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A method of dynamic union control for intelligent mould bed system in ship block building

SHIPS AND OFFSHORE STRUCTURES 2022年第8期17卷 1755-1763页

作者： Wang, Zhen Jing, xuwen Cai, Youhui Liu, Jinfeng Zhu, Tianhu Zhou, Honggen tang, Mingming Li, Lei Li, Chunjin Dong, Lei Jiangsu Univ Sci & Technol Sch Mech Engn Zhenjiang 212003 Jiangsu Peoples R China Univ Chinese Acad Sci Shenyang Inst Comp Technol Beijing Peoples R China

Mould bed is the most important equipment to control the deformation in the process of block construction. However, its height needs to be controlled separately based on the known height, and it affects the construction precision of block severely. Therefore, a dynamic union control method is proposed in this paper. Firstly, in order to realize the union control of mould bed system, the distribution types of mould bed system are defined, and a dynamic relationship is established, the determination algorithm number, position and height compensation layer number is proposed. Secondly, the fuzzy PID control based on neural network is used to realize the adaptive control of height according to the changes of pressure, so as to control the construction quality better of block. Thirdly, the MATLAB/Simulink module is used to verify the proposed method and shows that the response time is significantly shortened by 41% and 37.5% respectively.

关键词： Ship block construction dynamic control intelligence mould bed fuzzy neural network PID

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Association Between Nutritional Risk Screening Score and Prognosis of Patients with Sepsis

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INFECTION AND DRUG RESISTANCE 2021年 14卷 3817-3825页

作者： Gao, Qiqing Cheng, Yao Li, Zhuohong tang, Qingyun Qiu, Rong Cai, Shaohang Xu, xuwen Peng, Jie Xie, Hongyan Southern Med Univ Nanfang Hosp Dept Infect Dis Guangzhou 510515 Guangdong Peoples R China

Background: Malnutrition is one of the most critical factors affecting patients' risk of infection and length of stay, and it may affect the prognosis of patients with sepsis. There have been no studies that have applied nutritional risk screening tools to stratify patients with sepsis according to prognosis. Methods: We retrospectively analyzed the clinical data of 425 adult sepsis inpatients who were grouped based on nutritional risk screening (NRS) score, including a nutrition score, disease severity score, and age score. Prognostic factors were analyzed using univariate and multivariate regression analyses. Results: Of the enrolled patients, 174 had an NRS score of >3;these patients were older and had a longer hospitalization time but lower body mass index (BMI), albumin (ALB) than others. Univariate Cox regression analysis showed that age, ALB, C-reactive protein (CRP), and NRS score were significantly (P<0.05) associated with in-hospital mortality. Multivariate analysis showed that age (hazard ratio [HR]=1.020, 95% confidence interval [CI]: 1.005- 1.036;P=0.008) and ALB (HR=0.924, 95% CI: 0.885-0.966;P<0.001) were independent risk factors for sepsis-related mortality. The Kaplan-Meier analysis revealed that the cumu-lative in-hospital mortality of sepsis patients with an NRS score of >3 was significantly higher than that of patients with an NRS score of <3 (P=0.022). Conclusion: NRS scores can effectively risk stratify sepsis patients. Patients with high NRS scores should be monitored more closely to halt further disease progression.

关键词： sepsis malnutrition NRS risk stratification prognostic assessment

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Synthesis and biological evaluation of 1,3,4-thiadiazole derivatives as type III secretion system inhibitors against Xanthomonas oryzae

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PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY 2019年 160卷 87-94页

作者： Tao, Hui Tian, Hao Jiang, Shan Xiang, xuwen Lin, Yinuo Ahmed, Wasim tang, Riyuan Cui, Zi-Ning South China Agr Univ Guangdong Prov Key Lab Microbial Signals & Dis Co Integrat Microbiol Res Ctr State Key Lab Conservat & Utilizat Subtrop Agrobi Guangzhou 510642 Guangdong Peoples R China South China Agr Univ Coll Mat & Energy Dept Appl Chem Guangzhou 510642 Guangdong Peoples R China

Xanthomonas oryzae pv. oryzae (Xoo) infection directly leads to a severe disease known as leaf blight, which is a major cause of yield loss of rice. Use of traditional bactericides has resulted in severe resistance in pathogenic bacteria. A new approach screening compounds that target the virulence factors rather than killing bacterial pathogens is imperative. In gram-negative bacteria, the type III secretion system (T3SS) is a conserved and significant virulence factor considered as a target for drug development. Therefore, we designed and synthesized a new series of 5-phenyl-2-furan carboxylic acid derivatives stitched with 2-mercapto-1,3,4-thiadiazole. Bioassays revealed that the title candidates attenuated the hypersensitive response through suppressing the promoter activity of a harpin gene hpa1 without affecting bacterial growth. Quantitative real time polymerase chain reaction (qRT-PCR) analysis demonstrated reduced the expression of several genes associated with T3SS, when title compounds were applied. Additionally, hrp gene cluster members, including hrpG and hrpX, had reduced mRNA levels. In vivo greenhouse tests showed that candidate compounds could alleviate the effects of Xoo infection in rice (Oryza sativa) and possess better protective activity against rice bacterial leaf blight than bismerthiazol and thiodiazole copper. All tested compounds were safe to rice. This work suggests there are new safe options for Xoo control in rice from these 1,3,4-thiadiazole derivatives.

关键词： 2-mercapto-1,3,4-thiadiazole Inhibitors Type III secretion system (T3SS) Anti-virulence factors Xanthomonas oryzae pv. oryzae (Xoo)

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Effects of Micellization Behavior on the Interfacial Adsorption in Binary Anionic/Nonionic Surfactant Systems: A Molecular Simulation Study

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LANGMUIR 2021年第40期37卷 11835-11843页

作者： Lian, Peng Jia, Han Yan, Hui Yuan, Jie tang, Hongtao Li, Zhe Fan, Fangning Qin, xuwen Lv, Kaihe Liu, Dexin China Univ Petr East China Sch Petr Engn Qingdao 266580 Peoples R China China Univ Petr East China Sch Petr Engn Shandong Key Lab Oilfield Chem Qingdao 266580 Peoples R China Liaocheng Univ Sch Pharmaceut Sci Liaocheng 252059 Shandong Peoples R China SINOPEC Shengli Oilfield Co Shengli Oil Prod Plant Dongying 257000 Peoples R China

A surfactant interfacial adsorption process is highly associated with its micellization behaviors in the water phase, which is of great fundamental and practical significance in enhanced oil recovery. In this paper, the typical anionic surfactant 1-dodecanesulfonic acid sodium (DAS) and nonionic surfactants octylphenol polyoxyethylene ether-n (OP-n, n = 1, 5, and 10) are introduced to investigate their micellization behavior and interfacial adsorption process via molecular dynamics simulation. Number density profiles reveal that the additional OP5 molecules in the water phase generate the mixed micelle with DAS molecules and greatly promote its interfacial adsorption. Interaction energy calculation is employed to confirm the interaction of anionic/nonionic surfactants in the mixed micelle. Then, the radial distribution function, solvent-accessible surface area, and solvation free energy are calculated to further explore and verify the adsorption mechanism of the mixed micelle. It is found that the nonionic surfactant obviously decreases the hydrophilicity of the mixed micelle in the water phase, which should be responsible for its intensive tendency of the interfacial adsorption.

关键词： Adsorption Molecules Micelles Surfactants Water

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Impermeability performance and corrosion resistance mechanism of basalt fiber recycled concrete under the coastal tidal environment

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CONSTRUCTION AND BUILDING MATERIALS 2024年 411卷

作者： Yang, Wenrui Huang, Yuewen tang, Zhiyi Xiong, Xiaolong Li, Chengwei Zhong, xuwen Liu, Liai Zhou, Hai Zhang, Xun East China Univ Technol Sch Civil & Architectural Engn Nanchang 330012 Peoples R China Wuhan Univ Technol Sch Transportat & Logist Engn Wuhan 430063 Peoples R China

The application of Recycled Aggregate Concrete (RAC) can effectively reduce resource consumption and mitigate environmental pollution. Under the coastal tidal environments, the performance of concrete is significantly impacted by environmental degradation. Incorporating fibers into RAC can enhance its performance in such special conditions. This study investigates the variations in properties of RAC with different Basalt Fiber (BF) volume ratios (0%, 0.5%, 1.0%, 1.5%) under composite salt dry-wet cyclic erosion cycles (0 d, 30 d, 60 d, 90 d). The results from apparent corrosion morphology analysis, internal microstructure examination, and impermeability testing demonstrate that BF can effectively inhibit the expansion of micro cracks and micropores within the test block while improving the overall compactness of the internal structure of RAC. When the BF content reaches 1.0%, it exhibits an optimal toughening effect on RAC with significantly improved impermeability and corrosion resistance properties. Furthermore, this paper comprehensively summarizes and verifies the corrosion damage mechanism of Basalt Fiber Recycled Aggregate Concrete (BFRAC) under composite salt dry-wet cycles through chemical reaction principles. A salt solution erosion model for BFRAC is proposed to elucidate fiber crack resistance mechanisms and explain accelerated corrosion caused by ion crack channels within salt solutions. This proposed model provides theoretical support for understanding salt erosion damage in fiberreinforced concrete.

关键词： Coastal tidal environment Basalt fiber Recycled concrete Impermeability Corrosion mechanism

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Step-Controlled Povarov-Type Reaction with 1,2-Dihydroquinolines as Precursors of Dienophiles: Direct Synthesis of Spirocyclic Bi-tetrahydroquinolines and Functionalized 1,2-Dihydroquinolines

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ORGANIC LETTERS 2017年第1期19卷 58-61页

作者： Ren, xuwen Li, Guangxun Huang, Jin Wang, Weidong Zhang, Yongpo Xing, Guomin Gao, Chunyan Zhao, Gang Zhao, Jinzhong tang, Zhuo Shanxi Agr Univ Taigu Coll Art & Sci Jinzhong 030800 Shanxi Peoples R China Chinese Acad Sci Chengdu Inst Biol Nat Prod Res Ctr Chengdu 610041 Sichuan Peoples R China Sichuan Univ Coll Chem Engn Chengdu 610041 Sichuan Peoples R China

A novel Povarov-type reaction for straightforward synthesis of novel spiro bi-tetrahydroquinolines with readily available 1,2-DHQs (1,2-dihydroquinolines) and aromatic imines was developed. The reaction could be selectively stopped at the first stage under a Bronsted acid catalyst to afford the corresponding functionalized 1,2-DHQs conveniently.

关键词： QUINOLINE synthesis CHEMICAL reactions CHEMICAL precursors DIENOPHILES SPIRO compounds synthesis

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Development of computer aided quality system based on knowledge

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Jixie Kexue Yu Jishu/Mechanical Science and Technology 1999年第3期18卷 499-500,503页

作者： tang, Wenxian Jing, xuwen Zhao, Liangcai

This article discusses development process of product quality and quality management conception. The structure model of computer aided quality system based on knowledge is proposed. Expert system based on knowledge is established to achieve computer aided quality management and control, and product quality management and control system is developed with the object of marine diesel engine.

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Factors associated with blooms of cyanobacteria in a large shallow lake, China

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ENVIRONMENTAL SCIENCES EUROPE 2018年第1期30卷 1-15页

作者： Li, Di Wu, Naicheng tang, Song Su, Guanyong Li, xuwen Zhang, Yong Wang, Guoxiang Zhang, Junyi Liu, Hongling Hecker, Markus Giesy, John P. Yu, Hongxia Nanjing Univ Sch Environm State Key Lab Pollut Control & Resource Reuse Nanjing 210046 Jiangsu Peoples R China Jiangsu Environm Monitoring Ctr Nanjing 210036 Jiangsu Peoples R China Univ Kiel Dept Hydrol & Water Resources Management D-24118 Kiel Germany Chinese Ctr Dis Control & Prevent Natl Inst Environm Hlth Beijing 100021 Peoples R China Nanjing Univ Sci & Technol Sch Environm & Biol Engn Jiangsu Key Lab Chem Pollut Control & Resources R Nanjing 210094 Jiangsu Peoples R China Nanjing Normal Univ Sch Environm Nanjing 210023 Jiangsu Peoples R China Wuxi Environm Monitoring Ctr Wuxi 214000 Jiangsu Peoples R China Univ Saskatchewan Toxicol Ctr Saskatoon SK S7N 5B3 Canada Univ Saskatchewan Sch Environm & Sustainabil Saskatoon SK S7N 5C3 Canada Univ Saskatchewan Dept Vet Biomed Sci Saskatoon SK S7N 5B3 Canada Univ Saskatchewan Toxicol Ctr Saskatoon SK S7N 5B3 Canada Michigan State Univ Dept Zool E Lansing MI 48824 USA Michigan State Univ Ctr Integrat Toxicol E Lansing MI 48824 USA Univ Hong Kong Sch Biol Sci Hong Kong Hong Kong Peoples R China

Background: Eutrophication of freshwater systems can result in blooms of phytoplankton, in many cases cyanobacteria. This can lead to shifts in structure and functions of phytoplankton communities adversely affecting the quality of drinking water sources, which in turn impairs public health. Relationships between structures of phytoplankton communities and concentrations of the toxicant, microcystin-leucine-arginine (MC-LR), have not been well examined in large shallow lakes. The present study investigated phytoplankton communities at seven locations from January to December of 2015 in Tai Lake, and relationships between structures and diversities of phytoplankton communities and water quality parameters, including concentrations of MC-LR and metals, were analyzed. Results: A total of 124 taxa of phytoplankton were observed, and the predominant taxa were Microcystis sp. and Dolichospermum flos-aquae of Cyanophyta and Planctonema sp. of Chlorophyta. The greatest diversities of phytoplankton communities, as indicated by species richness, Simpson, Shannon-Wiener, the Berger and Parker, and the Pielou evenness indices, were observed in spring. Furthermore, productivity of phytoplankton was significantly and negatively correlated with diversities. These results demonstrated that Simpson, Shannon-Wiener, the Berger and Parker, and the Pielou evenness indices of phytoplankton communities were significantly related to trophic status and overall primary productivity in Tai Lake. In addition, temperature of surface water, pH, permanganate index, biochemical oxygen demand, total phosphorus, arsenic, total nitrogen/total phosphorous ratio, and MC-LR were the main factors associated with structures of phytoplankton communities in Tai Lake. Conclusion: The present study provided helpful information on phytoplankton community structure and diversity in Tai Lake from January to December of 2015. Our findings demonstrated that Simpson, Shannon-Wiener, the Berger and Parker, and the

关键词： Eutrophication Nutrients Phosphorus Nitrogen Phytoplankton productivity Diversity Microcystin-LR

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Paecilomyces variotii extracts (ZNC) enhance plant immunity and promote plant growth

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PLANT AND SOIL 2019年第1-2期441卷 383-397页

作者： Lu, Chongchong Liu, Haifeng Jiang, Depeng Wang, Lulu Jiang, Yanke tang, Shuya Hou, xuwen Han, Xinyi Liu, Zhiguang Zhang, Min Chu, Zhaohui Ding, Xinhua Shandong Agr Univ State Key Lab Crop Biol Shandong Prov Key Lab Biol Vegetable Dis & Insect Tai An 271018 Shandong Peoples R China Shandong Pengbo Biotechnol Co LTD Tai An 271018 Shandong Peoples R China Shandong Agr Univ Natl Engn Lab Efficient Utilizat Soil & Fertilize Coll Recourses & Environm Tai An 271018 Shandong Peoples R China

Background and aims The crude extract of the endophyte Paecilomyces variotii known as ZhiNengCong (ZNC) has function of promoting plant growth and enhancing disease resistance and is widely used in China. Our study aims to evaluate the molecular mechanisms of plant growth promotion and disease protection. Methods We generated transcriptome profiles from ZNC-treated seedlings using RNA sequencing. The function of salicylic acid (SA) in ZNC-mediated immunity was examined using SA biosynthesis and signaling pathway mutants. The concentrations of nitrogen (N) and phosphorus (P) in seedlings under ZNC treatment were measured. The effect of ZNC on the level of the hormone auxin in roots was tested using transgenic plants containing DR5::GFP. Results ZNC exhibited ultrahigh activity in promoting plant growth and enhancing disease resistance, even at concentrations as low as 1-10 ng/ml. ZNC induced ROS accumulation, callose deposition, and expression of PR genes. SA biosynthesis and signaling pathways were required for the ZNC-mediated defense response. Moreover, in improving plant growth, ZNC increased the level of auxin in root tips and regulated the absorption of N and P. Conclusion According to these results, ZNC is a highly effective plant elicitor that promotes plant growth by inducing auxin accumulation at the root tip at low concentrations and enhances plant disease resistance by activating the SA signaling pathway at high concentrations.

关键词： Plant elicitors Plant growth promotion Plant endophyte Disease resistance Auxin Salicylic acid

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Oral immunization of mice with a probiotic Lactobacillus casei constitutively expressing the α-toxoid induces protective immunity against Clostridium perfringens α-toxin

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VIRULENCE 2019年第1期10卷 166-179页

作者： Gao, xuwen Ma, Yingying Wang, Zhuo Bai, Jing Jia, Shuo Feng, Baohua Jiang, Yanping Cui, Wen tang, Lijie Li, Yijing Wang, Li Xu, Yigang Northeast Agr Univ Coll Vet Med Harbin Heilongjiang Peoples R China China Minist Agr Key Lab Anim Pathogen Biol Northeastern Sci Inspect Stn Harbin Heilongjiang Peoples R China Northeast Agr Univ Heilongjiang Key Lab Anim Dis Control & Pharmaceu Harbin Heilongjiang Peoples R China

Clostridium perfringens alpha-toxin is one of the major virulence factors during C. perfringens infection, causing hemolysis of erythrocytes in various species. Here, genetically engineered Lactobacillus casei (pPG-alpha/L. casei 393) constitutively expressing the toxoid of C. perfringens alpha-toxin was generated and its immunogenicity in mice for induction of protective immunity against the alpha-toxin was evaluated via oral immunization. The alpha-toxoid was constitutively expressed by pPG-alpha/L. casei 393 without a specific inducer, as confirmed by western blotting, laser confocal microscopy, and flow cytometry. In an experiment on BALB/c mice to evaluate the oral immunogenicity of pPG-alpha/L. casei 393, significant levels of a specific secretory IgA (sIgA) antibody in the intestinal mucus and feces and an IgG antibody in the serum of the probiotic vaccine group were detected after booster immunization (p < 0.05) as compared with the pPG/L. casei 393 and PBS control groups. These antibodies effectively neutralized C. perfringens natural alpha-toxin. Moreover, significantly higher levels of cytokines IL-2, IL-4, IL-10, IL-12, IL-17, and interferon (IFN) gamma in the serum and increased proliferation of spleen lymphocytes obtained from mice orally immunized with pPG-alpha/L. casei 393 were detected. With a commercial C. perfringens type A inactivated vaccine as a control, immune protection provided by the probiotic vaccine against C. perfringens alpha-toxin was evaluated, and 90% and 80% protection rates were observed, respectively. Therefore, strain pPG-alpha/L. casei 393 effectively elicited mucosal, humoral, and cellular immunity, suggesting that pPG-alpha/L. casei 393 is a promising candidate for development of a vaccine against C. perfringens alpha-toxin.

关键词： Clostridium perfringens alpha-toxoid genetically engineered Lactobacillus casei oral immunization

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