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Advances in the computational development of androgen receptor antagonists

DRUG DISCOVERY TODAY 2020年第8期25卷 1453-1461页

作者： Hu, Xueping Chai, Xin wang, xuwen Duan, Mojie Pang, Jinping Fu, Weitao Li, Dan Hou, Tingjun Zhejiang Univ Hangzhou Inst Innovat Med Coll Pharmaceut Sci Hangzhou 310058 Zhejiang Peoples R China Zhejiang Univ State Key Lab CAD&CG Hangzhou 310058 Zhejiang Peoples R China Chinese Acad Sci Wuhan Inst Phys & Math Natl Ctr Magnet Resonance Wuhan Key Lab Magnet Resonance Biol SystState Key Lab Wuhan 430071 Peoples R China

The androgen receptor is a ligand-dependent transcriptional factor and an essential therapeutic target for prostate cancer. Competitive binding of antagonists to the androgen receptor can alleviate aberrant activation of the androgen receptor in prostate cancer. In recent years, computer-aided drug design has played an essential part in the discovery of novel androgen receptor antagonists. This review summarizes the recent advances in the discovery of novel androgen receptor antagonists through computer-aided drug design approaches;and discusses the applications of molecular modeling techniques to understand the resistance mechanisms of androgen receptor antagonists at the molecular level.

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Phenotypic plasticity and genetic variation of cotton yield and its related traits under water-limited conditions

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The Crop Journal 2020年第6期8卷 966-976页

作者： Baoqi Li Qin Tian xuwen wang Bei Han Li Liu Xianhui Kong Aijun Si Juan wang Zhongxu Lin Xianlong Zhang Yu Yu Xiyan Yang National Key Laboratory of Crop Genetic Improvement Huazhong Agricultural UniversityWuhan 430070HubeiChina Cotton Institute Xinjiang Academy of Agriculture and Reclamation ScienceShihezi 832000XinjiangChina

Global warming is limiting availability of water resources in arid and semi-arid regions,and so understanding water use efficiency(WUE)is increasingly important for agricultural production in those *** China is the largest cotton producing area,the problem of balancing WUE and efficient cotton production is a major *** this study,we used a natural population of 517 Upland cotton accessions to conduct a water-controlled trial in south and north of Xinjiang over two years.A total of 18 traits including agronomic traits,fiber yield indices and fiber quality indices,were investigated for broad-sense heritability and coefficient of *** water limitation was found to promote the establishment of favorable agronomic traits in cotton,associated with an increased cotton yield of 8.46%in Xinjiang,at the expense of a certain degree of fiber quality,such as decreased fiber length and an over-higher micronaire *** detected 33 QTL related to response to water limitation using a drought resistance coefficient(DRC),and 6 QTL were found using a comprehensive indicator of CIDT(comprehensive index of drought tolerance)at the genetic level by integrating resequencing *** novel QTL-hotspots including six differentially expressed genes(DEGs)were further identified related to the drought response of *** findings not only suggested a new approach to irrigation of cotton fields in Xinjiang,but also provided abundant genetic evidence for genetic breeders to study drought improvement of crops.

关键词： Upland cotton Water-limited conditions Fiber yield Fiber quality QTL hotspot

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Al/HMX复合含能材料的制备及其燃烧特征参数研究

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固体火箭技术 2023年第2期46卷 213-223页

作者：扈颖慧王旭文张健梁家燕杨玉林林凯峰帅永哈尔滨工业大学化工与化学学院哈尔滨150001 哈尔滨工业大学能源科学与工程学院哈尔滨150001

奥克托今(HMX)包覆铝粉(Al)能够有效降低Al的团聚烧结现象并改善其能量释放效率。采用物理混合法、溶剂-反溶剂法和溶剂蒸发诱导自组装法分别制备了三种不同结构的Al/HMX-1、Al/HMX-2和Al/HMX-3复合含能材料。相较于Al/HMX-1和Al/HMX-2,... 详细信息

奥克托今(HMX)包覆铝粉(Al)能够有效降低Al的团聚烧结现象并改善其能量释放效率。采用物理混合法、溶剂-反溶剂法和溶剂蒸发诱导自组装法分别制备了三种不同结构的Al/HMX-1、Al/HMX-2和Al/HMX-3复合含能材料。相较于Al/HMX-1和Al/HMX-2,Al/HMX-3复合材料为球形包覆结构,D_(50)为6.651μm,各组分均匀分布。Al/HMX-3复合材料具备最优的热分解性能,其HMX的分解峰温降低到264.3℃,比Al/HMX-1和Al/HMX-2分别降低了~20.0℃和~19.2℃。燃烧性能分析表明,Al/HMX-3复合样品的燃烧更剧烈,团聚烧结现象降低,具有最高的燃烧热和燃烧温度。通过HMX均匀的包覆,HMX分解及时为Al燃烧提供氧化性气体“牢笼”促进Al氧化,并减少Al颗粒之间的相互碰撞导致的团聚。因此,燃烧性能和能量释放效率得到大幅度提升。

关键词：铝粉奥克托今包覆结构热分解性能燃烧温度

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HAZOP分析在火炸药工艺风险控制中的应用

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固体火箭技术 2024年第6期47卷 774-783页

作者：史喆邢峰康红艳赵媛媛马志伟王旭文张健杨玉林中国五洲工程设计集团有限公司北京100053 哈尔滨工业大学化工与化学学院新能源转换与存储关键材料技术工业和信息化部重点实验室哈尔滨150001

火炸药产品的加工制造过程具有显著的高能量性、高危险性和高敏感性,其工艺安全性和可靠性要求极为严格,需要对其设计、制造和生产全生命周期进行全方位分析,并做出相应的应急措施。危险与可操作性分析(HAZOP)是一种广泛应用于危险化学... 详细信息

火炸药产品的加工制造过程具有显著的高能量性、高危险性和高敏感性,其工艺安全性和可靠性要求极为严格,需要对其设计、制造和生产全生命周期进行全方位分析,并做出相应的应急措施。危险与可操作性分析(HAZOP)是一种广泛应用于危险化学品领域的安全分析方法,能够对工业过程或单元操作进行审查,识别、评估和预防潜在的危险或操作性问题,从而根据不同的问题制定相应的安全和管理措施,最终达到降低事故发生概率的目的。详述了HAZOP分析的流程和优势,就HAZOP分析应用于炸药、发射药、固体推进剂等涉火产品工艺安全风险控制领域的情况进行论述,对其在火炸药工艺风险控制中的适用性和目前在应用过程中存在的问题进行论证和展望,未来应加快火炸药产线物料的安全特性研究,提高HAZOP分析的全面性,加强HAZOP分析与故障模式与影响分析(FMEA)、保护层分析(LOPA)、安全完整性等级(SIL)及定量风险评估(QRA)等方法协同应用,使火炸药工艺安全风险控制得到进一步提升。

关键词： HAZOP分析火炸药工艺安全风险控制

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Dual-stage hybrid network for single-shot fringe projection profilometry based on a phase-height model

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OPTICS EXPRESS 2024年第1期32卷 891-906页

作者： wang, Lianpo Song, xuwen Northwestern Polytech Univ Sch Software Xian 710129 Peoples R China Northwestern Polytech Univ Shenzhen Res & Dev Inst Shenzhen 518063 Peoples R China

Single-shot fringe projection profilometry (FPP) is widely used in the field of dynamic optical 3D reconstruction because of its high accuracy and efficiency. However, the traditional single-shot FPP methods are not satisfactory in reconstructing complex scenes with noise and discontinuous objects. Therefore, this paper proposes a Deformable Convolution-Based HINet with Attention Connection (DCAHINet), which is a dual-stage hybrid network with a deformation extraction stage and depth mapping stage. Specifically, the deformable convolution module and attention gate are introduced into DCAHINet respectively to enhance the ability of feature extraction and fusion. In addition, to solve the long-standing problem of the insufficient generalization ability of deep learning-based single-shot FPP methods on different hardware devices, DCAHINet outputs phase difference, which can be converted into 3D shapes by simple multiplication operations, rather than directly outputting 3D shapes. To the best of the author's knowledge, DCAHINet is the first network that can be applied to different hardware devices. Experiments on virtual and real datasets show that the proposed method is superior to other deep learning or traditional methods and can be used in practical application scenarios.

关键词： Deep learning Fourier transforms Optical fields Phase unwrapping Stereo matching Three dimensional reconstruction

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Y-FFC Net for 3D Reconstruction of Highly Reflective Surfaces

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IEEE TRANSACTIONS ON INDUSTRIAL INFORMATICS 2024年第12期20卷 13966-13974页

作者： Song, xuwen wang, Lianpo Northwestern Polytech Univ Sch Software Xian 710072 Peoples R China Northwestern Polytech Univ Res & Dev Inst Shenzhen 518063 Peoples R China

3D reconstruction plays a pivotal role in intelligent manufacturing, industrial inspection, and other fields. Fringe projection profilometry is a widely used 3D reconstruction method due to its high accuracy and noncontact nature. However, when fringe projection profilometry (FPP) is applied to reconstruct highly reflective surfaces, there are not only diffuse reflections, but also undesired specular reflections. Intense specular reflection destroys the sinusoidal characteristics of the fringe pattern, leading to a decrease in 3D reconstruction accuracy. Traditional methods, such as Multiple exposures method, require multiple redundant shots to obtain high-quality fringe patterns, which makes efficiency difficult to meet industrial measurement requirements. Inspired by the application of deep learning in 3D vision, this article proposes a Y-shaped fast Fourier convolutional network (Y-FFC) for high reflection removal to provide high-quality fringe patterns. The cosine characteristics of the grayscale gradient of the sinusoidal fringe pattern make the detection of nonsinusoidal regions more accurate in the gradient domain. In addition, the undesired specular reflection component is easier to distinguish and filter out in the frequency domain. Therefore, the design of Y-FFC fully considers the gradient and frequency information. Experimental results show that the introduction of gradient and frequency information is beneficial for high reflection removal, enabling the reconstruction of industrial workpieces with highly reflective surfaces without the need for additional shots. The mean absolute error for depth measurements of an aircraft blade with a depth of 30 mm was reduced from 0.1332 to 0.0041 mm.

关键词： Decoding Convolution Frequency-domain analysis Three-dimensional displays Feature extraction Surface reconstruction Accuracy Fast Fourier convolutional (FFC) fringe projection profilometry high reflection removal industrial metrology

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中职数学教学中体验式教学法的运用探析

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成才之路 2021年第1期 72-73页

作者：王绪文甘肃省武威市民勤县职业中等专业学校甘肃民勤733399

体验式教学法在数学教学中的有效应用,能让学生在开放的思维空间里,通过自我实践,正确理解教学内容,有助于学生合作交流、自主学习、探索发展能力的提高。文章基于中职数学教学中存在的问题,结合运用体验式教学的可行性研究,从激发学习... 详细信息

体验式教学法在数学教学中的有效应用,能让学生在开放的思维空间里,通过自我实践,正确理解教学内容,有助于学生合作交流、自主学习、探索发展能力的提高。文章基于中职数学教学中存在的问题,结合运用体验式教学的可行性研究,从激发学习兴趣、注重联系生活、结合专业知识三个方面探讨中职数学教学中运用体验式教学法的策略。

关键词：中职数学体验式教学法学习兴趣联系生活专业知识

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ECCParaCorp: a cross-lingual parallel corpus towards cancer education, dissemination and application

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BMC MEDICAL INFORMATICS AND DECISION MAKING 2020年第3期20卷 122-122页

作者： Ma, Hetong Yang, Feihong Ren, Jiansong Li, Ni Dai, Min wang, xuwen Fang, An Li, Jiao Qian, Qing He, Jie Chinese Acad Med Sci & Peking Union Med Coll Inst Med Informat Lib Beijing Peoples R China Chinese Acad Med Sci & Peking Union Med Coll Off Canc Screening Natl Clin Res Ctr Canc Natl Canc CtrCanc Hosp Beijing 100021 Peoples R China Chinese Acad Med Sci & Peking Union Med Coll Dept Thorac Surg Natl Clin Res Ctr Canc Natl Canc CtrCanc Hosp Beijing Peoples R China

BackgroundThe increasing global cancer incidence corresponds to serious health impact in countries worldwide. Knowledge-powered health system in different languages would enhance clinicians' healthcare practice, patients' health management and public health literacy. High-quality corpus containing cancer information is the necessary foundation of cancer education. Massive non-structural information resources exist in clinical narratives, electronic health records (EHR) etc. They can only be used for training AI models after being transformed into structured corpus. However, the scarcity of multilingual cancer corpus limits the intelligent processing, such as machine translation in medical scenarios. Thus, we created the cancer specific cross-lingual corpus and open it to the public for academic *** to build an English-Chinese cancer parallel corpus, we developed a workflow of seven steps including data retrieval, data parsing, data processing, corpus implementation, assessment verification, corpus release, and application. We applied the workflow to a cross-lingual, comprehensive and authoritative cancer information resource, PDQ (Physician Data Query). We constructed, validated and released the parallel corpus named as ECCParaCorp, made it openly accessible *** proposed English-Chinese Cancer Parallel Corpus (ECCParaCorp) consists of 6685 aligned text pairs in Xml, Excel, Csv format, containing 5190 sentence pairs, 1083 phrase pairs and 412 word pairs, which involved information of 6 cancers including breast cancer, liver cancer, lung cancer, esophageal cancer, colorectal cancer, and stomach cancer, and 3 cancer themes containing cancer prevention, screening, and treatment. All data in the parallel corpus are online, available for users to browse and download (http://***/ECCParaCorp/).ConclusionsECCParaCorp is a parallel corpus focused on cancer in a cross-lingual form, which is openly accessible. It would make up the imbalan

关键词： Medical parallel corpus Cancer information Cross language Bilingual Cancer data HealthNLP

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医学知识标注体系设计与系统构建

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中国卫生标准管理 2023年第21期14卷 1-4页

作者：马鹤桐王序文沈柳李姣中国医学科学院医学信息研究所医学智能计算研究室北京100020

目前,海量医学数据,尤其是电子健康病历等有价值的数据仍亟待挖掘。然而以深度学习为代表的最新的模型更适用于结构化数据。因此需要标注实现非结构化数据到结构化数据的转换。医学知识标注则需要以标准的标注体系及标注系统为基础。针... 详细信息

目前,海量医学数据,尤其是电子健康病历等有价值的数据仍亟待挖掘。然而以深度学习为代表的最新的模型更适用于结构化数据。因此需要标注实现非结构化数据到结构化数据的转换。医学知识标注则需要以标准的标注体系及标注系统为基础。针对医学知识标注体系缺乏、标注系统功能缺失、知识标注方式单一的问题,提出医学知识标注体系设计以及医学知识标注系统构建范式,从标注体系设计、系统业务需求、用户分析、功能设计等方面,分析了医学知识标注体系的实现方法,并综合系统流程化标准需求、语义映射需求、标注可视化综合需求、人员管理需求等方面进行了详细描述,为医学知识标注的推广作为参考,并提供交互友好的医学知识标注平台。

关键词：知识标注标注系统医学标注人工标注医学标签医学标注系统

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Corrigendum to “Occurrence, transfer rule, and dietary risk assessment of aflatoxins in medicinal and edible seeds” [Food Bioscience 63 (2025) 105830]

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Food Bioscience 2025年 68卷

作者： Jianxin Lv Huiru Zhang xuwen wang Jiaoyang Luo Yudan wang Dandan Kong Chuang wang Mengyue Guo Meihua Yang Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine Ministry of Education Institute of Medicinal Plant Development Chinese Academy of Medical Sciences & Peking Union Medical College Beijing 100193 China Hainan Branch of the Institute of Medicinal Plant Development Chinese Academy of Medical Sciences & Peking Union Medical College Haikou 570311 China

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