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Seabed erosion and deposition formulas applied to a 2D hydrodynamic harbor engineering simulation

ARABIAN JOURNAL OF GEOSCIENCES 2022年第6期15卷 1-19页

作者： Li, Yuting Fang, xuwen Li, Ruijie Song, Zhiyao Peng, Guoqiang chen, Peng Nanjing Normal Univ Key Lab Virtual Geog Environm Minist Educ PRC Nanjing 210023 Peoples R China Nanjing Normal Univ State Key Lab Cultivat Base Geog Environm Evolut Nanjing 210023 Peoples R China Nanjing Normal Univ Jiangsu Ctr Collaborat Innovat Geog Informat Reso Nanjing 210023 Peoples R China Xiamen Univ Coll Ocean & Earth Sci Xiamen 361102 Peoples R China Hohai Univ Key Lab Coastal Disaster & Def Minist Educ Nanjing 210098 Peoples R China Hohai Univ Coll Oceanog Nanjing 210098 Peoples R China Hohai Univ Coll Harbour Coastal & Offshore Engn Nanjing 210098 Peoples R China Shaanxi Normal Univ Sch Geog & Tourism Xian 710062 Peoples R China

In coastal engineering, predicting seabed erosion and deposition can help understand hydrodynamic changes of the coastal area. The present work aims to address the prevalent challenge that there is often a shortage of measured data in coastal areas. In this paper, a new seabed erosion and deposition formula with four forms is proposed and combined with 2D hydrodynamic harbor engineering simulation of Daishan Island situated in Zhejiang province, China. The simulation shows that (1) in the open channel, the proposed new formula considers the friction coefficient before and after trenching, thus providing a more accurate prediction result;(2) in the sheltered channels, the proposed new formula can roughly estimate the deposition intensity;(3) in the basin entrance, the proposed new formula provides an estimation better aligned with reality than existing formulae. Meanwhile, the recovery saturation coefficient is not a constant;it can be set at 0.31 in the obtained formulas for calculations during the back silting, and at 0.11 during scouring. Therefore, the proposed new formula provides an improved solution to prediction of seabed erosion and deposition and is applicable to Daishan coastal area in different situations.

关键词： Tidal current and sediment Channel deposition Seabed erosion and deposition Erosion and deposition formula

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Targeting toll-like receptor 7 as a therapeutic development strategy for systemic lupus erythematosus

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Acta Pharmaceutica Sinica B 2024年第11期14卷 4899-4913页

作者： Meng Wang Hekai chen Tuan Zhang Zhikuan Zhang xuwen Xiang Meng Gao Yilan Guo Shuangshuang Jiang Kejun Yin Mintao chen Jian Huang Xincheng Zhong Umeharu Ohto Jing Li Toshiyuki Shimizu Hang Yin State Key Laboratory of Membrane Biology School of Pharmaceutical SciencesTsinghua-Peking Center for Life SciencesKey Laboratory of Bioorganic Phosphorous Chemistry and Chemical Biology(Ministry of Education)Tsinghua UniversityBeijing 100084China Graduate School of Pharmaceutical Sciences the University of TokyoTokyo 113-0033Japan Department of Rheumatology and Clinical Immunology Peking Union Medical College HospitalChinese Academy of Medical SciencesPeking Union Medical CollegeBeijing 100032China Toll Biotech Co. Ltd.(Beijing)Beijing 102209China

Endosomal TLRs(TLR3/7/8/9)are highly analogous innate immunity sensors for various viral or bacterial RNA/DNA molecular *** them,TLR7,in particular,has been suggested to be a target for various inflammatory disorders and autoimmune diseases including systemic lupus erythematosus(SLE);but few small-molecule inhibitors with elaborated mechanism have been reported in ***,we reported a well-characterized human TLR7-specific small-molecule inhibitor,TH-407b,with promising potency and negligible cytotoxicity through a novel binding ***,TH-407b not only effectively inhibited TLR7-mediated pro-inflammatory signaling in a variety of cultured cell lines but also demonstrated potent inflammation suppressing activities in primary peripheral blood mononuclear cells(PBMCs)derived from SLE ***,TH-407b showed prominent efficacy in vivo,improved survival rate and ameliorated symptoms of SLE model *** obtain molecular insights into the TH-407b derivatives’inhibition mechanism,we performed the structural analysis of TLR7/TH-407b complex using cryogenic electron microscopy(cryo-EM)*** an atomistic resolution cryo-EM structure of the TLR family,it not only of value to facilitate structure-based drug design,but also shed light to methodology development of small proteins using ***,TH-407b has unveiled an inhibition strategy for TLR7 via stabilizing its resting/inactivated *** a resting state could be generally applicable to all TLRs,rendering a useful method for targeting this group of important immunological receptors.

关键词： TLR7 Small-moleculeinhibitor Atomisticresolutioncryo-EM structure Resting state Systemiclupus erythematosus MRL

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新型城镇化背景下我国失地农民培训与就业机制研究

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北京联合大学学报（人文社会科学版） 2023年第3期21卷 116-124页

作者：丛旭文陈立行长春大学行政学院吉林长春130000 日本关西学院大学社会学研究科日本

“十四五”时期,我国仍处在新型城镇化高速发展期,推进新型城镇化的首要任务是促进失地农民的稳定就业,失地农民的就业培训及就业质量问题有待进一步解决。本文是在针对新型城镇化背景下失地农民培训与就业问题实证分析基础上,从多主体... 详细信息

“十四五”时期,我国仍处在新型城镇化高速发展期,推进新型城镇化的首要任务是促进失地农民的稳定就业,失地农民的就业培训及就业质量问题有待进一步解决。本文是在针对新型城镇化背景下失地农民培训与就业问题实证分析基础上,从多主体协同提升失地农民培训质量、加强失地农民培训意愿和需求分析、建立线上线下融合培训模式、完善失地农民就业培训监督机制、拓展失地农民就业公共服务渠道、构建失地农民新就业形态劳动者权益保障等方面,提出新型城镇化背景下失地农民培训与就业的对策建议,提升失地农民的培训质量、保障失地农民的就业质量。

关键词：新型城镇化失地农民培训与就业农民就业

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Decreased intestinal abundance of Akkermansia muciniphila is associated with metabolic disorders among people living with HIV

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ANNALS OF MEDICINE 2025年第1期57卷 2474730页

作者： Qian, Zhe chen, Suling Liao, Xiaoyang Xie, Jingfang Xu, Yuyuan Zhong, Huiqun Ou, Lang Zuo, Xiang Xu, xuwen Peng, Jie Wu, Jian Cai, Shaohang Southern Med Univ Guangdong Prov Peoples Hosp Guangdong Acad Med Sci Guangdong Prov Geriatr InstDept Elderly Resp 2 Guangzhou 510030 Peoples R China Southern Med Univ Nanfang Hosp Dept Infect Dis Guangzhou 510515 Peoples R China Southern Med Univ Guangdong Prov Peoples Hosp Guangdong Acad Med Sci Guangdong Prov Geriatr InstDept Geriatr Guangzhou Peoples R China Univ South China Affiliated Nanhua Hosp Dept Hepatobiliary Surg Hengyang Peoples R China Southern Med Univ Nanfang Hosp Dept Gen Surg Div Hepatobiliopancreat Surg Guangzhou Peoples R China South China Univ Technol Sch Med Guangzhou Peoples R China

BackgroundPrevious studies have shown changes in gut microbiota after human immunodeficiency virus (HIV) infection, but there is limited research linking the gut microbiota of people living with HIV (PLWHIV) to metabolic *** total of 103 PLWHIV were followed for 48 weeks of anti-retroviral therapy (ART), with demographic and clinical data collected. Gut microbiome analysis was conducted using metagenomic sequencing of fecal samples from 12 individuals. Nonalcoholic fatty liver disease (NAFLD) was diagnosed based on controlled attenuation parameter (CAP) values of 238 dB/m from liver fibro-scans. Participants were divided based on the presence of metabolic disorders, including NAFLD, overweight, and hyperlipidemia. Akkermansia abundance in stool samples was measured using RT-qPCR, and Pearson correlation and logistic regression were applied for *** sequencing revealed a significant decline in gut Akkermansia abundance in PLWHIV with NAFLD. STAMP analysis of public datasets confirmed this decline after HIV infection, while KEGG pathway analysis identified enrichment of metabolism-related genes. A prospective cohort study with 103 PLWHIV followed for 48 weeks validated these findings. Akkermansia abundance was significantly lower in participants with NAFLD, overweight, and hyperlipidemia at baseline, and it emerged as an independent predictor of NAFLD and overweight. Negative correlations were observed between Akkermansia abundance and both CAP values and body mass index (BMI) at baseline and at week 48. At the 48-week follow-up, Akkermansia remained a predictive marker for *** abundance was reduced in PLWHIV with metabolic disorders and served as a predictive biomarker for NAFLD progression over 48 weeks of ART.

关键词： HIV gut microbiota metabolic diseases NAFLD overweight Akkermansia muciniphila

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恩替卡韦联合贞芪扶正颗粒治疗HBeAg阳性慢性乙型肝炎的临床研究

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昆明理工大学学报（自然科学版） 2019年第2期44卷 81-85页

作者：巨煜华李发旺陈旭文白银市第一人民医院消化科甘肃白银730900 白银市第一人民医院中医科甘肃白银730900

观察恩替卡韦联合贞芪扶正颗粒治疗HBeAg阳性慢性乙型肝炎的疗效.将120例HBeAg阳性慢性乙型肝炎患者随机分为恩替卡韦组和恩替卡韦联合贞芪扶正颗粒组,恩替卡韦组58例,口服恩替卡韦0.5 mg/d,联合治疗组62例,给予恩替卡韦(0.5 mg/d)联合... 详细信息

观察恩替卡韦联合贞芪扶正颗粒治疗HBeAg阳性慢性乙型肝炎的疗效.将120例HBeAg阳性慢性乙型肝炎患者随机分为恩替卡韦组和恩替卡韦联合贞芪扶正颗粒组,恩替卡韦组58例,口服恩替卡韦0.5 mg/d,联合治疗组62例,给予恩替卡韦(0.5 mg/d)联合贞芪扶正颗粒(5g/次,BID),两组疗程均为48周.使用流式细胞仪检测外周血T淋巴细胞亚群的变化.在治疗24周时,联合治疗组的HBeAg的阴转率和HBeAg/HBeAb的血清转换率均显著高于对照组(P<0.01).在治疗24、48周时,两组HBVDNA阴转率、丙氨酸氨基转移酶复常率比较差异无统计学意义(P>0.05).48周时,两组HBeAg的阴转率和HBeAg/HBeAb的血清转换率比较差异有统计学意义(P<0.05).治疗前治疗组和对照组患者CD4^+、CD8^+T淋巴细胞和CD4^+/CD8^+比值比较,差异均无统计学意义,治疗结束后两组比较,差异有统计学意义(P<0.05).恩替卡韦联合贞芪扶正颗粒治疗HBeAg阳性慢性乙型肝炎,能够显著提高HBeAg的阴转率和HBeAg/HBeAb的血清转换率,明显提高T淋巴细胞亚群、改善患者免疫状态.

关键词： HBeAg阳性慢性乙型肝炎恩替卡韦贞芪扶正颗粒联合治疗 T淋巴细胞亚群

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Engineered Bacterial Outer Membrane Vesicles-Based Doxorubicin and CD47-siRNA Co-Delivery Nanoplatform Overcomes Immune Resistance to Potentiate the Immunotherapy of Glioblastoma

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ADVANCED MATERIALS 2025年第15期37卷 e2418053页

作者： You, Haoyu Zhang, Shilin Zhang, Yiwen chen, Qinjun Wu, Yuxing Zhou, Zheng Zhao, Zhenhao Su, Boyu Li, xuwen Guo, Yun chen, Yun Tang, Weiyi Liu, Bing Fan, Hongrui Geng, Shuo Fang, Mingzhu Li, Fangxin Liu, Guangna Jiang, chen Sun, Tao Fudan Univ Sch Pharm State Key Lab Med Neurobiol Minhang HospInnovat Ctr New Drug Dev Immune Infla Shanghai 201203 Peoples R China Fudan Univ MOE Frontiers Ctr Brain Sci Sch Pharm Dept Pharmaceut Shanghai 201203 Peoples R China Fujian Med Univ Affiliated Hosp 1 Natl Reg Med Ctr Dept Orthoped Binhai Campus Fuzhou 350212 Peoples R China Quzhou Fudan Inst Quzhou 324003 Peoples R China

Apart from the blood-brain barrier (BBB), the efficacy of immunotherapy for glioblastoma (GBM) is limited by the presence of intrinsic and adaptive immune resistance, implying that co-delivery of various immunotherapeutic agents or simultaneous regulation of different cells is urgently needed. Bacterial outer membrane vesicles (OMVs) offer a unique advantage in the treatment of GBM, owing to their multifunctional properties as carriers and immune adjuvants and their ability to cross the BBB. However, traditional OMVs can lead to toxic side effects and disruption of tight junctions in the BBB. Therefore, to enhance the in vivo safety and targeting capability of OMVs, we introduced engineered OMVs to reduce toxicity and further constructed a modularly assembled nanoplatform by performing simple peptide modifications. This nanoplatform demonstrates satisfactory biosafety and is able to continuously cross the BBB and target GBM with the assistance of Angiopep-2. Subsequently, immunogenic substances on OMVs, along with carried small-interfering RNA (siRNA) and doxorubicin, can promote and enhance the reprogramming and phagocytic abilities of macrophages and microglia, respectively, and increase the immunogenicity of GBM, ultimately overcoming GBM immune resistance to enhance the efficacy of immunotherapy. This OMVs-based nanoplatform provides a new paradigm and insights into the development of immunotherapy for GBM.

关键词： engineering technology glioblastoma immune resistance immunotherapy outer membrane vesicles

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A Study on Genotype-by-Environment Interaction Analysis for Agronomic Traits of Maize Genotypes Across Huang-Huai-Hai Region in China

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Phyton-International Journal of Experimental Botany 2022年第1期91卷 57-81页

作者： Haiwang Yue Jianwei Wei Junliang Xie Shuping chen Haicheng Peng Hongmei Cao Junzhou Bu xuwen Jiang Dryland Farming Institute Hebei Academy of Agriculture and Forestry SciencesHebei Provincial Key Laboratory of Crops Drought Resistance ResearchHengshui053000China Soil and Fertilizer Workstation of Hengshui Agriculture and Rural Bureau Hengshui053000China Maize Research Institute/College of Agronomy Qingdao Agricultural UniversityQingdao266109China

Facing the trend of increasing population,how to increase maize grain yield is a very important issue to ensure food *** this study,28 nationally approved maize hybrids were evaluated across 24 different climatic conditions for two consecutive years(2018-2019).The purpose of this study was to select high-yield with stable genotypes and identify important agronomic traits for maize breeding program *** results of this study showed that the genotypeenvironment interaction effects of the 12 evaluated agronomic traits was highly significant(P<0.001).We introduced a novel multi-trait genotype-ideotype distance index(MGIDI)to select genotypes based on multiple agronomic *** selection process exhibited by this method is unique and easy to understand,so the MGIDI index will have more and more important applications in future multi-environment trials(METs)*** genotypes selected by the MGIDI index were G22,G10,G12 and G1 as the high yielding and stable *** parents of these selected genotypes have the ability to play a greater role as the basic germplasm in the breeding process.A new form of genotype(G)main effects and genotype(G)-by-environment(E)interaction(GGE)technician,genotypeyieldtrait(GYT)biplot,based on multiple traits for genotypes selection was also applied in this *** GYT biplot ranked genotypes by combining grain yield with other evaluated agronomic traits,and displayed the distribution of their traits,namely strengths and weaknesses.

关键词： GEI MGIDI GYT biplot AMMI model GGE

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Optimal Clearing Model of Centralized Market Considering Path Constraints 1

Optimal Clearing Model of Centralized Market Considering Pat...

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International Symposium on Energy Environment and Green Development (EEGD)

作者： Zheng, Zhao chen, Kening Jiang, Yu Liu, xuwen State Grid Energy Res Inst Beijing Peoples R China State Grid JiangSu Elect Power Co Ltd Nanjing Jiangsu Peoples R China

China's electricity market is now still in the mode of "Unified market and two-tier operation" including provincial and inter-provincial market. The inter-provincial market is divided into the medium and long-term market and spot market. This study takes the inter provincial spot market as the research object, and proposes a unified optimization clearing algorithm for inter provincial spot market considering path constraints. The proposed method is able to handle AC-DC hybrid electricity network, and sort and determine the trading pairs using power flow tracing algorithm. The power market software PLEXOS and practical market data are used to simulate the proposed model, and the results show the accuracy and effectiveness.

关键词： Power markets

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Feasibility analysis of 3D printed concrete with sludge incineration slag: Mechanical properties and environmental impacts

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CONSTRUCTION AND BUILDING MATERIALS 2024年 449卷

作者： Shen, Kaige Ding, Tao Cai, chen Xiao, Jianzhuang Xiao, xuwen Liang, Wan Tongji Univ Coll Civil Engn Dept Struct Engn Shanghai 200092 Peoples R China Tongji Univ Coll Environm Sci & Engn Shanghai 200092 Peoples R China Tongji Univ Inst Carbon Neutral Shanghai 200092 Peoples R China Shanghai Guohui Environm Protect Technol Grp Co Lt Shanghai 201702 Peoples R China

This study substituted sludge incineration slag for natural sand in the application of 3D printed concrete technology (3DCP). It analyzed the influence of the sludge incineration slag incorporation on the workability, printability, mechanical properties, and the solidifying effect of heavy metals in 3DCP. Furthermore, the environmental and economic benefits were also examined. The results indicated that the incorporation of sludge incineration slag accelerated the loss of workability factors such as flowability and consistency in 3DCP. However, it significantly enhanced the early strength of 3DCP and improved its buildability. Additionally, the addition of sludge incineration slag diminished the mechanical properties of 3DCP. When the substitution rate reached 50 % of natural sand with sludge incineration slag, the strength of the 3D printed specimens decreased by 22.1 %. Experimental investigations at a micro-scale indicated that the porosity of interlayer interfaces was a crucial factor causing strength reduction and could be ameliorated by appropriately increasing the extrusion amount to address excessive pore sizes. Toxicity leaching tests for heavy metals demonstrated that the maximum heavy metal leaching concentration in 3DCP specimens with sludge incineration slag incorporation was 0.14 mg/ L, meeting the specified requirements. The 3DCP with sludge incineration slag incorporation not only addressed the difficulty in handling incineration bottom slag but also conserved natural sand resources, presenting outstanding environmental and economic benefits. For instance, by substituting 100 % natural sand with sludge incineration slag, there were 5 % reduction in carbon emissions and 30 % increase in economic benefits.

关键词： 3D-printed concrete Sludge incineration slag Printability Mechanical properties Environmental benefits

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3D printed concrete with sewage sludge ash: Fresh and hardened properties

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CEMENT & CONCRETE COMPOSITES 2024年 148卷

作者： Ding, Tao Shen, Kaige Cai, chen Xiao, Jianzhuang Xiao, xuwen Liang, Wan Tongji Univ Coll Civil Engn Dept Struct Engn Shanghai 200092 Peoples R China Tongji Univ Coll Environm Sci & Engn Shanghai 200092 Peoples R China Tongji Univ Inst Carbon Neutral Shanghai 200092 Peoples R China Shanghai Guohui Environm Protect Technol Grp Co Lt Shanghai 201702 Peoples R China

In this study, the possibility of application of sewage sludge ash (SSA) in 3D printed concrete (3DCP) technology was explored. The replacement of partial cement with SSA in the concrete mix design was investigated, followed by a comprehensive analysis of its impact on the workability, printability, and mechanical properties of the 3DCP. The findings indicated that the incorporation of SSA accelerated the loss of workability of 3DCP, such as fluidity and consistency. However, it significantly improved the green strength and buildability. Further investigation revealed that the addition of SSA hampered the hydration process of cement, resulting in a reduction in the mechanical properties of the hardened material. CT scanning indicated that the addition of SSA increased the interlayer porosity, leading to further degradation of the mechanical properties. The toxicity characteristic leaching procedure demonstrated that the maximum leaching concentration of 3DCP incorporating SSA was 0.14 mg/L. This result confirmed the effective immobilization of heavy metals, fulfilling the prerequisites for the application of 3DCP incorporating SSA.

关键词： 3D printed concrete Sewage sludge ash Workability Printability Mechanical properties

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