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Interplay of student characteristics multidimensional engagement and influencing factors in online computer science education

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SCIENTIFIC REPORTS 2025年第1期15卷 1-15页

作者： Zhang, wuwen Guan, Yurong Hu, Zhihua Wang, Chencheng Lu, Douming Lu, Huaiyu Huanggang Normal Univ Coll Educ Huanggang 438000 Peoples R China Huanggang Normal Univ Coll Comp Sci Huanggang 438000 Peoples R China Donghua Grp Dongguan Guangdong Peoples R China Shishi Expt Sch Foshan Guangdong Peoples R China

Digital technology is reshaping the landscape of higher education, especially in the field of computer science. As digital platforms become central to the learning process, understanding student engagement in these continuously evolving environments is increasingly vital. This study explores the current state of online learning among undergraduate computer science students, investigates factors influencing their engagement, and proposes strategies to enhance online education. The research framework is grounded in the TPACK model, behaviorist learning theory, learning engagement theory, and situated cognition learning theory, encompassing student characteristics, multidimensional online learning engagement, and key influencing factors. Data on participants' basic attributes, levels of engagement, and the major determinants of these engagement levels were collected via a questionnaire survey. Analyses using SPSS 25.0-employing t-tests, ANOVA, and Pearson correlation-revealed significant trends and relationships. Findings show a notable positive correlation between the duration of online learning and overall engagement, whereas gender, home location, and academic major exerted relatively limited influence. Subjective intention, attitude, and motivation emerged as crucial determinants, and interactions with instructors and Peers-reinforced by teaching approaches and feedback-played an essential role in fostering emotional involvement. Building on these insights, the study recommends initiatives to strengthen self-motivation, nurture meaningful online interactions, enhance technical support systems, and reinforce mechanisms for assessing learning outcomes. This work provides empirical evidence for a deeper understanding of online education while indicating directions for ongoing improvement.

关键词： Online learning Learning engagement Influencing factors Computer science major

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Revisiting traditional Chinese exercise in prediabetes: effects on glycaemic and lipid metabolism - a systematic review and meta-analysis

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DIABETOLOGY & METABOLIC SYNDROME 2025年第1期17卷 1-18页

作者： Yan, Ruixiang Peng, wuwen Lu, Di He, Jiaxin Sun, Jian Guan, Lingju Liu, Shufang Li, Duanying Guangzhou Sport Univ Sch Athlet Training Guangzhou Peoples R China Guangzhou Sport Univ Dept Sport & Hlth Guangzhou Peoples R China Guangdong Prov Inst Sports Sci Guangzhou Peoples R China

Background and objectivesMost existing studies have primarily focused on the effects of Traditional Chinese Exercises (TCEs) on glycemic control in individuals with prediabetes, while specific recommendations for managing dyslipidemia in this population remain insufficient. Moreover, there is a lack of systematic research and conclusive evidence regarding the optimal exercise dose required to achieve metabolic improvements in individuals with prediabetes. Therefore, this meta-analysis aims to comprehensively evaluate the efficacy of TCEs in improving glycemic and lipid profiles in individuals with prediabetes and to explore the potential impact of exercise dose on these metabolic parameters. MethodsA comprehensive search of six databases (PubMed, Web of Science, Cochrane Library, Embase, CNKI, and WanFang Data) followed PRISMA guidelines to identify randomized controlled trials (RCTs) on TCEs (e.g., "Tai Chi," "Yijinjing," "Baduanjin") and prediabetes (e.g., "impaired glucose tolerance," "impaired glucose regulation") published up to November 10, 2024. Three reviewers independently screened studies, extracted data, and assessed bias risk. Meta-analysis and subgroup/meta-regression analyses were conducted using Stata 17 software. The review protocol is registered in PROSPERO (CRD42024615150). ResultsA total of 15 studies involving 1,839 participants were included. The meta-analysis revealed that TCEs significantly improved HbA1c (MD = -0.28%;95% CI: -0.38% to -0.18%;P = 0.001), FBG (MD = -0.44 mmol/L;95% CI: -0.53 to -0.34 mmol/L;P < 0.001), 2hPG (MD = -1.16 mmol/L;95% CI: -1.48 to -0.85 mmol/L;P < 0.001), TC (MD = -0.31 mmol/L;95% CI: -0.50 to -0.11 mmol/L;P = 0.002), TG (MD = -0.28 mmol/L;95% CI: -0.50 to -0.06 mmol/L;P = 0.012), and HDL (MD = -0.28 mmol/L;95% CI: -0.50 to -0.06 mmol/L;P = 0.012) compared to control groups. ConclusionsTCEs significantly improve prediabetics' blood glucose and lipid levels. The recommended exercise regimen is 30-50 min per session,

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Cu2O1-x -Superlattices Induced Oxygen Vacancy for Localized Surface Plasmon Resonance

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NANO LETTERS 2025年第2期25卷 922-930页

作者： Yao, Chang Feng, Haochuan Weng, Shirui Li, Junxiang Huo, Ying-Fei Yan, wuwen Dong, Ronglu Yang, Liangbao Univ Sci & Technol China Hefei 230026 Anhui Peoples R China Chinese Acad Sci Inst Hlth & Med Technol Hefei Inst Phys Sci Hefei 230031 Peoples R China Nankai Univ Natl Inst Adv Mat Sch Mat Sci & Engn Tianjin 300350 Peoples R China Chinese Acad Sci Hefei Canc Hosp Dept Pharm Hefei 230031 Anhui Peoples R China

Metallic oxide can induce localized surface plasmon resonance (LSPR) through creating vacancies, which effectively achieve high carrier concentrations and offer advantages such as versatility and tunability. However, vacancies are typically created by altering the stoichiometric ratio of elements through doping, and it is challenging to achieve LSPR enhancement in the visible spectral range. Here, we have assembled Cu2O1-x -superlattices to induce a high concentration of oxygen vacancies, resulting in LSPR within the visible spectrum. Combining this technique with theoretical models, we have elucidated the mechanism behind the origin of LSPR. We also provide evidence of strong and uniform LSPR exhibited by this structure under visible light. This significantly enhances the electromagnetic field in semiconductor-based surface-enhanced Raman scattering (SERS), with a detection limit concentration reaching 10-9 M compared to conventional gold nanoparticles (55 nm). Our strategy provides a new perspective and potential for controlling carrier concentration and generating LSPR in metal oxide nanoparticles.

关键词： Cu2O1-x -superlattices localized surface plasmonresonance oxygen vacancy surface-enhanced Ramanscattering

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Fuzi alleviates cold-related rheumatoid arthritis via regulating gut microbiota and microbial bile acid metabolism

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Chinese Medicine (United Kingdom) 2025年第1期20卷 1-18页

作者： Liu, Juan Zhang, Dandan Zhou, Yaochuan Wu, Jinlu Feng, wuwen Peng, Cheng State Key Laboratory of Southwestern Chinese Medicine Resources School of Pharmacy Chengdu University of Traditional Chinese Medicine Chengdu 611137 China TCM Regulating Metabolic Diseases Key Laboratory of Sichuan Province Hospital of Chengdu University of Traditional Chinese Medicine Chengdu 610032 China Key Laboratory of the Ministry of Education for Standardization of Chinese Medicine Chengdu University of Traditional Chinese Medicine Chengdu 611137 China

Background: Rheumatoid arthritis (RA) with cold pattern is an important type of RA according to the theory of traditional Chinese medicine. Fuzi (also known as the lateral roots of Aconitum carmichaelii Debx.) represents a typical traditional Chinese medicine that has been clinically used for treatment of the RA especially cold-related RA for thousands of years, yet its mechanism remains unknown. Purpose: The purpose of the research was to study the therapeutic effects of Fuzi on cold-related RA, and to investigate the mechanism of its action. Methods: Here, we investigated the pharmacological effects of Fuzi on cold-related RA using micro-CT, histopathological analysis, and inflammatory cytokine test. Then, a gut microbiota composition analysis in combination with fecal microbiota transplantation were used to confirm the role of gut microbiota in the therapeutic effects of Fuzi. Further, targeted bile acid metabolomics was used to screen the possible differential microbial bile acids involved in the mechanism of Fuzi. In vitro bioactivity analysis of differential bile acids was used to assess their anti-inflammation activity. Finally, western blot was used to investigate the signaling pathways of Fuzi in reducing the inflammation of cold-related RA. Results: The results showed that Fuzi alleviates cold-related RA by improving arthritis index, paw swelling, bone damage, and inflammatory cytokines. In addition, the ameliorative effect of Fuzi is dependent on gut microbiota such as the taxa Lachnospiraceae and Ruminococcaceae. Targeted analysis of fecal and serum bile acids showed that TCA and THDCA were the main differential metabolites. In vitro, TCA and THDCA showed anti-inflammation effects on RAW264.7 cells. Western blot showed that Fuzi regulates TGR5-cAMP-PKA signaling and NLRP3 inflammasome to reduce cold-related arthritis. Conclusion: Overall, our results demonstrated that Fuzi could regulate gut microbiota and microbial bile acid metabolism, the microbial me

关键词： Fuzi Gut microbiota NLRP3 inflammasome Rheumatoid arthritis TGR5-cAMP-PKA signaling

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Effect of unilateral and bilateral plyometric training on jumping, sprinting, and change of direction abilities: a meta-analysis

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BMC Sports Science, Medicine and Rehabilitation 2025年第1期17卷 1-17页

作者： Zhang, Zhanming Qu, Wenhao Peng, wuwen Sun, Jian Yue, Jiyang Guan, Lingju Lu, Min Li, Duanying Graduate School Guangzhou Sport University Guangdong Guangzhou China School of Athletic Training Guangzhou Sport University No.1268 Guangzhou Avenue Central Tianhe District Guangdong Guangzhou 510500 China Guangdong Provincial Institute of Sports Science Guangdong Guangzhou China School of Wushu Guangzhou Sport University Guangdong Guangzhou China Guangdong Provincial Key Laboratory of Human Sports Performance Science Guangdong Guangzhou China

Background: Plyometric training is a commonly employed method to enhance explosive strength in athletes. However, to date, no study has provided a comprehensive and systematic evaluation of the effects of unilateral (UNI) versus bilateral (BI) plyometric training. Objectives: This meta-analysis investigates the impact of UNI and BI plyometric training on jumping, sprinting, and Change of Direction (COD) abilities. Study eligibility criteria: To be eligible for inclusion in the meta-analysis, the study had to be:(1)healthy individuals;(2)UNI and BI plyometric training;(3)conducted on rigid surfaces;(4)the outcome indicators were jumping ability, sprinting, and change of direction ability;(5)randomized controlled trials (RCTs). Study appraisal and synthesis methods: We used the random-effects model for meta-analyses. Effect sizes (standardized mean difference), calculated from measures of horizontally oriented performance, were represented by the standardized mean difference and presented alongside 95% confidence intervals (CI). Data sources: PubMed, Web of Science, Scopus, ProQuest, CNKI and Google Scholar. Results: A total of 11 papers met the inclusion criteria. The meta-analysis revealed that UNI contrast training was more effective than BI contrast training in improving single-leg jump performance (ES = 0.53, 95% CI: 0.02–1.04;Z = 2.05, p = 0.04), double-legs jump performance (ES = -0.07, 95% CI: -0.23–0.09;Z = 0.88, p = 0.38),sprint performance (ES = -0.04, 95% CI: -0.07–-0.01;Z = 2.32, p = 0.02), as well as COD (ES = − 0.08, 95% CI: − 0.12 to − 0.03;Z = 3.29, p = 0.001 < 0.01). Conversely, BI contrast training showed a greater effect on bilateral jump performance (ES = -0.07, 95% CI: -0.12–-0.03;Z = 3.39, p = 0.0007). Training with low-ground-contact frequencies (LGCF, fewer than 900 contacts) was found to significantly enhance vertical jump performance (ES = 0.64, 95% CI: 0.01–1.27;Z = 2.00, p = 0.05). Conclusions: UNI and BI plyometric training offer modality

关键词： Lower Limb Athletic Performance Plyometric training Unilateral training

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PRMT3 gene expression and methylation levels in arrested embryos: Implications for developmental arrest defects

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DEVELOPMENTAL BIOLOGY 2025年 520卷 264-271页

作者： Zhang, wuwen Li, Shifeng Li, Kai Sun, Ningyu Lv, Rong Ma, Jie Yin, Ping Tong, Guoqing Chen, Yuanyuan Lu, Lu Li, Yun Wu, Yuanyuan Yan, Hua Shanghai Univ Tradit Chinese Med Dept Infertil & Reprod Med Shuguang Hosp 528 Zhangheng Rd Shanghai 201203 Peoples R China Chinese Acad Sci Ctr Excellence Mol Cell Sci Shanghai 200031 Peoples R China Shanghai Univ Tradit Chinese Med Sch Tradit Chinese Med Shanghai 201203 Peoples R China Shanghai Univ Tradit Chinese Med Sch Acupuncture Moxibust & Tuina Shanghai 201203 Peoples R China

Embryos generated through in vitro fertilization (IVF) frequently experience developmental arrests or blocks, which significantly reduces the success rate of IVF therapy. Recent studies have shown that the protein arginine methylase 3 (PRMT3) plays a crucial role in the regulating of gene expression during early embryonic development. However, the exact regulatory mechanisms of PRMT3 involved in early embryonic development are still unclear. In this study, we used discarded arrested and polyspermic embryos from IVF for experiments, employing confocal techniques and qRT-PCR to examine PRMT3 expression and changes in H4R3me2a methylation during various stages of early development. Furthermore, PRMT3 was re-expressed in the arrested embryos to observe their subsequent development. Our findings revealed that PRMT3 nucleic acid and protein were significantly lower in arrested embryos than in control embryos (P < 0.05). Additionally, methylation levels of H4R3me2a were significantly lower in arrested embryos (P < 0.05). Re-expression of PRMT3 could partially rescue embryos that are developmentally arrested, and even a few arrested embryos have the potential to develop into morula or blastocysts. In summary, the reduction or deletion of PRMT3 gene in early embryo may lead to developmental arrested defects. Therefore, it is crucial to regulate the expression and functioning of PRMT3 for the proper development of early embryos, and further research is required to investigate potential therapeutic interventions for embryonic development arrest in vitro.

关键词： Early embryonic development Developmentally arrested Protein arginine methylase 3 In vitro fertilization Epigenetic regulation

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The high efficiency protective effectiveness of a newly isolated myoviruses bacteriophage vB_AceP_PAc in protecting mice from Aeromonas caviae infection in mice

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BMC MICROBIOLOGY 2025年第1期25卷 1-18页

作者： Feng, Chao Wang, Lu Bai, Huifang Huang, Qixing Liang, Shuang Liang, Ruiqi Yu, Jiahao Wang, Shun Guo, Hui Raza, Sayed Haidar Abbas Shan, Xiaofeng Zhang, Dongxing Sun, wuwen Zhang, Lei Jilin Agr Univ Coll Anim Sci & Technol Changchun 130118 Peoples R China Chongqing Univ Inst Intelligent Oncol Chongqing 400030 Peoples R China Changchun Borui Sci & Technol Co Ltd Postdoctoral Sci Res Workstat Changchun 130000 Peoples R China Northwest A&F Univ Coll Anim Sci & Technol Yangling 712100 Shaanxi Peoples R China

Phage therapy is an effective strategy to combat multidrug resistance in bacteria and has been increasingly utilized to protect animals from bacterial infections. This study involved the isolation and purification of a novel myoviruses phage, vB_AceP_PAc, from a drug-resistant bacterial strain Aeromonas caviae. Genome sequence analysis based on nucleotide sequences revealed that vB_AceP_PAc shared significant similarity with the genomes of 10 other Aeromonas phages, with the highest coverage rate of 52% with phiA047. Intraperitoneal injection of 1 x 10(9) CFU/mL (100 mu L/mouse) A. caviae AC-CY resulted in diarrhea in mice three days later. At this time, oral administration of 1 x 109 PFU/mL (100 mu L/mouse) vB_AceP_PAc effectively alleviated the diarrhea induced by Pseudomonas aeruginosa infection in the mice. Furthermore, oral administration of 1 x 10(9) PFU/ml vB_AceP_PAc (100 mu l/mouse) in healthy mice significantly reduced inflammatory cytokine levels, increased tight junction molecule levels, and improved intestinal barrier function. Moreover, the consumption of vB_AceP_PAc by health mice led to a significant increase in the abundance of Lactobacillaceae in the gut, while the expression of CD3(+)CD4(+)/CD3(+)CD8(+) was minimally affected. Overall, the findings of this study confirmed the promising potential of bacteriophage vB_AceP_PAc in treating diarrhea caused by A. caviae.

关键词： Bacteriophage Genome analysis Gut microbiota Intestinal barrier function Diarrhoea

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Biological analysis of phage vB_AhaP_PT2 and treatment rescued crucian carp infected with Aeromonas hydrophila

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AQUACULTURE 2025年第Part2期595卷

作者： Liang, Shuang Liang, Ruiqi Raza, Sayed Haidar Abbas Huang, Qixing Li, Tingxuan Bai, Huifang Feng, Chao Xin, Liang Guo, Hui Wang, Shun Yu, Jiahao Cao, Yuan Liu, Ning Almalki, Fatemah Zhang, Dongxing Sun, wuwen Zhang, Lei Jilin Agr Univ Coll Anim Sci & Technol Changchun 130000 Peoples R China Changchun Borui Technol Co Ltd Changchun 130000 Peoples R China Yangzhou Univ Coll Vet Yangzhou 225009 Peoples R China South China Agr Univ Guangdong Prov Key Lab Food Qual & Safety Guangzhou 510642 Peoples R China Jilin Lanpu Haoye Technol Co Changchun 130000 Peoples R China Northeast Agr Univ Coll Vet Med Harbin 150030 Peoples R China Shaqra Univ Coll Sci & Humanities Al Quwaiiyah Biol Dept Al Quwaiiyah 19257 Saudi Arabia

Phage therapy is an alternative approach to overcoming the problem of multidrug resistance in bacteria. In this study, we isolated and purified a virulent phage named vB_AhaP_PT2 from A. hydrophila-TPS. We examined the biological characteristics and genome sequences of vB_AhaP_PT2. After intraperitoneal injection of bacteriophage (8 x 107 PFU/mL) into crucian carp, most of the phage distributed in the liver, spleen, kidney, intestine, and peripheral blood, and disappeared within 72 h. No substantial adverse symptoms were found in major organs after receiving phage injections continuously for 14 days. Vitro and Vivo results indicated that phage can effectively eliminate A. hydrophila-TPS. The phage vB_AhaP_PT2 (8 x 107 PFU/mL, 100 mu L) can effectively protect the fish that exhibited a double median lethal dose of bacteria (2 x 106 CFU/fish). Although phage vB_AhaP_PT2 triggered the generation of phage-specific antibodies in carp, when the antibody titer was maximum, 8 x 107 PFU doses of bacteriophage could still protect crucian carp with lethal bacterial infections, the survival rate could reach 80%. We also found that members of the genus Aeromonas could enter and colonize the intestine. The phage vB_AhaP_PT2 reduced the number of colonies of the genus Aeromonas. However, no significant changes were observed in alpha-diversity and beta-diversity parameters, which suggested that the consumed phage had little effect on the intestine microflora. All the above results suggested that vB_AhaP_PT2 was a safe and effective therapeutic that can be considered as a potential tool to treat the infection caused by A. hydrophilaTPS in aquaculture.

关键词： Aeromonas hydrophila Bacteriophage therapy Distribution of phage Antibody

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Time-dependent effects of acute stretching on power, balance, and flexibility in contemporary dancers: a randomized crossover trial

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Scientific Reports 2025年第1期15卷 1-11页

作者： Yan, Ruixiang Lin, Gesheng Peng, wuwen Chen, Yuhuan Sun, Pengpeng Sun, Jian Li, Duanyin School of Athletic Training Guangzhou Sport University Guangdong Guangzhou China School of Physical Education Guangdong Business and Technology University Guangzhou China School of Wushu Guangzhou Sport University Guangzhou China Guangdong Provincial Key Laboratory of Human Sports Performance Science Guangzhou Sport University Guangzhou China

To evaluate the acute effects of proprioceptive neuromuscular facilitation (PNF), static (SS) and dynamic (DS) stretching on flexibility, power, and balance in contemporary dancers and to analyze the time-dependent flexibility changes to optimize stretching strategies for training and performance. A randomized crossover trial was conducted with 24 university-level contemporary dancers. In phase one, participants completed sit-and-reach (S&R), countermovement jump (CMJ), and Y-balance (YBT) tests immediately post-stretching. In phase two, only S&R was measured before stretching, immediately after, and at 5, 10, and 15 min post-stretching. PNF (ES = 0.329, p <.001), SS (ES = 0.263, p <.01), and DS (ES = 0.306, p <.01) significantly improved S&R, with PNF and DS being more effective than control (CON) (p <.05). DS and PNF showed progressive improvements over 15 min (p <.01), while SS peaked at 10 min (ES = 0.389, p <.01) before slightly declining (ES = 0.343, p <.01). No significant changes were found in CMJ or YBT (p >.05). For contemporary dancers who require high flexibility, SS, DS, and PNF stretching effectively enhance flexibility within 15 min post-stretching without negatively impacting power or balance. © The Author(s) 2025.

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Numerical modelling of compressible hyperelasticity via smoothed state-based peridynamics

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ENGINEERING ANALYSIS WITH BOUNDARY ELEMENTS 2022年 140卷 476-493页

作者： Yao, wuwen Zhou, Xiaoping Chongqing Univ Sch Civil Engn Chongqing 400045 Peoples R China

A simply and effective method, smoothed state-based peridynamics, is proposed to simulate the large deformation and fracture behaviors of general compressible hyperelasticity. The proposed method is developed from the state-based peridynamics, which can be defined directly from the given classical model by a corresponding deformation gradient. The handling way of modelling general hyperelastic material through the proposed method is described detailedly in this paper. The compressible Neo-Hookean model, density solution and other numerical technology are investigated. Some popular benchmark problems of hyperelasticity are solved successfully, including the Inflation of a hollow spherical ball, compressed cuboid, pinched cylinder and the elastomer fracture problems.

关键词： Compressible hyperelastic Numerical modelling Smoothed state-based peridynamics Density variable Large deformation Elastomer fracture

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