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Interferon Regulatory Factor 4: An Alternative Marker for Plasma Cells in Daratumumab-Treated Patients With Multiple Myeloma

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INTERNATIONAL JOURNAL OF LABORATORY HEMATOLOGY 2025年第1期47卷 110-119页

作者： Yang, suwen Hu, Qianwen wang, Xiaofen Qiao, Sai Qi, Chao Jin, Hong Zhong, Yuhong Zhejiang Univ Sir Run Run Shaw Hosp Sch Med Clin Lab Hangzhou Zhejiang Peoples R China Key Lab Precis Med Diag & Monitoring Res Zhejiang Hangzhou Zhejiang Peoples R China

Introduction: Anti- CD38 therapeutic modalities (e.g., daratumumab) can impede classical CD38 and CD138 gating use for plasma cell (PC) detection in multiple myeloma (MM) patients with minimal residual disease (MRD). We assessed the applicability of CD229, CD269, and interferon regulatory factor (IRF- 4) for PC detection in MM MRD patients. Methods: Bone marrow samples were collected from patients with MM. Through multiparameter flow cytometry, we evaluated the suitability of CD229, CD269, and IRF- 4 for distinguishing PCs from other hematopoietic cells and compared their expression pattern on normal PCs (nPCs) and aberrant PCs (aPCs). We also assessed IRF- 4 expression stability after sample storage under different conditions. A 10- color MRD antibody panel was used to determine whether IRF- 4 is an alternative primary PC- gating marker for MM MRD assessment. Results: IRF- 4 was expressed specifically on all PCs;its mean fluorescence intensity (MFI) was highest on PCs among all hematopoietic cells. This MFI did not decrease even after sample storage at 4 degrees C or 25 degrees C for 72 h. In all 42 MRD assessment samples, except for samples (n n = 10) with no PCs, the use of IRF- 4 enabled accurate nPC (n n = 12), aPC (n n = 13), and nPC + aPC (n n = 7) identification. Even samples from daratumumab- treated patients had high IRF- 4 MFI, with no difference between pre- treatment and post- treatment (n n = 7;p = 0.610). Conclusions: IRF- 4 demonstrates high MFI on PCs, and it is not expressed on other leukocytes. In MM patients with MRD, daratumumab treatment does not affect IRF- 4 expression. IRF- 4 is a promising marker for PC identification in MRD assessment of MM patients undergoing anti- CD38 therapy.

关键词： daratumumab interferon regulatory factor 4 minimal residual disease multiparameter flow cytometry multiple myeloma

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Vertical-Space-Limit Synthesis of Bifunctional Fe, N-Codoped 2D Multilayer Graphene Electrocatalysts for Zn-Air Battery

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ENERGY TECHNOLOGY 2019年第6期7卷 1900123-1900123页

作者： wang, Chen Li, Zhongfang wang, Likai Lu, Xuewei wang, suwen Niu, Xueliang Shandong Univ Technol Sch Chem & Chem Engn Zibo 255049 Peoples R China

Developing a green, cost-efficient air-cathode catalyst with high oxygen evolution and reduction reaction (OER/ORR) performance for rechargeable Zn-air batteries (ZABs) has gained attention. Iron-containing nitrogen-doped graphene (Fe/N-G) that contains Fe-N-x coordination sites is prepared by pyrolyzing the complex of iron ion and PANI sheets intercalated with the unique layer gaps of H-montmorillonite nanoreactors. The transmission electron microscopy (TEM), X-ray diffraction (XRD), and X-ray photoelectron spectroscopy (XPS) analysis confirm that there are no crystalline materials, such as iron lattice, iron carbide, or iron nitride. The as-prepared Fe/N-G show a high electrocatalytic activity in ORR with a 4e(-) transfer process and the half-wave potential of Fe/N-G (0.877 V vs reversible hydrogen electrode-RHE), which is better than that of Pt/C in oxygen saturated 0.1 m KOH solution. In an acid electrolyte, the Fe/N-G possesses a half-wave potential similar to that of 20 wt% Pt/C. For OER, the Fe/N-G exhibits the overpotential of 400 mV versus RHE at 10 mA cm(-2). However, the Fe/N-G as the air-cathode of the homemade rechargeable ZABs exhibits a high power density (156.8 mW cm(-2)) and an excellent long discharge-charge cycling stability (787 cycles) at 20 mA cm(-2). This work provides an inspiring guideline to prepare a high-performance bifunctional air-cathode for a rechargeable ZAB.

关键词： bifunctional oxygen electrocatalysts Fe-N-doped graphene H-montmorillonite nanoreactors OER ORR Zn-air batteries

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Construction and expression of multi-stage antigen fusion protein RPC4 vaccine for Mycobacterium tuberculosis and its immunogenicity analysis in combination with adjuvant DIMQ

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TUBERCULOSIS 2025年 152卷 102635-102635页

作者： wang, Xiaochun Xu, Yun Zhong, Qiangsen Zhang, Zian Kong, LingYun Zhou, Mingming wang, Runlin Pi, Xinxin Qiao, suwen Anhui Univ Sci & Technol Affiliated Hosp 1 Huainan 232001 Peoples R China Anhui Univ Sci & Technol Sch Med Dept Pathogen Biol Huainan 232001 Peoples R China Anhui Univ Sci & Technol Sch Med Dept Immunol Huainan 232001 Peoples R China

Mycobacterium tuberculosis (M. tb) serves as the main pathogen responsible for Tuberculosis (TB). It predominantly targets the lungs and leads to a persistent infectious disease. The spread of drug-resistant tuberculosis and the exacerbation of economic burdens due to co-infections with Human Immunodeficiency Virus (HIV)/M. tb pose significant challenges in prevention and treatment. The BCG vaccine is currently the only approved (TB) vaccine, but its protective effect is limited for adults. In this research, we engineered the fusion protein gene RPC4, incorporating four crucial antigens from M. tb. The study revealed that the IFN-gamma levels in the peripheral blood of infected patients significantly surpassed those in healthy individuals. To assess the immune response of RPC4 as a BCG-enhanced vaccine following initial immunity, researchers administered it alongside the novel adjuvant DIMQ to immunize mice. Experiments revealed that the BCG + RPC4/DIMQ vaccine induces a substantial immunogenic response in the mice.

关键词： Fusion proteins Subunit vaccines Immunogenicity Mycobacterium tuberculosis

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CA3 Pyramidal Neuron Activation Promotes Cognitive Resilience to Inflammation-Induced Cognitive Inflexibility

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CNS NEUROSCIENCE & THERAPEUTICS 2025年第2期31卷 e70271页

作者： Zuo, Wenqiang Fang, suwen Xu, Tiantian Li, Yumeng Zhao, Jianshuai Xie, Xiaoyan wang, Taozhi Hou, Wugang wang, Minghui Fourth Mil Med Univ Xijing Hosp Dept Anesthesiol & Perioperat Med Xian Peoples R China

Aims Cognitive dysfunction represents a prominent symptom in numerous prevalent mental illnesses, with systemic inflammation induced by cytokines recognized as a critical factor contributing to cognitive impairments. However, a significant proportion of individuals exposed to systemic inflammation do not develop cognitive dysfunction;instead, they exhibit adaptive responses to this adverse condition. This study aims to investigate the neural activity patterns within the hippocampus and the potential mechanisms that mediate cognitive resilience, particularly in the context of inflammation. Methods We investigated the effects of systemic IL-1 beta (Interleukin-1 beta) on learning, spatial memory, and cognitive flexibility using the Barnes maze test (BMT). We further analyzed specific activity changes in the hippocampus of mice exhibiting cognitive resilience versus susceptibility through immunofluorescence, fiber photometry, and behavioral assessments. Additionally, we employed chemogenetic modulation to explore the role of dCA3 pyramidal neurons in cognitive inflexibility induced by systemic inflammation. Results Systemic inflammation induces cognitive inflexibility while leaving learning and memory intact. Notably, dCA3 activity was elevated in cognitively resilient mice compared to their susceptible counterparts. Fiber photometry data revealed higher activity in the dorsal CA3 (dCA3) when the mice approached the previous target quadrant during the reversal stage of BMT. Importantly, the activation of CaMKII+ pyramidal neurons in the dCA3 mitigated cognitive inflexibility induced by systemic IL-1 beta administration. Conclusions Activation of hippocampal dCA3 neurons, rather than dentate gyrus (DG) neurons, enhances cognitive resilience by improving cognitive flexibility during BMT-related paradigm shifting under sustained inflammation.

关键词： cognitive flexibility cognitive resilience cornu ammonis area 3 IL-1 beta systemic inflammation

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Three-Dimensional Graphene-Supported Cobalt Phthalocyanine as Advanced Electrocatalysts for Oxygen Reduction Reaction

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JOURNAL OF THE ELECTROCHEMICAL SOCIETY 2018年第2期165卷 F24-F31页

作者： Sun, Chongyun Li, Zhongfang Zhong, Xizhan wang, suwen Yin, Xiaoyan wang, Likai Shandong Univ Technol Sch Chem & Chem Engn Zibo 255049 Shandong Peoples R China

Cobalt phthalocyanine (CoPc) is supported on homemade three-dimensional graphene (3D-G) to prepare CoPc/3D-G catalysts used for oxygen reduction reaction (ORR). 3D-G is made from coal tar pitch with nano MgO as template and KOH as activation agent. Raman spectra indicate that 3D-G is multi-layered. Transmission electron microscopy images show that CoPc/3D-G retains the mesoporous foam structure of 3D-G and CoPc is dispersed homogeneously on the surface of 3D-G. CoPc/3D-G shows a half-wave potential of 0.85 V vs. RHE in oxygen-saturated solution of 0.1 M KOH, which is 50 mV higher than that of 6 wt% Pt/C. The electron transfer number of CoPc/3D-G is 3.99 at 0.65 V vs. RHE, indicating that oxygen reduction is catalyzed mainly via a four-electron process. CoPc/3D-G exhibits a current density loss of 10% after 40,000 s in chronoamperometry tests, while CoPc/C lost 17.5% after the same period. (C) 2018 The Electrochemical Society.

关键词： Magnesia

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Regulation of Perovskite Nucleation and Orientated Crystal Growth via In Situ Self-Crosslinking Polymer for Bright Perovskite Light-Emitting Diodes

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ADVANCED OPTICAL MATERIALS 2025年第11期13卷

作者： Cheng, suwen Zhang, Yupeng Chu, Ying wang, Yanchen Xie, Yuan Yu, Chen Dong, Jingjin Cao, Jiupeng wang, Fangfang Huang, Wei wang, Aifei Qin, Tianshi Nanjing Tech Univ Jiangsu Natl Synerget Innovat Ctr Adv Mat SICAM Key Lab Flexible Elect KLOFE Nanjing 211816 Jiangsu Peoples R China Nanjing Tech Univ Inst Adv Mat IAM Jiangsu Natl Synerget Innovat Ctr Adv Mat SICAM Nanjing 211816 Jiangsu Peoples R China Henan Inst Flexible Elect HIFE Zhengzhou 450046 Henan Peoples R China Sun Yat Sen Univ Sch Flexible Elect SoFE Shenzhen 510275 Guangdong Peoples R China Sun Yat Sen Univ State Key Lab Optoelect Mat & Technol OEMT Shenzhen 510275 Guangdong Peoples R China

Hybrid halide perovskite films are becoming increasingly efficient in various applications, but several challenges still remain to be overcome. In this study, thermally polymerized additive N-vinyl-2-pyrrolidone (NVP) is utilized to tune the crystallization and orientation of mixed organo-metal perovskite films. Using in situ spectroscopy, it is demonstrated that NVP plays a crucial role in prolonging the crystallization process and separating the nucleation and crystal growth by forming an NVP-precursor intermediate phase. Additionally, the intermediate adduct effectively passivates defects, reduces nonradiative recombination, improves crystallinity, and enhances the transmission of charge carriers. NVP-containing perovskite light-emitting diodes (PeLEDs) are subsequently developed that exhibit stable and bright green luminance exceeding 240 000 cd m-2. These findings provide valuable insights into manipulating the crystallization behavior of mixed organo-metal perovskite films.

关键词： hybrid halide perovskite films light-emitting diodes perovskite nucleation regulation perovskite orientation regulation self-crosslinking polymer

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Pre-Oxidized Acrylic Fiber Reinforced Ferric Sulfophenyl Phosphate-Doped Polybenzimidazole-Based High-Temperature Proton Exchange Membrane

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MACROMOLECULAR MATERIALS AND ENGINEERING 2017年第7期302卷 n/a-N.PAG页

作者： Sun, Peng Li, Zhongfang Jin, Lei Yang, Yangong wang, suwen Yin, Xiaoyan wang, Yuxin Shandong Univ Technol Sch Chem Engn Zibo 255049 Peoples R China Shandong Univ Technol Sch Mat Sci & Engn Zibo 255049 Peoples R China Tianjin Univ State Key Lab Chem Engn Sch Chem Engn Tianjin 300072 Peoples R China

Pre-oxidized acrylic fiber (POAF) and ferric sulfophenyl phosphate (FeSPP) are incorporated into polybenzimidazole (PBI) membrane for the first time to prepare high-temperature proton exchange membranes (PEMs). The strong hydrogen bonds formed between PBI/POAF and FeSPP lead to good dispersion of POAF and FeSPP, facilitate the construction of proton channels, and enhance the dimensional and mechanical stability of the membranes. PBI/FeSPP (30 wt%) shows good proton conductivity (5.43 x 10(-2) and 4.13 x 10(-2) S cm(-1) at 180 degrees C at 50% and 0 relative humidity (RH), respectively) and improved dimensional and mechanical stability compared with pristine PBI. By incorporating 5 wt% POAF into PBI/FeSPP (30 wt%), the swelling ratios are halved and the mechanical strength is enhanced by almost 30% while the proton conductivity is slightly affected (3.84 x 10(-2) and 2.97 x 10(-2) S cm(-1) at 180 degrees C at 50% and 0 RH for PBI/FeSPP (30 wt%)/POAF (5 wt%), respectively). This work offers a new route in the preparation of high-temperature PEMs with enhanced properties.

关键词： composites ion exchangers membranes polybenzimidazole pre-oxidized acrylic fiber

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Investigation of cell development and tissue structure network based on natural Language processing of scRNA-seq data

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JOURNAL OF TRANSLATIONAL MEDICINE 2025年第1期23卷 1-12页

作者： Wei, suwen Lu, Yuer wang, Peng Li, Qichao Shuai, Jianwei Zhao, Qi Lin, Hai Peng, Yuming Univ Chinese Acad Sci Wenzhou Inst Oujiang Lab Zhejiang Lab Regenerat Med Vis & Brain Hlth Wenzhou 325001 Zhejiang Peoples R China Wenzhou Med Univ Postgrad Training Base Alliance Wenzhou 325001 Zhejiang Peoples R China Univ Sci & Technol Liaoning Sch Comp Sci & Software Engn Anshan 114051 Peoples R China Cent Hosp Karamay Dept Gen Practice Karamay 834000 Xinjiang Peoples R China

BackgroundSingle-cell multi-omics technologies, particularly single-cell RNA sequencing (scRNA-seq), have revolutionized our understanding of cellular heterogeneity and development by providing insights into gene expression at the single-cell level. Investigating the influence of genes on cellular behavior is crucial for elucidating cell fate determination and differentiation, cell development processes, and disease *** by NLP, we present a novel scRNA-seq analysis method that treats genes as analogous to words. Using word2vec to embed gene sequences derived from gene networks, we generate vector representations of genes, which are then used to represent cells by summing gene vectors and subsequently tissues by aggregating cell *** NLP-based approach analyzes scRNA-seq data by generating vector representations of genes, cells, and tissues. This multi-scale analysis includes mapping cell states in vector space to reveal developmental trajectories, quantifying cell similarity using Euclidean distance, and constructing inter-tissue relationship networks from aggregated cell *** method offers a computationally efficient approach for analyzing scRNA-seq data by constructing embedding representations similar to those used in large language model pre-training, but without requiring high-performance computing clusters. By generating gene embeddings that capture functional relationships, this method facilitates the study of cell development trajectories, the impact of gene perturbations, cell clustering, and the construction and analysis of tissue networks. This provides a valuable tool for single-cell data analysis.

关键词： Single-cell RNA sequencing technology Natural Language processing Embedding Network structure

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Catena-Poly[[[diaqua(6-carboxypyridine2-carboxylato)holmium(III)]-μ-pyridine2,6-dicarboxylato]tetrahydrate]

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ACTA CRYSTALLOGRAPHICA SECTION E-CRYSTALLOGRAPHIC COMMUNICATIONS 2007年第9期63卷 M2438-U1704页

作者： Li, Zhongfang wang, suwen Zhang, Qian Yu, Xianjin Shandong Univ Technol Coll Chem Engn Zibo 255049 Peoples R China

The title compound, {[Ho(C7H3NO4)(C7H4NO4)(H2O)(2)]center dot 4H(2)O}(n), prepared by hydrothermal synthesis, is isostructural with its La-III-, Ce-III-, Pr-III-, Nd-III-, Sm-III-, Gd-III- and Tb-III- containing analogues. The Ho-III ion is nine-coordinated by four O and two N atoms from two independent pyridine-2,6-dicarboxylate groups, one carboxylate O atom belonging to a neighboring pyridine-2,6-dicarboxylate ligand and two water molecules. The bridging pyridine-2,6-dicarboxylate ligand gives rise to infinite chains. The crystal structure contains O-H center dot center dot center dot O hydrogen bonds, which connect the chains into a three-dimensional network.

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Poly[[aqua(2,2′-bipyridine)(μ₃-pyridine-3,4-dicarboxylato)nickel(II)] monohydrate]

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ACTA CRYSTALLOGRAPHICA SECTION E-CRYSTALLOGRAPHIC COMMUNICATIONS 2007年第10期63卷 M2604-U1574页

作者： Li, Zhongfang wang, suwen Zhang, Qian Yu, Xianjin Shandong Univ Technol Coll Chem Engn Zibo 250049 Peoples R China

The asymmetric unit of the title compound, {[Ni(C7H3NO4)(C10H8N2)(H2O)]·H2O}n, contains one nickel cation chelated by a 2,2′-bipyridine ligand and further coordinated by two monodentate carboxylate groups belonging to two independent pyridine-3,4-dicarboxylate ligands and one water molecule. The NiII atom is six-coordinate, exhibiting octahedral geometry with three N and three O atoms. Each pair of neighbouring NiII cations is bridged by two independent pyridine-3,4-dicarboxylate ligands, which are coordinated to two further NiII cations through pyridine N atoms to give corrugated layers parallel to the (110) plane. The coordinated and uncoordinated water molecules act as donors in O—H...O hydrogen bonds.

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