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矛盾纠纷调处化解标准化实践路径研究与建议——以湖州市吴兴区社会综合治理省级标准化战略重大试点为例

中国质量与标准导报 2022年第3期 103-105,111页

作者：郑玲陈旭文吴新惠陆芸陈群浙江蓝箭万帮标准技术有限公司浙江省方大标准信息有限公司湖州市吴兴区社会矛盾纠纷调处化解中心

标准化对完善社会矛盾纠纷多元预防调处化解综合机制,提升地方社会矛盾纠纷调处化解工作系统规范性和调处效率具有重要作用。本文以吴兴区社会综合治理省级标准化战略重大试点标准体系构建与实践经验为基础,对“顶层设计体系化、资源管... 详细信息

标准化对完善社会矛盾纠纷多元预防调处化解综合机制,提升地方社会矛盾纠纷调处化解工作系统规范性和调处效率具有重要作用。本文以吴兴区社会综合治理省级标准化战略重大试点标准体系构建与实践经验为基础,对“顶层设计体系化、资源管理标准化、调处机制链条化、调处人员职业化、统筹研判数字化”的标准化实践路径进行研究总结,为全国社会矛盾纠纷调处化解标准化长效发展提供经验与借鉴。

关键词：矛盾纠纷调处化解社会治理标准化

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A Power Take-Off Device With an HTS Synchronous Reluctance Linear Generator

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IEEE TRANSACTIONS ON APPLIED SUPERCONDUCTIVITY 2020年第8期30卷 1页

作者： Jing, Hailian Cao, Bin Zou, Yutong Izumi, Mitsuru Maki, Naoki chen, xuwen Xu, Peng Chengdu Univ Technol Coll Nucl Technol & Automat Engn Chengdu 610059 Peoples R China Tokyo Univ Marine Sci & Technol Grad Sch Marine Sci & Technol Tokyo 1358533 Japan

To utilize wave energy, we propose a power take-off device mainly composed of a novel buoy and a high-temperature superconducting synchronous reluctance linear generator (HTS-SRLG). We describe the conceptual structure and function of the buoy, which makes use of seawater to provide more power to the HTS-SRLG. Then, we introduce the configuration and the key electrical design process of the HTS-SRLG. Design result of the HTS-SRLG is presented and compared with that of counterparts to demonstrate its advantages in performance and in application. This article is conducted from the viewpoint of promoting the industrial application of HTS machines. The proposed buoy gives an insight of improving the utilizing efficiency of wave energy. And the HTS-SRLG contributes to simplify the generator cooling.

关键词： Buoy electrical design high-temperature superconductor (HTS) synchronous reluctance generator wave energy

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浙江知识产权公共服务数字化集成平台设计与研究

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中国科技纵横 2024年第6期 26-29页

作者：张潞璐曹杭平黄健民朱明陈旭文傅潇杭国家市场监管技术创新中心(市场监管数字化研究与应用) 浙江杭州 310000 浙江省标准化研究院浙江杭州 310000

建设知识产权公共服务数字化集成平台是深化知识产权服务事项改革的重要方式,为进一步提升浙江知识产权公共服务数字化集成水平,以"知识产权在线"为例,充分运用"互联网+知识产权"、大数据和信息化技术,分析建设背... 详细信息

建设知识产权公共服务数字化集成平台是深化知识产权服务事项改革的重要方式,为进一步提升浙江知识产权公共服务数字化集成水平,以"知识产权在线"为例,充分运用"互联网+知识产权"、大数据和信息化技术,分析建设背景与实际需求,提出浙江融合优化知识产权各类资源和服务的知识产权平台设计与建设方式,为全国类似平台的功能设计以及服务能力和效率的提升提供经验借鉴.

关键词：知识产权集成公共服务数字化

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TRIM66 reads unmodified H3R2K4 and H3K56ac to respond to DNA damage in embryonic stem cells

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NATURE COMMUNICATIONS 2019年第1期10卷 1-17页

作者： chen, Jiajing Wang, Zikang Guo, Xudong Li, Fudong Wei, Qingtao chen, xuwen Gong, Deshun Xu, Yanxin chen, Wen Liu, Yongrui Kang, Jiuhong Shi, Yunyu Univ Sci & Technol China Hefei Natl Lab Phys Sci Microscale Hefei 230026 Anhui Peoples R China Univ Sci & Technol China Sch Life Sci Hefei 230026 Anhui Peoples R China Tongji Univ Shanghai Matern & Infant Hosp 1Clin & Translat R Shanghai Key Lab Signaling & Dis ResInst Adv Stu Collaborat Innovat Ctr Brain SciSch Life Sci & T Shanghai 200092 Peoples R China Tsinghua Univ Beijing Adv Innovat Ctr Struct Biol Tsinghua Peking Joint Ctr Life Sci Sch Life Sci Beijing 100084 Peoples R China

Recognition of specific chromatin modifications by distinct structural domains within "reader" proteins plays a critical role in the maintenance of genomic stability. However, the specific mechanisms involved in this process remain unclear. Here we report that the PHD-Bromo tandem domain of tripartite motif-containing 66 (TRIM66) recognizes the unmodified H3R2-H3K4 and acetylated H3K56. The aberrant deletion of Trim66 results in severe DNA damage and genomic instability in embryonic stem cells (ESCs). Moreover, we find that the recognition of histone modification by TRIM66 is critical for DNA damage repair (DDR) in ESCs. TRIM66 recruits Sirt6 to deacetylate H3K56ac, negatively regulating the level of H3K56ac and facilitating the initiation of DDR. Importantly, Trim66-deficient blastocysts also exhibit higher levels of H3K56ac and DNA damage. Collectively, the present findings indicate the vital role of TRIM66 in DDR in ESCs, establishing the relationship between histone readers and maintenance of genomic stability.

关键词： DNA damage and repair Embryonic stem cells Structural biology

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Threshold Huffman-Based Covert Timing Channel Detection

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International Journal of Network Security 2025年第1期27卷 61-71页

作者： Lin, Yuwei chen, Yonghong Zhuang, Xiaolong Huang, xuwen School of Computer Science and Technology Huaqiao University Fujian Xiamen361000 China Xiamen Key Laboratory of Data Security and Blockchain Technology Huaqiao University Fujian Xiamen361000 China

Network covert timing channels in computer networks evade effective detection by traditional security mechanisms such as firewalls, posing a significant threat to network security. However, most existing methods struggle to detect such channels when the window size is small. Additionally, the emergence of the new ϵ-κlibur channel has resulted in a decline in performance for detection methods such as GAS, SnapCatch, and DNN when detecting this particular channel. In this paper, we investigate a Huffman tree-based approach for detecting anomalous nodes in traffic and achieving the classification of channels through the design of weight intervals. Our method achieves an average detection rate of over 95% for each channel. Additionally, compared to GAS, SnapCatch, and DNN, our method improves the detection rates for the ϵ-κlibur channel by 11.75%, 8.46%, and 4.81%, respectively. The experimental results demonstrate that our proposed approach successfully detects ϵ-κlibur and achieves detection in a small window. © (2025), (Femto Technique Co., Ltd.). All rights reserved.

关键词： Computer system firewalls

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数字化改革下医养结合标准化建设的研究与建议

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中国质量与标准导报 2021年第4期 80-82页

作者：王春聪陈旭文张桓彰陈群浙江省方大标准信息有限公司

医养结合是我国养老服务体系中的重要内容,论文以问题和发展导向为基础,对数字化改革下医养结合标准化建设进行了分析研究,进而提出建立标准体系、统一数据规范、深化场景应用等建议。

关键词：数字化改革医养结合标准化

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Decoding the bitter taste of Idesia polycarpa var. vestita Diels fruit: Bitterness contribution and mechanisms

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FOOD CHEMISTRY 2024年第Part2期460卷 140609页

作者： Xiang, xuwen chen, Kewei Li, Aijun Yang, Gang An, Xiaofeng Kan, Jianquan Southwest Univ Coll Food Sci 2 Tiansheng Rd Chongqing 400715 Peoples R China Minist Agr & Rural Affairs Peoples Republ China Lab Qual & Safety Risk Assessment Agroprod Storage Chongqing 400715 Peoples R China Chinese Hungarian Cooperat Res Ctr Food Sci Chongqing 400715 Peoples R China Chongqing Key Lab Special Food Cobuilt Sichuan & C Chongqing 400715 Peoples R China Chongqing Shanlinyuan Forestry Comprehens Dev Co L Chongqing 400800 Peoples R China

To comprehensively explore the contribution and mechanisms of identified low-threshold bitter substances in Idesia polycarpa var. vestita Diels (I. vestita) fruit, we performed quantification and elucidated their interactions with main bitter taste receptors through molecular docking. The established method for quantifying bitter compounds in I. vestita fruit was validated, yielding satisfactory parameters for linearity, stability, and accuracy. Idescarpin (17.71-101.05 mg/g) and idesin (7.88-77.14 mg/g) were the predominant bitter compounds in terms of content. Taste activity values (TAVs) exceeded 10 for the bitter substances, affirming their pivotal role as major contributors to overall bitterness of I. vestita fruit. Notably, idescarpin with the highest TAV, played a crucial role in generating the bitterness of I. vestita fruit. Hydrogen bonds and hydrophobic interactions were the main driving forces. This study holds potential implications for industrial development of I. vestita fruit by providing novel insights into the mechanism underlying its bitterness formation.

关键词： Idesia polycarpa var. vestita Diels Bitterness contribution Quantitative analysis Molecular docking Bitterness mechanism Taste activity value

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Effect of Carburized Layer Depth on the Wear Reliability of Cams

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INTERNATIONAL JOURNAL OF AUTOMOTIVE TECHNOLOGY 2025年第3期26卷 799-812页

作者： Tang, Jie chen, Jianzhi Shang, Fanmin Jing, xuwen Zhou, Honggen Li, Guochao Jiangsu Univ Sci & Technol Sch Mech Engn Zhenjiang 212003 Peoples R China Jiangsu Univ Sci & Technol Sch Mat Sci & Engn Zhenjiang 212003 Peoples R China

The carburizing process is the key technology to improve the wear properties of cams;however, the influence mechanisms of the carburized depth on the wear reliability of cams are still unclear. In this work, the multi-body dynamic simulation with the AVL_EXCITE TD software and the accelerated wear experiments of the cam-roller pairs were combined to analyze the wear reliability of cams with different carburized depths of 0 mm, 0.8 mm and 1.4 mm. The results indicate that allowable wear depth of the cam is predicted to be 0.916 mm according to the degradation rule of the valve fullness coefficient. The maximum wear failure life of different carburized cams corresponding to the wear reliability of 99% was determined to be 1.0 x 107 cycles, 3.2 x 109 cycles and 3.5 x 109 cycles based on the combination of online detection data and the multi-body dynamics simulation. The relationship model between the wear failure life of the carburized cams and the carburized depth is established, and the optimal carburized layer depth of 1.20 mm is speculated from the model. The present work can provide new clues for improving the wear resistance of mechanical components.

关键词： Carburized layer depth Wear reliability Simulation Accelerated wear experiments Cam

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Prediction and optimization method for welding quality of components in ship construction

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SCIENTIFIC REPORTS 2024年第1期14卷 1-18页

作者： Liu, Jinfeng cheng, Yifa Jing, xuwen Liu, Xiaojun chen, Yu Jiangsu Univ Sci & Technol Zhenjiang 212100 Jiangsu Peoples R China Southeast Univ Nanjing 211189 Peoples R China

Welding process, as one of the crucial industrial technologies in ship construction, accounts for approximately 70% of the workload and costs account for approximately 40% of the total cost. The existing welding quality prediction methods have hypothetical premises and subjective factors, which cannot meet the dynamic control requirements of intelligent welding for processing quality. Aiming at the low efficiency of quality prediction problems poor timeliness and unpredictability of quality control in ship assembly-welding process, a data and model driven welding quality prediction method is proposed. Firstly, the influence factors of welding quality are analyzed and the correlation mechanism between process parameters and quality is determined. According to the analysis results, a stable and reliable data collection architecture is established. The elements of welding process monitoring are also determined based on the feature dimensionality reduction method. To improve the accuracy of welding quality prediction, the prediction model is constructed by fusing the adaptive simulated annealing, the particle swarm optimization, and the back propagation neural network algorithms. Finally, the effectiveness of the prediction method is verified through 74 sets of plate welding experiments, the prediction accuracy reaches over 90%.

关键词： Quality prediction Components welding Welding quality Process parameter optimization

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Preliminary studies on the molecular mechanism of intramuscular fat deposition in the longest dorsal muscle of sheep

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BMC GENOMICS 2024年第1期25卷 592页

作者： Shao, xuwen Lu, Xintan Sun, Xinming Jiang, Huaizhi chen, Yang Jilin Agr Univ Coll Anim Sci & Technol Changchun 130118 Peoples R China Minist Agr & Rural Affairs Key Lab Livestock & Poultry Resources Sheep & Goat Changchun Peoples R China

Background Intramuscular fat content is an important index reflecting the quality of mutton, which directly affects the flavor and tenderness of mutton. Livestock and poultry intramuscular fat content is influenced by genetics, nutritional level, and environmental factors. Key regulatory factors play a crucial role in intramuscular fat deposition. However, there is a limited amount of research on the identification and function of key genes involved in intramuscular fat content deposition specifically in sheep. Results Histological differences in the longest dorsal muscle of the small-tailed frigid sheep increased in diameter and decreased in several muscle fibers with increasing monthly age;The intramuscular fat content of the longest dorsal muscle of the small-tailed cold sheep varied with age, with a minimum of 1 month of age, a maximum of 6 months of age, and a minimum of 12 months of age. Transcriptomic sequencing and bioinformatics analysis revealed a large number of differential genes in the longest dorsal muscles of little-tailed billy goats of different months of age, which were enriched in multiple GO entries and KEGG pathways. Among them, the pathway associated with intramuscular fat was the AMPK signaling pathway, and the related genes were PPARGC1A and ADIPOQ;Immunohistochemical studies showed that PPARGC1A and ADIPOQ proteins were expressed in connective tissues, cell membranes, and, to a lesser extent, the cytoplasm of the longest dorsal muscle of the little-tailed frigid sheep;Real-time PCR and Western Blot validation showed that PPARGC1A and ADIPOQ were both expressed in the longest dorsal muscle of the little-tailed frigid sheep at different ages, and there were age differences in the amount of expression. The ADIPOQ gene was negatively correlated with the intramuscular fat content of the longest dorsal muscle, and the PPARGC1A gene was positively correlated with the intramuscular fat content of the longest dorsal muscle;As inferred from the above

关键词： Small-tailed frigid sheep Longest dorsal muscle Intramuscular fat Growth and development Transcriptomics

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