检索结果-内蒙古大学图书馆

Impacts of elemental contents and components on APB energy and its role in precipitation-strengthened multi-principal component alloys

引用

JOURNAL OF ALLOYS AND COMPOUNDS 2025年 1018卷

作者： wang, qiuju Zhu, Yaxin Zhou, Longjun Han, Kangning wang, Changwei Zhao, Lv Liang, Shuang Huang, Minsheng Li, Zhenhuan Huazhong Univ Sci & Technol Sch Aerosp Engn Dept Engn Mech Wuhan 430074 Peoples R China Hubei Key Lab Engn Struct Anal & Safety Assessment Wuhan 430074 Peoples R China Wuhan Maritime Commun Res Inst Hubei Prov Key Lab Low Frequency Electromagnet Com Wuhan 430079 Peoples R China

Precipitation-strengthened multi-principal component alloys, characterized by cubic L12-structured precipitate phases embedded within FCC-structured matrixes, have attracted significant attention due to their exceptional strength and thermal stability. Antiphase boundary (APB) forms when dislocations penetrate the L12 precipitates, playing a critical role in strengthening these materials. This study systematically explored the effects of elemental content and component variations on the APB energy in a precipitation-strengthened multi-principal component alloy, with a focus on their role in enhancing the alloy's strength. By quantitatively calculating the critical shear stress required for a dislocation to penetrate the L12 precipitate, the order strengthening associated with APB formation was assessed. The results reveal that APB energy generally decreases with increasing Co, Cr or Fe contents in most ternary, quaternary and quinary alloys. Additionally, a higher number of alloying components typically leads to in a reduction in the APB energy. However, the addition of Co mitigates this reduction. Variations in the APB energy are strongly correlated with the changes of the ordering energy in those alloys. Notably, order-strengthening accounts for approximately 30 % of the total strength in ternary, quaternary and quinary systems, underscoring the significant role of APB in strengthening the alloys. The findings offer valuable insights for tailoring the components and contents of precipitation-strengthened multi-principal component alloys to advance high-performance materials for high-temperature applications.

关键词： Multi-principal component alloy Dislocation Anti-phase boundary Precipitate Molecular dynamics

来源：评论

学校读者我要写书评

暂无评论

Identification of genetic mechanisms of non-isolated auditory neuropathy with various phenotypes in Chinese families

引用

ORPHANET JOURNAL OF RARE DISEASES 2025年第1期20卷 1-17页

作者： Cao, Yang Zhang, Xiaolong Lan, Lan Li, Danyang Li, Jin Xie, Linyi Xiong, Fen Yu, Lan Wu, Xiaonan wang, Hongyang wang, qiuju Chinese Peoples Liberat Army Gen Hosp Chinese PLA Med Sch Med Ctr 6 Sr Dept Otolaryngol Head & Neck Surg Beijing 100048 Peoples R China State Key Lab Hearing & Balance Sci Beijing 100853 Peoples R China Natl Clin Res Ctr Otolaryngol Dis Beijing 100853 Peoples R China

BackgroundNon-isolated auditory neuropathy (AN), or syndromic AN, is marked by AN along with additional systemic manifestations. The diagnostic process is challenging due to its varied symptoms and overlap with other syndromes. This study focuses on two mitochondrial function-related genes which result in non-isolated AN, FDXR and TWNK, providing a summary and enrichment analysis of genes associated with non-isolated AN to elucidate the genotype-phenotype correlation and underlying *** independent Chinese Han patients with mutations in FDXR and TWNK underwent comprehensive clinical evaluations, genetic testing, and bioinformatics analyses. Diagnostic assessments included auditory brainstem response and distortion product otoacoustic emissions, supplemented by other examinations. Whole exome sequencing and Sanger sequencing validated genetic findings. Pathogenicity was assessed following American College of Medical Genetics and Genomics guidelines. Genes associated with non-isolated AN were summarized from prior reports, and functional enrichment analysis was conducted using Gene Ontology *** total of 11 variants linked to non-isolated AN were identified in this study, eight of which were novel. Patients' age of hearing loss onset ranged from 2 to 25 years, averaging 11 years. Hearing loss varied from mild to profound, with 57.1%(4/7) of patients having risk factors and 71.4%(5/7) exhibiting additional systemic symptoms such as muscle weakness, ataxia, and high arches. Functional enrichment analysis revealed that genes associated with non-isolated AN predominantly involve mitochondrial processes, affecting the central and peripheral nervous, musculoskeletal, and visual *** study identifies novel mutations in FDXR and TWNK that contribute to non-isolated AN through mitochondrial dysfunction. The findings highlight the role of mitochondrial processes in non-isolated AN, suggesting potential relevance as biomarkers f

关键词： Non-isolated auditory neuropathy Hereditary deafness FDXR TWNK Syndrome

来源：评论

学校读者我要写书评

暂无评论

Observational study to preliminarily characterize the audiological profile of chinese children with williams syndrome

引用

Journal of Otology 2025年第1期20卷 5-11页

作者： Jiao Zhang Minghui Zhao Wei Shi Haina Ding Lan Lan Dayong wang qiuju wang College of Otolaryngology Head and Neck Surgery Chinese PLA Institute of OtolaryngologyChinese PLA General HospitalChinese PLA Medical SchoolBeijingChina National Clinical Research Center for Otolaryngologic Diseases BeijingChina Key Lab of Hearing Science Ministry of EducationBeijingChina Beijing Key Lab of Hearing Impairment for Prevention and Treatment BeijingChina

Purpose It is essential to investigate the audiological profiles of Williams syndrome in a multicultural *** study aims to examine the characteristics and management of hearing loss in Chinese children with Williams syndrome and provide references for future clinical *** Between January 2007 and March 2022,families with at least 1 WS patient was recruited from the Newborn Cohort Study of Hearing *** tests were performed,and then appropriate medical management was ***,an overview of the hearing loss phenotype in Williams syndrome in different locations was *** A total of two families with at least 1 Williams syndrome patient were recruited from the Newborn Cohort Study of Hearing Loss(ChiCTR2100049765).We identified moderately severe sensorineural or conductive hearing loss that emerged as early as the infancy period in Williams syndrome subjects in Chinese *** results extended the reported onset ages of hearing loss in WS from late childhood or early adulthood to the infancy *** also found that with early diagnosis,proper management,and regular monitoring,children with Williams syndrome could return to a normal or near-normal school *** Our study demonstrated the distinct hearing profile in Chinese children with Williams syndrome for the first *** cohort of WS subjects extends the reported onset ages of hearing loss in WS from late childhood or early adulthood to the infancy period,indicating the importance of clinicians screening and monitoring the hearing status of individuals with WS as early as *** data provide references for otolaryngologists and paediatricians to inform the clinical understanding and management of hearing loss in Williams syndrome.

关键词： williams syndrome hearing loss audiological profile children clinical management

来源：评论

学校读者我要写书评

暂无评论

Perinatal risk factors and preliminary prediction of conductive hearing loss in infancy

引用

Journal of Otology 2025年第1期20卷 33-38页

作者： Jiao Zhang Minghui Zhao Wei Shi Haina Ding Lan Lan Yun Gao Dayong wang qiuju wang Department of Audiology and Vestibular Medicine Senior Department of OtolaryngologyHead and Neck Surgerythe sixth Medical Center of Chinese PLA General HospitalBeijing100853China National Clinical Research Center for Otolaryngologic Diseases Beijing100853China The Third Affiliated Hospital of Zhejiang Chinese Medical University Haangzhou310005ZhejiangChina

Purpose To investigate the perinatal risk factors for conductive hearing loss(CHL)in infancy and develop an initial prediction model to facilitate accurate diagnosis and early detection of *** This retrospective study utilized data from the Newborn Cohort Study of Hearing Loss(ChiCTR2100049765).Infants who underwent diagnostic audiological assessments at our hospital between January 2003 and June 2024 were *** analysis was conducted using R(version 4.4.1)to construct an initial prediction model for CHL in infancy,applying the LASSO regression *** A total of 661 infants(1322 ears)were included,with 1253 ears in the normal hearing group and 69 ears in the CHL *** significant differences were observed between the groups in the following factors:parent-reported infant response to sound,craniofacial deformities,neonatal hemolysis,jaundice treatment,and neonatal hypoglycemia.A multivariate prediction model and nomogram for CHL in infancy were developed and validated,achieving an accuracy of 92.5%and a specificity of 91.3%.Conclusions This study identified key risk factors for CHL in infancy and developed a preliminary predictive model,improving the diagnostic accuracy for *** diagnostic precision can decrease misdiagnoses,reduce delays in treatment,and limit unnecessary antimicrobial prescriptions for infants.

关键词： conductive hearing loss infant perinatal risk factors prediction

来源：评论

学校读者我要写书评

暂无评论

Unlocking academic success: the impact of time management on college students' study engagement

引用

BMC PSYCHOLOGY 2025年第1期13卷 1-12页

作者： Fu, Yangyang wang, qiuju wang, Xiaofeng Zhong, Haoxuan Chen, Junqi Fei, Haoyu Yao, Yipeng Xiao, Yao Li, Wenfu Li, Na Jining Med Univ Sch Mental Hlth Jining 272013 Peoples R China Jining Med Univ Off Student Work Jining 272013 Peoples R China

BackgroundIn this study, the purpose was to examine the impact of time management on college students' study engagement and to determine the mechanisms involved. Consequently, we examined the relationship between time management and engagement in study, as well as self-control and mobile phone dependence. MethodsThe Adolescence Time Management Disposition Scale (ATMD), College Student Mobile Phone Dependence Questionnaire (CSMPDQ), Utrecht Work Engagement Scale-student (UWES-S), and Self-Control Scale (SCS) were administered to 1016 college students. A Pearson's correlation analysis and a mediation analysis using bootstrapping were performed in order to test for standard method bias using SPSS 22.0. Results(1)Time management was positively associated with self-control and study engagement, and negatively associated with mobile phone dependence (p <.001). self-control was positively associated with study engagement, and negatively associated with mobile phone dependence (p <.001). Mobile phone dependence was negatively associated with study engagement (p <.01). (2)Time management can not only directly predict study engagement (95%CI, 0.102 - 0.208) but also affects study engagement through three indirect paths: self-control was a mediator (95%CI, 0.066 - 0.158), mobile phone dependence was a mediator (95%CI, 0.043 - 0.109), and self-control and mobile phone dependence were a chain mediator (95%CI, 0.012 - 0.032). ConclusionTime management not only influences study engagement directly, but also through the mediating effect of self-control and mobile phone dependence indirectly.

关键词： Chinese college students Time management Self-control Mobile phone dependence Study engagement

来源：评论

学校读者我要写书评

暂无评论

MB based RT-qPCR increase the clinical application of cfEBV DNA for NPC in non-endemic area of China

引用

SCIENTIFIC REPORTS 2025年第1期15卷 1-12页

作者： He, Qiao Tuo, Yi Zhou, Yi Yan, Yue Liu, Xin Zhao, Dan wang, qiuju Luo, Hao Zhang, Zhengyao Meng, Fanping Ying, Binwu wang, Dongsheng Yang, Mu Huang, Yecai Univ Elect Sci & Technol China Sichuan Canc Hosp & Inst Sichuan Clin Res Ctr Canc Sichuan Canc CtrDept Clin LabSch Med Chengdu 610000 Peoples R China Sichuan Univ West China Hosp Dept Lab Med Chengdu 610041 Peoples R China Chengdu Univ Tradit Chinese Med Coll Med Technol Chengdu 611137 Peoples R China Chong Qing Univ Dept Clin Lab Three Gorges Hosp Chongqing Peoples R China Univ Elect Sci & Technol China Sichuan Canc Hosp & Inst Sichuan Clin Res Ctr Canc Sichuan Canc CtrDept Expt Res Chengdu 610000 Peoples R China Univ Elect Sci & Technol China Dept Radiat Oncol Radiat Oncol Key Lab Sichuan Prov Sichuan Clin Res Ctr CancSichuan Canc Hosp & Inst Chengdu 610000 Peoples R China Univ Elect Sci & Technol China Sichuan Canc Hosp & Inst Sichuan Canc Ctr Dept Clin LabSichuan Clin Res Ctr Canc Chengdu 610000 Sichuan Peoples R China

To compare the performance of magnetic bead (MB) and the concentrated precipitation (CP) based RT-qPCR to qualify cell free EBV DNA (cfEBV DNA) for nasopharyngeal carcinoma (NPC) in non-endemic area of China. From January 2014 to June 2024, a retrospective analysis of 2 cohort studies on cfEBV DNA in NPC patients was conducted to assess the diagnostic value, positive detection rate and clinical application. cfEBV DNA detection with CP based RT-qPCR in cohort 1 and MB based RT-qPCR method in cohort 2. The MB based RT-qPCR for the quantitative measurement of cfEBV DNA load was higher than the CP based RT-qPCR in the same plasma samples from NPC patients (P < 0.001). CP based RT-qPCR measured cfEBV DNA in 1405 NPC and 244 healthy controls in cohort 1 with 40.8% sensitivity (AUC = 0.704, 95% CI: 0.676-0.731). In cohort 2(683 naive NPC and 303 controls), cfEBV DNA had a sensitivity of 75.84% (AUC = 0.879, 95% CI: 0.86-0.90). There were no significant differences in TNM stage among NPC between the two cohorts (P > 0.05). The MB method considerably increased the positive detection rate of cfEBV DNA in NPCs at stages III-IV, T2-T4, N1-N3, and M0 (P < 0.001). At the end of treatment, 97.51% of patients had no detectable EBV and just 2.49% had detectable cfEBV DNA. Those who received <= 2 or >= 3 cycles of NAC had a median t(1/2) clearance rate of 9.8 days and 12.6 days, respectively. MB based RT-qPCR increased the quantity of cfEBV DNA. MB based RT-qPCR demonstrated superior sensitivity and positive detection rates for cfEBV DNA. cfEBV DNA can be more positively noticed, with a higher diagnostic value and a broader variety of clinical applications among NPC in non-endemic areas.

关键词： RT-qPCR MB CP cfEBV DNA NPC

来源：评论

学校读者我要写书评

暂无评论

线相——现象学视角下中国纤维艺术的线之禅性

引用

美术 2025年第4期 144-147页

作者：王秋菊慈程东北大学外语学院东北大学艺术学院

纤维艺术的“线”是构建作品的材料与形式,其有“相”亦无“相”,是物质的延展,而中国纤维艺术中的线透露出中国特有的禅性。在禅宗视野下,线成为艺术精神观念的具象化表达。本文以线的禅性为切口,结合现象学的方法,旨在为中国纤维艺术... 详细信息

纤维艺术的“线”是构建作品的材料与形式,其有“相”亦无“相”,是物质的延展,而中国纤维艺术中的线透露出中国特有的禅性。在禅宗视野下,线成为艺术精神观念的具象化表达。本文以线的禅性为切口,结合现象学的方法,旨在为中国纤维艺术提供一种理解维度,揭示两者之间在本质与现象中的交融,从而在“无形”与“有形”之间建立起哲学与艺术的对话。

关键词：纤维艺术线禅宗现象学

来源：评论

学校读者我要写书评

暂无评论

Comparative study on growth performance and nutritional quality of Eriocheir sinensis between Liaohe River strain and Yangtze River strain under rice field culture environment

引用

JOURNAL OF FOOD COMPOSITION AND ANALYSIS 2025年 137卷

作者： Zhang, Baoyuan Hou, Yuelin Zhu, Rui wang, Wenjin Liu, Hongjian Yang, Zhinan Wu, Min wang, qiuju Jilin Agr Univ Coll Anim Sci & Technol Changchun 130118 Jilin Peoples R China Aquaculture Technol Extens Stn Jilin Prov Changchun 130012 Peoples R China

This study investigated the similarities and differences in catch rates, growth performance, proximate composition, amino acid content, and fatty acid profiles between the Yangtze River crab and the Liaohe River crab in rice aquaculture systems in northern China. A three-month culture experiment was conducted for the Yangtze River crab and the Liaohe River crab in a rice located at longitude 124.82 degrees and latitude 43.50 degrees. The results revealed that Liaohe River crab had higher catch rate and faster growth rates than Yangtze River crab, and the female crab had earlier ovaries. The edible tissues of Liaohe River crabs contain higher crude protein and fat contents, featuring a more reasonable amino acid composition and structure. Meanwhile, the gonads of male and female Yangtze River crabs had higher PUFA content. In conclusion, under the conditions of this experiment, the Liaohe River crab demonstrated a significant growth advantage.

关键词： Liaohe River crab Yangtze River crab Rice-crab system Amino acid composition Fatty acid composition

来源：评论

学校读者我要写书评

暂无评论

难治性内耳病研究现状与未来对策

引用

临床耳鼻咽喉头颈外科杂志 2025年第3期39卷 185-190页

作者：王秋菊余力生杨仕明中国人民解放军总医院第六医学中心耳鼻咽喉头颈外科医学部北京100853 国家耳鼻咽喉疾病临床医学研究中心解放军医学院北京大学人民医院耳鼻咽喉科

难治性内耳病是指经现有的临床实践指南推荐的规范化治疗后仍不能达到良好疗效的系列内耳疾病谱。该疾病谱发病因素多样,表型异质性高,分型特征不清、致病机制不详,预后转归多样,难以精确定义。难治性内耳病在内耳病总人群中占重要比例... 详细信息

难治性内耳病是指经现有的临床实践指南推荐的规范化治疗后仍不能达到良好疗效的系列内耳疾病谱。该疾病谱发病因素多样,表型异质性高,分型特征不清、致病机制不详,预后转归多样,难以精确定义。难治性内耳病在内耳病总人群中占重要比例,至今未得到系统总结、提炼和深入研究。本文首次明确提出了难治性内耳病的理念、定义和范畴,并就难治性内耳病的研究现状、面临问题和应对策略进行了阐述。相信随着科学技术的发展和进步,未来我们将见证更多新质的创新技术与新药物应用于难治性内耳病的治疗领域,为患者带来治愈的希望。

关键词：难治性内耳病定义精准分型问题与挑战对策

来源：评论

学校读者我要写书评

暂无评论

基于散发耳聋核心家系的基因新发突变(DNM)特征分析及遗传咨询策略

引用

遗传 2025年第3期47卷 329-341页

作者：关静吴萧男李进谌国会王洪阳王秋菊中国人民解放军总医院第六医学中心耳鼻咽喉头颈外科医学部北京100048 国家耳鼻咽喉疾病临床医学研究中心北京100048

新发突变(de novo mutation, DNM)是导致散发耳聋的重要遗传因素,也是复杂耳聋综合征发病的重要致病原因。为了分析散发耳聋DNM遗传学特征及其致病因素,本文以2015年10月~2023年10月纳入“中国聋病基因组计划”的410个散发耳聋核心家系... 详细信息

新发突变(de novo mutation, DNM)是导致散发耳聋的重要遗传因素,也是复杂耳聋综合征发病的重要致病原因。为了分析散发耳聋DNM遗传学特征及其致病因素,本文以2015年10月~2023年10月纳入“中国聋病基因组计划”的410个散发耳聋核心家系为对象,对收集到的先证者及其父母的临床信息进行了回顾性分析,同时通过靶向捕获高通量测序、线粒体基因组及全基因组拷贝数变异检测,进行了“父+母+先证者”核心家系遗传学比对分析,应用同源等位基因检测方法来计算DNM先证者核心家系成员之间关系系数。结果发现,这些散发耳聋核心家系中有7.3%(30例)先证者携带17种常染色体显性基因新发SNV、Indel和1种新发拷贝数变异,涵盖所有DNM类型,其中WFS1 c.2051C>T、ATP1A3 c.2452G>A、ACTG1 c.94C>T是散发耳聋中常见DNM,基因型C>T变异占比最高(34.6%);临床特征分析也显示有56.7%(17/30)先证者为非综合征性耳聋,但其中有半数以上(52.9%,9/17)携带明确与“综合征性耳聋”相关的致病基因型,可能存在暂时性“拟”非综合征性耳聋表型特征。本组30例先证者父母的平均生育年龄分别为29.4岁和28.3岁,其中父亲或母亲生育年龄≥35岁的各占13.3%;同时在遗传咨询的先证者家庭结构中,63.3%为独生子女家庭且有明确再生育意愿,16.7%先证者父母为孕育“二孩”产前遗传咨询。遗传咨询时,需要以“父+母+先证者”核心家系为单位进行检测,以便分析DNM在聋病发生中的遗传贡献度;由于DNM发生与父母生育年龄的增加存在一定相关性,因此对于已生育DNM散发耳聋患者家庭,还需要采集听力健康父母的生育年龄及孕产史等临床信息,当这些家庭再生育时建议受孕后进行已明确DNM致病变异的产前诊断并重视妊娠结局。

关键词：散发性耳聋新发突变遗传咨询年龄因素生育健康

来源：评论

学校读者我要写书评

暂无评论

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

请选择保存的检索档案：

请选择收藏分类：

通借通还

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：