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Protective Effect of sRAGE on Fetal Development in Pregnant Rats with Gestational Diabetes Mellitus

CELL BIOCHEMISTRY AND BIOPHYSICS 2015年第2期71卷 549-556页

作者： tang, xuwen Qin, Qingxin Xie, Xiaobin He, Ping Guangzhou Women & Childrens Med Ctr Dept Obstet Guangzhou 510623 Guangdong Peoples R China First Peoples Municipal Hosp Guangzhou Dept Endocrinol Guangzhou 510180 Guangdong Peoples R China Guangzhou Med Univ Dept Pathol Guangzhou 510180 Guangdong Peoples R China

To investigate the protective effect of secretory receptor for advanced glycation endproducts (sRAGE) on the fetal development using rat model of gestational diabetes mellitus (GDM). The model of pregnant rats with intrauterine hyperglycemia was established by intraperitoneal injection of 25 mg/kg streptozotocin (STZ). Rats with established GDM were randomly grouped, and the pregnant rats in the experimental group were subsequently injected with recombinant sRAGE protein (5 mg/kg, in 0.2 mL PBS) at tail vein every 24 h, while the rats in control group were injected with the same dosage of albumin solution. Blood glucose, serum levels of advanced glycation endproducts (AGEs), and levels of RAGE protein in brain and heart tissues of pregnant rats were measured at 3, 13, and 19 days postconception. At 19 days fetuses were delivered by cesarean section, number of fetuses, their weight and placental weights were recorded, and fetal malformations and defects were analyzed visually and pathologically. The expression level of RAGE, NOX2, MCP-1, p65, VCAM-1, and VEGF mRNA in placenta was evaluated by real-time PCR. p65 protein localization was detected by immunohistochemistry in fetal brain and heart tissue sections. We analyzed the correlation between AGEs and RAGE level and the development of fetal rats, and the protective effect of blocking AGEs-RAGE pathway on the fetal development in the rat model of GDM was investigated. (1) The concentration of blood glucose and AGEs in serum of pregnant rats with GDM was significantly higher than in control group (p < 0.05), with strong correlation between blood glucose and levels of AGEs (r = 0.693, p < 0.05). (2) While both the number of fetuses and placental wet weight in pregnant rat model of GDM were similar to control group, pups from GDM group exhibited higher incidence of developmental abnormalities and higher average weight (p < 0.05). sRAGE treatment slightly but not significantly reduced the probability of the fetal develo

关键词： Gestational diabetes mellitus Secretory receptor for advanced glycation endproducts Protection Fetal development

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Micro-compound tissue grafting for repairing linear scars

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Chinese Journal of Plastic and Reconstructive Surgery 2021年第4期3卷 202-203页

作者： xuwen tang Yang Liu Dongyun Yang Yong Zhang Department of Chongqing Kewei Scar Medical Institute/Dongshang Medical Aesthetic Clinic Chongqing 400010China

This study explored the clinical application and therapeutic effect of micro-compound tissue grafting(MCTG)for linear *** February 2019,one patient received MCTG treatment and the recovery at 20 months postoperative was *** patient was completely satisfied with the *** MCTG technique is simple and reliable and can significantly improve scar *** technique may be an effective method for treating linear scars,but it requires further validation in large samples.

关键词： Linear scar Micro-compound tissue grafting Excision and suture

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Treatment of Keloids in A Child with Surgery Alone:Clinical Application of the LBD Suturing Technique

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Chinese Journal of Plastic and Reconstructive Surgery 2021年第1期3卷 46-50页

作者： Yong ZHANG xuwen tang Yang LIU Dongyun YANG Department of Chongqing Kewei Scar Medical Institute/Dongshang Medical Aesthetic Clinic Chongqing 400038China

Keloids are fibroproliferative disorders that can result from cutaneous injuries to the reticular *** rates as high as 100%have been reported following surgical excision ***,a variety of post-surgical techniques have been employed to prevent keloid recurrence,including the use of *** numerous studies have shown that post-excisional X-rays,electron beams,lasers,and brachytherapy can reduce the rate of keloid recurrence,numerous inconsistencies,including a wide range of definitions for keloid recurrence,render it difficult to compare the *** treatment of severe keloids in children is much more challenging,and there have been few previous *** is generally believed that children with keloids should be treated with nonsurgical treatment such as hormone injections and *** severe keloids,these methods require a long treatment period,and their efficacy is not ***,the side effects of the treatment can affect children’s *** keloid scars are not effectively treated,they will often seriously affect the physical and mental health of *** purpose of this review is to discuss case studies of children with severe keloids who were only treated with surgery and their postoperative *** this case,the deep-embedded circular mattress suture technique(LBD,the looped,broad,and deep buried suturing technique)was used in the scar *** 18 months of follow-up,the surgical scar was evaluated using the Vancouver Scar Scale(VSS).The scar was stable and did not *** child was *** case shows that it is completely feasible to treat severe keloids with surgery alone,as long as the tension is reduced during the operation to prevent surgical scar hyperplasia.

关键词： Keloid Child Scar resection Surgery LBD suturing technique Recurrence

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Looped,Broad,and Deep Buried Suturing Technique for Wound Closure

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Chinese Journal of Plastic and Reconstructive Surgery 2021年第2期3卷 85-88页

作者： xuwen tang Yong ZHANG Liu YANG Dongyun YANG Department of Chongqing Kewei Scar Medical Institute/Dongshang Medical Aesthetic Clinic Chongqing 400038China

This study explores the clinical application of the circular wide and deep(looped,broad,and deep buried,LBD)suture technique for scar resection and examines its clinical effectiveness for scar *** June 2017 to March 2019,a total of 68 patients with scars were sutured using LBD technique,and recovery was achieved 24 months *** all 68 patients,postoperative scars were slightly evident in two cases of cervical scar,one case of leg scar,and one case of chest *** addition,the remaining 62 patients were completely satisfied with the *** LBD suturing technique could provide sustained and stable tension-reducing effects postoperatively and significantly improve scar formation in *** method is most applicable to incisions with ***,it should be more widely used for clinical scar treatment.

关键词： Suture technology Looped,broad,and deep buried suturing technique Scar resection Cosmetic technology

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Self-supervised Network Evolution for Few-shot Classification 30

Self-supervised Network Evolution for Few-shot Classificatio...

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30th International Joint Conference on Artificial Intelligence (IJCAI)

作者： tang, xuwen Teng, Zhu Zhang, Baopeng Fan, Jianping Beijing Jiaotong Univ Beijing Peoples R China Lenovo Res Res Triangle Pk NC USA

ISBN: (纸本)9780999241196

Few-shot classification aims to recognize new classes by learning reliable models from very few available samples. It could be very challenging when there is no intersection between the already-known classes (base set) and the novel set (new classes). To alleviate this problem, we propose to evolve the network (for the base set) via label propagation and self-supervision to shrink the distribution difference between the base set and the novel set. Our network evolution approach transfers the latent distribution from the already-known classes to the unknown (novel) classes by: (a) label propagation of the novel/new classes (novel set);and (b) design of dual-task to exploit a discriminative representation to effectively diminish the overfitting on the base set and enhance the generalization ability on the novel set. We conduct comprehensive experiments to examine our network evolution approach against numerous state-of-the-art ones, especially in a higher way setup and cross-dataset scenarios. Notably, our approach outperforms the second best state-of-the-art method by a large margin of 3.25% for one-shot evaluation over miniImageNet.

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Effect of Carburized Layer Depth on the Wear Reliability of Cams

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INTERNATIONAL JOURNAL OF AUTOMOTIVE TECHNOLOGY 2025年第3期26卷 799-812页

作者： tang, Jie Chen, Jianzhi Shang, Fanmin Jing, xuwen Zhou, Honggen Li, Guochao Jiangsu Univ Sci & Technol Sch Mech Engn Zhenjiang 212003 Peoples R China Jiangsu Univ Sci & Technol Sch Mat Sci & Engn Zhenjiang 212003 Peoples R China

The carburizing process is the key technology to improve the wear properties of cams;however, the influence mechanisms of the carburized depth on the wear reliability of cams are still unclear. In this work, the multi-body dynamic simulation with the AVL_EXCITE TD software and the accelerated wear experiments of the cam-roller pairs were combined to analyze the wear reliability of cams with different carburized depths of 0 mm, 0.8 mm and 1.4 mm. The results indicate that allowable wear depth of the cam is predicted to be 0.916 mm according to the degradation rule of the valve fullness coefficient. The maximum wear failure life of different carburized cams corresponding to the wear reliability of 99% was determined to be 1.0 x 107 cycles, 3.2 x 109 cycles and 3.5 x 109 cycles based on the combination of online detection data and the multi-body dynamics simulation. The relationship model between the wear failure life of the carburized cams and the carburized depth is established, and the optimal carburized layer depth of 1.20 mm is speculated from the model. The present work can provide new clues for improving the wear resistance of mechanical components.

关键词： Carburized layer depth Wear reliability Simulation Accelerated wear experiments Cam

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Hydroxyl groups and vacancy defects modified Mo2C MXene as peroxymonosulfate activator for antibiotics degradation

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JOURNAL OF CLEANER PRODUCTION 2025年 486卷

作者： Chen, xuwen Zhou, Zhou Gudda, Fredrick Owino tang, Lei Wang, Hefei Czech, Bozena Oleszczuk, Patryk Gao, Yanzheng Nanjing Agr Univ Inst Organ Contaminant Control & Soil Remediat Coll Resources & Environm Sci Nanjing 210095 Peoples R China Marie Curie Sklodowska Univ Inst Chem Sci Fac Chem Dept Radiochem & Environm Chem Pl M Curie Sklodowskiej 3-541 PL-20031 Lublin Poland

Antibiotic pollution poses significant threats to ecological health and food safety, highlighting the need for effective pollution control strategies. A novel Mo2C MXene-OH&V-Mo (hydroxyl groups and Mo vacancy defects modified Mo2C MXene) was developed through etching and hydrothermal methods, which facilitated the construction of a degradation system utilizing peroxymonosulfate for antibiotics degradation. The Mo2C MXeneOH&V-Mo demonstrated enhanced adsorption of HSO5-, achieving an adsorption energy of-1.73 eV, which is superior to that of unmodified Mo2C MXene (-0.42 eV). The activation of HSO5- by Mo vacancies involved the transfer of 0.63 e, leading to the generation of reactive oxygen species ('OH, O-1(2) , SO4'-and O-2'- ) responsible for degrading three antibiotics with degradation percentages exceeding 97.00%. The presence of hydroxyl groups further improved the activation efficiency of HSO5- by optimizing the electron arrangement of Mo2C MXeneOH&V-Mo. The extent of antibiotic degradation was influenced by atomic charge distribution. Additionally, Mo2C MXene-OH&V-Mo exhibited remarkable repeatability, maintaining degradation percentages above 88.00% after four cycles. The condensed Fukui function was utilized to identify highly active sites of antibiotics, and combined with degradation products analyzed by HPLC-MS/MS, commonalities in detailed degradation pathways were revealed. Furthermore, the products were found to pose negligible toxicity risks to ecological receptors and humans. These findings hold significant implications for the future use of MXene-based catalyst' advanced oxidation technology in the treatment of organic pollutants and offer sustainable solutions for environmental remediation. Insights into the development of new catalysts through surface modification engineering were also presented in this study.

关键词： Hydroxyl functional groups Vacancy defects Antibiotics Peroxymonosulfate Mo2C MXene- OH & V-Mo Hydroxyl functional groups Vacancy defects Antibiotics Peroxymonosulfate

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负压封闭引流技术在四肢创伤患者中的临床效果及对创面愈合的影响研究

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中国医学创新 2018年第5期15卷 102-105页

作者：唐绪文湖北省潜江市中医院湖北潜江433100

目的:探讨分析负压封闭引流技术在四肢创伤患者中的临床效果及对创面愈合的影响。方法:选取2016年9月-2017年9月本院收治的四肢创伤患者90例,按照随机数字表法分为对照组与研究组,每组45例。对照组施以常规的换药治疗方法,研究组施以负... 详细信息

目的:探讨分析负压封闭引流技术在四肢创伤患者中的临床效果及对创面愈合的影响。方法:选取2016年9月-2017年9月本院收治的四肢创伤患者90例,按照随机数字表法分为对照组与研究组,每组45例。对照组施以常规的换药治疗方法,研究组施以负压封闭引流技术进行治疗,观察比较两组临床疗效、创面面积变化、住院费用与住院时间、创面愈合情况以及并发症发生情况。结果:治疗后,研究组治疗有效率明显优于对照组,差异有统计学意义(P<0.05),且研究组创面面积大幅度减小,住院时间也明显缩短,住院费用也大大减少,与对照组比较差异均有统计学意义(P<0.05);治疗后,研究组创面愈合情况显著优于对照组,且并发症发生情况比对照组少,差异均有统计学意义(P<0.05)。结论:应用负压封闭引流技术对四肢创伤患者进行治疗,可以有效提高临床疗效,降低并发症发生率,安全可靠,值得临床推广应用。

关键词：负压封闭引流技术四肢创伤临床效果创面愈合

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老年股骨颈骨折内固定术后股骨头坏死发生率及影响因素研究

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中国继续医学教育 2017年第34期9卷 61-63页

作者：唐绪文潜江市中医院骨科湖北潜江433100

目的探讨老年股骨颈骨折经闭合复位内固定术后股骨头坏死的发生率及影响因素。方法选取2016年5月—2017年5月我院收治的股骨颈骨折患者120例作为研究对象,将其随机分为两组,研究组行闭合复位内固定术进行治疗,对照组采取一般方法进行治... 详细信息

目的探讨老年股骨颈骨折经闭合复位内固定术后股骨头坏死的发生率及影响因素。方法选取2016年5月—2017年5月我院收治的股骨颈骨折患者120例作为研究对象,将其随机分为两组,研究组行闭合复位内固定术进行治疗,对照组采取一般方法进行治疗。对随访记录完整的120例进行统计学分析,并运用logistic回归进行因素分析。结果患者在不同时期股骨头坏死的发生率不同,研究组术后1个月及2个月发生率低于对照组,差异具有统计学意义(P<0.05);单因素分析结果显示,患者在复位时间、完全负重时间、手术方式方面均存在差异(P<0.05);多因素分析结果显示,患者在复位时间、完全负重时间、手术方式方面均存在差异(P<0.05)。结论老年股骨颈骨折患者经闭合复位内固定术后股骨头坏死率并未高于平均水平,取得较为满意的效果。患者的骨折类型、受伤至手术时间、骨折复位质量与股骨头坏死的发生明显相关。

关键词：老年股骨颈骨折闭合复位内固定术股骨头坏死发生率影响因素研究

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晚期糖基化终产物水平及其受体的表达与妊娠期糖尿病围生儿结局关系的研究

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实用妇产科杂志 2012年第6期28卷 497-500页

作者：汤栩文林斯谢晓斌广东省广州市妇女儿童医疗中心广东广州510623 广州医学院病理学教研室广东广州510623

目的:探讨妊娠期糖尿病(GDM)孕妇血清晚期糖基化终产物(AGEs)水平与围生儿结局间的关系,并观察晚期糖基化终产物受体(RAGE)蛋白在胎盘组织中的蛋白表达。方法:选择孕24～28周来我院产前检查被诊断患有GDM的孕妇100例为研究对象(GDM组),... 详细信息

目的:探讨妊娠期糖尿病(GDM)孕妇血清晚期糖基化终产物(AGEs)水平与围生儿结局间的关系,并观察晚期糖基化终产物受体(RAGE)蛋白在胎盘组织中的蛋白表达。方法:选择孕24～28周来我院产前检查被诊断患有GDM的孕妇100例为研究对象(GDM组),另选择同孕期、相应年龄的正常妊娠妇女50例作为正常对照组。检测GDM组孕妇治疗前、后和同孕期正常对照组孕妇的空腹血糖、糖化血红蛋白(HbA1c)和AGEs水平。分娩后立即收集两组胎盘低温保存,用于分析组织中RAGE蛋白的表达。并收集母婴临床信息,根据GDM组围生儿结局分为GDM围生儿正常组和GDM围生儿异常组。结果:①GDM组治疗前孕妇血清AGEs水平、HbA1c和空腹血糖值均明显高于同孕期正常对照组(P<0.05,P<0.01)。②GDM组经干预治疗后其空腹血糖和HbA1c水平与同孕期正常对照组比较,差异无统计学意义(P>0.05);但血清AGEs水平仍然高于正常对照组(P<0.01)。③GDM围生儿异常组孕妇血清AGEs水平高于GDM围生儿正常组(P<0.05)。④Logistic回归分析显示AGEs是GDM围生儿结局异常的危险因子(OR=6.197,P<0.01,95%CI2.514～15.453)。⑤Western印迹法测定胎盘组织中RAGE蛋白表达水平,GDM围生儿异常组高于GDM围生儿正常组和正常对照组(P<0.01)。结论:高AGEs血症是GDM围生儿结局的一个不利因素,高AGEs水平可作为GDM围生儿结局异常的预测指标。

关键词：晚期糖基化终产物妊娠期糖尿病胎盘围生儿预测

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