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检索条件"作者=Suwen Zhao"
368 条 记 录,以下是111-120 订阅
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Identification of an Underside Binding Site in Smoothened Receptor
Identification of an Underside Binding Site in Smoothened Re...
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第十一届全国化学生物学学术会议
作者: Fang Zhou Kang Ding Yiqing Zhou Yang Liu Youli Xiao suwen zhao Houchao Tao iHuman Institute ShanghaiTech University CAS Key Laboratory of Synthetic Biology Institute of Plant Physiology and EcologyShanghai Institutes for Biological SciencesChinese Academy of Sciences
An underside binding site was identified in the transmembrane domain of smoothened receptor(SMO) by a colocalization *** structurally complementary photoaffinity probes were designed by appending azide group at two en... 详细信息
来源: 评论
Salvianolic acids from antithrombotic Traditional Chinese Medicine Danshen are antagonists of human P2Y1 and P2Y12 receptors
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SCIENTIFIC REPORTS 2018年 第1期8卷 8084-8084页
作者: Liu, Xuyang Gao, Zhan-Guo Wu, Yiran Stevens, Raymond C. Jacobson, Kenneth A. zhao, suwen ShanghaiTech Univ iHuman Inst Shanghai 201210 Peoples R China ShanghaiTech Univ Sch Life Sci & Technol Shanghai 201210 Peoples R China Chinese Acad Sci Shanghai Inst Biol Sci CAS MPG Partner Inst Computat Biol Key Lab Computat Biol Shanghai 20031 Peoples R China Univ Chinese Acad Sci 19A Yuquan Rd Beijing 100049 Peoples R China NIDDK Mol Recognit Sect Lab Bioorgan Chem NIH Bethesda MD 20892 USA
Many hemorheologic Traditional Chinese Medicines (TCMs) that are widely-used clinically lack molecular mechanisms of action. We hypothesized that some of the active components of hemorheologic TCMs may function throug...
来源: 评论
A core epitope targeting antibody of SARS-CoV-2
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Protein & Cell 2023年 第1期14卷 74-78页
作者: Simeng zhao Fengjiang Liu Shizhen Qiu Qiaoshuai Lan Yiran Wu Wei Xu Junzi Ke Jie Yang Xiaoyan Liu Kun Wang Hangtian Guo Shuai Xia Fangfang Zhang Jiabei Wang Xiaowen Hu Lu Lu Shibo Jiang suwen zhao Lianxin Liu Youhua Xie Xiuna Yang Haopeng Wang Guisheng Zhong iHuman Institute ShanghaiTech UniversityShanghai 201210China Shanghai Institute for Advanced Immunochemical Studies ShanghaiTech UniversityShanghai 201210China Innovative Center for Pathogen Research Guangzhou LaboratoryGuangzhou 510005China School of Life Science and Technology ShanghaiTech UniversityShanghai 201210China Key Laboratory of Medical Molecular Virology(MOE/NHC/CAMS) School of Basic Medical Sciences and Biosafety Level 3 LaboratoryFudan UniversityShanghai 200032China Department of Hepatobiliary Surgery Anhui Province Key Laboratory of Hepatopancreatobiliary SurgeryThe First Affiliated Hospital of USTCDivision of Life Sciences and MedicineThe University of Science and Technology of ChinaHefei 230001China Department of Pulmonary and Critical Care Medicine Division of Life Sciences and MedicineThe First Affiliated Hospital of USTCThe University of Science and Technology of ChinaHefei 230026China Division of Life Sciences and Medicine The First Affiliated Hospital of USTCThe University of Sciences and Technology of ChinaHefei 230001China
Dear Editor,Tremendous efforts have been made globally to develop therapeutics and prophylactics against severe acute respiratory syndrome coronavirus-2(SARS-CoV-2)which has caused thousands of millions of infections ... 详细信息
来源: 评论
?406.4mm尾管悬挂技术在深水钻井中的应用
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石油钻采工艺 2015年 第1期37卷 103-106页
作者: 赵苏文 黄小龙 熊爱江 赵德 中海油能源发展股份有限公司工程技术深圳分公司 广东深圳518606
针对深水钻井水下井口系统的表层套管尺寸限制后续套管层次的问题,介绍了?406.4 mm超大尺寸尾管悬挂技术以及与其对应的注水泥工艺。悬挂装置由承载环和配套的悬挂器组成,承载环最大外径508 mm,最小内径445.8 mm,出厂前预制在?508 mm套... 详细信息
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Structural and Functional Evaluation of Decellularized Jellyfish Matrices for Cell Culture and Wound Repair
SSRN
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SSRN 2022年
作者: zhao, Jie Yu, Wenjun Zhang, Qi Li, Xiaojing zhao, suwen Huang, Yongjie Li, Tao Li, Yang Shan, Hong Guangdong Provincial Key Laboratory of Biomedical Imaging Guangdong Provincial Engineering Research Center of Molecular Imaging The Fifth Affiliated Hospital Sun Yat-sen University Zhuhai519000 China Department of Radiology The Fifth Affiliated Hospital Sun Yat-sen University Zhuhai519000 China Cardiac Surgery and Structural Heart Disease Unit of Cardiovascular Center The Fifth Affiliated Hospital Sun Yat-sen University Zhuhai519000 China Department of Interventional Medicine The Fifth Affiliated Hospital Sun Yat-sen University Zhuhai519000 China
Extracellular matrices decellularized from marine animal tissues are emerging scaffolds in tissue engineering. Jellyfish tissues are suitable for making functional and safe decellularized matrices thanks to their simp... 详细信息
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基于分片聚合编码的云存储策略的研究
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南开大学学报(自然科学版) 2014年 第2期47卷 1-8页
作者: 邵秀丽 许杨 赵素文 刘瑞琴 南开大学计算机与控制工程学院 天津300071 天津航海仪器研究所 天津300131
针对HDFS采用的完全复制存储方案会占据较多的存储空间,且对数据的恶意窃取和攻击缺少防御措施,提出了基于分片聚合编码的HDFS数据存储策略,其中采用STAR码对数据进行编码处理,产生编码数据片,然后通过聚合操作将每个数据段中位置相同... 详细信息
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H2B Lys34 Ubiquitination Induces Nucleosome Distortion to Stimulate Dot1L Activity
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NATURE CHEMICAL BIOLOGY 2022年 第9期18卷 972-+页
作者: Ai, Huasong Sun, Maoshen Liu, Aijun Sun, Zixian Liu, Tingting Cao, Lin Liang, Lujun Qu, Qian Li, Zichen Deng, Zhiheng Tong, Zebin Chu, Guochao Tian, Xiaolin Deng, Haiteng zhao, suwen Li, Jia-Bin Lou, Zhiyong Liu, Lei Tsinghua Univ Tsinghua Peking Joint Ctr Life Sci Dept Chem MOE Key Lab Bioorgan Phosphorus Chem & Chem Biol Beijing Peoples R China Tsinghua Univ Sch Life Sci MOE Key Lab Prot Sci Beijing Peoples R China Tsinghua Univ Sch Med Beijing Peoples R China Chinese Univ Hong Kong Sch Life & Hlth Sci Kobilka Inst Innovat Drug Discovery Shenzhen Guangdong Peoples R China ShanghaiTech Univ iHuman Inst Shanghai Peoples R China Nankai Univ Coll Life Sci State Key Lab Med Chem Biol Frontiers Sci Ctr Cell Response Tianjin Peoples R China Nankai Univ Coll Pharm Tianjin Peoples R China Tsinghua Univ Sch Life Sci MOE Key Lab Bioinformat Beijing Peoples R China ShanghaiTech Univ Sch Life Sci & Technol Shanghai Peoples R China Soochow Univ Coll Pharmaceut Sci Suzhou Peoples R China
Ubiquitination-dependent histone crosstalk plays critical roles in chromatin-associated processes and is highly associated with human diseases. Mechanism studies of the crosstalk have been of the central focus. Here o...
来源: 评论
Identification of natural products as novel ligands for the human 5-HT2C receptor
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Biophysics Reports 2018年 第1期4卷 50-61页
作者: Yao Peng Simeng zhao Yiran Wu Haijie Cao Yueming Xu Xiaoyan Liu Wenqing Shui Jianjun Cheng suwen zhao Ling Shen Jun Ma Ronald J.Quinn Raymond C.Stevens Guisheng Zhong Zhi-Jie Liu National Laboratory of Biomacromolecules Institute of BiophysicsChinese Academy of Sciences Institute of Molecular and Clinical Medicine Kunming Medical University iHuman Institute Shanghai Tech University University of Chinese Academy of Sciences School of Life Science and Technology Shanghai Tech University College of Pharmacy Nankai University High-throughput Molecular Drug Discovery Center Tianjin Joint Academy of Biotechnology and Medicine Eskitis Institute for Drug Discovery Griffith University
G protein-coupled receptors(GPCRs) constitute the largest human protein family with over 800 members,which are implicated in many important medical conditions. Serotonin receptors belong to the aminergic GPCR subfam... 详细信息
来源: 评论
Development of Yin-Yang Ligand for Cannabinoid Receptors
SSRN
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SSRN 2022年
作者: Qiu, Yanli zhao, Yitian Hu, Tao Yang, Meifang Li, Fei Li, Cuixia Gu, Weiliang Yang, Xiaodi zhao, suwen Tao, Houchao Shanghai Frontiers Science Center of TCM Chemical Biology Innovation Research Institute of Traditional Chinese Medicine Shanghai University of Traditional Chinese Medicine Shanghai201203 China iHuman Institute ShanghaiTech University Shanghai201210 China School of Life Science and Technology ShanghaiTech University Shanghai201210 China Department of pharmacology School of Pharmacy Shanghai University of Traditional Chinese Medicine China
Cannabinoid receptors (CBs), including CB1 and CB2, are the key components of a lipid signaling endocannabinoid system (ECS). Development of synthetic cannabinoids has been attractive to modulate ECS functions. CB1 an... 详细信息
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Structures of the human cholecystokinin receptors bound to agonists and antagonists
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NATURE CHEMICAL BIOLOGY 2021年 第12期17卷 1230-1237页
作者: Zhang, Xuefeng He, Chenglin Wang, Mu Zhou, Qingtong Yang, Dehua Zhu, Ya Feng, Wenbo Zhang, Hui Dai, Antao Chu, Xiaojing Wang, Jia Yang, Zhenlin Jiang, Yi Sensfuss, Ulrich Tan, Qiuxiang Han, Shuo Reedtz-Runge, Steffen Xu, H. Eric zhao, suwen Wang, Ming-Wei Wu, Beili zhao, Qiang Chinese Acad Sci Shanghai Inst Mat Med State Key Lab Drug Res Shanghai Peoples R China Chinese Acad Sci Shanghai Inst Mat Med CAS Key Lab Receptor Res Shanghai Peoples R China Univ Chinese Acad Sci Beijing Peoples R China Fudan Univ Sch Pharm Shanghai Peoples R China ShanghaiTech Univ Sch Life Sci & Technol Shanghai Peoples R China ShanghaiTech Univ iHuman Inst Shanghai Peoples R China Fudan Univ Sch Basic Med Sci Dept Pharmacol Shanghai Peoples R China Chinese Acad Sci Shanghai Inst Mat Med Natl Ctr Drug Screening Shanghai Peoples R China Novo Nordisk AS Malov Denmark Univ Chinese Acad Sci Hangzhou Inst Adv Study Sch Pharmaceut Sci & Technol Hangzhou Peoples R China Chinese Aacademy Sci Inst Drug Discovery Zhongshan Inst Drug Discovery Guangzhou Guangdong Peoples R China Chinese Aacademy Sci Inst Dev Zhongshan Inst Drug Discovery Guangzhou Guangdong Peoples R China
Cholecystokinin receptors, CCKAR and CCKBR, are important neurointestinal peptide hormone receptors and play a vital role in food intake and appetite regulation. Here, we report three crystal structures of the human C... 详细信息
来源: 评论