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Estimated Pulse Wave Velocity as a Novel Non-Invasive Biomarker for Metabolic Syndrome Among People Living with HIV

DIABETES METABOLIC SYNDROME AND OBESITY 2024年 17卷 1999-2010页

作者： chen, Suling Jiang, Yuanhui Lin, Xiaoli chen, Hongjie Wu, Xiaoxuan Qian, Zhe Xu, xuwen Zhong, Huiqun Peng, Jie Cai, Shaohang Southern Med Univ Nanfang Hosp Dept Infect Dis Guangzhou 510515 Peoples R China Haizhu Dist Ctr Dis Control & Prevent Dept Communicable & Endem Dis Control & Prevent Guangzhou Peoples R China Guangdong Acad Med Sci Guangdong Prov Peoples Hosp Guangdong Prov Geriatr Inst Dept Elderly Resp 2 Guangzhou Peoples R China

Purpose: This study aims to investigate the relationship between estimated pulse wave velocity (ePWV) and metabolic syndrome (MetS) in people living with HIV (PLWH), proposing a novel and convenient predictor for early detection of MetS in PLWH. Patients and Methods: A total of 485 PLWH were enrolled. These participants were categorized into two groups based on the estimated pulse wave velocity (ePWV) level. Demographic and clinical data were collected to investigate the correlation between ePWV and MetS. Results: The cohort of 485 PLWH was categorized into high-ePWV and low-ePWV groups based on ePWV cutoff value of 10 m/s. We observed significant differences in components of MetS including triglycerides (TG, P < 0.05), HDL cholesterol (HDL-C, P < 0.01), systolic blood pressure (SBP, P < 0.001), diastolic blood pressure (DBP, P < 0.05), and fasting plasma glucose (FPG, P < 0.001) between the two groups. Furthermore, we employed receiver operating characteristic (ROC) curves to demonstrate the effectiveness of ePWV as a predictive indicator for MetS in PLWH (AUC = 0.739, P < 0.001). According to the ROC curve, the optimal cut-off value of ePWV was 7.4 m/s, and its sensitivity and specificity in diagnosing MetS in PLWH were 79.03% and 64.07%, respectively. Although the 7.4 m/s cutoff increased the false positive rate compared to the traditional cutoff, it significantly reduced the rate of missed diagnoses, effectively identifying 79.03% of PLWH with MetS. Conclusion: ePWV is a non-invasive and convenient novel biomarker with predictive capabilities for MetS in PLWH.

关键词： HIV/AIDS highly active antiretroviral therapy metabolic syndrome estimated pulse wave velocity

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Short-term photovoltaic power prediction based on VMD-SSA-LSTM

Short-term photovoltaic power prediction based on VMD-SSA-LS...

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2024 International Conference on Optoelectronic Information and Functional Materials, OIFM 2024

作者： Zhang, Tingyi Li, Shaowu chen, Jinbiao Liu, xuwen Guo, Weihao College of Intelligent Systems Science and Engineering Hubei Minzu University Enshi445000 China

ISBN: (纸本)9781510680517

Photovoltaic power prediction is crucial for maintaining the safe, stable operation, and economic benefits of the power grid. However, the long short-term memory (LSTM) neural network faces limitations in parameter selection, affecting its effectiveness in photovoltaic power prediction. Additionally, photovoltaic power data exhibits volatility and non-stationarity, leading to inaccurate predictions. To address these issues, this paper proposes a coupled model named VMD-SSA-LSTM, which combines variational mode decomposition (VMD), sparrow search algorithm (SSA), and LSTM. The model initially employs VMD to decompose photovoltaic power data, reducing the impact of volatility and non-stationarity on prediction results. Subsequently, SSA is used to optimize LSTM parameters. Finally, the predicted values from each sequence are summed to obtain the photovoltaic power prediction. Simulation experiments demonstrate the model's high adaptability in short-term photovoltaic power prediction. Compared to the LSTM model, the VMD-SSA-LSTM model exhibits superior performance in prediction accuracy, stability, and robustness. Therefore, this model provides an effective solution to enhance the accuracy of photovoltaic power prediction, contributing to the safety, stability, and economic efficiency of power grid operation. © 2024 SPIE.

关键词： Variational mode decomposition

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Detection of Network Time Covert Channels Based on Image Processing 23

Detection of Network Time Covert Channels Based on Image Pro...

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4th International Conference on Computing, Networks and Internet of Things, CNIOT 2023

作者： Huang, xuwen chen, Yonghong Li, Zhiqiang Zhan, Teng School of Computer Science and Technology Huaqiao University Xiamen Fujian China Xiamen Key Laboratory of Data Security and Blockchain Technology Huaqiao University Xiamen Fujian China

ISBN: (纸本)9798400700705

Network covert timing channels (NCTCs) utilize Inter-Packet Delay (IPD) encoding to hide data. It can be used for spreading malware and data leakage, posing severe threats to network security. With the increasing risk, the research on NCTC detection has become an important and urgent task. However, the detection methods based on IPD statistics are only effective for few types of channels and require large IPD sampling samples. The recent ML-based detection methods have multiple limitations due to their coarse-grained feature extraction method. In this paper, we propose a multi-channel image transformation method for extracting IPD features and select the lightweight network MobileVit for detection. We encode IPD one-dimensional time-series data into Gramian Angular Field (GAF), Markov Transition Field (MTF), and Recurrence plot (RP) images and stack them into dual-channel and three-channel images. After image transformation, we compare mainstream image classification networks and a self-built CNN. Experimental results show that our feature extraction image classification is more effective than the existing IPD extraction image transformation method. The MobileVit network shows better detection performance and accuracy, requiring fewer IPD sampling samples for detection windows. © 2023 ACM.

关键词： Sampling

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Photovoltaic MPPT control based on IJAYA algorithm

Photovoltaic MPPT control based on IJAYA algorithm

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2024 International Conference on Optoelectronic Information and Functional Materials, OIFM 2024

作者： Guo, Weihao Li, Shaowu Zhang, Tingyi chen, Jinbiao Liu, xuwen College Of Intelligent Systems Science and Engineering Hubei Minzu University Hubei Enshi445000 China

ISBN: (纸本)9781510680517

This paper introduces an MPPT control methodology utilizing the IJAVA algorithm. This approach merges the traditional JAVA algorithm with a Levy flight strategy, enabling the algorithm to evade local optima and conduct a comprehensive global search for the optimal solution., so that the algorithm can ensure the convergence speed and give attention to the convergence accuracy, further accelerate the tracking speed by optimizing the initialization position of the population, and reduce the voltage and power oscillation in the tracking process by adding out-of-bounds processing mechanism. Based on the modeling and simulation outcomes, the MPPT control utilizing the IJAVA algorithm demonstrates the capability to effectively and precisely trace the optimum power point in the presence of partial shading, as evidenced by the results. © 2024 SPIE.

关键词： Solar energy

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苦荞酸奶配方研制的研究

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中国乳业 2025年第4期 104-109页

作者：张鑫周静付帅王练陈旭雯西昌新希望三牧乳业有限公司四川西昌615000

[目的]以牛奶、白砂糖、苦荞米、菌种为主要原料,开发一款苦荞酸奶。[方法]通过单因素试验,研究苦荞米浸泡时间、苦荞米添加量、白砂糖添加量、菌种添加量、发酵时间对苦荞酸奶感官品质的影响,并通过正交试验优化苦荞酸奶最优配方。[结... 详细信息

[目的]以牛奶、白砂糖、苦荞米、菌种为主要原料,开发一款苦荞酸奶。[方法]通过单因素试验,研究苦荞米浸泡时间、苦荞米添加量、白砂糖添加量、菌种添加量、发酵时间对苦荞酸奶感官品质的影响,并通过正交试验优化苦荞酸奶最优配方。[结果]牛奶100 g,苦荞米浸泡时间20 min和蒸煮时间15 min,苦荞米添加量3 g,白砂糖添加量9.0 g,菌种添加量10 UC/T,发酵时间10 h,通过该最优方案制得苦荞酸奶的感官评价为90分。[结论]苦荞酸奶质地均匀,呈乳白色,酸甜适中,口感细腻、稍甜或稍酸,苦荞味和麦粒感较明显,符合大众对独特风味的需求,为消费者提供了更多选择,其市场发展潜力较大。

关键词：酸奶苦荞米配方研制正交试验

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质量基础设施"一站式"服务平台现状、关键技术及发展趋势研究

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中国科技纵横 2025年第2期 128-130页

作者：陈旭文魏春梅曹伟马琳朱明浙江省质量科学研究院浙江杭州 310018

质量基础设施(NQI)作为国家质量发展的基石,对于提升产品和服务质量、促进产业升级和经济发展具有重要意义.随着全球化和信息化的加速发展,企业和消费者对质量的要求越来越高,传统的质量服务模式已难以满足多样化需求.基于此,本文通过... 详细信息

质量基础设施(NQI)作为国家质量发展的基石,对于提升产品和服务质量、促进产业升级和经济发展具有重要意义.随着全球化和信息化的加速发展,企业和消费者对质量的要求越来越高,传统的质量服务模式已难以满足多样化需求.基于此,本文通过研究国内外质量基础设施"一站式"服务的现状,分析国内"一站式"服务平台发展存在的主要问题,揭示了平台关键技术及发展趋势,以期为相关工作提供有益参考和借鉴.

关键词：质量基础设施"一站式"服务现状关键技术发展趋势

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Thermally-activated upconversion based on triplet fusion for deep red photoactivation of Ru(ii) complexes

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NEW JOURNAL OF CHEMISTRY 2024年第15期48卷 6886-6892页

作者： Niu, Pengfei Da, xuwen Hu, Rui Yu, Tianjun chen, Jinping Zhou, Qianxiong Luo, Guiwen Zeng, Yi Li, Yi Tech Inst Phys & Chem Chinese Acad Sci Key Lab Photochem Convers & Optoelect Mat Beijing 100190 Peoples R China Inst Chem Chinese Acad Sci Key Lab Photochem Beijing 100190 Peoples R China Univ Chinese Acad Sci Beijing 100049 Peoples R China

Expanding the anti-Stokes shift in triplet-triplet annihilation upconversion (TTA-UC) systems and harvesting light within the biological transparency window (700-900 nm) are of great importance for their biomedical applications. In this study, we have developed a TTA-UC system that converts deep red-light into blue photons using a highly endothermic sensitization pair, wherein the triplet energy level of the sensitizer is 0.19 eV below that of the acceptor. The thermally activated triplet energy transfer compensates the energy loss during intersystem crossing (ISC) of the sensitizer, achieving a 0.82 eV anti-Stokes shift upconversion with over 6% quantum yield. This TTA-UC system activates a Ru(ii)-based photoactivated chemotherapeutic agent, causing DNA to bleach under 700 nm LED irradiation. These results demonstrate a feasible way to develop upconversion systems that operate within the biological transparency window, with potential applications in biological phototherapy.

关键词： Transparency

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Hemostatic Interventions and All-Cause Mortality in Hemodynamically Unstable Pelvic Fractures: A Systematic Review and Meta-Analysis

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EMERGENCY MEDICINE INTERNATIONAL 2024年第1期2024卷 6397444页

作者： Zheng, xuwen chen, Maobing Zhuang, Yi Xu, Jin Zhao, Liang Qian, Yongjun Shen, Wenming Chu, Ying Jiangsu Univ Wujin Peoples Hosp Truama Ctr Changzhou 213017 Peoples R China Xuzhou Med Univ Wujin Clin Coll Changzhou 213017 Peoples R China Jiangsu Univ Wujin Inst Mol Diagnost & Precis Canc Med Changzhou 213017 Peoples R China

Objective. To conduct a systematic review and meta-analysis of the all-cause mortality associated with the most commonly used hemostatic treatments in patients with hemodynamically unstable pelvic fractures. Methods. Up to April 30, 2023, we searched PubMed, Embase, Web of Science, and Cochrane, including the references to qualified papers. A meta-analysis was performed on studies that reported odds ratios (ORs) or the number of events needed to calculate them. The PROSPERO registration number was CRD42023421137. Results. Of the 3452 titles identified in our original search, 29 met our criteria. Extraperitoneal packing (EPP) (OR = 0.626 and 95% CI = 0.413-0.949), external fixation (EF) (OR = 0.649 and 95% CI = 0.518-0.814), and arterial embolism (AE) (OR = 0.459 and 95% CI = 0.291-0.724) were associated with decreased mortality. Resuscitative endovascular balloon occlusion of the aorta (REBOA) (OR = 2.824 and 95% CI = 1.594-5.005) was associated with increased mortality. A random effect model meta-analysis of eight articles showed no difference in mortality between patients with AE and patients with EPP for the initial treatments for controlling blood loss (OR = 0.910 and 95% CI = 0.623-1.328). Conclusion. This meta-analysis collectively suggested EF, AE, or EPP as life-saving procedures for patients with hemodynamically unstable pelvic fractures.

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Paeonol increases the antioxidant and anti-inflammatory capacity of gibel carp (Carassius auratus gibelio) challenged with Aeromonas hydrophila

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FISH & SHELLFISH IMMUNOLOGY 2022年第0期123卷 479-488页

作者： Gu, Yipeng chen, Kai Xi, Bingwen Xie, Jun Bing, xuwen Nanjing Agr Univ Wuxi Fisheries Coll Wuxi 214081 Peoples R China Chinese Acad Fishery Sci Freshwater Fisheries Res Ctr Key Lab Freshwater Fisheries & Germplasm Resources Minist Agr Wuxi 214081 Peoples R China

Paeonol, a naturally occurring polyphenol isolated from medical plant, has been known to exhibit anti-oxidative and anti-inflammatory effects. In order to evaluate the effect of paeonol on Carassius auratus gibelio infected by pathogenic bacteria Aeromonas hydriphila. 750 fish were randomly divided into 5 groups, which separately treated with 0.85% sterile saline (blank), A. hydriphila (negative control), A. hydriphila with paeonol (4 mg/kg, 64 mg/kg), and A. hydriphila with enrofloxacin (12 mg/kg, positive control). Fish were anaesthetized with MS -222 (100 mg/L), and samples were collected at 6 and 72 h after A. hydriphila challenge. The results showed that compared with the negative group, the survival in paeonol groups marked increased by 14.75% and 18.94%. The plasma immunoglobulin M (IgM) was notably increased, and low density lipoprotein (LDL) was significantly decreased in paeonol groups at 6 h (P < 0.05). The antioxidative enzymes catalase (CAT), total antioxidant capacity (T-AOC) and glutathione peroxidase (GSH-Px) were significantly increased in paeonol groups at 6 h, while malondialdehyde (MDA) and myeloperoxidase (MPO) contents were lower (P < 0.05). The inflammatory related genes MyD88 and TLR-5 were significantly downregulated, and the TLR-3 was significantly increased in paeonol groups at 72 h (P < 0.05). In addition, histopathological analyses showed that the lesion in liver, spleen and caudal kidney were considerably attenuated in paeonol groups. In conclusion, paeonol could increase the survival rate, mitigate oxidative damage, inflammation, tissue lesions, and improve the immunity of gibel carp challenged with A. hydrophila.

关键词： Carassius auratus gibelio Paeonol Immune response Antioxidant capacity Inflammation

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A Methionine Allocation Nanoregulator for the Suppression of Cancer Stem Cells and Support to the Immune Cells by Epigenetic Regulation

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ADVANCED SCIENCE 2025年第15期12卷 e2415207页

作者： Su, Boyu chen, Qinjun Li, xuwen Fang, Mingzhu Wang, Yu Song, Haolin You, Haoyu Zhou, Zheng Wu, Yuxing Zhao, Zhenhao chen, Yun Fan, Hongrui Li, Chufeng Jiang, chen Sun, Tao Fudan Univ State Key Lab Med Neurobiol Sch Pharm Dept PharmaceutKey Lab Smart Drug DeliveryMinist Shanghai 201203 Peoples R China MOE Frontiers Ctr Brain Sci Shanghai 201203 Peoples R China Fujian Med Univ Affiliated Hosp 1 Natl Reg Med Ctr Dept Digest Dis Binhai Campus Fuzhou 350212 Peoples R China Quzhou Fudan Inst Quzhou 324003 Peoples R China

Epigenetic dysregulation is prevalent in human cancers, affecting gene expression and metabolic patterns to meet the demands of malignant evolution and abnormal epigenetic processes, and resulting in a protumor immune microenvironment. Tumors require a steady supply of methionine for maintaining epigenetic flexibility, which is the only exogenous precursor of methyl donor S-adenosylmethionine for methylation, crucial for their resistance to therapies and survival in a nutrient-deficient microenvironment. Thus, tumor cells upregulate the Lat4 transporter to compete and deprive methionine in the microenvironment, sustaining their malignant phenotypes and also impairing immune cell functions. Addressing this methionine addiction is the key to overcoming drug resistance and improving immune response. Despite the challenge of lacking specific Lat4 inhibitors, an oxaliplatin prodrug crosslinked fluorinated polycation/anti-Lat4 small interfering RNA complex nanoregulator (AS-F-NP) has been designed and developed here. This nanoregulator restricted the greedy methionine uptake of tumor cells by knocking down Lat4, which in turn inhibited the malignant evolution of the tumor while restoring the viability and function of tumor-infiltrating immune cells.

关键词： cancer therapy epigenetic immune methionine oxaliplatin siRNA

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