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Alleviation effect of macrophage depletion on hepatotoxicity of triptolide: A new insight based on metabolomics and proteomics

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JOURNAL OF ETHNOPHARMACOLOGY 2025年 343卷 119485页

作者： Zhang, Xiaoguang Zhang, Jia Xun, Ge Gao, Yanhua Zhao, Jie Fu, Yan Su, suwen Kong, Dezhi wang, Qiao wang, Xu Hebei Med Univ Core Facil & Ctr Shijiazhuang Hebei Peoples R China Hebei Med Univ Sch Pharm Shijiazhuang Hebei Peoples R China China Acad Chinese Med Sci Inst Chinese Mat Med Beijing Peoples R China Henan Univ Chinese Med Acad Chinese Med Sci Zhengzhou Henan Peoples R China Hebei Med Univ Dept Pharmacol Key Lab Neural & Vasc Biol Key Lab New Drug Pharmacol & ToxicolMinist Educ Shijiazhuang Hebei Peoples R China Hebei Med Univ Inst Chinese Integrat Med Shijiazhuang Hebei Peoples R China

Ethnopharmacological relevance: Triptolide (TP) is an abietane-type diterpenoid isolated from the traditional Chinese herb Tripterygium wilfordii Hook. F, which is used to relieve rheumatism, alleviate joint pain and swelling, and promote blood circulation for more than 600 years in China. The most common preparations containing TP from Tripterygium wilfordii Hook F, which are Tripterygium tablets and Tripterygium glycoside tablets, are widely used in clinical for treating rheumatoid arthritis and other autoimmune diseases at present. However, the clinical application is hindered by severe systemic toxicity induced by TP, especially hepatotoxicity. It is crucial to discover potent and specific detoxification strategy for TP. Aim of study: According to our previous study, TP-induced hepatotoxicity is primarily related to macrophages. This study aimed to investigate the alleviation effects of macrophage depletion on the TP-induced liver injury in mice and to explore the related mechanisms by integration of metabolomics and proteomics. Materials and methods: Mice were treated with clodronate liposomes to deplete macrophage before administration of triptolide. The alleviation effects were evaluated by biochemical analysis of serum and histopathology observation of the hepatic tissues. Metabolomics and proteomics were carried out to explore the mechanism of macrophage depletion on triptolide-induced liver injury. The levels of mRNA and protein of TLR4- MyD88-NF-kappa B axis were further detected. Results: The altered levels of biochemistry indicators, including aminotransferase (ALT) and aspartate aminotransferase (AST), albumin (ALB), and gamma-glutamyltranspeptidase (GGT) were significantly recovered, and histopathological liver injury also showed restoring tendency in mice with macrophage depletion compared to mice with TP-treatment. The inflammation indicator interleukin-6 (IL-6) and interleukin-1 beta (IL-1 beta) were recovered significantly after depletion of macro

关键词： Macrophages Triptolide Hepatotoxicity Multi-omics

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火驱尾气中H_2S与O_2化学反应热力学研究

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西安石油大学学报（自然科学版） 2019年第1期34卷 95-99,114页

作者：梁建军王苏雯陈龙王寿喜王勇中国石油新疆油田公司工程技术研究院新疆克拉玛依834000 西安石油大学石油工程学院陕西西安710065 西安石油大学陕西省油气田特种增产技术重点实验室陕西西安710065

为了研究火驱尾气回注过程中H2S与O2的化学反应趋势,判断尾气回注工艺的安全性,运用化学反应热力学模型计算了给定组分中的H2S与O2化学反应参数,分析温度对反应过程的影响,进一步确定二者的反应边界条件及爆炸极限范围。研究结果表明,... 详细信息

为了研究火驱尾气回注过程中H2S与O2的化学反应趋势,判断尾气回注工艺的安全性,运用化学反应热力学模型计算了给定组分中的H2S与O2化学反应参数,分析温度对反应过程的影响,进一步确定二者的反应边界条件及爆炸极限范围。研究结果表明,现场工况条件下火驱尾气中H2S与O2发生缓慢的氧化反应,主要产物为SO2与H2O,但随着温度的升高,反应自发程度减小。同时,根据混合物爆炸极限计算可知,火驱尾气在现场回注条件下无爆炸风险。

关键词：火驱尾气硫化氢化学反应爆炸极限

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Hyperoside inhibits pancreatic lipase activity in vitro and reduces fat accumulation in vivo

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FOOD & FUNCTION 2023年第10期14卷 4763-4776页

作者： Zhang, Xinyue Li, Dan wang, Kexin Xie, Jiao Liu, Yaojie wang, Tianxin Liu, suwen Huang, Qun Guo, Qingbin wang, Hao Tianjin Univ Sci & Technol State Key Lab Food Nutr & Safety Tianjin 300457 Peoples R China Guizhou Med Univ Key Lab Environm Pollut Monitoring & Dis Control Minist Educ Guizhou 550025 Peoples R China Shaanxi Normal Univ Coll Food Engn & Nutr Sci Xian 710062 Shaanxi Peoples R China Hebei Normal Univ Sci & Technol Coll Food Sci & Technol Qinhuangdao 066004 Hebei Peoples R China

Hyperoside, the main component of many anti-obesity plants, might exhibit a lipase inhibition effect to reduce fat accumulation. The anti-obesity effect of hyperoside was investigated by studying its inhibitory effect and mechanism on pancreatic lipase in vitro and evaluating its ability to reduce lipid accumulation in vivo. Hyperoside is a mixed-type inhibitor of lipase with an IC50 of 0.67 +/- 0.02 mmol L(-)in vitro. Hyperoside changed the secondary conformation of lipase, increased the alpha-helix content, and changed the microenvironment of lipase through static quenching. The interaction between hyperoside and lipase results from a strong binding spontaneous exothermic reaction, mainly through hydrogen bonding, van der Waals force and electrostatic force. Hyperoside protected hepatic lipid accumulation and adipose tissue hypertrophy and reduced the expression of inflammatory factors in high-fat diet-induced rats. Moreover, hyperoside had a good inhibitory effect on lipase activity in serum and increased fecal fat excretion, thereby reducing lipid absorption in vivo. This study provides theoretical support for the research and development of hyperoside in fat-reducing functional foods.

关键词： Hydrogen bonds

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A Low-Latency and Area-Efficient ORBGRAND Decoder for Polar Codes 4

A Low-Latency and Area-Efficient ORBGRAND Decoder for Polar ...

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4th Information Communication Technologies Conference, ICTC 2023

作者： Xiao, Jiayu Zhou, Yangcan Song, suwen wang, Zhongfeng Nanjing University School of Electronic Science and Engineering Nanjing China

ISBN: (纸本)9781665462587

The ultra-reliable low-latency communication (URLLC), one of the three main scenarios in the fifth-generation (5G) mobile communication system, is promising to be used in various emerging applications with stringent latency and performance requirements. Recently, the guessing random additive noise decoding (GRAND) is proposed, which can perform well for the URLLC due to its excellent error-correction performance with short code length. Compared to other variants of the GRAND, the ordered reliability bits GRAND (ORBGRAND) can provide a good trade-off between error-correction performance and hardware overhead. In this work, the ORBGRAND with a reduced schedule for polar codes is implemented for the first time, which utilizes the special structure of the parity-check matrix of polar codes to reduce the decoding latency while keeping the error-correction performance unaltered. Besides, the sorter employed in the ORBGRAND decoder is well optimized to reduce the area occupation. At a target frame error rate of 10-5 when using a (128, 105) 5G polar code, the average decoding latency of the proposed decoder is only 2.46 ns. Moreover, compared to the state-of-the-art ORBGRAND decoder, the proposed decoder can achieve 15% higher decoding throughput and 71% higher area efficiency without any error-correction performance loss. © 2023 IEEE.

关键词： Additive noise

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Diosgenin ameliorating non-alcoholic fatty liver disease via Nrf2-mediated regulation of oxidative stress and ferroptosis

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DIABETES OBESITY & METABOLISM 2024年第12期26卷 5745-5756页

作者： Zhang, Xin Yin, Guoliang Chen, suwen Meng, Decheng Yu, Wenfei Liu, Hongshuai wang, Linya Zhang, Fengxia Shandong Univ Tradit Chinese Med Dept Clin Med Coll 1 Jinan Peoples R China China Acad Chinese Med Sci Guanganmen Hosp Dept Cardiol Beijing Peoples R China Shandong Univ Tradit Chinese Med Dept Neurol Affiliated Hosp Jinan 250000 Peoples R China

AimThis study aimed to investigate the mechanisms through which diosgenin inhibits the pathogenesis of non-alcoholic fatty liver disease, focusing particularly on ferroptosis-related pathways and its reliance on nuclear factor erythroid 2-related factor 2. Materials and MethodsUsing a rat model, we showed diosgenin's efficacy in reducing lipid deposition throughout the body and examined its impact on ferroptosis-related gene expression in vivo. Moreover, in vitro experiments using human hepatocellular liver carcinoma cell line cells were conducted to assess oxidative stress and ferroptosis levels. ResultsDiosgenin decreased lipid accumulation and steatosis;lowered serum levels of total cholesterol, triglycerides, low-density lipoprotein cholesterol, glutamic pyruvic transaminase and glutamic oxaloacetic transaminase;reduced interleukin-1 beta and tumour necrosis factor-alpha;diosgenin decreased malondialdehyde levels;and increased serum superoxide dismutase levels in a rat model of high-fat diet-induced non-alcoholic fatty liver disease. Diosgenin upregulated the expression of nuclear factor erythroid 2-related factor 2 and its downstream ferroptosis-related genes to inhibit ferroptosis in the livers of rats with non-alcoholic fatty liver disease. Diosgenin decreased reactive oxygen species levels and enhanced the expression of ferroptosis-related genes in human hepatocellular liver carcinoma cells induced by free fatty acids, with its effects being dependent on nuclear factor erythroid 2-related factor 2. ConclusionsThis study highlights the potential of diosgenin from Dioscoreaceae plants in mitigating oxidative stress and ferroptosis levels through nuclear factor erythroid 2-related factor 2 regulation, offering novel insights into the treatment of non-alcoholic fatty liver disease and other metabolic disorders through traditional Chinese medicine.

关键词： fatty liver disease liver lipid-lowering therapy mouse model pharmacodynamics

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Hyperoside Prevents Aβ42-Induced Neurotoxicity in PC12 Cells and Caenorhabditis elegans

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MOLECULAR NEUROBIOLOGY 2023年第12期60卷 7136-7150页

作者： wang, Kexin Zhang, Xinyue Zhang, Miaosi Li, Xin Xie, Jiao Liu, suwen Huang, Qun wang, Jilite Guo, Qingbin wang, Hao Tianjin Univ Sci & Technol State Key Lab Food Nutr & Safety Econ & Technol Dev Area TEDA 2913Th Ave Tianjin 300457 Peoples R China Guizhou Med Univ Key Lab Environm Pollut Monitoring & Dis Control Minist Educ Guiyang 550025 Guizhou Peoples R China Hetao Coll Dept Agr Inner Mongolia Bayannur 015000 Peoples R China Hebei Normal Univ Sci & Technol Coll Food Sci & Technol Qinhuangdao 066004 Hebei Peoples R China

Traditional Chinese medicines such as hyperoside-rich Acanthopanax senticosus and Crataegus pinnatifida have been confirmed to exhibit anti-oxidative stress properties. Hyperoside, the main ingredient of numerous antioxidant herbs, may have the ability to postpone the onset of neurodegenerative diseases. This study investigates the possible therapeutic mechanism of hyperoside as a natural antioxidant against Alzheimer's disease (AD) in Caenorhabditis elegans and PC12 cells. Specifically, hyperoside reduced reactive oxygen species (ROS) level and A beta 42-induced neurotoxicity in C. elegans worms. Meanwhile, hyperoside reduced ROS production and increased mitochondrial membrane potentialin A beta 42-induced PC12 cells, which possibly due to the increase of antioxidant enzymes activity and the diminution of malondialdehyde levels. Hoechst 33,342 staining and flow cytometry analysis results suggested that hyperoside reverses cell apoptosis. Network pharmacology predicts potentially relevant hyperoside targets and pathways in AD therapy. As anticipated, hyperoside reversed A beta 42-stimulated downregulation of the PI3K/Akt/Nrf2/HO-1. The PI3K inhibitor LY294002 partially abolished the protective capability of hyperoside. The results of molecular docking further indicated that the PI3K/Akt pathways may be involved in the protection of A beta 42-induced PC12 cells by hyperoside treatment. The study provides theoretical information for research and development of hyperoside as an antioxidant dietary supplement.

关键词： Alzheimer's disease Hyperoside PC12 cells Apoptosis Oxidative stress

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Molecular profiling of core immune-escape genes highlights TNFAIP3 as an immune-related prognostic biomarker in neuroblastoma

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INFLAMMATION RESEARCH 2024年第9期73卷 1529-1545页

作者： Yang, Linyu Huang, Kai Cao, Lijian Ma, Yue Li, suwen Zhou, Jianwu Zhao, Zhenzhen wang, Shan Chongqing Med Univ Natl Clin Res Ctr Child Hlth & Disorders Dept Pediat Surg OncolChongqing Key Lab Pediat Me Minist EducKey Lab Child Dev & DisordersChildren Chongqing Peoples R China

BackgroundNeuroblastoma (NB) is the most prevalent and deadliest pediatric solid tumor. With of over 50% of high-risk neuroblastoma cases relapse, the imperative for novel drug targets and therapeutic strategies is accentuated. In neuroblastoma, the existence of tumor-associated macrophages (TAMs) correlates with an unfavorable patient prognosis. However, the clinical relevance and prognostic implications of regulatory genes linked to TAMs infiltration in neuroblastoma remain unclear, and further study is *** conducted a comprehensive analysis utilizing transcriptome expression profiles from three primary datasets associated with neuroblastoma (GSE45547, GSE49710, TARGET) to identify hub genes implicated in immune evasion within neuroblastoma. Subsequently, we utilized single-cell RNA sequencing analysis on 17 clinical neuroblastoma samples to investigate the expression and distribution of these hub genes, leading to the identification of TNFAIP3. The above three public databases were merged to allowed for the validation of TNFAIP3's molecular functions through GO and KEGG analysis. Furthermore, we assessed TNFAIP3's correlation with immune infiltration and its potential immunotherapeutic impact by multiple algorithms. Our single-cell transcriptome data revealed the role of TNFAIP3 in macrophage polarization. Finally, preliminary experimental verifications to confirm the biological functions of TNFAIP3-mediated TAMs in *** total of 6 genes related to immune evasion were screened and we found that TNFAIP3 exhibited notably higher expression in macrophages than other immune cell types, based on the scRNA-sequencing data. GO and KEGG analysis showed that low expression of TNFAIP3 significantly correlated with the activation of multiple oncogenic pathways as well as immune-related pathways. Then validation affirmed that individuals within the TNFAIP3 high-expression cohort could potentially derive greater advantages from immunotherapeutic interven

关键词： Neuroblastoma Macrophage TNFAIP3 Immune infiltration Tumor immune microenvironment

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Fatty acid binding protein 4 regulates doxorubicin-induced renal injury via mediating lipid metabolism and apoptosis

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CHEMICO-BIOLOGICAL INTERACTIONS 2025年 408卷 111419页

作者： wang, Chuchu Zhang, Tao Guan, Yufeng Han, Boye Wu, Shang wang, Xu Yu, Jing Zhang, Junxia Zhang, Guoqiang Miao, Qingfeng Su, suwen Hebei Med Univ Dept Pharmacol Key Lab Pharmacol & Toxicol New Drugs Key Lab Neural & Vasc BiolMinist Educ Shijiazhuang Peoples R China Hebei Med Univ Dept Intens Care Unit ICU Hosp 4 Shijiazhuang Hebei Peoples R China Hebei Med Univ Breast Ctr Hosp 4 Shijiazhuang Hebei Peoples R China Hebei Med Univ Sch Pharm Shijiazhuang 050017 Peoples R China Hebei Med Univ Dept Pharm Hosp 1 Shijiazhuang Peoples R China Hebei Hosp Tradit Chinese Med Dept Nephrol Shijiazhuang Hebei Peoples R China Hebei Med Univ Dept Dermatol Hosp 1 Shijiazhuang Hebei Peoples R China

Doxorubicin(DOX) is an anthracycline chemotherapeutic drug used in the treatment of a wide range of tumors. However, the nephrotoxicity has limited the clinical application of DOX. Fatty acid-binding protein 4 (FABP4), a key adipokine mainly expressed in adipocytes, is strongly associated with kidney dysfunction and kidney disease. This study aims to investigate the role of FABP4 in DOX-induced nephrotoxicity. In vivo experiments, the mice were divided into 4 groups randomly: CON group, DOX group, 4T1 group, and 4T1 + DOX group respectively. DOX was given by intraperitoneal injection at a dose of 15 mg/kg. The kidney function indicators, the morphology and lipid deposition in renal tissues and the preliminary mechanism were assessed. In vitro experiment, HK-2 cell was used to detect DOX-induced kidney cell injury with or without BMS309403. DOX caused renal dysfunction in both DOX group and 4T1 + DOX group, with a more severe kidney injury in DOX group. DOX also induced kidney lipid deposition, glycerophospholipids metabolism dysfunction, apoptosis accompanied by increased FABP4 and decreased Peroxisome Proliferator Activated Receptor- gamma (PPAR-gamma) levels in the kidney tissues. The decreased cell viability, increased apoptotic ratio, elevated protein levels of apoptosis and the lipid deposition caused by DOX were all alleviated by BMS309403. FABP4 mediated DOX induced kidney damage in normal mice and tumor-bearing mice by lipid metabolism disorders and cell apoptosis. This study may enhance the clinical management of DOX-induced kidney injury and provide new therapeutic targets and preventive strategies for the clinical application of DOX.

关键词： Doxorubicin Kidney damage FABP4 Lipid metabolisim Apoptosis Tumor-bearing animal

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An Efficient Hardware Design for Fast Implementation of HQC 36

An Efficient Hardware Design for Fast Implementation of HQC

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36th IEEE International System-on-Chip Conference (SOCC)

作者： Li, Chen Song, suwen Tian, Jing wang, Zhongfeng Koc, Cetin Kaya Nanjing Univ Sch Elect Sci & Engn Nanjing Peoples R China Univ Calif Santa Barbara Santa Barbara CA USA

ISBN: (纸本)9798350300116

Hamming Quasi-Cyclic (HQC), as a code-based Key Encapsulation Mechanism (KEM) algorithm, has been selected as one of the three code-based candidates in the fourth round of standardizing post-quantum cryptographic primitives. Efforts are needed for the efficient hardware implementation for HQC. However, in existing hardware designs for HQC, they cost too many clock cycles in the polynomial multiplication module and do not pay enough attention to the decoders used in the decryption. Therefore, this paper presents an improved hardware design for HQC. Through applying a low-latency polynomial multiplication design, every stage of our design saves amounts of clock cycles. Moreover, an efficient Reed-Solomon (RS) decoder based on the enhanced Parallel Inversionless Berlekamp-Massey (ePIBM) algorithm and a Reed-Muller (RM) decoder based on the Fast Hadamard Transform (FHT) algorithm are introduced to reduce the overhead in the decryption. A complete architecture is finally implemented on the Xilinx Artix 7 FPGA (xc7a200t-3). Experimental results show that the proposed design for the HQC-128 requires 25% less area-delay product (ADP) than the latest one in decryption. Furthermore, the proposed design can perform key generation in 0.11ms, encapsulation in 0.22ms, and decapsulation in 0.38 ms, which significantly outperforms the state-of-the-art design.

关键词： Post-quantum cryptography Hamming quasi-cyclic Reed-Solomon decoder Reed-Muller decoder hardware implementation

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Establishment of CFD-ANN-NSGA-II model for stirred reactor design

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CHEMICAL ENGINEERING SCIENCE 2025年 311卷

作者： Jiang, Zhou Chen, Jiajun Xie, suwen Li, Xingyan Liu, Huazong wang, Luyao Hong, Chen Li, Ganlu Li, Hui Chen, Kequan Nanjing Tech Univ Coll Biotechnol & Pharmaceut Engn State Key Lab Mat Oriented Chem Engn Nanjing 211816 Peoples R China Jiangxi Vocat Coll Appl Technol Ganzhou 342800 Peoples R China

Herein, the multiobjective optimization method based on the CFD-ANN-NSGA-II model is proposed to efficiently optimize the structural parameters of the stirred reactor, thereby improving its gas-liquid mass transfer efficiency and reducing its energy consumption. Coupling CFD simulations with the ANN-NSGA-II model enabled accurate performance predictions. The R2 values of the parameters epsilon, kLa, t, and P/V were 0.940, 0.989, 0.956, and 0.970, respectively, and their mean square error values were 0.0010, 0.0224, 0.0218, and 0.0521, respectively. The optimal reactor structural parameters were H/D = 2.16, d/D = 0.38, w/d = 0.50, and C1/D = 0.30. The epsilon and kLa values of the structure increased with optimization to 13.5 % and 0.171 s-1, respectively, while the t and P/V values decreased. The study describes an efficient and reliable theoretical method for the multiobjective optimization of chemical equipment, verifying the potential of adopting artificial intelligence in complex fluid system optimization, with important value for engineering applications.

关键词： Stirred reactor Computational fluid dynamics simulation Artificial neural network Genetic algorithm Volumetric mass transfer coefficient

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