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4rth International Conference on Applied Mathematics, Modelling, and Intelligent Computing, CAMMIC 2024

作者： Jin, Hailei wang, xuwen Huang, Kun Xiong, Xiaomin Zhang, Minshu Li, Jiang Xinyu Power Supply Branch of State Grid jiangxi Power Co. Ltd. Xinyu338000 China Shanghai University of Electric Power Shanghai200090 China

ISBN: (纸本)9781510681637

Nowadays, most of the 10 kV distribution network cable lines are laid underground in the form of direct burial or casing, and the cable is cut off by the construction machinery, resulting in the accident of line tripping. In the construction of urban construction, third-party external forces such as manual excavation, mechanical excavation and illegal invasion will cause serious damage to underground cables. Therefore, it is of great engineering application value to develop cable marking piles with sound source localization function and find the location of damage points in time. In order to improve the accuracy and effectiveness of positioning, but also to achieve rapid positioning of the source of damage, this paper is based on the sound sensor, using its flexibility, efficiency and timeliness, by controlling the number and location of the sound sensor, combined with the sound intensity to locate the sound source. At the same time, the sound sensor is connected with the number and position of the marking pile, and the traditional cable marking pile is improved to accurately locate the damage source in time. © 2024 SPIE.

关键词： Excavation

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A synergistic water-saving strategy combining stage-specific irrigation and application of exogenous thiamine enhances drought resistance of Xinjiang cotton

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PLANT AND SOIL 2025年 1-14页

作者： Zhao, Fuxiang Xia, Linjie Sun, Simin Li, Hang Rong, Yuxuan wang, Yuxin wang, xuwen Kong, Xianhui Zhu, Longfu Zhang, Xianlong Yu, Yu Yang, Xiyan Xinjiang Acad Agr & Reclamat Sci Cotton Inst Shihezi 832000 Xinjiang Peoples R China Huazhong Agr Univ Natl Key Lab Crop Genet Improvement Wuhan 430070 Hubei Peoples R China Hubei Hongshan Lab Wuhan Peoples R China

Background and aimsXinjiang is the largest cotton planting area in China. However, the perennial water shortage in Xinjiang restricts the development of the cotton industry, making drought one of the important limiting factors. The aim of this study was to evaluate the effectiveness of water-saving scheme and thiamine (Thi) application on alleviating the adverse effects of drought stress on the growth and development of *** this study, five Xinjiang-released cotton varieties (Jinken1775, Jinken1565, Huamian702, Zhongmian979, and Jinfeng2) were selected as the research object, and Xinluzao8 served as the drought-sensitive control. Comprehensive drought resistance index (D) of the drought resistance coefficient (DRC) of four yield and four quality traits were used to evaluate the drought resistant ability of the six cotton varieties under different water conditions and Thi spraying *** stage-specific irrigation strategy (60% during vegetative vs. 90% during the flowering and boll stage) concurrently maintained higher drought resistance across cultivars, with Jinken1565 exhibited the highest drought resistance. This scheme reduced irrigation by 26% while sustaining fiber quality. Exogenous 50 mM Thi further enhanced drought tolerance, reducing transpiration rate by 33% and blade damage by 55%. These results demonstrate that stage-specific water management optimizes drought adaptation in cotton cultivation under drought *** study suggests that a 26% water-saving scheme was proposed for most drought-resistant varieties planted in Xinjiang, and an appropriate scheme to achieve stable yield by Thi application during the early drought condition was proposed for varieties with low drought resistant ability.

关键词： Cotton Drought resistance Comprehensive drought resistance index Thiamine Water saving scheme

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PEcnv: accurate and efficient detection of copy number variations of various lengths

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BRIEFINGS IN BIOINFORMATICS 2022年第5期23卷 bbac375-bbac375页

作者： wang, xuwen Xu, Ying Liu, Ruoyu Lai, Xin Liu, Yuqian wang, Shenjie Zhang, Xuanping wang, Jiayin Xi An Jiao Tong Univ Sch Comp Sci & Technol Xian Peoples R China Xi An Jiao Tong Univ Sch Comp Sci & Technol Med Informat Xian Peoples R China

Copy number variation (CNV) is a class of key biomarkers in many complex traits and diseases. Detecting CNV from sequencing data is a substantial bioinformatics problem and a standard requirement in clinical practice. Although many proposed CNV detection approaches exist, the core statistical model at their foundation is weakened by two critical computational issues: (i) identifying the optimal setting on the sliding window and (ii) correcting for bias and noise. We designed a statistical process model to overcome these limitations by calculating regional read depths via an exponentially weighted moving average strategy. A one-run detection of CNVs of various lengths is then achieved by a dynamic sliding window, whose size is self-adopted according to the weighted averages. We also designed a novel bias/noise reduction model, accompanied by the moving average, which can handle complicated patterns and extend training data. This model, called PEcnv, accurately detects CNVs ranging from kb-scale to chromosome-arm level. The model performance was validated with simulation samples and real samples. Comparative analysis showed that PEcnv outperforms current popular approaches. Notably, PEcnv provided considerable advantages in detecting small CNVs (1 kb-1 Mb) in panel sequencing data. Thus, PEcnv fills the gap left by existing methods focusing on large CNVs. PEcnv may have broad applications in clinical testing where panel sequencing is the dominant strategy.

关键词： genomics sequencing data analysis variant detection copy number variation (CNV) exponentially weighted moving average clinical panel sequencing

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论基于不法原因给付的返还

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华东政法大学学报 2023年第2期26卷 176-192页

作者：汪绪文上海财经大学法学院

《民法典》并未明文规定不法原因给付制度,既往司法实践中关于该问题的争议还将继续存在,借鉴域外经验是求得法适用之统一的可能的路径。从比较法上看,不法原因给付制度滥觞于罗马法,并逐步发展出了“原则允许返还”与“原则上不得请求... 详细信息

《民法典》并未明文规定不法原因给付制度,既往司法实践中关于该问题的争议还将继续存在,借鉴域外经验是求得法适用之统一的可能的路径。从比较法上看,不法原因给付制度滥觞于罗马法,并逐步发展出了“原则允许返还”与“原则上不得请求返还”两种规范模式。“不得请求返还”之原则不仅在规范目的上难以得到合理解释,在实践中也引发了诸多困境,各国学说与判例通过多重限制竭力予以克服,这其中隐含了决定返还关系的实质因素。在现行法实际秉持“允许返还”立场的制度背景下,部分法院在限制返还关系以求个案公正方面进行了一定努力,但其理由均存在可驳斥之处。对不法原因给付所生的返还问题,可在考虑规范目的、不法目的是否达到、当事人双方的不法性程度诸因素的基础上,以限缩法律行为无效后所生返还关系的方式加以解决。

关键词：不法原因给付返还法律行为无效规范目的限制返还

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GhEXL3 participates in brassinosteroids regulation of fiber elongation in Gossypium hirsutum

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PLANT JOURNAL 2024年第2期120卷 491-504页

作者： Zhang, Changsheng Liu, Zhao Shu, Sheng Li, Xinyang Li, Yujun Liu, Le Liu, Li wang, xuwen Li, Fuguang Qanmber, Ghulam Yang, Zuoren Zhengzhou Univ Sch Agr Sci State Key Lab Cotton Biobreeding & Integrated Util Zhengzhou Res Base Zhengzhou Peoples R China Chinese Acad Agr Sci Inst Cotton Res State Key Lab Cotton Biobreeding & Integrated Util Anyang Peoples R China Chinese Acad Agr Sci Western Agr Res Ctr Changji Peoples R China Xinjiang Acad Agr & Reclamat Sci Cotton Res Inst Northwest Inland Reg Key Lab Cotton Biol & Genet B Shihezi Peoples R China

Cotton fiber (Gossypium hirsutum) serves as an ideal model for investigating the molecular mechanisms of plant cell elongation at the single-cell level. Brassinosteroids (BRs) play a crucial role in regulating plant growth and development. However, the mechanism by which BR influences cotton fiber elongation remains incompletely understood. In this study, we identified EXORDIUM-like (GhEXL3) through transcriptome analysis of fibers from BR-deficient cotton mutant pagoda 1 (pag1) and BRI1-EMS-SUPPRESSOR 1 (GhBES1.4, encoding a central transcription factor of BR signaling) overexpression cotton lines. Knockout of GhEXL3 using CRISPR/Cas9 was found to impede cotton fiber elongation, while its overexpression promoted fiber elongation, suggesting a positive regulatory function for GhEXL3 in fiber elongation. Furthermore, in vitro ovule culture experiments revealed that the overexpression of GhEXL3 partially counteracted the inhibitory effects of brassinazole (BRZ) on cotton fiber elongation, providing additional evidence of GhEXL3 involvement in BR signaling pathways. Moreover, our findings demonstrate that GhBES1.4 directly binds to the E-box (CACGTG) motif in the GhEXL3 promoter region and enhances its transcription. RNA-seq analysis revealed that overexpression of GhEXL3 upregulated the expression of EXPs, XTHs, and other genes associated with fiber cell elongation. Overall, our study contributes to understanding the mechanism by which BR regulates the elongation of cotton fibers through the direct modulation of GhEXL3 expression by GhBES1.4.

关键词： cotton fiber brassinosteroids GhEXL3 GhBES1.4 cell elongation

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The catalytic thermal decomposition of ammonium perchlorate on CuMxOy (M = Fe, Ni, Co and Zn) catalysts and their applications in solid propellant

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JOURNAL OF THERMAL ANALYSIS AND CALORIMETRY 2023年第13期148卷 6013-6026页

作者： Hu, Yinghui wang, xuwen Hao, Jingwei Jiang, Shouhang Zhang, Jian Yang, Yulin Lin, Kaifeng Zheng, Jian Shuai, Yong Harbin Inst Technol Sch Chem & Chem Engn MIIT Key Lab Crit Mat Technol New Energy Convers & Harbin 150001 Peoples R China Harbin Inst Technol Sch Energy Sci & Engn Harbin 150001 Peoples R China China Aerosp Sci & Technol Corp 16 Fucheng Rd Beijing 100048 Peoples R China

The excellent thermal decomposition efficiency of ammonium perchlorate (AP) is of great importance for obtaining propellant with fast specific impulse. In this study, four CuMxOy catalysts, including M = Fe, Ni, Co, and Zn, were synthesized and then used for catalyzing AP decomposition and hydroxyl-terminated polybutadiene (HTPB)-based solid propellant combustion. The existed synergistic effect in CuMxOy catalysts improved the catalytic activity and the most active CuZnO catalyst decreased the AP high-temperature decomposition temperature (HTD) from 412.5 to 289.4 ?. Kinetic studies indicated that CuMxOy catalysts inhibited the conversion of N2O to a fully oxidized product and decreased the activation energy (E-a) in HTD to concentrate AP decomposition to significantly decrease the heat loss, thereby increasing their decomposition efficiency. When applying the CuMxOy catalysts in the HTPB (hydroxyl-terminated polybutadiene)-based solid propellant, a faster burning rate and stronger optical emission spectrum were obtained. The CuMxOy catalyst is a potential additive for the preparation of outstanding combustion solid propellants.

关键词： Bimetal oxide catalyst Ammonium perchlorate Thermal decomposition Catalytic mechanism Burning rate

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Correction of Read Biases Induced by Complex Reference Genome Regions for Improving Copy Number Variation Detection Using a Gaussian Mixture Model

Correction of Read Biases Induced by Complex Reference Genom...

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2024 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2024

作者： wang, xuwen Chang, Zhili wang, Shenjie Liu, Ruoyu Liu, Yuqian Zhu, Xiaoyan Shao, Yang Lai, Xin Yang, Shuanying wang, Jiayin Second Affiliated Hospital Xi'an Jiaotong University Department of Respiratory Medicine Xi'an710003 China Xi'an Jiaotong University School of Computer Science and Technology Xi'an710049 China Xi'an Jiaotong University Shaanxi Engineering Research Center of Medical and Health Big Data Xi'an710049 China Nanjing Geneseeq Technology INC. China

ISBN: (纸本)9798350386226

Copy number variations are crucial in cancer research, but their detection through next-generation sequencing is often hindered by read biases, particularly in complex genomic regions. Existing bias-correction methods address common issues like GC content but often fail in regions with repetitive sequences or segmental duplications, leading to false-positive CNVs. We propose refMask, a hybrid Gaussian model-based method that dynamically identifies low-confidence regions in the reference genome, correcting read biases and improving CNV detection accuracy. By integrating features from hg38 and T2T genomes, refMask tailors a custom blacklist for each sequencing sample, enhancing the reliability of CNV detection across diverse conditions. Our method provides a more accurate and flexible solution compared to current fixed blacklists, offering improved performance in challenging genomic regions. © 2024 IEEE.

关键词： Copy number variation Gaussian model Next-generation sequencing Read biase

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Combining UAV multisensor field phenotyping and genome-wide association studies to reveal the genetic basis of plant height in cotton (Gossypium hirsutum)

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PLANT PHENOMICS 2025年第1期7卷

作者： Fan, Liqiang Yang, Jiajie wang, xuwen Liu, Zhao Xu, Bowei Liu, Li Gao, Chenxu Ai, Xiantao Li, Fuguang Gao, Lei Yu, Yu Yang, Zuoren Chinese Acad Agr Sci Inst Cotton Res State Key Lab Cotton Biobreeding & Integrated Util Anyang 455000 Henan Peoples R China CAAS Inst Western Agr Xinjiang Key Lab Crop Gene Editing & Germplasm Inn Changji 831100 Xinjiang Peoples R China Xinjiang Acad Agr & Reclamat Sci Cotton Res Inst Northwest Inland Reg Key Lab Cotton Biol & Genet B Minist Agr Urumqi Peoples R China Zhengzhou Univ Sch Agr Sci State Key Lab Cotton Biobreeding & Integrated Util Zhengzhou Res Base Zhengzhou 450001 Henan Peoples R China Xinjiang Univ Res Inst Coll Smart Agr Urumqi 830046 Xinjiang Peoples R China Xinjiang Agr Univ Coll Agr Engn Res Ctr Cotton Minist Educ 311 Nongda East Rd Urumqi 830052 Peoples R China

Plant height (PH) is a key agronomic trait influencing plant architecture. Suitable PH values for cotton are important for lodging resistance, high planting density, and mechanized harvesting, making it crucial to elucidate the mechanisms of the genetic regulation of PH. However, traditional field PH phenotyping largely relies on manual measurements, limiting its large-scale application. In this study, a high-throughput phenotyping platform based on UAV-mounted RGB and light detection and ranging (LiDAR) was developed to efficiently and accurately obtain time series PHs of 419 cotton accessions in the field. Different strategies were used to extract PH values from two sets of sensor data, and the extracted values were used to train using linear regression and machine learning methods to obtain PH predictions. These predictions were consistent with manual measurements of the PH for the LiDAR (R2 1/4 0.934) and RGB (R2 1/4 0.914) data. The predicted PH values were used for GWAS analysis, and 34 PH-related genes, two of which have been demonstrated to regulate PH in cotton, namely, GhPH1 and GhUBP15, were identified. We further identified significant differences in the expression of a new gene named GhPH_UAV1 in the stems of the G. hirsutum cultivar ZM24 harvested on the 15th, 35th, and 70th days after sowing compared with those from a dwarf mutant (pag1), which presented shortened stem and internode phenotypes. The overexpression of GhPH_UAV1 significantly promoted cotton stem development, whereas its knockout by CRISPR-Cas9 dramatically inhibited stem growth, suggesting that GhPH_UAV1 plays a positive regulatory role in cotton PH. This field-scale high-throughput phenotype monitoring platform significantly improves the ability to obtain high-quality phenotypic data from large populations, which helps overcome the imbalance between massive genotypic data and the shortage of field phenotypic data and facilitates the integration of genotype and phenotype research for cr

关键词： Plant height UAV RGB LiDAR Genome-wide association study

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Development of an Interactive Medical Knowledge Graph Based Tool Set 10

Development of an Interactive Medical Knowledge Graph Based ...

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10th International Conference on Information Technology and Quantitative Management, ITQM 2023

作者： Xu, Xiaowei wang, xuwen Wu, Meng Ma, Hetong Shen, Liu Li, Jiao Institute of Medical Information and Library Chinese Academy of Medical Sciences Peking Union Medical College Beijing100020 China Key Laboratory of Medical Information Intelligent Technology Chinese Academy of Medical Sciences Beijing100020 China

The field of clinical research has reached a turning point in terms of the range and diversity of available data and their potential to improve human health and well-being. However, due to discipline-specific variances in terminology and representation, the data is often compartmentalized, disorganized, and inaccessible to a broad audience. In response to these challenges, we designed and evaluated a pilot knowledge graph-based MedKaaS tool capable of integrating existing clinical datasets and translating those data into insights intended to augment human reasoning and accelerate scientific research. In this paper, we present the architecture and performance of our system, which has been applied to several real-world use cases in collaboration with subject-matter specialists. The MedKaaS Tools are actively developed, with regular updates to performance and features. Our future plans include developing a more user-friendly interface and expanding the visualization capabilities for knowledge exploration. © 2023 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (https://***/licenses/by-nc-nd/4.0) Peer-review under responsibility of the scientific committee of the Tenth International Conference on Information Technology and Quantitative Management.

关键词： Clinical research

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Genesis of the Hatu gold deposit: Constrained by in situ S-Pb isotope geochemistry of pyrite

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JOURNAL OF GEOCHEMICAL EXPLORATION 2023年第1期254卷

作者： An, Fang Zhu, Yongfeng wang, xuwen Li, Yuxuan Qiang, Jianli Northwest Univ Dept Geol State Key Lab Continental Dynam Xian 710069 Peoples R China Peking Univ Sch Earth & Space Sci Key Lab Orogen Belts & Crustal Evolut Beijing 100871 Peoples R China PetroChina Tarim Oilfield Co Explorat & Dev Res Inst Korla 84100 Peoples R China Northwest Univ Dept Geol Xian 710069 Peoples R China

As the largest gold deposit in west Junggar, the Hatu gold deposit is located between the Anqi and Hatu faults in the Hatu-Sartohay district. The orebodies, composed of gold-bearing quartz veins and auriferous altered wall-rocks, are controlled by NE-, NW-, and EW-trending faults in Early Carboniferous volcano-sedimentary rocks. In this study, integrated textural, in situ sulfur and lead isotope analyses of pyrite grains in the host rocks and ores reveal new information on the sources of the ore-forming fluids and metal, as well as the mechanism of gold deposition. Framboidal pyrite in tuffaceous siltstone has a large 834S range of-26.7 to +54.0 %o, which is attributed to sulfur-reducing bacterial (SRB) activity during sedimentary-diagenetic process. Fine-grained sub-hedral pyrite in meta-basalt shows negative 834S values from-26.7 to-12.1 %o, which may be generated by reduction of seawater sulfate by ferrous iron bearing minerals during metamorphism. The 834S values of four generations of hydrothermal pyrite (Py1-Py4) in the orebodies vary in a narrow range from +1.4 to-1.9 %o. The sulfur isotopic characteristics of the hydrothermal pyrite are similar to most magmatic hydrothermal deposits, but differ from the metamorphic pyrite in meta-basalt and the framboidal pyrite in tuffaceous siltstone. In addition, the uniform in situ lead isotope ratios of hydrothermal pyrite resemble the lead isotopic compositions of the granitic plutons in the west Junggar, but differ from those of pyrite in meta-basalt. The progressive decrease of 834S values from early-stage pyrite (+0.7 %o to +1.4 %o) to late-stage pyrite (-1.9 %o to +0.4 %o) corresponds to the major gold precipitation processes, which can be explained by gradual decrease of oxygen fugacity and increase of pH with decrease of temperature of a gold-bearing magmatic-hydrothermal system. A relatively stable environment for Au precipitation probably is a key factor controlling the scale of gold deposit, as the ore-forming

关键词： Pyrite In situ sulfur and lead isotope Ore genesis Hatu gold deposit

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