flavanone family. This study aims to clarify the mechanism of HES in preventing NAFLD which is caused by a high-fat diet (HFD). Serum and liver biochemical parameters, liver histology, lipid profiles, and mitochondrial function were evaluated in HFD-induced NAFLD Sprague-Dawley (SD) rats. HES treatment significantly reduced body weight gain, liver weight, and the liver index, while also improving hepatic steatosis, lipid metabolism disorders, and mitochondrial dysfunction in rats with NAFLD. The mechanism was investigated and confirmed using western blot and real-time quantitative polymerase chain reaction (RT-qPCR). We showed that in the liver of NAFLD rats, HES decreased the expression of dynamic-related protein 1 (Drp1), phosphorylated Drp1 at serine-616 (Drp1-pS616) and induced phosphorylated Drp1 at serine-637 (Drp1-pS637), PTENinduced kinase 1 (PINK1), and E3 Ubiquitin-Protein Ligase Parkin (Parkin) via an AMP-activated protein kinase alpha (AMPK alpha)-dependent mechanism. Moreover, HES increased the expression of the mitochondrial fusion proteins mitofusin-2 (Mfn2) and optic atrophy 1 (Opa1) while suppressing the expression of fission protein 1 (Fis1). In this work, we identify a unique mechanism by which HES prevents NAFLD from developing. HES may be an attractive potential therapeutic agent to cure NAFLD.

关键词： Hesperitin (HES) Non-alcoholic fatty liver disease (NAFLD) Mitochondrial dysfunction AMP-activated protein kinase alpha (AMPK alpha) Mitochondrial dynamics Mitophagy

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