检索结果-内蒙古大学图书馆

Parental category B vaccine hesitancy and associated factors in China: an online cross-sectional survey

EXPERT REVIEW OF VACCINES 2022年第1期21卷 145-153页

作者： Han, Ying wang, Qiang Zhao, Shuangyu wang, Jianli Dong, Shuheng Cui, Tingting Liu, Minqi Shi, Naiyang Yang, Liuqing Han, Yue Xiu, Shixin wang, xuwen Jin, Hui Southeast Univ Sch Publ Hlth Dept Epidemiol & Hlth Stat Nanjing Peoples R China Southeast Univ Sch Publ Hlth Key Lab Environm Med Engn Minist Educ Nanjing Peoples R China Wuxi Ctr Dis Control & Prevent Wuxi Jiangsu Peoples R China

Background Vaccine hesitancy is one of the top ten health threats. We aimed to (1) assess parental Category B vaccines hesitancy and associated sociodemographic factors in China, and (2) explore the association between attitude toward vaccines and self-reported hesitant behavior. Methods A cross-sectional study was performed through a web-based anonymous online questionnaire survey between 9 February and 7 April 2021. Chinese parents aged >= 18 years with one child aged < 6 years were included to assess vaccine hesitancy using the vaccine-hesitancy scale (VHS). Structural equation model was used to determine relationships between variables. Results Of 2952 Chinese parents included in the analysis, 17.5% were highly hesitant in Category B vaccines. Parents who were younger, less educated, engaged in health-related occupations, and had been vaccinated against influenza in the past year were more hesitant when vaccinating their children (P < 0.001). VHS score accuracy to identify vaccine-hesitant behavior was acceptable, and the optimal cutoff was 37.50 (with 61.96% parental vaccine hesitancy). Parents who lack confidence or believe vaccines were risk were more likely to show vaccine hesitant behavior (P < 0.001). Conclusions In China, effective interventions need to be implemented to eliminate parental Category B vaccines hesitancy.

关键词： Vaccine hesitancy Parents Structural equation model Online survey China

来源：评论

学校读者我要写书评

暂无评论

Delays in routine childhood vaccinations and their relationship with parental vaccine hesitancy: a cross-sectional study in Wuxi, China

引用

EXPERT REVIEW OF VACCINES 2022年第1期21卷 135-143页

作者： wang, Qiang Xiu, Shixin Yang, Liuqing Han, Ying Huang, Jinxin Cui, Tingting Shi, Naiyang Liu, Minqi wang, xuwen Lu, Bing Jin, Hui Lin, Leesa Southeast Univ Sch Publ Hlth Dept Epidemiol & Hlth Stat 87 Dingjiaqiao Nanjing 210009 Peoples R China Southeast Univ Sch Publ Hlth Key Lab Environm Med Engn Minist Educ Nanjing Peoples R China Wuxi Ctr Dis Control & Prevent Dept Immunizat Planning Wuxi Jiangsu Peoples R China London Sch Hyg & Trop Med Dept Infect Dis Epidemiol London England Hong Kong Sci Pk Lab Data Discovery Hlth D24H Hong Kong Peoples R China

Objectives This study aimed to examine childhood vaccination delay, explore the association between vaccination delay and parental vaccine hesitancy, and assess childhood vaccination delays during the coronavirus disease (COVID)-19 pandemic in China. Methods This cross-sectional survey was conducted in Wuxi City. Participants were recruited from local vaccination clinics. Questionnaires were used to collect information about socio-demographics, vaccine hesitancy, and immunization clinic evaluations. Vaccination records were obtained from the Jiangsu Information Management System of Vaccination Cases. Results Overall, 2728 participants were included. The coverage for seven category A vaccines (Expanded Program on Immunization (EPI)) was more than 95% at 24 months. The proportion of children vaccinated in a timely manner was the highest for the first dose of the hepatitis B vaccine (91.6%) and the lowest for the Bacillus-Calmette-Guerin vaccine (44.6%). More than 50% of the planned vaccinations were delayed in February and March 2020. The Vaccine Hesitancy Scale scores were not associated with vaccination delay (P = 0.842). Children's vaccination delays were negatively associated with parents who reported convenient access to clinics and satisfaction with immunization services (P = 0.020, P = 0.045). Conclusions EPI is highly successful in China. Despite vaccination delays due to the COVID-19 pandemic, coverage was recovered after lockdown restrictions were eased.

关键词： Childhood vaccination delay timeliness vaccine hesitancy COVID-19 pandemic

来源：评论

学校读者我要写书评

暂无评论

GhEXL3 participates in brassinosteroids regulation of fiber elongation in Gossypium hirsutum

引用

PLANT JOURNAL 2024年第2期120卷 491-504页

作者： Zhang, Changsheng Liu, Zhao Shu, Sheng Li, Xinyang Li, Yujun Liu, Le Liu, Li wang, xuwen Li, Fuguang Qanmber, Ghulam Yang, Zuoren Zhengzhou Univ Sch Agr Sci State Key Lab Cotton Biobreeding & Integrated Util Zhengzhou Res Base Zhengzhou Peoples R China Chinese Acad Agr Sci Inst Cotton Res State Key Lab Cotton Biobreeding & Integrated Util Anyang Peoples R China Chinese Acad Agr Sci Western Agr Res Ctr Changji Peoples R China Xinjiang Acad Agr & Reclamat Sci Cotton Res Inst Northwest Inland Reg Key Lab Cotton Biol & Genet B Shihezi Peoples R China

Cotton fiber (Gossypium hirsutum) serves as an ideal model for investigating the molecular mechanisms of plant cell elongation at the single-cell level. Brassinosteroids (BRs) play a crucial role in regulating plant growth and development. However, the mechanism by which BR influences cotton fiber elongation remains incompletely understood. In this study, we identified EXORDIUM-like (GhEXL3) through transcriptome analysis of fibers from BR-deficient cotton mutant pagoda 1 (pag1) and BRI1-EMS-SUPPRESSOR 1 (GhBES1.4, encoding a central transcription factor of BR signaling) overexpression cotton lines. Knockout of GhEXL3 using CRISPR/Cas9 was found to impede cotton fiber elongation, while its overexpression promoted fiber elongation, suggesting a positive regulatory function for GhEXL3 in fiber elongation. Furthermore, in vitro ovule culture experiments revealed that the overexpression of GhEXL3 partially counteracted the inhibitory effects of brassinazole (BRZ) on cotton fiber elongation, providing additional evidence of GhEXL3 involvement in BR signaling pathways. Moreover, our findings demonstrate that GhBES1.4 directly binds to the E-box (CACGTG) motif in the GhEXL3 promoter region and enhances its transcription. RNA-seq analysis revealed that overexpression of GhEXL3 upregulated the expression of EXPs, XTHs, and other genes associated with fiber cell elongation. Overall, our study contributes to understanding the mechanism by which BR regulates the elongation of cotton fibers through the direct modulation of GhEXL3 expression by GhBES1.4.

关键词： cotton fiber brassinosteroids GhEXL3 GhBES1.4 cell elongation

来源：评论

学校读者我要写书评

暂无评论

Genesis of the Hatu gold deposit: Constrained by in situ S-Pb isotope geochemistry of pyrite

引用

JOURNAL OF GEOCHEMICAL EXPLORATION 2023年第1期254卷

作者： An, Fang Zhu, Yongfeng wang, xuwen Li, Yuxuan Qiang, Jianli Northwest Univ Dept Geol State Key Lab Continental Dynam Xian 710069 Peoples R China Peking Univ Sch Earth & Space Sci Key Lab Orogen Belts & Crustal Evolut Beijing 100871 Peoples R China PetroChina Tarim Oilfield Co Explorat & Dev Res Inst Korla 84100 Peoples R China Northwest Univ Dept Geol Xian 710069 Peoples R China

As the largest gold deposit in west Junggar, the Hatu gold deposit is located between the Anqi and Hatu faults in the Hatu-Sartohay district. The orebodies, composed of gold-bearing quartz veins and auriferous altered wall-rocks, are controlled by NE-, NW-, and EW-trending faults in Early Carboniferous volcano-sedimentary rocks. In this study, integrated textural, in situ sulfur and lead isotope analyses of pyrite grains in the host rocks and ores reveal new information on the sources of the ore-forming fluids and metal, as well as the mechanism of gold deposition. Framboidal pyrite in tuffaceous siltstone has a large 834S range of-26.7 to +54.0 %o, which is attributed to sulfur-reducing bacterial (SRB) activity during sedimentary-diagenetic process. Fine-grained sub-hedral pyrite in meta-basalt shows negative 834S values from-26.7 to-12.1 %o, which may be generated by reduction of seawater sulfate by ferrous iron bearing minerals during metamorphism. The 834S values of four generations of hydrothermal pyrite (Py1-Py4) in the orebodies vary in a narrow range from +1.4 to-1.9 %o. The sulfur isotopic characteristics of the hydrothermal pyrite are similar to most magmatic hydrothermal deposits, but differ from the metamorphic pyrite in meta-basalt and the framboidal pyrite in tuffaceous siltstone. In addition, the uniform in situ lead isotope ratios of hydrothermal pyrite resemble the lead isotopic compositions of the granitic plutons in the west Junggar, but differ from those of pyrite in meta-basalt. The progressive decrease of 834S values from early-stage pyrite (+0.7 %o to +1.4 %o) to late-stage pyrite (-1.9 %o to +0.4 %o) corresponds to the major gold precipitation processes, which can be explained by gradual decrease of oxygen fugacity and increase of pH with decrease of temperature of a gold-bearing magmatic-hydrothermal system. A relatively stable environment for Au precipitation probably is a key factor controlling the scale of gold deposit, as the ore-forming

关键词： Pyrite In situ sulfur and lead isotope Ore genesis Hatu gold deposit

来源：评论

学校读者我要写书评

暂无评论

Remote sensing intelligent interpretation for geology: from the perspective of geological exploration

引用

INTERNATIONAL GEOLOGY REVIEW 2025年第10期67卷 1389-1391页

作者： Afandi, Achmad Chen, Weitao Li, Xianju Qin, xuwen wang, Lizhe Univ Pendidikan Indonesia Dept Phys Educ Bandung Indonesia

来源：评论

学校读者我要写书评

暂无评论

Synergistic optimization strategies for the development of multienzymatic cascade system-based electrochemical biosensors with enhanced performance

引用

BIOSENSORS & BIOELECTRONICS 2025年 274卷 117222页

作者： Zhu, Yuzhuo Cheng, Zhaoming wang, Xueqi Zhang, Chuanjun Li, xuwen Wei, Yanxue wang, Jiajia Fang, Yuxin wang, Yi Zhang, Di Tianjin Univ Tradit Chinese Med Coll Pharmaceut Engn Tradit Chinese Med Tianjin 301617 Peoples R China Tianjin Univ Tradit Chinese Med Inst Tradit Chinese Med Tianjin 301617 Peoples R China Tianjin Key Lab Intelligent & Green Pharmaceut Tra Tianjin 301617 Peoples R China State Key Lab Chinese Med Modernizat Tianjin 301617 Peoples R China Tianjin Univ Tradit Chinese Med Coll Acumox & Tuina Res Ctr Expt Acupuncture Sci Tianjin 301617 Peoples R China Natl Clin Res Ctr Chinese Med Acupuncture & Moxibu Tianjin 301617 Peoples R China

Multienzymatic cascade system (MCS) strategies have been a topic of growing interest in the electrochemical biosensor research field owing to their many advantages. By combining two or more enzymes in an appropriate manner, MCS approaches can extend the range of detection for particular analytes while improving the overall efficiency of biocatalytic cascade reactions. Compared with mono-enzyme biosensors, the integration of MCS and electrochemical biosensor platforms is inherently more challenging owing to the increased complexity of the resultant system. In recent years, substantial progress in the development of MCS-based electrochemical biosensors with enhanced analytical performance has been made. This review provides an overview of the types of MCS strategies and their biosensor applications, together with a summary of synergistic optimization approaches that can help improve key parameters including sensitivity, selectivity, and stability when designing MCS-based electrochemical biosensors. These discussions include examples of published biosensor platforms (2016-2024) while also surveying key advances in associated research areas including redox mediators/enzyme coimmobilization, enzyme engineering, multienzyme spatial regulation, enzyme-nanozyme integration and others. Lastly, a brief overview of current challenges and future perspectives pertaining to MCS-based electrochemical biosensor design is provided.

关键词： Multienzymatic system Electrochemical biosensor Cascade reaction Synergistic strategy Enzymatic biosensor

来源：评论

学校读者我要写书评

暂无评论

The relationship between geometry and hemodynamics of the stenotic carotid artery based on computational fluid dynamics

引用

CLINICAL NEUROLOGY AND NEUROSURGERY 2023年第1期231卷 107860-107860页

作者： Liu, Yongsheng Jiang, Guinan wang, xuwen An, Xiangbo wang, Feng Dalian Med Univ Dept Pathol Affiliated Hosp 1 Dalian Peoples R China 222 Zhongshan Rd Dalian Peoples R China

Objective: The purpose of this work was to investigate the relationship between the geometric factors and the hemodynamics of the stenotic carotid ***: We retrospectively reviewed data of patients with carotid stenosis (40%-95%). The Navier-Stokes equations were solved using ANSYS CFX 18.0. Correlation analysis was based on Spearman's test. Geometric variables (p < 0.1 in the univariate analysis) were entered into the logistical regression. A receiver-operating characteristics analysis was used to detect hemodynamically significant lesions. Results: 81 patients (96 arteries) were evaluated. The logistic regression analysis revealed that the translesional pressure ratio was significantly correlated with the stenosis degree (OR = 1.147, p < 0.001) and the angle between internal carotid artery and external carotid artery (angle ?) (OR = 0.933, p = 0.01). The translesional wall shear stress ratio was significantly correlated with stenosis degree (OR = 1.094, p < 0.001), lesion length (OR = 0.873, p = 0.01), lumen area of internal carotid artery (OR = 0.867, p = 0.002), and lumen area of common carotid artery (OR = 1.058, p = 0.01). For predicting low translesional pressure ratio, the AUC was 0.71 (p < 0.001) for angle ?, and was 0.87 (p < 0.001) for stenosis degree. For predicting high translesional wall shear stress ratio, the AUC was 0.62 (p = 0.04) for lumen area of internal carotid artery, and was 0.77 (p < 0.001) for stenosis ***: Apart from stenosis degree, other geometric characteristics of lesions may also have an influence on hemodynamics of the stenotic carotid artery.

关键词： Carotid artery Computational fluid dynamics Geometry Hemodynamics Stenosis

来源：评论

学校读者我要写书评

暂无评论

Correction of Read Biases Induced by Complex Reference Genome Regions for Improving Copy Number Variation Detection Using a Gaussian Mixture Model

Correction of Read Biases Induced by Complex Reference Genom...

引用

2024 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2024

作者： wang, xuwen Chang, Zhili wang, Shenjie Liu, Ruoyu Liu, Yuqian Zhu, Xiaoyan Shao, Yang Lai, Xin Yang, Shuanying wang, Jiayin Second Affiliated Hospital Xi'an Jiaotong University Department of Respiratory Medicine Xi'an710003 China Xi'an Jiaotong University School of Computer Science and Technology Xi'an710049 China Xi'an Jiaotong University Shaanxi Engineering Research Center of Medical and Health Big Data Xi'an710049 China Nanjing Geneseeq Technology INC. China

ISBN: (纸本)9798350386226

Copy number variations are crucial in cancer research, but their detection through next-generation sequencing is often hindered by read biases, particularly in complex genomic regions. Existing bias-correction methods address common issues like GC content but often fail in regions with repetitive sequences or segmental duplications, leading to false-positive CNVs. We propose refMask, a hybrid Gaussian model-based method that dynamically identifies low-confidence regions in the reference genome, correcting read biases and improving CNV detection accuracy. By integrating features from hg38 and T2T genomes, refMask tailors a custom blacklist for each sequencing sample, enhancing the reliability of CNV detection across diverse conditions. Our method provides a more accurate and flexible solution compared to current fixed blacklists, offering improved performance in challenging genomic regions. © 2024 IEEE.

关键词： Copy number variation Gaussian model Next-generation sequencing Read biase

来源：评论

学校读者我要写书评

暂无评论

TMRGM: A Template-Based Multi-Attention Model for X-Ray Imaging Report Generation

Journal of Artificial Intelligence for Medical Sciences

引用

Journal of Artificial Intelligence for Medical Sciences 2021年第1期2卷 21-32页

作者： wang, xuwen Zhang, Yu Guo, Zhen Li, Jiao Institute of Medical Information and Library Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China

The rapid growth of medical imaging data brings heavy pressure to radiologists for imaging diagnosis and report writing. This paper aims to extract valuable information automatically from medical images to assist doctors in chest X-ray image interpretation. Considering the different linguistic and visual characteristics in reports of different crowds, we proposed a template-based multi-attention report generation model (TMRGM) for the healthy individuals and abnormal ones respectively. In this study, we developed an experimental dataset based on the IU X-ray collection to validate the effectiveness of TMRGM model. Specifically, our method achieves the BLEU-1 of 0.419, the METEOR of 0.183, the ROUGE score of 0.280, and the CIDEr of 0.359, which are comparable with the SOTA models. The experimental results indicate that the proposed TMRGM model is able to simulate the reporting process, and there is still much room for improvement in clinical application.

关键词：

来源：评论

学校读者我要写书评

暂无评论

Identifying key elements for evidence-base medicine using pretrained model and graph convolution network 10

Identifying key elements for evidence-base medicine using pr...

引用

10th International Conference on Information Technology and Quantitative Management, ITQM 2023

作者： Yang, Fengchun Xu, Xiaowei Wu, Meng wang, xuwen She, Liu Qian, Qing Li, Jiao Institute of Medical Information Chinese Academy of Medical Sciences Peking Union Medical College Beijing100020 China Key Laboratory of Medical Information Intelligent Technology Chinese Academy of Medical Sciences Beijing100020 China

Objective: Evidence-based medicine (EBM) provides a framework to support clinicians' decision-making processes using the best evidence currently available in the field. The key elements of clinical research can be defined by a framework called PICO, which identifies the sentences in a medical literature text that belong to the four key elements reported in clinical trials: Participants/Problem (P), Intervention (I), Comparison (C) and Outcome (O). This study aims to establish an effective detection method for key elements of evidence-based medical research. Methods: Based on the text features of key elements framework, we propose a deep learning model BERTGCN which combined large-scale pretraining model and graph convolution network (GCN) for detecting key elements of evidence-based medicine. In this model, the sentences which are initialized with pre-trained BERT representations and the words in the EBM evidence were recognized as the sentence nodes and word of the graph which were used to train GCN model. At the same time, the sentences were used to fine tune the pretraining model. Results: We tested our proposed approach over PubMed-PICO dataset is a data set containing tens of thousands of EBM key elements extracted from PubMed. The F1-score of P/I/O in the model we proposed reached 91.3%, 85.8% and 90.0% respectively. Experimental results show that our model outperforms the current optimal model. Conclusions: BERTGCN is able to leverage the advantages of both worlds: large-scale pretraining and transudative learning to improve the efficiency of detecting evidence-based medical evidence from research publications. © 2023 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (https://***/licenses/by-nc-nd/4.0) Peer-review under responsibility of the scientific committee of the Tenth International Conference on Information Technology and Quantitative Management.

关键词： Convolution

来源：评论

学校读者我要写书评

暂无评论

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

请选择保存的检索档案：

请选择收藏分类：

通借通还

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：