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5th IEEE Advanced Information Management, Communicates, Electronic and Automation Control Conference, IMCEC 2022

作者： Chen, Zhaoyu wang, shuwen Song, Yingzi Army Logistics Academy Chongqing China

ISBN: (纸本)9781665479677

Optimizing the logistics matching process can enhance user satisfaction, enhance order processing capability and improve the degree of logistics automation, which is of great significance to promote economic and social development. After optimizing the logistics matching process, it is difficult to verify the feasibility of the optimization scheme in a short time through practice due to the rapid changes in the market. The Timed Petri Net theory, with the introduction of time parameters, can be used to model and simulate different schemes of the logistics matching process. By comparing and analyzing the simulation results of the optimization scheme and the original scheme, a conclusion on the verification of the optimization scheme is drawn, which provides a new idea for the feasibility verification of the logistics matching process optimization scheme. © 2022 IEEE.

关键词： Optimization

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References Maxwell-based Permanent Magnet Synchronous Motor Short Circuit Faults and Electromagnetic Losses

References Maxwell-based Permanent Magnet Synchronous Motor ...

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Energy, Power and Electrical Technology (ICEPET), International Conference on

作者： shuwen wang Aiming Zhao School of Electrical Engineering Shanghai Dianji University Shanghai China

ISBN: (数字)9798350352658

ISBN: (纸本)9798350352665

Permanent magnet synchronous motor (PMSM) is a type of motor that is widely used in industrial production, possessing the high efficiency of permanent magnet motor and the precise control characteristics of synchronous motor. With the increase of the motor running time and the change of the external environment, it may lead to the damage of the insulation layer of the stator-side windings, resulting in the turn-to-turn short-circuit faults, which will have an adverse effect on the performance of the motor. In this paper, a 15KW water pump PMSM is selected, and the PMSM model is established by Ansys Maxwell finite element analysis software to study and analyse the relationship between stator side winding turn-to-turn short-circuit and electromagnetic loss, and compare the electromagnetic loss waveforms of the motor in normal operation and various turn-to-turn short-circuit conditions, and the analysis results show that the electromagnetic loss increases the most when the number of short-circuit turns is six. When the stator winding is short-circuited for five turns, the stator's iron consumption increases the most. In the case of a six-turn short circuit, the eddy current loss of the permanent magnet grows the most, and the copper consumption of the stator decreases the most. This provides a reference basis for motor short circuit fault diagnosis and preventive maintenance.

关键词： Fault diagnosis Electromagnetic scattering Windings Stator windings Permanent magnet motors Synchronous motors Water pumps

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LncRNA Gm15232 Promotes Lipogenesis in Aging Mice Through the miR-192-3p/GCR Pathway

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JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES 2024年第4期79卷 glae066页

作者： Hu, Yaqi Zhang, Yifan wang, shuwen wang, Rui Yuan, Qi Wu, Wei Gui, Yibei Zhao, Jiale Li, Xueqing He, Yumin Yuan, Chengfu China Three Gorges Univ Hubei Key Lab Tumor Microenvironm & Immunotherapy Yichang Peoples R China China Three Gorges Univ Coll Basic Med Sci Yichang Peoples R China China Three Gorges Univ grade Pharmacol Lab Tradit Chinese Med 3 State Adm Tradit Chinese Med Yichang Peoples R China China Three Gorges Univ Coll Med & Hlth Sci Yichang Peoples R China

Recent scientific studies have highlighted the importance of long-chain noncoding RNAs (lncRNAs) in a variety of metabolic diseases, but the specific functions and mechanisms of lncRNAs in aberrant lipid synthesis associated with aging are unknown. In this work, we inspected the effects of lncRNAs on the lipid metabolism in aging mice, as substantial evidence suggests that aging disturbs lipid metabolism. The results revealed that the expression of lncRNA Gm15232 was significantly elevated in the epididymal white adipose tissue of aging mice compared to adult mice. This upregulation of Gm15232 functioned as a competitive endogenous RNA by inhibiting the expression of miR-192-3p, and the ensuing downregulation of miR-192-3p increased the expression of the glucocorticoid receptor gene, which ultimately stimulated fat synthesis. The upregulation of Gm15232 thus increased lipogenesis through this mechanism. This study reveals a potential target for the treatment of age-related abnormalities of lipid metabolism.

关键词： aging glucocorticoid receptor Gm15232 lipogenesis miR-192-3p

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Pathophysiological role and potential drug target of NLRP3 inflammasome in the metabolic disorders

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CELLULAR SIGNALLING 2024年 122卷 111320页

作者： Hu, Huiming wang, shuwen Chen, Chen Nanchang Med Coll Sch Pharm Nanchang Jiangxi Peoples R China Univ Queensland Sch Biomed Sci Brisbane Qld Australia Hlth Commiss Jiangxi Prov Key Lab Pharmacodynam & Safety Evaluat Nanchang Jiangxi Peoples R China Jiangxi Univ Chinese Med Nanchang Jiangxi Peoples R China

NLRP3 plays a role in the development of autoinflammatory diseases. NLRP3, ASC, and Caspases 1 or 8 make up the NLRP3 inflammasome, which is an important part of innate immune system. The NLRP3 inflammasomemediated inflammatory cytokines may also participate in metabolic disorders, such as diabetes, hyperlipidemia, atherosclerosis, non-alcoholic fatty liver disease, and gout. Hence, an overview of the NLRP3 regulation in these metabolic diseases and the potential drugs targeting NLRP3 is the focus of this review.

关键词： NLRP3 inflammasome Metabolic disease Diabetes Hyperlipidemia Gout Drug discovery

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Plasma long noncoding RNAs lncDC and THRIL as potential diagnostic markers of adult primary immune thrombocytopenia

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INTERNATIONAL JOURNAL OF LABORATORY HEMATOLOGY 2023年第4期45卷 481-488页

作者： Jiang, Nan wang, Yin Feng, Qi wang, shuwen Leng, Shaoqiu Zhang, Xiaoyu Liu, Qiang Peng, Jun Li, Xin Shandong Univ Dept Hematol Qilu Hosp 107 West Wenhua Rd Jinan 250012 Shandong Peoples R China Shandong Univ Cheeloo Coll Med Jinan Peoples R China Qilu Hosp Shandong Univ Shandong Prov Key Lab Immunohematol Jinan Shandong Peoples R China

Introduction: Immune thrombocytopenia (ITP) is a common acquired hemorrhagic disease without "gold standard" for the diagnosis, long non-coding RNA (lncRNAs) can participate in regulating gene expression through various mechanisms and may play a role in immune intolerance in ITP. Several previous studies have confirmed that lncRNA lncDC and THRIL are involved in the development of autoimmune diseases. This study investigates the relationship between expression levels of two plasma lncRNAs (lncDC and THRIL) and clinical characteristics of adult primary ITP patients, ascertain their potential applications as diagnostic markers of ITP. Methods: We recruited 102 subjects, including 41 ITP patients, 41 healthy controls (HCs) and 20 patients under myelosuppression phase after chemotherapy (MS). qRT-PCR was used to detect the expression of two lncRNAs in the peripheral blood plasma of the three groups. Receiver operating characteristic (ROC) curves were used to test the diagnostic efficacy of lncDC and THRIL in ITP. Results: The expression level of lncDC was downregulated in ITP patients compared with HCs (p = . 012) and MS (p = .035), whereas THRIL was significantly upregulated (p = .0005, p < . 0001). We further revealed that lncDC has a high sensitivity (78. 05%), while THRIL has a high specificity (97. 56%). The area under the curve (AUC) (0.869, 95% CI: 0.795-0.943, p < .0001) of the ROC curve for this combina-tion increased significantly. Conclusions: THRIL and lncDC expression levels were changed in adult ITP patients. The lncRNAs lncDC and THRIL can serve as potential diagnostic markers for adult primary ITP.

关键词： bleeding disorder immune thrombocytopaenia lncDC long non-coding RNA THRIL

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LncSNHG14 promotes nutlin3a resistance by inhibiting ferroptosis via the miR-206/SLC7A11 axis in osteosarcoma cells

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CANCER GENE THERAPY 2023年第5期30卷 704-715页

作者： Li, Luoying Zhang, Yifan Gao, Yan Hu, Yaqi wang, Rui wang, shuwen Li, Yuanyang He, Yumin Yuan, Chengfu China Three Gorges Univ Grade Pharmacol Lab Tradit Chinese Med 3 State Adm Tradit Chinese Med Yichang Peoples R China China Three Gorges Univ Hubei Key Lab Tumor Microenvironm & Immunotherapy Yichang 443002 Peoples R China China Three Gorges Univ Coll Basic Med Sci Yichang 443002 Peoples R China

The most prevalent form of primary osseous malignant tumor in adolescents and children is osteosarcoma (OS). A combination of surgery and neoadjuvant/post-surgery chemotherapy is currently the standard therapy. While the chemoresistance associated with OS generally leads to poor efficacy of therapeutic agents, the relevant molecular interaction is still elusive. Here, the lncRNA (long non-coding RNA) SNHG14 was found to be significantly upregulated in the nutlin3a-resistant OS cell line NR-SJSA1 and contributes to treatment resistance by suppressing ferroptosis. In NR-SJSA1 cells, knockdown of LncRNA SNHG14 resulted in a reversal of drug resistance and activation of ferroptosis, which disappeared when ferrostatin-1, a ferroptosis inhibitor, was added. Mechanistically, lncRNA SNHG14 targeted and down-regulated the expression of miR-206, further affecting the common ferroptosis inhibitor SLC7A11, and preventing NR-SJSA1 cells from undergoing ferroptosis. In conclusion, our findings highlight the involvement of lncRNA SNHG14 in ferroptosis and chemotherapy resistance of nutlin3a-resistant NR-SJSA1 cells, thus shedding new insight on how to overcome drug resistance in osteosarcoma cells and improve treatment efficacy.

关键词： Bone cancer Cell biology Molecular biology

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Selenium-enriched Polysaccharides from Pyracantha fortuneana (SePFP) Ameliorated Hepatic Lipid Accumulation through Enhancing Mitochondrial Fatty Acid β-Oxidation in Aging Mice

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JOURNAL OF OLEO SCIENCE 2023年第10期72卷 929-938页

作者： Hu, Yaqi wang, Rui wang, shuwen Yuan, Chengfu Yuan, Qi Zhang, Yifan Ren, Jianxia He, Yumin Wu, Xiaoshan Dai, Wenjun wang, Wenyong Xie, Shijun China Three Gorges Univ Coll Basic Med Sci Yichang 443002 Peoples R China China Three Gorges Univ Hubei Prov Clin Res Ctr Precise Prevent & Treatmen Peoples Hosp 2 Yichang 443002 Peoples R China China Three Gorges Univ Coll Med & Hlth Sci Yichang 443002 Peoples R China Chongqing Redjoy Hlth Ind Grp Co Ltd Chongqing 409600 Peoples R China Second Peoples Hosp Wufeng Tujia Autonomous Cty Dept Gastroenterol Yichang 443400 Peoples R China

Selenium-enriched polysaccharides from Pyracantha fortuneana ( SePFP) has many beneficial physiological activities, but how it improves the aging associated abnormal lipid metabolism is still unclear. Therefore, we explored the mechanisms of the regulatory role of SePFP on liver lipid accumulation in aging mice. Methods: 60 naturally aged C57BL/6J male mice were divided into 6 groups: adult group, aging group (21-month-old mice), aging mice treated with low-, medium- and high-doses of SePFP (SePFP-L, SePFP-M, SePFP-H), and aging mice treated with resveratrol (RSV). SePFP and RSV were administrated daily via oral gavage from 16 to 21 months old. The parameters of energy metabolism were measured in all mice before sacrifice, and liver tissues were collected to determine the levels of metabolism-related enzymes by real-time PCR and Western blot. Results: We found that SePFP significantly reduced the body weight, liver to bodyweight ratio, and white fat to body weight ratio in aging mice. SePFP also down-regulated the triglycerides and cholesterol levels in liver and serum, and decreased respiratory quotient in aging mice. The mechanism of SePFP regulating lipid metabolism was mainly through promoting fatty acid transportation to mitochondria and enhancing mitochondrial beta-oxidation and ketone body production. Conclusion: SePFP attenuates liver lipid deposition in aging mice by enhancing hepatic mitochondrial beta-oxidation.

关键词： selenium-enriched polysaccharides from Pyracantha fortuneana (SePFP) aging respiratory quotient lipid catabolism mitochondria beta-oxidation

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Pre-service student teachers' metacognition in an online learning community: An epistemic network analysis

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EDUCATION AND INFORMATION TECHNOLOGIES 2024年第11期29卷 14403-14429页

作者： Zhao, Li wang, shuwen Su, Yu-Sheng Nanjing Normal Univ Sch Educ Sci Nanjing Peoples R China Natl Chung Cheng Univ Dept Comp Sci & Informat Engn Chiayi Taiwan Natl Taiwan Ocean Univ Dept Comp Sci & Engn Keelung Taiwan

Pre-service student teachers (PSSTs) should improve their metacognition in order to support their long-term development in their future complex teaching and learning lives. Although previous studies have explored the role of metacognition in learners' learning effectiveness, the interrelationships pattern of metacognition elements in the process of metacognition and the metacognition characteristics of different genders and learning performance groups still remain unclear. This study clarified the intrinsic structure of metacognition, and gender and learning performance differences among PSSTs in an online learning community. We collected 33 PSSTs' self-reported reflection data on six learning topics. A total of 1,188 reflection paragraphs were coded and 2,335 metacognitive utterances were presented based on the metacognition model. Subsequently, this study identified metacognitive components among different groups of PSSTs by comparing epistemic networks of self-reported reflections via epistemic network analysis. Results show that metacognitive components of PSSTs in an online learning community were mainly metacognitive experiences (36.32%) and actions (or strategies) (28.01%). Female PSSTs used metacognitive knowledge (21.4%) and goals (or tasks) (15.8%) more frequently, and the relationship between their metacognitive knowledge and goals (or tasks) was closer compared with male PSSTs. Specifically, the ENA results showed that the associations between metacognitive knowledge and goals (or tasks) (connection coefficient: 0.24) of females were stronger than those of males. In addition, the high learning performance group used metacognitive knowledge (18.7%) and goals (or tasks) (15.9%) more frequently, and they also had a closer connection between metacognitive knowledge and goals (or tasks) compared with the high learning performance group. Specifically, the ENA results showed that compared with the low learning performance PSSTs, high learning performance PSSTs'

关键词： Epistemic network analysis Metacognition Online learning community Pre-service student teachers

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Total saponins from Panax japonicus mediate the paracrine interaction between adipocytes and macrophages to promote lipolysis in the adipose tissue during aging via the NLRP3 inflammasome/GDF3/ATGL axis

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PHYTOMEDICINE 2025年 136卷 156304页

作者： Xia, Fangqi Hu, Yaqi wang, Yaqi Xue, Mengzhen Zhu, Leiqi Li, Yuanyang Zhang, Yifan wang, shuwen wang, Rui Yuan, Qi He, Yumin Yuan, Ding Zhang, Jihong Yuan, Chengfu China Three Gorges Univ Grade Pharmacol Lab Tradit Chinese Med 3 State Adm Tradit Chinese Med Yichang 443002 Peoples R China China Three Gorges Univ Coll Basic Med Sci Yichang 443002 Peoples R China China Three Gorges Univ Coll Med & Hlth Sci Yichang 443002 Peoples R China China Three Gorges Univ Hubei Clin Res Ctr Funct Digest Dis Tradit Chinese Yichang 443002 Peoples R China China Three Gorges Univ Tradit Chinese Med Hosp Yichang 443002 Peoples R China

Adipocytic lipolysis is strongly related to the increase of visceral fat, decrease of exercise capacity, and various other metabolic syndromes during aging. It is significantly influenced by the paracrine relationship between adipocytes and the adipose tissue macrophages (ATMs), and the cytokines secreted by ATMs have endocrine effects on adjacent tissues. We previously reported that the total saponins from Panax japonicus (TSPJs) can enhance lipid metabolism. In this work, we for the first time proved that TSPJs promoted adipocytic lipolysis by preventing NLRP3 activation in ATMs to inhibit the expression of GDF3. The decrease of GDF3 by TSPJs restored the expression of the adipose triglyceride lipase (ATGL) and phosphorylated hormone-sensitive lipase (p-HSL), both of which are known to decrease with aging. Thus, the NLRP3 inflammasome/GDF3/ATGL axis may be a worthy target in developing future clinical solutions for aging-related obesity.

关键词： Aging Total saponins from Panax japonicus NLRP3 inflammasome Lipolysis

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Improving the Properties of Gray Cast Iron by Laser Surface Modification

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MATERIALS 2023年第16期16卷 5533-5533页

作者： Sai, Qingyi Hao, Jiale wang, shuwen wang, Zhi Univ Shanghai Sci & Technol Coll Energy & Power Engn Shanghai 200093 Peoples R China Univ Shanghai Sci & Technol Coll Mech Engn Shanghai 200093 Peoples R China

Laser surface modification is a widely used technology to improve the properties of functional surfaces. In this study, the properties of gray cast iron are modified by laser surface modification, and the influence of laser quenching on the properties of cast iron in terms of frictional vibration and noise, friction and wear, internal structure, residual stress, hardness, and corrosion resistance is investigated. The experimental results show that, after high-power laser quenching, the frictional vibrations and noise of most gray cast iron specimens are decreased, but the coefficients of friction against a bearing steel counterface are increased and more stable. The surface and sub-surface hardness of all laser-quenched cast iron specimens is significantly increased. The residual stresses on the surface of the cast iron specimens are significantly increased and changed from tensile to compressive residual stresses. Experimental modal testing results show that the modal damping ratios of the laser-treated specimens are increased significantly, although their modal frequencies are not significantly changed. In addition, through the metallographic observation, XRD (X-ray diffraction) analysis, and TEM (transmission electron microscopy) observation, it is found that the microstructures of the cast iron specimen after high-power laser modification become fine-grained, and the pearlite and ferrite in the matrix become fine martensite, which leads to the improvement of the dynamical, tribological, and chemical properties of cast iron after laser modification.

关键词： laser modification vibration and noise residual stress corrosion cast iron

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