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SSRN 2024年

作者： wang, Wei Pan, Yishan Xiao, Yonghui Gao, Xuepeng wang, shuwen Zhang, Xinping wang, Qingguo Dai, Lianpeng Li, Xiaoliang Bao, Xinyang Han, Dayong Key Laboratory of Ministry of Education on Safe Mining of Deep Metal Mines Northeastern University Shenyang110819 China School of Environment Liaoning University Shenyang100036 China School of Mechanics and Engineering Liaoning Technical University Fuxin123000 China School of Physics Liaoning University Shenyang100036 China Hongyang No.3 Mine Shenyang Coking Coal Co. LTD. Liaoyang111300 China Northeastern University United States Liaoning University China

In cable bolt reaming and anchoring of a soft-rock roadway tunnel, the cable bolt and its stirring end are in direct contact with the wall of the drilling hole, which can easily damage the structure of the drilling hole. The cable bolt cannot effectively break and stir the resin in the reaming area. The anchoring force of the cable bolt is low and the deformation of the surrounding rock is large. The characteristics of cable bolt reaming and anchoring in a soft-rock roadway are analyzed systematically. The influence of the cable bolt on the reaming and anchoring performance is calculated and analyzed in terms of cable bolt stirring, anchoring solid strength, pull-out force, cable bolt concentricity, and the influence of the drilling hole wall. A multi-stage reaming and anchoring reinforcement (MRAR) is developed, and the mechanism through which the MRAR strengthens the reaming and anchoring of a cable bolt is analyzed theoretically. Through numerical simulation and laboratory and field experiments, the working performance of the MRAR is verified comprehensively. The results show that the MRAR greatly improves the dynamic stirring action of the cable bolt, compactness and strength of the anchoring solid, drilling performance, concentricity, pull-out force, and pretension. It can ensure to the maximum extent that all the resin in the reaming area is stirred, reacted, and firmly bonded with the hole wall. It greatly improves the reaming and anchoring and roof deformation control of the cable bolt in the soft-rock roadway. This technology has practical significance for improving the reaming and anchoring of a cable bolt and the bearing capacity of the surrounding rock in a soft-rock roadway tunnel. © 2024, The Authors. All rights reserved.

关键词： Reinforcement

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Surface Engineering of Porphyrin Coordination on a Carbon Nanotube for Efficient Hydrogen Evolution

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CHEMCATCHEM 2020年第9期12卷 2469-2477页

作者： wang, Lidong Zhang, Zhaosheng Li, Meng Li, Qiuhan wang, Bo wang, shuwen Zhou, Huang Mao, Boyang North China Elect Power Univ Dept Environm Sci & Engn Baoding 071003 Peoples R China North China Elect Power Univ Coll Environm Sci & Engn MOE Key Lab Resources & Environm Syst Optimizat Beijing 102206 Peoples R China East China Univ Sci & Technol Key Lab Adv Mat Shanghai Key Lab Funct Mat Chem Shanghai 200237 Peoples R China East China Univ Sci & Technol Inst Fine Chem Shanghai 200237 Peoples R China Univ Sci & Technol China iChEM Collaborat Innovat Ctr Chem Energy Mat Dept Chem Hefei 230026 Peoples R China Univ Manchester Sch Phys & Astron Natl Graphene Inst Manchester M13 9PL Lancs England

Functionalised porphyrins have attracted considerable attention owing to their ability to coordinate with numerous metal ions. We design and synthesize a novel composite system based on functionalised Pt(II)-porphyrin and multiwalled carbon nanotubes for hydrogen evolution reaction (HER) electrocatalysis. Rather than qualitatively integrating porphyrin with carbon nanotubes, the optimized Pt(II)-porphyrin loading and precisely morphology control could be fine-tuned and quantitatively premeditated by using fluorescence and UV-vis titration based on the unique pi-pi interactions behaviour of the porphyrin for the first time. The as-prepared composites exhibit superior HER catalytic activity with an overpotential of 35 mV for an electrocatalytic current density of j=-10 mA cm(-2) and a Tafel slope of 32.3 mV dec(-1). Moreover, such catalysts do not exhibit observable activity decay after a 1000-cycle stability test, thus demonstrating their excellent durability. To further reduce Pt loading to achieve cost efficiency, we develop a Pt-Co bimetallic HER catalyst with an ultra-low platinum content through a straightforward synthesis pathway with high catalytic activity and stability. This study provides a new approach for preparing a highly active and stable HER catalyst, which could potentially be extended to other reactions to improve the utilization efficiency of precious metal catalysts.

关键词： porphyrin coordination carbon nanotube fluorescence Pt-Co bimetallic catalyst hydrogen evolution reaction

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Total saponins from Panax japonicus reduce inflammation in adipocytes through the miR155/SOCS1/NFKB signaling pathway

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PHYTOMEDICINE 2023年 115卷 154827页

作者： Gao, Yan wang, Rui Li, Luoying He, Yumin Yuan, Ding Zhang, Yifan Hu, Yaqi wang, shuwen Yuan, Chengfu China Three Gorges Univ Third Grade Pharmacol Lab Tradit Chinese Med State Adm Tradit Chinese Med Yichang 443002 Peoples R China China Three Gorges Univ Coll Basic Med Sci Yichang 443002 Peoples R China China Three Gorges Univ Coll Med & Hlth Sci Yichang 443002 Peoples R China China Three Gorges Univ Coll Basic Med Sci Dept Biochem Yichang 443002 Peoples R China

Background: The rising incidence of metabolic diseases due to chronic inflammation in the adipose tissue has been attributed to factors such as high fat diet (HFD). Previous studies have demonstrated that the total saponins from Panax japonicus (TSPJ) can reduce HFD-induced adipocyte inflammation, but the underlying mechanism remains unclear. In this work, we explored the molecular mechanism by which TSPJ reduces inflammation response in adipocytes. Methods: We first established C57BL/6 mouse and 3T3-L1 adipocyte models. Lentiviruses packaged with the plasmids were injected into mice through the tail vein or into adipocytes to generate the in vivo and in vitro models with miR155 knockdown and overexpression. The mice were fed with HFD to trigger inflammation and administered TSPJ (25 mg/kg center dot d and 75 mg/kg center dot d) by gavage. The adipocytes were treated with palmitic acid (PA) to trigger inflammation response, then treated with TSPJ (25 mu g/ml and 50 mu g/ml). Finally, the expression of miR155, inflammatory factors, SOCS1, and NFKB pathway-related proteins was explored. Results: TSPJ significantly inhibited the expression of inflammation-related genes and the miR155 expression in adipocytes both in vitro and in vivo. The dual luciferase reporter gene assay revealed that miR155 mediated the downregulation of SOCS1. TSPJ significantly inhibited and upregulated the phosphorylation of the NFKB protein and the SOCS1 proteins, respectively. Conclusion: TSPJ inhibits miR155 to upregulate the SOCS1 expression, which subsequently inhibits the NFKB signaling pathway, thereby mitigating the inflammatory response in the adipocytes of HFD mice.

关键词： total saponins from Panax japonicus adipose inflammation high fat diet miR155 SOCS1 NFKB

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冲击地压煤层智能开采关键技术研究与实践

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煤炭科学技术 2024年第9期52卷 112-124页

作者：祁和刚夏永学智宝岩秦子晗程健王凯王书文王宾昌杨光宇煤炭科学研究总院北京100013 中煤科工开采研究院有限公司北京100013 中煤陕西榆林大海则煤业有限公司陕西榆林719000 煤炭科学研究总院矿山人工智能研究院北京100013 北京天地玛珂电液控制系统有限公司北京100013 中国中煤能源集团有限公司北京100120

如何实现深部冲击地压煤层智能安全高效开采是煤炭开采面临的一项重大工程技术难题。该问题的核心内涵在于冲击地压煤层开采的智能化、无人化和本质安全化,通过煤岩冲击风险的智能精准感知与预警,以及采掘工程的自适应与自优化,形成智... 详细信息

如何实现深部冲击地压煤层智能安全高效开采是煤炭开采面临的一项重大工程技术难题。该问题的核心内涵在于冲击地压煤层开采的智能化、无人化和本质安全化,通过煤岩冲击风险的智能精准感知与预警,以及采掘工程的自适应与自优化,形成智能防冲控采技术,实现由工程致灾向工程防灾、工程减灾的根本转变。通过开采源头设计、顶板区域压裂、局部靶向治理、强化巷道支护等措施为冲击地压煤层安全高效开采创造低应力环境和巷道安全空间。在此基础上,开发融合静态地质、动态监测、工况环境、人员定位、生产组织、历史数据等信息的大数据分析软件平台,以及融合冲击地压决策信息的智能化开采控制系统,将防冲信息源转化为智能开采控制源,形成了“低压快推,中压慢采,高压停产”的柔性智能推采新模式。通过现场应用表明,在智能防冲控采区,工作面及巷道矿压显现程度更小,煤岩能量释放更稳定,有利于冲击产能的合理释放。

关键词：冲击地压智能控采区域卸压靶向防范风险感知

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Enhanced cadmium removal by a magnetic potassium ferrocyanide framework: Performance and mechanism study

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ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY 2024年 282卷 116702页

作者： Chen, Miaoling Liu, Heyao Pan, Jiaqi He, Shaoming Hong, Yang wang, shuwen Zhou, Ying Chen, Diyun Su, Minhua Guangzhou Univ Sch Environm Sci & Engn Guangzhou 510006 Peoples R China Beijing Normal Univ Adv Inst Nat Sci Ctr Water Res Zhuhai 519087 Peoples R China

Polluted environments often contain large amounts of toxic metals, such as cadmium, which pose a major threat to ecosystems and public health. Contamination by cadmium and its compounds is often observed in areas surrounding zinc mining sites and electroplating factories, and the control of cadmium pollution is essential for environmental safety and health. In this study, a highly efficient and straightforward separation strategy for K 4 Fe (CN) 6 @Fe 3 O 4 nanocomposites is successfully developed to capture the Cd ions in the water environment. Batch adsorption experiments revealed that K 4 Fe(CN) 6 @Fe 3 O 4 exhibited a high cadmium removal rate (greater than 98 %) at a pH level of 6.0 and solid-liquid ratio of 1.0 g/L at room temperature (298 K). Kinetic analysis revealed that the adsorption process followed a pseudo-second-order model and cadmium was rapidly removed in the first 10 min, with chemisorption dominating the capture of Cd 2+ by K 4 Fe(CN) 6 @Fe 3 O 4 . Adsorption isotherms revealed a heterogeneous adsorption behavior, with a maximum adsorption capacity of 40.78 mg/g. The intrinsic adsorption of Cd 2+ by K 4 Fe(CN) 6 @Fe 3 O 4 occurring primarily through electrostatic interaction and ion exchange. In addition, K 4 Fe(CN) 6 @Fe 3 O 4 exhibited an excellent regeneration capacity. Therefore, integrating Fe 3 O 4 into the metal cyanide not only provided the composite material with excellent chemical stability and selective adsorption sites for Cd 2+ , but also facilitated subsequent sorbent collection and recovery. Overall, this study presents a simple and feasible approach for integrating Fe 3 O 4 into potassium ferrocyanide frameworks for efficient cadmium removal from contaminated water.

关键词： Adsorption Cadmium Framework structure Magnetic potassium ferrocyanide

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公安院校实战化教学的实践与反思

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云南警官学院学报 2022年第5期 76-79页

作者：王曙文云南警官学院禁毒学院云南昆明650223

公安院校的生命力在于坚持实战化的导向,为公安机关培养符合实战需要的应用型人才。党中央和公安部先后发布多项政策或指导性意见,用以促进公安院校实战化教学。各公安院校探索实战化教学既有成功经验,又有值得深入探讨的问题,梳理总结... 详细信息

公安院校的生命力在于坚持实战化的导向,为公安机关培养符合实战需要的应用型人才。党中央和公安部先后发布多项政策或指导性意见,用以促进公安院校实战化教学。各公安院校探索实战化教学既有成功经验,又有值得深入探讨的问题,梳理总结经验和分析薄弱环节可以更好地指导公安院校实战化教学。完善公安院校实战化教学应从实战化教师培养、实战化教材建设、实战化考核及相关制度建设等方面入手,推进实战化教学改革纵深发展,为新时代公安工作培养更多高素质应用型人才。

关键词：公安院校实战化教学路径选择

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Deciphering transcriptome alterations in bone marrow hematopoiesis at single-cell resolution in immune thrombocytopenia

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Signal Transduction and Targeted Therapy 2022年第11期7卷 4190-4207页

作者： Yan Liu Xinyi Zuo Peng Chen Xiang Hu Zi Sheng Anli Liu Qiang Liu Shaoqiu Leng Xiaoyu Zhang Xin Li Limei wang Qi Feng Chaoyang Li Ming Hou Chong Chu Shihui Ma shuwen wang Jun Peng Department of Hematology Qilu HospitalCheeloo College of MedicineShandong UniversityJinan250012China State Key Laboratory of Experimental Hematology National Clinical Research Center for Blood DiseasesHaihe Laboratory of Cell EcosystemInstitute of Hematology&Blood Diseases HospitalChinese Academy of Medical Sciences&Peking Union Medical CollegeTianjin300020China Department of Hematology the Affiliated Hospital of Qingdao UniversityQingdao266000China Advanced Medical Research Institute Shandong UniversityJinan250012China Shangdong Key Laboratory of Immunochematology Qilu HospitalCheeloo College of MedicineShandong UniversityJinan250012China Key Laboratory of Cardiovascular Remodeling and Function Research Chinese Ministry of Education and Chinese Ministry of HealthQilu HospitalCheeloo College of MedicineShandong UniversityJinan250012China Department of Biomedical Informatics Harvard Medical SchoolBoston02115MAUSA

Immune thrombocytopenia(ITP)is an autoimmune disorder,in which megakaryocyte dysfunction caused by an autoimmune reaction can lead to thrombocytopenia,although the underlying mechanisms remain ***,we performed single-cell transcriptome profiling of bone marrow CD34+hematopoietic stem and progenitor cells(HSPCs)to determine defects in megakaryopoiesis in *** expression,cell-cell interactions,and transcriptional regulatory networks varied in HSPCs of ITP,particularly in immune cell *** expressed gene(DEG)analysis indicated that there was an impaired megakaryopoiesis of *** cytometry confirmed that the number of CD9+and HES1+cells from Lin−CD34+CD45RA−HSPCs decreased in *** culture assays demonstrated that CD9+Lin−CD34+CD45RA−HSPCs tended to differentiate into megakaryocytes;however,this tendency was not observed in ITP patients and more erythrocytes were *** percentage of megakaryocytes differentiated from CD9+Lin−CD34+CD45RA−HSPCs was 3-fold higher than that of the CD9−counterparts from healthy controls(HCs),whereas,in ITP patients,the percentage decreased to only 1/4th of that in the HCs and was comparable to that from the CD9−***,when co-cultured with pre-B cells from ITP patients,the differentiation of CD9+Lin−CD34+CD45RA−HSPCs toward the megakaryopoietic lineage was *** analysis revealed that megakaryocytic progenitors(MkP)can be divided into seven subclusters with different gene expression patterns and *** ITP-associated DEGs were MkP subtype-specific,with most DEGs concentrated in the subcluster possessing dual functions of immunomodulation and platelet *** study comprehensively dissects defective hematopoiesis and provides novel insights regarding the pathogenesis of ITP.

关键词： impaired alterations progenitor

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标题中“基于”或“考虑”样式对论文被引次数的影响

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图书情报知识 2023年第3期40卷 139-148页

作者：汪舒雯许元杰穆梦迪卢小莉吴登生中国科学院科技战略咨询研究院北京100190 中国科学院大学公共政策与管理学院北京100049 墨尔本大学工程学院墨尔本3010 中国地质图书馆北京100083

[目的/意义]标题在学术论文知识传播的过程中至关重要,准确而精练的标题可以在反映论文研究内容的同时体现作者的研究思想深度。针对特殊标题样式使用日益频繁的现象,分析了标题中经常出现的“基于”或“考虑”样式对论文被引次数的影响... 详细信息

[目的/意义]标题在学术论文知识传播的过程中至关重要,准确而精练的标题可以在反映论文研究内容的同时体现作者的研究思想深度。针对特殊标题样式使用日益频繁的现象,分析了标题中经常出现的“基于”或“考虑”样式对论文被引次数的影响。[研究设计/方法]首先,根据论文标题中是否含有“基于”或“考虑”样式以及该样式出现的位置,构建四个自变量。其次,在考虑多个影响论文引用次数因素的基础上,构建论文被引次数回归分析的基准模型,采用负二项回归来拟合样本数据。最后,以2018-2021年发表在《FMS管理科学高质量期刊推荐列表2022》索引的所有中文期刊上的42,594篇学术论文进行实证分析。[结论/发现]统计分析的结果表明,在管理科学领域,“基于”或“考虑”标题样式已经成为一种主流样式,42,594篇学术论文的标题中含有该样式的文章达12,372篇,占论文总数的29.05%。实证分析结果表明,标题中的“基于”或“考虑”样式对管理科学领域论文的引用有显著的负相关作用;当“基于”或“考虑”样式出现在论文标题开头时,文章不容易被引用;标题中“基于”或“考虑”的样式对论文引用的影响在不同学科领域上的体现不同。[创新/价值]通过构建计量经济模型,验证了“基于”或“考虑”这一类特殊标题样式对论文引用的影响。

关键词：论文标题标题样式引用优势管理科学

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SIRT1 single-nucleotide polymorphisms are associated with corticosteroid sensitivity in primary immune thrombocytopenia patients

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ANNALS OF HEMATOLOGY 2021年第10期100卷 2453-2462页

作者： wang, shuwen Zhang, Xiaoyu Leng, Shaoqiu Zhang, Yanqi Li, Ju Peng, Jun Zhou, Zeping Feng, Qi Hu, Xiang Shandong Univ Qilu Hosp Cheeloo Coll Med Dept Hematol Jinan Peoples R China Shandong Univ Qilu Hosp Cheeloo Coll Med Shandong Prov Key Lab Immunohematol Jinan Peoples R China Chinese Acad Med Sci & Peking Union Med Coll State Key Lab Expt Hematol Inst Hematol Tianjin Peoples R China Chinese Acad Med Sci & Peking Union Med Coll Blood Dis Hosp Tianjin Peoples R China Kunming Med Univ Affiliated Hosp 2 Dept Hematol Kunming Yunnan Peoples R China

Background Primary immune thrombocytopenia (ITP) is an autoimmune disorder characterized by decreased platelet count. While corticosteroids are a useful first-line therapy for ITP patients, their long-term effectiveness is limited, and the determinants of corticosteroid sensitivity in ITP patients remain largely unknown. Sirtuin 1 (SIRT1), a member of the mammalian sirtuin family, is related to the anti-inflammatory effects of corticosteroids. Here, we investigate the contribution of the SIRT1 single-nucleotide polymorphisms (SNPs) rs12778366 and rs4746720 to ITP susceptibility. Methods We recruited 330 ITP patients and 309 healthy controls from Han population, and performed genotyping of SIRT1 rs12778366 and rs4746720 using a MassARRAY system. The results were validated in another 55 ITP patients from ethnic minorities. Results Using clinical data of patients and controls from Han polulation, including corticosteroid sensitivity, susceptibility, refractoriness, and severity, our results revealed that the CC/TC genotypes of SIRT1 rs12778366 were associated with a 2.034-fold increased risk of corticosteroid resistance compared to the homozygous major TT genotype (dominant, CC/TC vs. TT, OR = 2.034, 95% CI = 1.039-3.984, p = 0.038). In contrast, the CC/CT genotype of SIRT1 rs4746720 showed a 0.560-fold decreased risk of corticosteroid resistance (dominant, 95% CI = 0.321-0.976, OR = 0.560, p = 0.041). The C allele substitute in SIRT1 rs12778366 was significantly associated with the corticosteroid sensitivity of ITP patients (p = 0.021). The similar results were obtained in minority ITP patients. Conclusion This study indicates that SIRT1 rs12778366 and rs4746720 may be genetic factors related to corticosteroid sensitivity in ITP patients.

关键词： Primary immune thrombocytopenia SIRT1 Single-nucleotide polymorphism Corticosteroid sensitivity

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加强禁毒社会工作者队伍建设的思考

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云南警官学院学报 2022年第1期 9-12页

作者：王曙文云南警官学院禁毒学院云南·昆明650221

禁毒社会工作者是主要为吸毒人员提供专业服务的人员,是社会工作者队伍的一部分和新力量。随着国内毒情形势的变化,禁毒工作遇到了新的挑战,这对禁毒社会工作者提出了更高的要求,加强禁毒社会工作者队伍建设是实现禁毒工作的社会化、职... 详细信息

禁毒社会工作者是主要为吸毒人员提供专业服务的人员,是社会工作者队伍的一部分和新力量。随着国内毒情形势的变化,禁毒工作遇到了新的挑战,这对禁毒社会工作者提出了更高的要求,加强禁毒社会工作者队伍建设是实现禁毒工作的社会化、职业化、专业化、科学化水平的有力手段,是落实国家发展禁毒社会工作人才政策的具体体现,是推进毒品问题治理体系和治理能力现代化的重要举措。

关键词：队伍社会工作禁毒社会工作者

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