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IEEE International Conference on Bioinformatics and Biomedicine (BIBM)

作者： wang, Shenjie wang, Jiayin Xiao, Xiao Zhang, Xuanping wang, xuwen Zhu, Xiaoyan Lai, Xin Xi An Jiao Tong Univ Sch Comp Sci & Technol Xian 710049 Shaanxi Peoples R China Xi An Jiao Tong Univ Shaanxi Engn Res Ctr Med & Hlth Big Data Xian 710049 Shaanxi Peoples R China Xi An Jiao Tong Univ Sch Publ Policy & Adm Xian 710049 Shaanxi Peoples R China

ISBN: (纸本)9781728118673

In recent decades, NGS data analysis has become a major research field in bioinformatics, which presents great advantages in many application scenarios. Many algorithms and software were designed for analyzing the NGS data, while simulation datasets are urgently needed for testing software and optimizing their parameter configurations. Thus, a series of NGS data simulators have been published. However, the existing simulators cannot satisfy the requirements from many specific scenarios. First, they do not support many newly discovered variations. Second, complex structural variations are difficult to generate. In addition, along with the increase of population data, it is urgent to increase population information simulation. In this paper, we propose GSDcreator, a comprehensive NGS simulator that overcome the three weaknesses mentioned above. It can produce all known types of variation, where the complex of variations are also supported. Furthermore, it can capture many important real data features including population polymorphism, insert size distribution, adjacent site depth distribution, overall depth distribution, quality score distribution, amplification bias, sequencing errors and so on. It's highlighted that 1000 Genomes Project Database is taken as a reference and integrates population genetic information to simulate population polymorphism. To test the performance, we did a lot of experiments and found that simulated data produced by GSDcreator are quit mimic to the real sequencing data.

关键词： population genomics next-generation sequencing data analysis data simulator population information

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ImageSem at ImageCLEF 2018 caption task: Image retrieval and transfer learning 19

ImageSem at ImageCLEF 2018 caption task: Image retrieval and...

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19th Working Notes of CLEF Conference and Labs of the Evaluation Forum, CLEF 2018

作者： Zhang, Yu wang, xuwen Guo, Zhen Li, Jiao Institute of Medical Information Chinese Academy of Medical Sciences Peking Union Medical College Beijing100020 China

This paper presents the participation of the Image Semantics group (ImageSem) of the Institute of Medical Information at the ImageCLEF 2018 caption task. We participated in both of the concept detection and the caption prediction tasks, with submitting 15 runs in total. In this study, we applied LIRE, an open source Lucene Image Retrieval, to index 222, 314 images in training and 9, 938 images in test sets. In concept detection subtask, we retrieved the similar images in the training set and applied Latent Dirichlet Allocation (LDA) for clustering concepts of the similar images. The transfer learning method was integrated to solve muti-label annotation in the concept detection task. In caption prediction, we used image retrieval strategies by tuning the parameters: the top similar images and number of candidate concepts. In the evaluation, ImageSem achieved the best Fl Score of 0.0928 in the concept detection subtask and the Mean BLEU score of 0.2501 in the caption prediction subtask.

关键词： Forecasting

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A novel hybrid battery thermal management system using TPMS structure and delayed cooling scheme

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APPLIED THERMAL ENGINEERING 2025年 259卷

作者： Yang, Haonan wang, Zhaohui Bao, Rongqing Zhang, Bowen Zhu, xuwen wang, Hongxia Wuhan Univ Sci & Technol Key Lab Met Equipment & Control Technol Minist Educ Wuhan 430081 Hubei Peoples R China Wuhan Univ Sci & Technol Hubei Key Lab Mech Transmiss & Mfg Engn Wuhan 430081 Hubei Peoples R China Wuhan Univ Technol Xiangyang Demonstrat Zone Hubei Longzhong Lab Xiangyang 441000 Hubei Peoples R China Hubei Univ Automot Technol Coll Mech Engn Shiyan 442002 Hubei Peoples R China

Phase change material (PCM) cooling plays an important role in battery thermal management systems (BTMS). However, PCM has been suffering from low thermal conductivity and inefficient latent heat recovery. Based on this, this study designs a hybrid BTMS combining triply periodic minimal surface (TPMS), PCM, and liquid cooling, and proposes a cooling scheme that determines the operating time of the coolant based on the battery temperature. The system aims to improve the utilization of PCM in two different ways: structural design and cooling scheme. Numerical analysis was used to compare the effects of different structures on the melting rate of PCM and to study the thermal performance of the battery module under various cooling schemes. The results show that the effective thermal conductivity of PCM/TPMS composites reaches 21 W/(m & sdot;K), which can effectively enhance the heat absorption rate of PCM. In particular, the I-graph-and-wrapped-package (IWP) structure combined with PCM is the most effective. Under the continuous cooling scheme, when the coolant flow rate is 0.04 m/s, the temperature of the battery at a 3C discharge rate can be controlled at 308.28 K, but the PCM utilization rate is only 0.25. After adopting the delayed cooling scheme, the performance of the BTMS cooling remains excellent, with the battery temperature at only 309.88 K and the liquid phase rate of PCM reaching 0.97. For the first time, the heat absorbed by passive cooling is comparable to that of active cooling in the BTMS heat absorption energy distribution, with a 73 % reduction in pumping energy consumption. Furthermore, under cycling conditions, the delayed cooling scheme still performs well, keeping the battery temperature below 313.15 K. In addition, it should be noted that the flow rate of the coolant should be determined by the charging rate. Additionally, the BTMS is capable of addressing the heat dissipation challenges in different ambient temperatures. This study can guide for

关键词： Phase change material Triply periodic minimal surface Delayed cooling scheme Battery thermal management system

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Laser Ultrasonic Lamb Wave Damage Detection Method Based on the Single Transmitter and Multiple Receivers Circular Array 4th

Laser Ultrasonic Lamb Wave Damage Detection Method Based on ...

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4th International Conference on Intelligent Systems in Production Engineering and Maintenance, ISPEM 2023

作者： Zheng, Shanpu Luo, Ying wang, xuwen Xu, Chenguang Faculty of Civil Engineering and Mechanics Jiangsu University Zhenjiang212013 China Ganzhou Special Equipment Supervision and Inspection Center Jiangxi Ganzhou341000 China School of Physics and Electronic Engineering Jiangsu University Zhenjiang212013 China

ISBN: (纸本)9783031442810

Laser ultrasonic Lamb wave detection technology provides technical support for noncontact and online large plate/shell structure detection. Improving detection accuracy and efficiency has always been the goal of inspection personnel. In this paper, we have built a noncontact laser ultrasonic Lamb wave detection platform to achieve rapid localization of abnormal damage in aluminum alloy plates. First, analyze laser ultrasonic Lamb waves’ modal types and wavelength components. Design and optimize a circular laser array based on near-field beamforming theory, with a single transmitter at the center and multiple receivers around the circumference. After extracting single-frequency components using wavelet transform, the azimuth of the scattering wave is estimated using the near-field 2D multiple signal classification(2D-MUSIC). The advantage is that there is no need to collect the reference signal or add window filtering to intercept the wave packet. The results indicate that damage within the 900 cm2 area can be localized within 0.7 s, and the orientation error is within 6°. This method is an efficient method to achieve damage orientation in a large area. However, the problem of the low resolution and artifact interference in multi-damage estimation presented by this method is urgent to be solved in the future. © 2024, The Author(s), under exclusive license to Springer Nature Switzerland AG.

关键词： Beamforming

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The catalytic thermal decomposition of ammonium perchlorate on CuMxOy (M = Fe, Ni, Co and Zn) catalysts and their applications in solid propellant

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JOURNAL OF THERMAL ANALYSIS AND CALORIMETRY 2023年第13期148卷 6013-6026页

作者： Hu, Yinghui wang, xuwen Hao, Jingwei Jiang, Shouhang Zhang, Jian Yang, Yulin Lin, Kaifeng Zheng, Jian Shuai, Yong Harbin Inst Technol Sch Chem & Chem Engn MIIT Key Lab Crit Mat Technol New Energy Convers & Harbin 150001 Peoples R China Harbin Inst Technol Sch Energy Sci & Engn Harbin 150001 Peoples R China China Aerosp Sci & Technol Corp 16 Fucheng Rd Beijing 100048 Peoples R China

The excellent thermal decomposition efficiency of ammonium perchlorate (AP) is of great importance for obtaining propellant with fast specific impulse. In this study, four CuMxOy catalysts, including M = Fe, Ni, Co, and Zn, were synthesized and then used for catalyzing AP decomposition and hydroxyl-terminated polybutadiene (HTPB)-based solid propellant combustion. The existed synergistic effect in CuMxOy catalysts improved the catalytic activity and the most active CuZnO catalyst decreased the AP high-temperature decomposition temperature (HTD) from 412.5 to 289.4 ?. Kinetic studies indicated that CuMxOy catalysts inhibited the conversion of N2O to a fully oxidized product and decreased the activation energy (E-a) in HTD to concentrate AP decomposition to significantly decrease the heat loss, thereby increasing their decomposition efficiency. When applying the CuMxOy catalysts in the HTPB (hydroxyl-terminated polybutadiene)-based solid propellant, a faster burning rate and stronger optical emission spectrum were obtained. The CuMxOy catalyst is a potential additive for the preparation of outstanding combustion solid propellants.

关键词： Bimetal oxide catalyst Ammonium perchlorate Thermal decomposition Catalytic mechanism Burning rate

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A Cross-Lingual Effort Towards Managing English-Chinese Cancer Education Resources 17

A Cross-Lingual Effort Towards Managing English-Chinese Canc...

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17th World Congress of Medical and Health Informatics (MEDINFO)

作者： Ma, Hetong Ren, Jiansong wang, xuwen Fang, An Li, Jiao Qian, Qing Chinese Acad Med Sci Inst Med Informat Lib Peking Union Med Coll Beijing Peoples R China Chinese Acad Med Sci Natl Canc Ctr Peking Union Med Coll Canc Hosp Beijing Peoples R China

ISBN: (纸本)9781643680033;9781643680026

As translated education resource plays an important role in healthcare providers' training and medical knowledge dissemination, we proposed a method to manage cross-lingual education resources with the goal of facilitating the medical education and physician training. We created an English Chinese cancer knowledge base including bilingual description on cancer diagnosis, prevention, screening, treatments, etc. We developed a workflow to create the bilingual corpus, and applied it to six cancer monographs in PDQ (Physician Data Query).

关键词： Cancer education resource Cross language Parallel corpus

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Reliability of Docking-Based Virtual Screening for GPCR Ligands with Homology Modeled Structures: A Case Study of the Angiotensin II Type I Receptor

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ACS CHEMICAL NEUROSCIENCE 2019年第1期10卷 677-689页

作者： Chen, Haiyi Fu, Weitao wang, Zhe wang, xuwen Lei, Tailong Zhu, Feng Li, Dan Chang, Shan Xu, Lei Hou, Tingjun Zhejiang Univ Coll Pharmaceut Sci Hangzhou 310058 Zhejiang Peoples R China Zhejiang Univ State Key Lab CAD&CG Hangzhou 310058 Zhejiang Peoples R China Jiangsu Univ Technol Sch Elect & Informat Engn Inst Bioinformat & Med Engn Changzhou 213001 Peoples R China

The number of solved G-protein-coupled receptor (GPCR) crystal structures has expanded rapidly, but most GPCR structures remain unsolved. Therefore, computational techniques, such as homology modeling, have been widely used to produce the theoretical structures of various GPCRs for structure-based drug design (SBDD). Due to the low sequence similarity shared by the transmembrane domains of GPCRs, accurate prediction of GPCR structures by homology modeling is quite challenging. In this study, angiotensin II type I receptor (AT1R) was taken as a typical case to assess the reliability of class A GPCR homology models for SBDD. Four homology models of angiotensin II type I receptor (AT1R) at the inactive state were built based on the crystal structures of CXCR4 chemokine receptor, CCRS chemo-kine receptor, and delta-opioid receptor, and refined through molecular dynamics (MD) simulations and induced-fit docking, to allow for backbone and side-chain flexibility. Then, the quality of the homology models was assessed relative to the crystal structures in terms of two criteria commonly used in SBDD: prediction accuracy of ligand-binding poses and screening power of docking-based virtual screening. It was found that the crystal structures outperformed the homology models prior to any refinement in both assessments. MD simulations could generally improve the docking results for both the crystal structures and homology models. Moreover, the optimized homology model refined by MD simulations and induced-fit docking even shows a similar performance of the docking assessment to the crystal structures. Our results indicate that it is possible to establish a reliable class A GPCR homology model for SBDD through the refinement by integrating multiple molecular modeling techniques.

关键词： Docking-based virtual screening homology model class A GPCRs antagonist MD simulation induced-fit docking

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Phenotypic plasticity and genetic variation of cotton yield and its related traits under water-limited conditions

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The Crop Journal 2020年第6期8卷 966-976页

作者： Baoqi Li Qin Tian xuwen wang Bei Han Li Liu Xianhui Kong Aijun Si Juan wang Zhongxu Lin Xianlong Zhang Yu Yu Xiyan Yang National Key Laboratory of Crop Genetic Improvement Huazhong Agricultural UniversityWuhan 430070HubeiChina Cotton Institute Xinjiang Academy of Agriculture and Reclamation ScienceShihezi 832000XinjiangChina

Global warming is limiting availability of water resources in arid and semi-arid regions,and so understanding water use efficiency(WUE)is increasingly important for agricultural production in those *** China is the largest cotton producing area,the problem of balancing WUE and efficient cotton production is a major *** this study,we used a natural population of 517 Upland cotton accessions to conduct a water-controlled trial in south and north of Xinjiang over two years.A total of 18 traits including agronomic traits,fiber yield indices and fiber quality indices,were investigated for broad-sense heritability and coefficient of *** water limitation was found to promote the establishment of favorable agronomic traits in cotton,associated with an increased cotton yield of 8.46%in Xinjiang,at the expense of a certain degree of fiber quality,such as decreased fiber length and an over-higher micronaire *** detected 33 QTL related to response to water limitation using a drought resistance coefficient(DRC),and 6 QTL were found using a comprehensive indicator of CIDT(comprehensive index of drought tolerance)at the genetic level by integrating resequencing *** novel QTL-hotspots including six differentially expressed genes(DEGs)were further identified related to the drought response of *** findings not only suggested a new approach to irrigation of cotton fields in Xinjiang,but also provided abundant genetic evidence for genetic breeders to study drought improvement of crops.

关键词： Upland cotton Water-limited conditions Fiber yield Fiber quality QTL hotspot

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The synthesis of an iron tailings-based geopolymer with synergistic electromagnetic wave consumption property

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ENVIRONMENTAL RESEARCH 2025年 268卷 120744页

作者： wang, Tianyu Ning, xuwen Yang, Lang Rao, Feng Jiang, Kaixi Fuzhou Univ Sch Mat Sci & Engn Fuzhou 350108 Fujian Peoples R China Fuzhou Univ Zijin Sch Geol & Min Fuzhou 350108 Fujian Peoples R China Fuzhou Univ Fujian Key Lab Green Extract & High Value Utilizat Fuzhou 350108 Fujian Peoples R China

In this study, combination of wave absorption materials with different loss mechanisms are added into iron ore tailings-blast furnace slag (IOT-BFS) based geopolymers. The employed materials are hollow glass microsphere (HGM), carbon nanotubes (CNT) and carbonyl iron powder (CIP). Microstructures of the geopolymers are characterized by X-ray diffraction (XRD), scanning electron microscopy (SEM) and concrete porous structure analyzer. Conductivity and electromagnetic absorption property of the geopolymers are measured by a conductivity tester and a vector network analyzer (VNA). As increasing the content of wave absorption materials, compressive strength of the geopolymer decreased from 60.5 to 33.8 MPa. Compared with geopolymers containing HGM and CNT, wave absorption band below -5 dB of the geopolymers with HGM and CIP was wider, particularly at frequencies below 7 GHz, due to the synergism of space and magnetic loss. Its absorption bandwidth with the reflection loss less than -5 dB reaches 15.6 GHz. This study gives a clue for preparation of geopolymers with satisfactory electromagnetic wave absorption properties in the utilization as construction materials.

关键词： Geopolymers Electromagnetic wave absorption Iron ore tailings Microstructure

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Identifying Adverse Drug Reactions of hypolipidemic drugs from Chinese adverse event reports 6

Identifying Adverse Drug Reactions of hypolipidemic drugs fr...

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6th IEEE International Conference on Healthcare Informatics (ICHI)

作者： Zhang, Yu wang, xuwen Shen, Liu Hou, Zhen Guo, Zhen Li, Jiao Chinese Acad Med Sci Peking Union Med Coll Inst Med Informat Beijing Peoples R China

ISBN: (纸本)9781538667774

Hyperlipidemia is one of the important risk factors of cardiovascular and cerebrovascular diseases. Monitoring of adverse reactions of hypolipidemic drugs is very crucial for clinical administration. In this study, in order to explore the occurrence characteristics of ADRs for hypolipidemic drugs, we manually annotated and normalized the ADRs of hypolipidemic drugs from Chinese adverse event reports. Totally 579 records are involved in the study. Also we constructed a new dictionary of ADRs and a classification standard of the Severity of ADR to standardize the description of adverse drug reactions. Finally, we got a dictionary of ADR which have 171 terms, of 129 are from WHO-ART and 42 are self-defined. A new classification criteria for the severity of ADRs were built and each record were annotated by the criteria. Our annotated corpus, ADR dictionary and the classification standard can provide data source and dictionary resource to support future machine-learning-based ADR mining to better explore ADRs of hypolipidemic drugs.

关键词： Adverse drug reaction Hypolipidemic drug

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