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Association of metformin treatment and outcome in adult patients with ITP and pre-existing T2DM

BRITISH JOURNAL OF HAEMATOLOGY 2022年第3期197卷 367-372页

作者： Li, Chaoyang Sun, Meng Li, Ranran wang, shuwen Shao, Linlin Xu, Miao Yao, Meiyue wang, Lin Hou, Ming Feng, Qi Peng, Jun Shandong Univ Qilu Hosp Cheeloo Coll Med Dept Hematol Jinan 250012 Peoples R China Jinan Vocat Coll Nursing Jinan Peoples R China Shandong Univ Cheeloo Coll Med Sch Pharmaceut Sci Dept Pharmaceut Jinan Peoples R China Ningjin Cty Peoples Hosp Dept Radiol Dezhou Peoples R China Shandong Univ Qilu Hosp Cheeloo Coll Medcine Shandong Prov Key Lab Immunohematol Jinan 250012 Peoples R China Qilu Inst Technol Med Coll Jinan Peoples R China Shandong Univ Cheeloo Coll Med Adv Med Res Inst Jinan Peoples R China

Primary immune thrombocytopenia (ITP) is an autoimmune haemorrhagic disease that could manifest with comorbid type 2 diabetes mellitus (T2DM). However, the exact impact of T2DM in patients with ITP remains uncertain. In this study, we performed a retrospective cohort study of 458 participants with ITP. The prevalence of T2DM was 7.6% in this population (35 patients), which was slightly lower than the Chinese nationwide prevalence of T2DM, calculated to be approximately 10.9%. The participants with pre-existing T2DM displayed a significantly higher response to therapy than those without T2DM (71% vs. 53%). Furthermore, in the T2DM cohort, the response rate reached 88% when metformin was included in the treatment regimen. This clinical evidence suggests that metformin therapy might improve the clinical outcomes of ITP.

关键词： ITP metformin T2DM

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多负责人模式对科研项目产出绩效的影响:以美国国家卫生研究院为例

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中国软科学 2024年第11期 46-55页

作者：汪舒雯黄柯境郑知敏吴登生中国科学院科技战略咨询研究院北京100190 中国科学院大学公共政策与管理学院北京100049 国家自然科学基金委员会计划局北京100085 深圳大学管理学院广东深圳518055

随着科学问题复杂化和科研合作日益频繁,多负责人模式的科研项目应运而生。然而,目前中国的科学基金资助机构在多负责人项目的实施上仍处于探索阶段,决策过程缺乏实证研究支撑。基于2006~2022年美国国立卫生研究院资助的项目,结合产出... 详细信息

随着科学问题复杂化和科研合作日益频繁,多负责人模式的科研项目应运而生。然而,目前中国的科学基金资助机构在多负责人项目的实施上仍处于探索阶段,决策过程缺乏实证研究支撑。基于2006~2022年美国国立卫生研究院资助的项目,结合产出论文和专利绩效指标,构建计量经济模型,评估了多负责人项目与单一负责人项目的产出绩效差异,且对多负责人模式在不同经费额度项目中的异质性影响进行研究探讨。研究表明,多负责人项目在论文数量、专利数量、引用次数和创新性上优于单一负责人项目。同时,项目负责人数量与产出绩效之间存在复杂的非线性关系,且在经费额度较高的项目中,多负责人模式对产出绩效的正面影响更加明显。研究结果为国家自然科学基金委推广和实施科研项目多负责人政策提供了重要的实证依据。

关键词：多负责人科研合作科研资助产出绩效

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A Novel Environmentally Friendly Z-Scheme Heterojunction Nh2-Mil-68(In)/Biocl1-Xix Efficient Photodegradation of Tetracycline Under Visible Light: Synthesis, Mechanism, Degradation Pathway, and Toxicological Evaluation

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SSRN 2023年

作者： Liu, Haicheng Huang, Zhe Zhang, Wenhao wang, shuwen wang, Weiyue School of Environmental Science and Engineering Suzhou University of Science and Technology Suzhou215009 China

The environmental safety implications of antibiotics have attracted widespread attention. A series of Z-scheme heterojunctions (NMB-X) consisting of functionalized metal-organic framework NH2-MIL-68(In) (NM) and BiOCl1-xIx (B-X) composites were established for the efficient photodegradation of tetracycline (TC) in water. The incorporation of an internal built-in electric field significantly bolstered the photoresponse capability and charge carrier separation efficiency. Notably, NMB-0.3 exhibited the most remarkable photocatalytic performance, accomplishing an impressive 86.79% degradation of TC within just 90 minutes, surpassing the degradation rates of pure NM and B-0.3 by 14.07 and 1.67 times, respectively. Moreover, an in-depth investigation of the kinetics and mechanism of TC degradation was conducted. Holes (h+) and superoxide radicals (·O2-) were identified as the principal active radicals accountable for the effective photocatalytic degradation of TC. Additionally, the intermediates and pathways of TC photodegradation were thoroughly discussed, taking into consideration the surface electrostatic potential and frontier electron theory. Furthermore, the environmental toxicity of TC photocatalytic intermediates was meticulously assessed based on representative intermediate products. Remarkably, the intermediates generated during the photodegradation process exhibited lower environmental toxicity than TC itself, underscoring the eco-friendliness of the photocatalytic process. © 2023, The Authors. All rights reserved.

关键词： Heterojunctions

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Empagliflozin modulates CD4⁺ T-cell differentiation via metabolic reprogramming in immune thrombocytopenia

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BRITISH JOURNAL OF HAEMATOLOGY 2022年第4期198卷 765-775页

作者： Qin, Jing Liu, Qiang Liu, Anli Leng, Shaoqiu wang, shuwen Li, Chaoyang Ma, Ji Peng, Jun Xu, Miao Shandong Univ Qilu Hosp Dept Hematol Cheeloo Coll Med Wenhuaxi Rd Jinan Peoples R China First Med Univ Shandong Canc Hosp & Inst Dept Med Oncol Jinan Peoples R China Shandong Acad Med Sci Jinan Peoples R China Chinese Acad Med Sci & Peking Union Med Coll Inst Hematol & Blood Dis Hosp State Key Lab Expt Hematol Tianjin Peoples R China

Immune thrombocytopenia (ITP) is an acquired autoimmune disease, in which the imbalance of CD4(+) T cell subsets play a key role in the pathogenesis. Since T cells highly depend on metabolism for their function, we hypothesized that T cell dysfunction may be due to intracellular metabolic reprogramming. We found that in ITP, T cell metabolism shifts from oxidative phosphorylation to glycolysis. Empagliflozin, a sodium-glucose cotransporter 2 inhibitor, has shown regulatory metabolic effects on proximal tubular epithelial cells and cardiac cells beyond glucose lowering. However, the effects of empagliflozin on T cells remain unknown. To further investigate the metabolic dysfunction of CD4(+) T cells in ITP, we explored the effect of empagliflozin on CD4(+) T-cell differentiation in ITP. Our results are the first to show that increased glycolysis in CD4(+) T cells resulted in an unbalanced CD4(+) T-cell population. Furthermore, empagliflozin can affect the differentiation of CD4(+) T-cell subsets by inhibiting Th1 and Th17 cell populations while increasing Tregs. Empagliflozin appears to regulate CD4(+) T cells through inhibiting the mTOR signal pathway. Considering these results, we propose that empagliflozin could be used as a potential therapeutic option for ITP by modulating metabolic reprogramming in CD4(+) T cells.

关键词： glycolysis immune thrombocytopenia oxidative phosphorylation SGLT2 inhibitor T subsets

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SAP30 promotes clear cell renal cell carcinoma proliferation and inhibits apoptosis through the MT1G axis

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EUROPEAN JOURNAL OF MEDICAL RESEARCH 2025年第1期30卷 1-15页

作者： Guo, Wei wang, shuwen Yang, Zitong Dong, Yu Xia, Zhinan Xue, Wei Zhang, Cheng Zhejiang Univ Ctr Oncol Med Sch Med Affiliated Hosp 4Dept Urol Yiwu 322000 Peoples R China Zhejiang Univ Int Inst Med Int Sch Med Yiwu 322000 Peoples R China China Med Univ Dept Urol Shengjing Hosp Shenyang 110004 Peoples R China

Sin3A-associated protein 30 (SAP30) is a crucial component of the SIN/HDAC histone deacetylase complex and acts as a scaffold that facilitates target gene binding. SAP30 is highly expressed in various tumours;however, its role in renal cell carcinoma (RCC) remains unclear. In our study, we observed the upregulation of SAP30 in clear cell renal cell carcinoma (ccRCC) tissues, and its elevated expression was correlated with a poor prognosis. Previous research has suggested that SAP30 may influence the growth, proliferation, and apoptosis of RCC cells. Gene Ontology (GO) analysis of the downstream regulatory targets of SAP30 revealed that SAP30 suppressed the expression of MT1G, a protein that binds to p53. Mechanistically, SAP30 inhibited MT1G transcription, thereby impairing the function of MT1G in delivering zinc ions to p53, which diminished p53 activity. Moreover, reduced MT1G levels attenuated the inhibitory effect of MT1G on MDM2, further destabilizing p53. Consequently, this cascade promoted RCC progression. In conclusion, our findings indicate that SAP30 inhibits the p53 pathway through MT1G suppression, suggesting that SAP30 and MT1G are potential prognostic markers and therapeutic targets for RCC.

关键词： Transcription factor p53 SAP30 MT1G ccRCC

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Construction of Functionalized In-Based Metal Organic Framework/Biocl1-Xix Z-Scheme Heterojunction for Efficient Photocatalytic Degradation of Tetracycline: Performance And Mechanism

SSRN

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SSRN 2024年

作者： Liu, Haicheng Huang, Zhe Zhang, Wenhao Zhang, Chuang wang, shuwen wang, Weiyue School of Environmental Science and Engineering Suzhou University of Science and Technology Suzhou215009 China

The environmental implications of antibiotics have drawn widespread attention. Numerous monomer-based bismuth oxide halide catalysts have been extensively studied to remove tetracycline (TC) from aquatic environments. Integrating bismuth oxide halide composites with In-based metal organic framework (NH2-MIL-68(In)) might potentially serve as a novel strategy. By meticulously adjusting Cl and I within the composite bismuth halide oxide (B-x), a suite of purpose built heterojunctions (NMB-x) were synthesized, which were engineered to facilitate the efficient photodegradation of TC in simulated and actual aquatic environments. The incorporation of Z-scheme heterojunctions yielded a significant enhancement in photocatalytic responsiveness and charge carrier separation. Notably, NMB-0.3 demonstrated remarkable TC removal efficiency of 86.79%, which is 3.74 times of B-0.3 within 90 minutes. The removal of TC from natural water bodies was also assessed. Moreover, the photocatalyst concentration, assessed using response surface method, was found to show influential factors on TC removal. In addition, density functional theory (DFT) simulations were employed to identify vulnerable sites within TC. Intermediates and pathways in the photodegradation of TC have also been inferred. Furthermore, a comprehensive environmental toxicity assessment of representative intermediates demonstrated that these intermediates exhibited significantly reduced environmental toxicity compared to TC. This study provides a new approach to the design strategy of efficient and environmentally friendly MOF-based photocatalysts. © 2024, The Authors. All rights reserved.

关键词： Organometallics

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The subtracting pore effect method for an accurate and reliable surface area determination of porous carbons

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CARBON 2021年 175卷 77-86页

作者： wang, shuwen Vallejos-Burgos, Fernando Furuse, Ayumi Yoshikawa, Yasunori Tanaka, Hideki Kaneko, Katsumi Shinshu Univ Res Initiat Supramat Nagano 3808553 Japan Morgan Adv Mat Carbon Sci Ctr Excellence State Coll PA 16803 USA

The Ar (87.3 K) and N-2 (77.4 K) adsorption isotherms of six non-graphitized carbon blacks are compared to choose the best reference material for an accurate determination of surface area of porous carbons with subtracting pore effect (SPE) method using high resolution alpha(s)-plot. Microporous carbon blacks cannot be used as references for SPE method since they underestimate the surface area. On the other hand, reference carbon blacks exhibiting capillary condensation underestimate external surface areas. The total surface area from SPE method using Ar adsorption at 87.3 K has a stronger dependence on the microporosity of reference carbon blacks than that using N-2 adsorption at 77.4 K. The surface area of carbons whose pore widths are >1 nm result more affected by the reference carbon black than those with widths <1 nm. The optimized reference data and calculation programs are provided in an open repository (https://***/zjg8a) for quick and easy use of the SPE method to characterize the porous carbons precisely. (C) 2020 The Author(s). Published by Elsevier Ltd.

关键词： Subtracting pore effect method Carbon black Pore structure External surface

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基于稀疏可学习proposal的车间工具目标检测

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电子测量与仪器学报 2024年第7期38卷 13-21页

作者：刘珍兵孙巧榆王述文夏嘉伟江苏海洋大学电子工程学院连云港222005

针对车间工具不同型号之间尺寸存在较大差异、形状种类繁多等问题,提出了一种基于稀疏可学习proposal的车间工具检测算法。首先,融入稀疏表示和可学习的proposal机制来提升模型的鲁棒性,并减少检测过程中所需的参数量;其次,引入Swin-Tra... 详细信息

针对车间工具不同型号之间尺寸存在较大差异、形状种类繁多等问题,提出了一种基于稀疏可学习proposal的车间工具检测算法。首先,融入稀疏表示和可学习的proposal机制来提升模型的鲁棒性,并减少检测过程中所需的参数量;其次,引入Swin-Transformer结构,旨在增强模型的全局以及细节学习能力,有效地解决传统卷积神经网络在高层语义信息融合方面存在的不足;然后,使用一种改进的多尺度特征融合网络架构,通过有效融合不同尺度的特征,提高了模型对于各种尺度目标的检测能力;最后,将多头注意力和动态卷积结合,在不同特征层之间建立更精确且细致的联系,从而进一步提升了目标检测的准确性;采用了CIoU损失函数,通过综合考虑位置、尺度和形状信息,使得模型对边界框的回归预测更加全面与准确。实验结果显示,本文算法在车间工具目标检测任务上的平均检测精度达到了91%,较当前主流算法至少提升了2.3%以上。同时,单张图片的检测速度大约为53 ms,满足了实时检测的需求,体现了综合性能优越。

关键词：工具检测稀疏可学习多尺度特征 Swin-Transformer 多头注意力

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Elucidating photolysis mechanisms of ketamine by quantum chemical calculations

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COMPUTATIONAL AND THEORETICAL CHEMISTRY 2022年 1216卷

作者： Shen, Yifan wang, shuwen wang, Se Hao, Ce Nanjing Univ Informat Sci & Technol Collaborat Innovat Ctr Atmospher Environm & Equipm Sch Environm Sci & Engn Jiangsu Key Lab Atmospher Environm Monitoring & Po Nanjing 210044 Peoples R China Dalian Univ Technol State Key Lab Fine Chem Dalian 116024 Liaoning Peoples R China

Ketamine (KET) is a common psychoactive substance, but its photochemical transformation mechanism in aqueous environment has not been elucidated. Density functional theory and time-dependent density functional theory were used to investigate the photodegradation process of KET in water. The calculation results show that during direct photodegradation: The photodegradation reaction of KET in the S-1 state is the cleavage of the nitrogen atom connected to the cyclohexanone group and the methyl bond;KET in the T-1 state can be photo-dechlorinated. During indirect photodegradation: Electron rearrangement occurs after the reaction of KET with fluorenone (FL), thereby sensitizing and degrading KET. Cleavage of nitrogen and methyl bonds;photo-dechlorination and FL degradation of KET are the main reactions during photodegradation.

关键词： Ketamine Photolysis pathways Dissolved organic matter DFT

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Nanoporosity changes of graphene oxide colloids on linkage-treatment with molecular linker and heating after the linkage-treating

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CHEMICAL PHYSICS LETTERS 2024年 848卷

作者： Nagae, Miu Otsuka, Hayato Bairi, Partha wang, shuwen Arai, Takayoshi Sakai, Toshio Kaneko, Katsumi Shinshu Univ Dept Chem & Mat Engn 4-17-1 Wakasato Nagano 3808553 Japan Shinshu Univ Res Initiat Supramat 4-17-1 Wakasato Nagano 3808553 Japan Chiba Univ Grad Sch Sci Dept ChemSoft Mol Activat Res Ctr SMARC Mol Chiral Res Ctr MCRCChiba Iodine Resource Inno 1-33 Yayoi Inage Chiba 2638522 Japan

This study examined the nanoporosity of graphene oxide (GO) and graphene colloids bridge-treated with amino linkers using comparative nanoporosimetry with N2 and Ar adsorption. The spectroscopic measurements revealed the linkage via amino linkers in the linkage-treated GO and graphene colloids. The linkage-treatment expanded the d-spacing of GO by 0.21 nm and the d-spacing of the linkage-treated GO colloid decreased from 1.01 to 0.35 nm upon heating. The linkage-treated graphene colloids exhibited significant adsorption and an adsorption hysteresis, regardless of the reduction of d-spacing. Heating of linkage bonds induced the local structural deformation, providing open pores and the assembled mesoscale structure.

关键词： Graphene Oxide N 2 adsorption Ar adsorption Nanopore structure Molecular linkage

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