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The great gerbil (Rhombomys opimus) as a host for tick species in Gurbantunggut Desert

PARASITES & VECTORS 2024年第1期17卷 1页

作者： Liu, Gang Tan, Wenbo Wang, Huiqian Han, Xiaoshuang Hornok, Sandor zhao, Shanshan Mi, Ligu Wang, suwen Yang, Meihua Wang, Yuanzhi Shihezi Univ Sch Med Key Lab Prevent & Control Emerging Infect Dis & Pu XPCC Shihezi Peoples R China Univ Vet Med Dept Parasitol & Zool Budapest Hungary New Blood Sucking Parasites & Vector Borne Pathoge HUN REN UVMB Climate Change Budapest Hungary Shihezi Univ Coll Agr Dept Forest Xinjiang Uygur Autonomous Reg Shihezi Peoples R China

Background Rodents play an important role in the life cycle of ixodid and argasid ticks, particularly as hosts of larvae and nymphs. The great gerbil (Rhombomys opimus), the preferred prey item of several carnivores (e.g. the red fox and marbled polecat), is the dominant rodent species in the Gurbantunggut Desert in northwestern China. The aim of this study was to investigate tick species associated with different hosts in the habitat of great gerbils, including wildlife and livestock. Methods During 2018-2023, ticks were removed from 326 great gerbils, two red foxes (Vulpes vulpes), three marbled polecats (Vormela peregusna), 35 pastured sheep (Ovis aries), and one long-eared desert hedgehog (Hemiechinus auritus) in the Gurbantunggut Desert. Ticks were identified according to standard morphological keys. Then, they were further analyzed by molecular and phylogenic methods based on two mitochondrial markers, 16S rDNA and cytochrome c oxidase subunit I (COI) genes. Results A total of 889 ticks were collected, representing five species. These included Hyalomma asiaticum (n = 425: 24 larvae, 79 nymphs and 322 adults), Rhipicephalus turanicus (n = 153: 2 nymphs and 151 adults), Haemaphysalis erinacei (n = 298: 4 larvae, 7 nymphs and 287 adults), Ixodes acuminatus (n = 7: 4 nymphs and 3 adults) and Ornithodoros tartakovskyi (6 adults). Based on COI sequences, molecular and phylogenetic analyses showed that (i) I. acuminatus from great gerbils and marbled polecats clustered with I. acuminatus reported from Europe;(ii) O. tartakovskyi found in northwestern China belonged to an independent clade;(iii) Hy. asiaticum, R. turanicus and Ha. erinacei had 100% sequence identities to conspecific ticks sampled previously in China. Conclusions The great gerbil is an important host for the developmental stages of I. acuminatus, O. tartakovskyi, Ha. erinacei, Hy. asiaticum and R. turanicus, thus supporting the life cycle of several tick species which, as adults, parasitize predators (

关键词： Gurbantunggut desert Great gerbil Ticks Wild rodents

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Activation and Signaling Mechanism Revealed by Cannabinoid Receptor-Gi Complex Structures

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CELL 2020年第4期180卷 655-+页

作者： Hua, Tian Li, Xiaoting Wu, Lijie Iliopoulos-Tsoutsouvas, Christos Wang, Yuxia Wu, Meng Shen, Ling Brust, Christina A. Nikas, Spyros P. Song, Feng Song, Xiyong Yuan, Shuguang Sun, Qianqian Wu, Yiran Jiang, Shan Grim, Travis W. Benchama, Othman Stahl, Edward L. Zvonok, Nikolai zhao, suwen Bohn, Laura M. Makriyannis, Alexandros Liu, Zhi-Jie ShanghaiTech Univ iHuman Inst Shanghai 201210 Peoples R China Northeastern Univ Ctr Drug Discovery Boston MA 02115 USA Northeastern Univ Dept Pharmaceut Sci Boston MA 02115 USA ShanghaiTech Univ Sch Life Sci & Technol Shanghai 201210 Peoples R China Scripps Res Dept Mol Med Jupiter FL 33458 USA Scripps Res Dept Neurosci Jupiter FL 33458 USA Dezhou Univ Sch Life Sci Dezhou 253023 Shandong Peoples R China Kunming Med Univ Inst Mol & Clin Med Kunming 650500 Yunnan Peoples R China Chinese Acad Sci Shenzhen Inst Adv Technol Res Ctr Comp Aided Drug Discovery Shenzhen 518055 Peoples R China Northeastern Univ Dept Chem Boston MA 02115 USA Northeastern Univ Dept Biol Chem Boston MA 02115 USA

Human endocannabinoid systems modulate multiple physiological processes mainly through the activation of cannabinoid receptors CB1 and CB2. Their high sequence similarity, low agonist selectivity, and lack of activation and G protein-coupling knowledge have hindered the development of therapeutic applications. Importantly, missing structural information has significantly held back the development of promising CB2-selective agonist drugs for treating inflammatory and neuropathic pain without the psychoactivity of CB1. Here, we report the cryoelectron microscopy structures of synthetic cannabinoid-bound CB2 and CB1 in complex with G(i), as well as agonist-bound CB2 crystal structure. Of important scientific and therapeutic benefit, our results reveal a diverse activation and signaling mechanism, the structural basis of CB2-selective agonists design, and the unexpected interaction of cholesterol with CB1, suggestive of its endogenous allosteric modulating role.

关键词： G protein-coupled receptor cannabinoid receptors cryo-EM structures CB2-Gi crystal structure activation subtype selectivity allosteric modulation cholesterol

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Enhanced piezoelectric properties and thermal stability of BiFeO3-BaTiO3-based ceramics with local structural heterogeneity

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Ceramics International 2025年第14期51卷 18587-18596页

作者： Fang, Juan Mao, suwen Jiang, Minhong Zhou, Changrong Yu, Hongbao Rao, Guanghui zhao, Jingtai Han, Jin Hou, Long Sun, Kang Cheng, Shuai Guangxi Key Laboratory of Information Materials and Property for New Energy Materials Guilin University of Electronic Technology Guangxi Guilin541004 China School of Material Science and Engineering Guilin University of Electronic Technology Guangxi Guilin541004 China College of Material Science and Engineering Kunming University of Science and Technology Kunming650093 China School of Materials Science and Engineering Shanghai University Shanghai200444 China

Pb-free piezoceramics have been extensively studied as alternatives to commercial Pb-based ceramics because of environmental concerns. However, their intrinsic thermal degradation of piezoelectric properties limits their industrial applications. Herein, by designing a sandwich-structured BaTi0.93Sn0.07O3/0.75BiFeO3-0.25BaTiO3-0.1 wt%MnO2/BaTi0.93Sn0.07O3 (SWS-BFBT), we achieve significant improvements in piezoelectric properties and depolarization temperature (Td) by forming a heterogeneity on the surface of BFBT ceramics. The wide temperature range of phase boundaries and enhanced relaxor behavior resulting from the reduced domain size and the increased number of polar nanoregions (PNRs) are attained in the diffusion layer of the SWS-BFBT ceramic, thereby enhancing piezoelectricity and thermal stability with the synergistic effect of polar pinning by more defects collectively. Compared to the Td of BFBT ceramic below 300 °C, we have designed SWS-BFBT ceramics with a heterogeneity, which improves Td to 423 °C and piezoelectric constant (d33) to 137 pC/N. Furthermore, their d33 can still maintain above a value of 111 pC/N at temperatures below 423 °C. We believe our finding will contribute significantly to the design of high-temperature lead-free piezoelectric materials. © 2025

关键词： Piezoelectricity

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Determination of the melanocortin-4 receptor structure identifies Ca²⁺ as a cofactor for ligand binding

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SCIENCE 2020年第6489期368卷 428-+页

作者： Yu, Jing Gimenez, Luis E. Hernandez, Ciria C. Wu, Yiran Wein, Ariel H. Han, Gye Won McClary, Kyle Mittal, Sanraj R. Burdsall, Kylie Stauch, Benjamin Wu, Lijie Stevens, Sophia N. Peisley, Alys Williams, Savannah Y. Chen, Valerie Millhauser, Glenn L. zhao, suwen Cone, Roger D. Stevens, Raymond C. ShanghaiTech Univ IHuman Inst Shanghai 201210 Peoples R China ShanghaiTech Univ Sch Life Sci & Technol Shanghai 201210 Peoples R China Univ Chinese Acad Sci CAS Ctr Excellence Mol Cell Sci Shanghai Inst Biochem & Cell Biol Chinese Acad Sci Shanghai 200031 Peoples R China Univ Michigan Life Sci Inst Ann Arbor MI 48109 USA Univ Southern Calif Dept Biol Sci Bridge Inst USC Michelson Ctr Convergent Biosci Los Angeles CA 90089 USA Univ Southern Calif Dept Chem Bridge Inst USC Michelson Ctr Convergent Biosci Los Angeles CA 90089 USA Univ Calif Santa Cruz Dept Chem & Biochem Santa Cruz CA 95064 USA Univ Michigan Sch Med Dept Mol & Integrat Physiol Ann Arbor MI 48109 USA

The melanocortin-4 receptor (MC4R) is involved in energy homeostasis and is an important drug target for syndromic obesity. We report the structure of the antagonist SHU9119-bound human MC4R at 2.8-angstrom resolution. Ca2+ is identified as a cofactor that is complexed with residues from both the receptor and peptide ligand. Extracellular Ca2+ increases the affinity and potency of the endogenous agonist alpha-melanocyte-stimulating hormone at the MC4R by 37- and 600-fold, respectively. The ability of the MC4R crystallized construct to couple to ion channel Kir7.1, while lacking cyclic adenosine monophosphate stimulation, highlights a heterotrimeric GTP-binding protein (G protein)-independent mechanism for this signaling modality. MC4R is revealed as a structurally divergent G protein-coupled receptor (GPCR), with more similarity to lipidic GPCRs than to the homologous peptidic GPCRs.

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Structural characterization of different starch-fatty acid complexes and their effects on human intestinal microflora

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JOURNAL OF FOOD SCIENCE 2023年第8期88卷 3562-3576页

作者： Li, Dan Wang, Xin Wang, Jilite Wang, Mingchun Zhou, Jiaping Liu, suwen zhao, Juan Li, Jing Wang, Hao Tianjin Univ Sci & Technol TUST State Key Lab Food Nutr & Safety Tianjin Peoples R China Hetao Coll Dept Agr Bayannur Inner Mongolia Peoples R China Anhui Agr Univ Dept Food Sci & Engn Hefei Peoples R China Hebei Normal Univ Sci & Technol Coll Food Sci & Technol Qinhuangdao Hebei Peoples R China Tianjin Univ Sci & Technol TUST State Key Lab Food Nutr & Safety Tianjin 300457 Peoples R China Tianjin Univ Sci & Technol Res Ctr Modern Anal Technol Tianjin 300457 Peoples R China

Resistant starch type 5 (RS5), a starch-lipid complex, exhibited potential health benefits in blood glucose and insulin control due to the low digestibility. The effects of the crystalline structure of starch and chain length of fatty acid on the structure, in vitro digestibility, and fermentation ability in RS5 were investigated by compounding (maize, rice, wheat, potato, cassava, lotus, and ginkgo) of different debranched starches with 12-18C fatty acid (lauric, myristic, palmitic, and stearic acids), respectively. The complex showed a V-type structure, formed by lotus and ginkgo debranched starches, and fatty acid exhibited a higher short-range order and crystallinity, and lower in vitro digestibility than others due to the neat interior structure of more linear glucan chains. Furthermore, a fatty acid with 12C (lauric acid)-debranched starches complexes had the highest complex index among all complexes, which might be attributed to the activation energy required for complex formation increased with the lengthening of the lipid carbon chain. Therefore, the lotus starch-lauric acid complex (LS12) exhibited remarkable ability in intestinal flora fermentation to produce short-chain fatty acid (SCFAs), reducing intestinal pH, and creating a favorable environment for beneficial bacteria.

关键词： fecal fermentation in vitro digestion short-chain fatty acids starch-fatty acid complexes

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Correction to "A Novel G Protein-Biased and Subtype-Selective Agonist for a G Protein-Coupled Receptor Discovered from Screening Herbal Extracts"

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ACS central science 2020年第5期6卷 823-824页

作者： Bingjie Zhang Simeng zhao Dehua Yang Yiran Wu Ye Xin Haijie Cao Xi-Ping Huang Xiaoqing Cai Wen Sun Na Ye Yueming Xu Yao Peng suwen zhao Zhi-Jie Liu Guisheng Zhong Ming-Wei Wang Wenqing Shui

[This corrects the article DOI: 10.1021/acscentsci.9b01125.].

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Identification of an Underside Binding Site in Smoothened Receptor

Identification of an Underside Binding Site in Smoothened Re...

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第十一届全国化学生物学学术会议

作者： Fang Zhou Kang Ding Yiqing Zhou Yang Liu Youli Xiao suwen zhao Houchao Tao iHuman Institute ShanghaiTech University CAS Key Laboratory of Synthetic Biology Institute of Plant Physiology and EcologyShanghai Institutes for Biological SciencesChinese Academy of Sciences

An underside binding site was identified in the transmembrane domain of smoothened receptor(SMO) by a colocalization *** structurally complementary photoaffinity probes were designed by appending azide group at two ends of a known ligand *** on the comprehensive analysis of digestive MS data,the binding was determined which was further corroborated by docking and simulation *** key interactions include two pairs of hydrogen bonds,a stable cage involving several π-π interactions,and hydrophobic interaction between Allo-1 and its contacting *** results reveal the molecular base of Allo-1 binding and more importantly,the possible mechanism for its anti-drug resistance activity.

关键词： Smoothened receptor colocalization strategy binding site drug resistance

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Virus Disinfection from Environmental Water Sources Using Living Engineered Biofilm Materials

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ADVANCED SCIENCE 2020年第14期7卷 1903558页

作者： Pu, Jiahua Liu, Yi Zhang, Jicong An, Bolin Li, Yingfeng Wang, Xinyu Din, Kang Qin, Chong Li, Ke Cui, Mengkui Liu, Suying Huang, Yuanyuan Wang, Yanyi Lv, Yanan Huang, Jiaofang Cui, Zongqiang zhao, suwen Zhong, Chao ShanghaiTech Univ Sch Phys Sci & Technol Mat & Phys Biol Div Shanghai 201210 Peoples R China ShanghaiTech Univ iHuman Inst Shanghai 201210 Peoples R China ShanghaiTech Univ Sch Life Sci & Technol Shanghai 201210 Peoples R China Chinese Acad Sci Wuhan Inst Virol State Key Lab Virol Wuhan 430071 Peoples R China Wuxi Biol Co Ltd Suzhou 215100 Peoples R China Chinese Acad Sci Shanghai Inst Appl Phys Shanghai 201800 Peoples R China Chinese Acad Sci Mat Synthet Biol Ctr Shenzhen Inst Synthet Biol Shenzhen Inst Adv Technol Shenzhen 518055 Peoples R China Chinese Acad Sci Shenzhen Inst Synthet Biol Shenzhen Inst Adv Technol CAS Key Lab Quantitat Engn Biol Shenzhen 518055 Guangdong Peoples R China

Waterborne viruses frequently cause disease outbreaks and existing strategies to remove such viral pathogens often involve harsh or energy-consuming water treatment processes. Here, a simple, efficient, and environmentally friendly approach is reported to achieve highly selective disinfection of specific viruses with living engineered biofilm materials. As a proof-of-concept, Escherichia coli biofilm matrix protein CsgA was initially genetically fused with the influenza-virus-binding peptide (C5). The resultant engineered living biofilms could correspondingly capture virus particles directly from aqueous solutions, disinfecting samples to a level below the limit-of-detection for a qPCR-based detection assay. By exploiting the surface-adherence properties of biofilms, it is further shown that polypropylene filler materials colonized by the CsgA-C5 biofilms can be utilized to disinfect river water samples with influenza titers as high as 1 x 10(7) PFU L-1. Additionally, a suicide gene circuit is designed and applied in the engineered strain that strictly limits the growth of bacterial, therefore providing a viable route to reduce potential risks confronted with the use of genetically modified organisms. The study thus illustrates that engineered biofilms can be harvested for the disinfection of pathogens from environmental water samples in a controlled manner and highlights the unique biology-only properties of living substances for material applications.

关键词： engineered biofilms living materials water disinfection

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Corrigendum "Evaluation of chemical cross-linkers for in-depth structural analysis of G protein-coupled receptors through cross-linking mass spectrometry" [Analytica Chimica Acta 1102 (2020) 53-62]

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Analytica chimica acta 2021年 1165卷 338471页

作者： Lisha Xia Ziliang Ma Jiahui Tong Yuliang Tang Shanshan Li Shanshan Qin Ronghui Lou suwen zhao Xiaoguang Lei Wenqing Shui iHuman Institute ShanghaiTech University 201210 Shanghai China School of Life Science and Technology ShanghaiTech University 201210 Shanghai China CAS Center for Excellence in Molecular Cell Science Shanghai Institute of Biochemistry and Cell Biology Chinese Academy of Sciences Shanghai 200031 China University of Chinese Academy of Sciences Beijing 100049 China. School of Life Science and Technology ShanghaiTech University 201210 Shanghai China. Beijing National Laboratory for Molecular Sciences Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education Department of Chemical Biology College of Chemistry and Molecular Engineering Synthetic and Functional Biomolecules Center And Peking-Tsinghua Center for Life Sciences Peking University Beijing 10087 China. iHuman Institute ShanghaiTech University 201210 Shanghai China. Beijing National Laboratory for Molecular Sciences Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education Department of Chemical Biology College of Chemistry and Molecular Engineering Synthetic and Functional Biomolecules Center And Peking-Tsinghua Center for Life Sciences Peking University Beijing 10087 China. Electronic address: xglei@***. School of Life Science and Technology ShanghaiTech University 201210 Shanghai China. Electronic address: shuiwq@***.

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Genetic Diversity, Antibiotic Resistance, and Virulence Gene Features of Methicillin-Resistant Staphylococcus aureus Epidemics in Guiyang, Southwest China

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INFECTION AND DRUG RESISTANCE 2022年 15卷 7189-7206页

作者： Yang, suwen Wang, Bing Li, Jing zhao, Xue Zhu, Yan Sun, Qian Liu, HongMei Wen, XiaoJun Guizhou Med Univ Sch Basic Med Sci Basic Med Sch Guiyang 550025 Peoples R China Guizhou Med Univ Engn Res Med Biotechnol Guiyang 550025 Guizhou Peoples R China Peoples Hosp Kaiyang Guiyang 550300 Peoples R China Guizhou Med Univ Key Lab Biol & Med Engn Guiyang 550025 Guizhou Peoples R China Guizhou Med Univ Sch Biol & Engn Guiyang 550025 Guizhou Peoples R China Guizhou Med Univ Affiliated Hosp 1 Dept Microbial Immunol Guiyang 550004 Peoples R China First Peoples Hosp Dept Clin Lab Guiyang 550002 Peoples R China Fourth Peoples Hosp Guiyang Dept Clin Lab Guiyang 550002 Peoples R China First Peoples Hosp Guiyang Dept Emergency Med Guiyang 550002 Peoples R China Guizhou Med Univ Guiyang 550025 Peoples R China

Purpose: Methicillin-resistant Staphylococcus aureus (MRSA) is one of the most common pathogens of community-and hospital-acquired infections, and its prevalence is increasing globally. Guiyang is the capital city of Guizhou Province, Southwest China;as the transport and tourism centre of Southwest China, Guizhou Province is bordered by Yunnan, Sichuan, Chongqing, and Guangxi Provinces. Although MRSA prevalence is increasing, little is known about its aspects in the area. The purpose of this study was to analyse MRSA molecular characteristics, antimicrobial resistance, and virulence genes in ***: In total, 209 MRSA isolates from four hospitals (2019-2020) were collected and analysed by antimicrobial susceptibility testing and molecular classification by the MLST, spa, and SCCmec typing methods. Isolate antibiotic resistance rates were detected by a drug susceptibility assays. PCR amplification was used to detect the virulence gene-carrying ***: Twenty-four STs, including 4 new STs (ST7346, ST7347, ST7348, and ST7247) and 3 new allelic mutations, were identified based on MLST. The major prevalent ST type and clone complex were ST59 (49.8%) and CC59 (62.7%), respectively. Spa type t437 (42.1%) and SCCmec IV (55.5%) were identified by spa and SCCmec typing methods as the most important types. Drug sensitivity data showed that the multidrug resistance rate was 79.0%. There were significant differences in multidrug resistance rates and virulence gene-carrying rates for seb, hla, hlb, cna and bap between ST59 and non-ST59 ***: ST59-SCCmecIV-t437 is a major epidemic clone in Guiyang that should be monitored by local medical and health institutions. The situation differs from other adjacent or middle provinces of China, which may be due to the special geographical location of the region and the trend in antibiotic use or lifestyle. This study provides empirical evidence for local medical and health departments to prevent and control the s

关键词： methicillin-resistant Staphylococcus aureus MRSA multilocus sequence type MLST Staphylococcal protein A type SPA Staphylococcal chromosomal cassette mec type SCCmec multidrug-resistant organism virulence gene

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