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Elucidating Synergies of Single-Atom Catalysts in a Model Thin Film Photoelectrocatalyst to Maximize Hydrogen Evolution Reaction

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ADVANCED SCIENCE 2024年第41期11卷 e2407598页

作者： zhao, Zichu Law, Cheryl suwen zhao, Yanzhang Jaimez, Jairo Alberto Baron Talebian-Kiakalaieh, Amin Li, Haobo Ran, Jingrun Jiao, Yan Abell, Andrew D. Santos, Abel Univ Adelaide Sch Chem Engn Adelaide SA 5005 Australia Univ Adelaide Inst Photon & Adv Sensing IPAS Adelaide SA 5005 Australia Univ Adelaide Dept Chem Adelaide SA 5005 Australia

Realization of the full potential of single-atom photoelectrocatalysts in sustainable energy generation requires careful consideration of the design of the host material. Here, a comprehensive methodology for the rational design of photoelectrocatalysts using anodic titanium dioxide (TiO2) nanofilm as a model platform is presented. The properties of these nanofilms are precisely engineered to elucidate synergies across structural, chemical, optoelectronic, and electrochemical properties to maximize the efficiency of the hydrogen evolution reaction (HER). These findings clearly demonstrate that thicker TiO2 nanofilms in anatase phase with pits on the surface can accommodate single-atom platinum catalysts in an optimal configuration to increase HER performance. It is also evident that the electrolyte temperature can further enhance HER output through thermochemical effect. A judicious design incorporating all these factors into one system gives rise to a ten-fold HER enhancement. However, the reusability of the host photoelectrocatalyst is limited by the leaching of the Pt atom, worsening HER. Density-functional theory calculations have provided insights into the mechanism underlying the experimental observations in terms of moderate hydrogen adsorption and enhanced gas generation. This improved understanding of the critical factors determining HER performance in a model photoelectrocatalyst paves the way for future advances in scalable and translatable photoelectrocatalyst technologies. Creating a rationale toward the design of high-performing single-atom photoelectrocatalysts. Synergistic effects combining thickness, morphology, crystallographic phase, quantity of single-atom catalyst, and electrolyte temperature are harnessed as a design approach to maximize hydrogen evolution reaction efficiency. A mechanistic framework to describe these phenomena is also developed. image

关键词： hydrogen evolution reactions materials design semiconductor thin films single atom photoelectrocatalysts

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Author Correction: Salvianolic acids from antithrombotic Traditional Chinese Medicine Danshen are antagonists of human P2Y1 and P2Y12 receptors

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Scientific reports 2018年第1期8卷 11380页

作者： Xuyang Liu Zhan-Guo Gao Yiran Wu Raymond C Stevens Kenneth A Jacobson suwen zhao iHuman Institute ShanghaiTech University Shanghai 201210 China. School of Life Science and Technology ShanghaiTech University Shanghai 201210 China. Key Laboratory of Computational Biology CAS-MPG Partner Institute for Computational Biology Shanghai Institutes for Biological Sciences Chinese Academy of Sciences Shanghai 20031 China. University of Chinese Academy of Sciences No. 19A Yuquan Road Beijing 100049 China. Molecular Recognition Section Laboratory of Bioorganic Chemistry National Institute of Diabetes and Digestive and Kidney Diseases National Institutes of Health Bethesda Maryland 20892 USA. iHuman Institute ShanghaiTech University Shanghai 201210 China. zhaosw@***. School of Life Science and Technology ShanghaiTech University Shanghai 201210 China. zhaosw@***.

A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has not been fixed in the paper.

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Exploring the Mutational Robustness of Nucleic Acids by Searching Genotype Neighborhoods in Sequence Space

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JOURNAL OF PHYSICAL CHEMISTRY LETTERS 2017年第2期8卷 407-414页

作者： Zhou, Qingtong Sun, Xianbao Xia, Xiaole Fan, Zhou Luo, zhaofeng zhao, suwen Shakhnovich, Eugene Liang, Haojun ShanghaiTech Univ iHuman Inst Shanghai 201210 Peoples R China Univ Sci & Technol China Collaborat Innovat Ctr Chem Energy Mat Hefei Natl Lab Phys Sci Microscale CAS Key Lab Soft Matter ChemDept Polymer Sci & E Hefei 230026 Anhui Peoples R China Jiangnan Univ Sch Biotechnol Key Lab Ind Biotechnol Minist Educ Wuxi 214122 Jiangsu Peoples R China Chinese Acad Sci CAS MPG Partner Inst Computat Biol Max Planck Independent Res Grp Populat Genom Key Lab Computat BiolShanghai Inst Biol Sci Shanghai 200031 Peoples R China Univ Chinese Acad Sci Beijing 100049 Peoples R China ShanghaiTech Univ Sch Life Sci & Technol Shanghai 201210 Peoples R China Univ Sci & Technol China Sch Life Sci Hefei 230026 Anhui Peoples R China Harvard Univ Dept Chem & Chem Biol Cambridge MA 02138 USA

To assess the mutational robustness of nucleic acids, many genome- and protein-level studies have been performed, where nucleic acids are treated as genetic information carriers and transferrers. However, the molecular mechanisms through which mutations alter the structural, dynamic, and functional properties of nucleic acids are poorly understood. Here we performed a SELEX in silico study to investigate the fitness distribution of the L-Arm-binding aptamer genotype neighborhoods. Two novel functional genotype neighborhoods were isolated and experimentally verified to have comparable fitness as the wild-type. The experimental aptamer fitness landscape suggests the mutational robustness is strongly influenced by the local base environment and ligand-binding mode, whereas bases distant from the binding pocket provide potential evolutionary pathways to approach the global fitness maximum. Our work provides an example of successful application of SELEX in silico to optimize an aptamer and demonstrates the strong sensitivity of mutational robustness to the site of genetic variation.

关键词： Free energy Nucleic acids Peptides and proteins Ligands Genetics

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Taenia laticollis and a potentially novel Taenia species from the Eurasian lynx (Lynx) in Northwestern China

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INTERNATIONAL JOURNAL FOR PARASITOLOGY-PARASITES AND WILDLIFE 2021年 16卷 183-186页

作者： Liu, Gang zhao, Shanshan Hornok, Sandor Chen, Xueling Wang, suwen Tan, Wenbo Gu, Xinli Wang, Yuanzhi Shihezi Univ Sch Med Dept Basic Med Shihezi Xinjiang Uygur Peoples R China Univ Vet Med Dept Parasitol & Zool Budapest Hungary Shihezi Univ Coll Anim & Sci Dept Vet Med Shihezi Xinjiang Uygur Peoples R China Shihezi Univ Sch Med Affiliated Hosp 1 NHC Key Lab Prevent & Treatment Cent Asia High In Shihezi City Xinjiang Uygur Peoples R China

The Eurasian lynx (Lynx) is a medium-sized wild cat species distributed throughout Eurasia. There has been no report on Taenia species (Cestoda: Cyclophyllidea) infecting this felid in China. In this study, 24 tapeworms were found in two Eurasian lynxes (#1 and #2) in Xinjiang Uygur Autonomous Region (XUAR), northwestern China. Based on the number, measurements and the shape of rostellar hooks, these tapeworms belong to two Taenia species. According to the number (n = 32) and length (185-194 mu m) of small hooks, the first Taenia species (n = 1, found in #2 lynx) was identified as Taenia laticollis. Phylogenetically, this species was clustered with T. laticollis genotype C (JX860623) based on its cytochrome c oxidase subunit 1 (cox1) and 16S rDNA sequences. The second Taenia species (n = 23, provisionally named as "Taenia sp.") may represent a potentially novel tapeworm species, because of its obvious differences in the shape and lengths (174-182 mu m, 98-113 mu m) of large and small rostellar hooks in comparison with ten taxonomically related species. Molecular and phylogenetic analyses of the cox1 gene revealed that "Taenia sp." has the highest rate of sequence identity (92.93%, 368/396 bp) with Taenia hydatigena reported from sheep (Ovis aries) in Slovakia. To sum up, a potentially novel tapeworm species, "Taenia sp.", is found in Eurasian lynx. In addition, T. laticollis was found for the first time in China.

关键词： Cestoda Tapeworms Cyclophyllidea Taeniidae cox1

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Effect of the mRNA decapping enzyme scavenger (DCPS) inhibitor RG3039 on glioblastoma

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JOURNAL OF TRANSLATIONAL MEDICINE 2024年第1期22卷 880页

作者： Duan, Hao Xie, Yuan Wu, suwen zhao, Guangyin Zeng, Zhen Hu, Hongrong Yu, Yanjiao Hu, Wanming Yang, Yuanzhong Chen, Yukun Xie, Haoqun Chen, Zexin Zhang, Gao Flaherty, Keith T. Hu, Shanshan Xu, Haineng Ma, Wenjuan Mou, Yonggao Sun Yat sen Univ Guangdong Prov Clin Res Ctr Canc Dept Neurosurg Neurooncol State Key Lab Oncol South ChinaCanc Ctr Guangzhou Peoples R China Sun Yat sen Univ Guangdong Prov Clin Res Ctr Canc Dept Thorac Surg State Key Lab Oncol South ChinaCanc Ctr Guangzhou Peoples R China Sun Yat Sen Univ Affiliated Hosp Sun Yat 1 Expt Anim Ctr Guangzhou Peoples R China Sichuan Univ West China Hosp Inst Thorac Oncol Dept Thorac Surg Chengdu 610041 Peoples R China Sun Yat sen Univ Guangdong Prov Clin Res Ctr Canc Dept Pathol State Key Lab Oncol South China Guangzhou Peoples R China Sun Yat sen Univ Guangdong Prov Clin Res Ctr Canc Dept Med Oncol State Key Lab Oncol South ChinaCanc Ctr Guangzhou Peoples R China Guangdong Res Ctr Organoid Engn & Technol Guangzhou Peoples R China Univ Hong Kong Fac Dent Hong Kong Peoples R China Harvard Med Sch Massachusetts Gen Hosp Massachusetts Gen Hosp Canc Ctr Dept Med Boston MA USA Rutgers State Univ Dept Stat New Brunswick NJ USA Univ Penn Ovarian Canc Res Ctr Dept Obstet & Gynecol Div Gynecol OncolPerelman Sch Med Philadelphia PA 19104 USA Sun Yat sen Univ Guangdong Prov Clin Res Ctr Canc Intens Care Unit State Key Lab Oncol South ChinaCanc Ctr Guangzhou Peoples R China

BackgroundPatients with glioblastoma (GBM) have a poor prognosis and limited treatment options. The mRNA decapping enzyme scavenger (DCPS) is a cap-hydrolyzing enzyme. The DCPS inhibitor RG3039 exhibited excellent central nervous system bioavailability in vivo and was safe and well tolerated in healthy volunteers in a phase 1 clinical trial. In this study, we investigated the expression of DCPS in GBM and the anti-tumor activity of RG3039 in various preclinical models of *** expression was examined in human GBM and paired peritumoral tissues. Its prognostic role was evaluated together with clinicopathological characteristics of patients. The anti-GBM effect of RG3039 was determined using GBM cell lines, patient-derived organoids, and orthotopic mouse models. The therapeutic mechanisms of DCPS inhibition were *** is overexpressed in GBM and is associated with poor survival of patients with GBM. The DCPS inhibitor RG3039 exhibited robust anti-GBM activities in GBM cell lines, patient-derived organoids and orthotopic mouse models, with drug exposure achievable in humans. Mechanistically, RG3039 downregulated STAT5B expression, thereby suppressing proliferation, survival and colony formation of GBM *** is a promising target for GBM. Inhibition of DCPS with RG3039 at doses achievable in humans downregulates STAT5B expression and reduces proliferation, survival and colony formation of GBM cells. Given the excellent anti-cancer activity and central nervous system bioavailability in vivo and good tolerance in humans, RG3039 warrants further study as a potential GBM therapy.

关键词： Glioblastoma DCPS RG3039 STAT5B

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Lasing from Narrow Bandwidth Light-Emitting One-Dimensional Nanoporous Photonic Crystals

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ACS PHOTONICS 2022年第4期9卷 1226-1239页

作者： Gunenthiran, Satyathiran Wang, Juan zhao, Wanxia Law, Cheryl suwen Lim, Siew Yee McInnes, Jamie A. Ebendorff-Heidepriem, Heike Abell, Andrew D. Alwahabi, Zeyad T. Santos, Abel Univ Adelaide Sch Chem Engn & Adv Mat Adelaide SA 5005 Australia Univ Adelaide Inst Photon & Adv Sensing Adelaide SA 5005 Australia Monash Univ Monash Inst Pharmaceut Sci Parkville Vic 3052 Australia Univ Adelaide Dept Chem Adelaide SA 5005 Australia

Nanoporous anodic alumina (NAA) is an emerging platform material for photonics and light-based applications. However, demonstrations of narrow bandwidth lasing emissions from this optical material remain limited. Here, we demonstrate that narrow bandwidth NAA-based gradient-index filters (NAA-GIFs) can be optically engineered to achieve high-quality visible lasing. NAA-GIFs fabricated by a modified sinusoidal pulse anodization approach feature a well-resolved, intense, high-quality photonic stopband (PSB). The inner surface of NAA-GIFs is functionalized with rhodamine B (RhoB) fluorophore molecules through micellar solubilization of sodium dodecyl sulfate (SDS) surfactant. Systematic variation of the ratio of SDS and RhoB enables the precise engineering of the light-emitting functional layer to maximize light-driven lasing associated with the slow photon effect at the red edge of NAA-GIFs' PSB. It is found that the optimal surfactant-to-fluorophore ratio, namely, 20 mM SDS to 0.81 mM RhoB, results in a strong, polarized lasing at similar to 612 nm. This lasing was characterized by a remarkably high-quality-gain product of similar to 536, a Purcell factor of 2.2, a lasing threshold of similar to 0.15 mJ per pulse, and a high-quality polarization ratio of similar to 0.7. Our results benefit the advancement of the NAA-based lasing technology for a variety of photonic disciplines such as sensing, tweezing, light harvesting, and photodetection.

关键词： laser emission nanoporous photonic crystals fluorophore functionalization photonic engineering

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E2F2 is upregulated by the ERK pathway and regulates decidualization via MCM4

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GENE 2023年第1期871卷 147400页

作者： Zheng, Wenling zhao, Shanfei He, Hong Gu, Xinru Long, Guanyun Chen, Xiaowen Liang, Guanglin Li, suwen Maoming Peoples Hosp Maoming Peoples R China

Cell cycle modulation is an important event during decidualization. E2F2 is a transcription regulator that plays a vital role in cell cycle regulation. However, the biological role of E2F2 in decidualization has not yet been identified. In this study, estrogen (E2) and progestin (P4)-induced in vitro and in vivo decidualization models were applied. Our data showed that the expression levels of E2F2 and its downstream target MCM4 were downregulated in the uterus tissues of E2P4-treated mice compared with control mice. In hESCs, exposure to E2P4 resulted in a significant decrease in E2F2 and MCM4 expression. E2P4 treatment reduced hESC prolifer-ation and ectopic expression of E2F2 or MCM4 elevated the viability of E2P4-treated hESCs. In addition, ectopic expression of E2F2 or MCM4 restored the expression of G1 phase-associated proteins. The ERK pathway was inactivated in E2P4-treated hESCs. Treatment with ERK agonist Ro 67-7476 restored the expression of E2F2, MCM4, and G1 phase-associated proteins that were inhibited by E2P4. Moreover, Ro 67-7476 retracted the levels of IGFBP1 and PRL that were induced by E2P4. Collectively, our results indicate that E2F2 is regulated by ERK signaling and contributes to decidualization via regulation of MCM4. Therefore, E2F2/MCM4 cascade may serve as promising targets for alleviating decidualization dysfunction.

关键词： Stromal cells Decidualization MCM4 ERK

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Structural insights into the committed step of bacterial phospholipid biosynthesis

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NATURE COMMUNICATIONS 2017年第1期8卷 1691页

作者： Li, Zhenjian Tang, Yannan Wu, Yiran zhao, suwen Bao, Juan Luo, Yitian Li, Dianfan Chinese Acad Sci Shanghai Inst Biochem & Cell Biol Ctr Excellence Mol Cell Sci Natl Ctr Prot Sci ShanghaiState Key Lab Mol Biol 333 Haike Rd Shanghai 201210 Peoples R China Univ Chinese Acad Sci Shanghai 201210 Peoples R China ShanghaiTech Univ iHuman Inst 333 Middle Huaxia Rd Shanghai 201210 Peoples R China ShanghaiTech Univ Sch Life Sci & Technol 333 Middle Huaxia Rd Shanghai 201210 Peoples R China

The membrane-integral glycerol 3-phosphate (G3P) acyltransferase PlsY catalyses the committed and essential step in bacterial phospholipid biosynthesis by acylation of G3P, forming lysophosphatidic acid. It contains no known acyltransferase motifs, lacks eukaryotic homologs, and uses the unusual acyl-phosphate as acyl donor, as opposed to acyl-CoA or acyl-carrier protein for other acyltransferases. Previous studies have identified several PlsY inhibitors as potential antimicrobials. Here we determine the crystal structure of PlsY at 1.48 angstrom resolution, revealing a seven-transmembrane helix fold. Four additional substrate-and product-bound structures uncover the atomic details of its relatively inflexible active site. Structure and mutagenesis suggest a different acylation mechanism of 'substrate-assisted catalysis' that, unlike other acyltransferases, does not require a proteinaceous catalytic base to complete. The structure data and a high-throughput enzymatic assay developed in this work should prove useful for virtual and experimental screening of inhibitors against this vital bacterial enzyme.

关键词： Nanocrystallography Phospholipids

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Crystal Structure of the Human Cannabinoid Receptor CB2

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CELL 2019年第3期176卷 459-+页

作者： Li, Xiaoting Hua, Tian Vemuri, Kiran Ho, Jo-Hao Wu, Yiran Wu, Lijie Popov, Petr Benchama, Othman Zvonok, Nikolai Locke, K'ara Qu, Lu Han, Gye Won Iyer, Malliga R. Cinar, Resat Coffey, Nathan J. Wang, Jingjing Wu, Meng Katritch, Vsevolod zhao, suwen Kunos, George Bohn, Laura M. Makriyannis, Alexandros Stevens, Raymond C. Liu, Zhi-Jie ShanghaiTech Univ iHuman Inst Shanghai 201210 Peoples R China ShanghaiTech Univ Sch Life Sci & Technol Shanghai 201210 Peoples R China Chinese Acad Sci Shanghai Inst Biol Sci Inst Biochem & Cell Biol Shanghai Peoples R China Univ Chinese Acad Sci Beijing 100049 Peoples R China Northeastern Univ Dept Chem & Chem Biol Ctr Drug Discovery Boston MA 02115 USA Northeastern Univ Dept Pharmaceut Sci Boston MA 02115 USA Scripps Res Dept Mol Med Jupiter FL 33458 USA Univ Southern Calif Bridge Inst Dept Biol Sci Los Angeles CA 90089 USA NIAAA Lab Physiol Studies NIH Bethesda MD 20892 USA Moscow Inst Phys & Technol Dolgoprudnyi Russia Skolkovo Inst Sci & Technol Moscow Russia

The cannabinoid receptor CB2 is predominately expressed in the immune system, and selective modulation of CB2 without the psychoactivity of CB1 has therapeutic potential in inflammatory, fibrotic, and neurodegenerative diseases. Here, we report the crystal structure of human CB2 in complex with a rationally designed antagonist, AM10257, at 2.8 angstrom resolution. The CB2-AM10257 structure reveals a distinctly different binding pose compared with CB1. However, the extracellular portion of the antagonist-bound CB2 shares a high degree of conformational similarity with the agonist-bound CB1, which led to the discovery of AM10257's unexpected opposing functional profile of CB2 antagonism versus CB1 agonism. Further structural analysis using mutagenesis studies and molecular docking revealed the molecular basis of their function and selectivity for CB2 and CB1. Additional analyses of our designed antagonist and agonist pairs provide important insight into the activation mechanism of CB2. The present findings should facilitate rational drug design toward precise modulation of the endocannabinoid system.

关键词： G-protein coupled receptor cannabinoid receptor CB2 crystal structure ligand design subtype selectivity

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Self-Powered Wireless Monitoring of Obstacle Position and State in Gas Pipe via Flow-Driven Triboelectric Nanogenerators

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ADVANCED MATERIALS TECHNOLOGIES 2020年第10期5卷 1-10页

作者： zhao, Xue Zhang, Ding Xu, suwen Qian, Weiqi Han, Wei Yang, Ya Jilin Univ Key Lab Phys & Technol Adv Batteries Minist Educ Changchun 130012 Peoples R China Chinese Acad Sci CAS Ctr Excellence Nanosci Beijing Inst Nanoenergy & Nanosyst Beijing Key Lab Micronano Energy & Sensor Beijing 100083 Peoples R China Univ Chinese Acad Sci Sch Nanosci & Technol Beijing 100049 Peoples R China Guangxi Univ Ctr Nanoenergy Res Sch Phys Sci & Technol Nanning 530004 Guangxi Peoples R China

Triboelectric nanogenerator (TENG) has attracted increasingly attention in a new energy field. However, it is still a huge challenge for TENG to transmit electricity or be self-powered sensing without hard wires, which can reduce the efficiency of power generation and further cause inconvenience for connecting device. Here, a flow-driven wireless TENG for efficient power transmission, ultrasensitive distance sensing, and obstacle monitoring in the gas pipe is reported. The wireless TENG can generate a voltage/current signal of about 121.0 V/4.4 mu A at the receiving distance of 1.5 cm with a wind speed of 18.0 m s(-1). When the distance is increased to 10.0 cm, the output voltage can be decreased to 8.0 V with a sensitivity of 92% owing to the decrease of induced charges on receiving electrodes. The relationship that the output voltage decreases with increasing the receiving distance has been confirmed, suggesting the possibility of the wireless TENG as a self-powered distance sensor. Moreover, by installing several wireless TENGs uniformly in a gas pipe, the position and specific placement state of an obstacle in gas pipe can be effectively monitored with the self-powered way.

关键词： obstacle monitoring self-powered sensing triboelectric nanogenerators wireless sensing

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