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Effects of inulins with various molecular weights and added concentrations on the structural properties and thermal stability of heat-induced gliadin and glutenin gels

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LWT-FOOD SCIENCE AND TECHNOLOGY 2021年 149卷 111891-111891页

作者： Guo, Zehang Liu, Min Xiang, xuwen Wang, Zhirong Yang, Bing chen, Xuhui chen, Guangjing Kan, Jianquan Southwest Univ Coll Food Sci 2 Tiansheng Rd Chongqing 400715 Peoples R China Chinese Hungarian Cooperat Res Ctr Food Sci Chongqing 400715 Peoples R China Minist Agr & Rural Affairs Peoples Republ China Lab Qual & Safety Risk Assessment Agriprod Storag Chongqing 400715 Peoples R China Agr Univ Hebei Coll Food Sci & Technol Baoding 071001 Hebei Peoples R China Guiyang Univ Coll Food Guiyang 550005 Guizhou Peoples R China Guiyang Univ Pharmaceut Engn Inst Guiyang 550005 Guizhou Peoples R China

This study investigated the influence of inulins with different molecular weights (Mw) and added concentrations on the structure and thermal stability of gliadin and glutenin gels. All inulins reduced hydrophobicity index (H0) and hindered disulfide bond (S-S) formation of both glutenin and gliadin. The H0 of glutenin reduced by 72.6%, 64.8% and 77.1% after the addition of 400 g/kg low, middle and high molecular weight inulins (L-, M-, and Hinulin, respectively), whereas the H0 of gliadin decreased by 11.7%, 31.9% and 48.6%. Furthermore, inulin increased random coils and decreased alpha-helix and beta-sheet prevalence for gliadin, while it increased alpha-helix and beta-turn prevalence and decreased beta-sheets and random coils for glutenin. Inulin also triggered S-S configuration of these two proteins to vary from g-g-g to t-g-g or t-g-t. H-inulin deepened gel electrophoresis bands of the 30-35 kDa gliadin molecules, and all inulins reduced band strength for the 30-35 kDa glutenin subunits. Inulin limited interactions between glutenin/gliadin and water, resulting in more fragile and open network structure. Moreover, the thermal stability of heat-induced inulin-gliadin gel was higher than that of inulin-glutenin gel. The impact of inulin on glutenin was stronger than on gliadin, and the effect was Mw-dependent (H-inulin > Minulin > L-inulin).

关键词： Dietary fiber Heat-induced gel Gluten components Structure Thermal property

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Function-oriented synthesis of Imidazo[1,2-a]pyrazine and Imidazo[1,2-b] pyridazine derivatives as potent PI3K/mTOR dual inhibitors

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EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY 2023年第1期247卷 115030页

作者： Li, Chuchu Han, Yuqiao Wang, Zhengyang Yu, Yanan Wang, chen Ren, Ziwei Guo, Yanzhi Zhu, Tong Li, xuwen Dong, Suzhen Ma, Mingliang East China Normal Univ Shanghai Engn Res Ctr Mol Therapeut & New Drug Dev Sch Chem & Mol Engn Shanghai 200062 Peoples R China Shanghai Inst Mat Med Chinese Acad Sci State Key Lab Drug Res 555 Zu Chong Zhi RdZhangjiang Hitech Pk Shanghai 201203 Peoples R China Shanghai Univ Engn Sci Sch Math Phys & Stat Shanghai 201620 Peoples R China Bohai Rim Adv Res Inst Drug Discovery Shandong Lab Yantai Drug Discovery Yantai 264117 Peoples R China East China Normal Univ Key Lab Brain Funct Genom Minist Educ Shanghai 200062 Peoples R China

The PI3K-Akt-mTOR signaling pathway is a highly frequently activated signal transduction pathway in human malignancies, which has been a hot target for anti-tumoral drug discovery. Based on our previous research, a function-oriented synthesis (FOS) of imidazo[1,2-a]pyrazines and imidazo[1,2-b]pyridazines was conducted, and their anticancer activities in vitro and in vivo were evaluated. Among them, compound 42 exhibited excellent dual PI3K/mTOR inhibitory activity, with IC50 values on PI3K alpha and mTOR of 0.06 nM and 3.12 nM, respectively, much better than our previous reported compound 15a. Furthermore, compound 42 exhibited significant in vitro and in vivo anti-tumoral activities, great kinase selectivity, low hepatotoxicity, modest plasma clearance and acceptable oral bioavailability, which is a promising PI3K/mTOR targeted anti-cancer drug candidate.

关键词： PI3K mTOR dual inhibitors Cancer Antitumor activity Hepatotoxicity

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“哨兵-2”卫星影像及C2RCC算法在太湖冬春季水色分析中的应用

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中国环境监测 2024年第3期40卷 271-282页

作者：李旭文张悦姜晟王甜甜崔嘉宇纪轩禹陈冰魏玉强陈栋江苏省环境监测中心江苏省太湖水质监测中心站江苏南京210019 南京信息工程大学遥感与测绘工程学院江苏南京210044

利用太湖2019—2022年冬春季“哨兵-2”卫星10 m分辨率的MSI影像和SNAP软件C2RCC(Case 2 Regional CoastColour)模块,以适合浑浊、富营养程度较高、光学复杂的“二类水体”的C2X-nets为模式,开展太湖叶绿素a、总悬浮物浓度、透明度等水... 详细信息

利用太湖2019—2022年冬春季“哨兵-2”卫星10 m分辨率的MSI影像和SNAP软件C2RCC(Case 2 Regional CoastColour)模块,以适合浑浊、富营养程度较高、光学复杂的“二类水体”的C2X-nets为模式,开展太湖叶绿素a、总悬浮物浓度、透明度等水色参数反演。结果表明:冬春季太湖各湖区叶绿素a浓度处于较低水平,但4月中旬起有明显抬升;太湖西部沿岸区、南部沿岸区和湖心区总悬浮物浓度较高,表明这些湖区易受风浪影响,造成沉积物再悬浮;太湖东部沿岸区、北部湖湾及东太湖遥感反演的水体清澈度较高,可能与这些湖区冬春季沉水植物菹草的分布有关,菹草生长对水质有较好的净化效果。总体来看,基于C2X-nets模式的C2RCC反演算法从较高分辨率卫星遥感影像中提取的水色信息,能有效反映太湖冬春季水色指标的空间分布特征,可为湖体生态状况及动态变化的长期监测评估提供有价值的参考。

关键词：哨兵-2 遥感 C2RCC算法水色反演太湖

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Recent advances in designing conductive hydrogels for flexible electronics

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InfoMat 2020年第5期2卷 843-865页

作者： Qiongyao Peng Jingsi chen Tao Wang xuwen Peng Jifang Liu Xiaogang Wang Jianmei Wang Hongbo Zeng Department of Chemical and Materials Engineering University of AlbertaEdmontonAlbertaCanada The Fifth Affiliated Hospital Guangzhou Medical UniversityGuangzhouGuangdongChina Heavy Machinery Engineering Research Center of Education Ministry Taiyuan University of Science and TechnologyTaiyuanChina

Flexible electronics have emerged as an exciting research area in recent years,serving as ideal interfaces bridging biological systems and conventional electronic *** electronics can not only collect physiological signals for human health monitoring but also enrich our daily life with multifunctional smart materials and *** hydrogels(CHs)have become promising candidates for the fabrication of flexible electronics owing to their biocompatibility,adjustable mechanical flexibility,good conductivity,and multiple stimuli-responsive *** achieve on-demand mechanical properties such as stretchability,compressibility,and elasticity,the rational design of polymer networks via modulating chemical and physical intermolecular interactions is ***,the type of conductive components(eg,electron-conductive materials,ions)and the incorporation method also play an important role in the conductivity of ***-CHs usually possess excellent conductivity,while ion-CHs are generally transparent and can generate ion gradients within the hydrogel *** mini review focuses on the recent advances in the design of CHs,introducing various design strategies for electron-CHs and ion-CHs employed in flexible electronics and highlighting their versatile applications such as biosensors,batteries,supercapacitors,nanogenerators,actuators,touch panels,and displays.

关键词： biosensor composite hydrogel conductive hydrogel flexible electronics supercapacitor

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基于3种时间序列模型的九龙江河流库区藻华预测

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环境科学学报 2022年第11期42卷 172-183页

作者：任树顺高萌王煦雯余镒琦陈纪新陈能汪厦门大学环境与生态学院福建省海陆界面生态环境重点实验室厦门361102 厦门大学近海海洋环境科学国家重点实验室厦门361102 罗德岛大学海洋学研究生院纳拉甘西特美国罗德岛028824 中国海洋大学环境科学与工程学院青岛266100

湖库富营养化和有害藻华是全球性生态环境问题,藻华预测与早期预警是保障湖库水源地供水安全的关键技术.如何基于高频水生态在线监测数据进行藻华的实时动态预测成为水生态管理领域的重大需求.本研究以福建省九龙江江东库区(水源地)为例... 详细信息

湖库富营养化和有害藻华是全球性生态环境问题,藻华预测与早期预警是保障湖库水源地供水安全的关键技术.如何基于高频水生态在线监测数据进行藻华的实时动态预测成为水生态管理领域的重大需求.本研究以福建省九龙江江东库区(水源地)为例,利用3年连续观测的逐时平均总叶绿素a浓度数据,对比研究了SARIMA、Prophet和LSTM(长短期记忆神经网络)3种时间序列模型在藻华(日平均叶绿素a大于15μg·L^(-1))预测方面的效果.结果表明:(1)时间序列模型要求参数少,灵活性强,能清晰反映水质特征和未来变化趋势,可弥补传统藻类监测预警方法的局限性;(2)基于深度学习框架的LSTM模型,具有独特的迭代优化算法,对藻类非线性变化特征的识别和预测能力较强,其总叶绿素a逐日预测和7日预测效果均显著优于SARIMA模型和Prophet模型;(3)输入数据长度会在一定程度上影响模型预测效果,最优的输入数据时间长度为7 d;输入数据频率对预测效果也有影响,在预测非藻华日时,小时数据的预测效果优于日频率数据;在预测藻华日时,两种频率数据无显著差异,但日频率数据能更准确识别藻华日特征.总结起来,基于LSTM模型实现总叶绿素a浓度的短期预测,可为九龙江河流库区藻华早期预警和供水安全保障提供技术支撑.

关键词：藻华预测模型人工神经网络高频监测叶绿素a 九龙江

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Prediction of hypertensive disorders in pregnancy based on placental growth factor

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TECHNOLOGY AND HEALTH CARE 2021年第1_suppl期29卷 S165-S170页

作者： Xu, Qi Sun, Ge Zhang, Song Liu, Guoli Yang, Lin Meng, Yu chen, Aiqing Yang, Yimin Li, xuwen Hao, Dongmei Liu, Xiaohong Shao, Jing Peking Univ Peoples Hosp Beijing 100044 Peoples R China Beijing Univ Technol Fac Environm & Life Sci Beijing 100124 Peoples R China Beijing Int Sci & Technol Cooperat Base Intellige Beijing 100124 Peoples R China Beijing Yes Med Devices Co Ltd Beijing 100152 Peoples R China

BACKGROUND: The prediction of hypertensive disorders in pregnancy (HDP) mainly involves various aspects such as maternal characteristics and biomarkers. OBJECTIVE: We aimed to study the effect of the HDP prediction model with or without placental growth factor (PlGF). METHODS: This study used maternal factors and PlGF, and standardized the data uniformly. At 12-20 weeks, the comprehensive comparison of model quality with or without PlGF was conducted by logistic regression. RESULTS: The area under curve and the model accuracy of the model with PlGF were higher than those of the model without PlGF. The accuracy of the model with PlGF was above 90%. CONCLUSIONS: Adding PlGF to the model for predicting HDP improved the accuracy and effectiveness of the model. This study confirmed the predictive performance of PlGF.

关键词： Model accuracy placental growth factor logistic regression

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Association between structural brain features and gene expression by weighted gene co-expression network analysis in conversion from MCI to AD

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BEHAVIOURAL BRAIN RESEARCH 2021年第0期410卷 113330-113330页

作者： Wang, xuwen Huang, Kexin Yang, Fan chen, Dihun Cai, Suping Huang, Liyu Xidian Univ Sch Life Sci & Technol Xian 710071 Shaanxi Peoples R China

Alzheimer's disease (AD) is a neurodegenerative disease. Mild cognitive impairment (MCI) represents a state of cognitive function between normal cognition and dementia. Longitudinal studies showed that some MCI patients remained in a state of MCI, and some developed AD. The reason for these different conversions from MCI remains to be investigated. 180 MCI participants were followed for eight years. 143 MCI patients maintained the MCI state (MCI_S), and the remaining thirty-seven MCI patients were re-evaluated as having AD (MCI_AD). We obtained 1,036 structural brain characteristics and 15,481 gene expression values from the 180 MCI participants and applied weighted gene co-expression network analysis (WGCNA) to explore the relationship between structural brain features and gene expression. Regulating mediator effect analysis was employed to explore the relationships among gene expression, brain region measurements and clinical phenotypes. We found that 60 genes from the MCI_S group and 18 genes from the MCI_AD group respectively had the most significant correlations with left paracentral lobule and sulcus (***) and right subparietal sulcus (***) thickness;CTCF, UQCR11 and WDR5B were the mutual genes between the two groups. The expression of CTCF gene and clinical score are completely mediated by *** thickness, and the UQCR11 and WDR5B gene expression levels significantly regulate the mediating effect pathway. In conclusion, the factors affecting the different conversions from MCI are closely related to *** thickness and the CTCF, UQCR11 and WDR5B gene expression levels. Our results add a theoretical foundation of imaging genetics for conversion from MCI to AD.

关键词： Weighted gene co-expression network analysis Structural magnetic resonance imaging CTCF UQCR11 and WDR5B genetic expression Regulatory mediator effect analysis Conversion

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煤矿矿井水处理技术现状与展望

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工业水处理 2024年第9期44卷 1-8页

作者：李福勤王丛郑煚州陈宇航何绪文代其彬田莉河北工程大学能源与环境工程学院河北邯郸056038 河北省水污染控制与水生态修复技术创新中心河北邯郸056038 污水处理及资源化利用河北省工程研究中心河北邯郸056038 中国矿业大学(北京)化学与环境工程学院北京100083 冀中能源峰峰集团有限公司河北邯郸056107

煤矿矿井水是重要的非常规水源,矿井水的资源化利用对缓解矿区水资源短缺和环境保护具有重要意义。分析了矿井水的来源和水质特点,综述了含悬浮物、高矿化度、酸性和含特殊污染物等不同类型矿井水的主要处理技术,总结了各处理技术的特... 详细信息

煤矿矿井水是重要的非常规水源,矿井水的资源化利用对缓解矿区水资源短缺和环境保护具有重要意义。分析了矿井水的来源和水质特点,综述了含悬浮物、高矿化度、酸性和含特殊污染物等不同类型矿井水的主要处理技术,总结了各处理技术的特点和存在问题。大部分矿井水都含有一定量悬浮物,且水质水量变化较大,应着力提高井下水仓和地面调节池的预沉作用,开发和完善矿井水井下处理技术,结合自动化、智能化,实现无人值守;随高矿化度矿井水数量不断增加,其处理技术已成为矿井水处理领域的研究重点,应强化预处理,开发高效除硅除硬技术,引入能量回收装置,结合新能源和可再生能源开发绿色节能耦合脱盐技术,整体优化零排放工艺,降低浓盐废水处理成本;酸性和含特殊污染物矿井水是目前矿井水处理中的难点,应采取分布式高效定向处理技术,探索耦合工艺和自然修复治理。在国家政策引领下,矿井水处理技术将朝着更加节能、高效、智能和环保的方向发展。

关键词：矿井水水质特点含悬浮物矿井水高矿化度矿井水

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Predicting hypertensive disorders in pregnancy using multiple methods: Models with the placental growth factor parameter

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TECHNOLOGY AND HEALTH CARE 2021年第1_suppl期29卷 S427-S432页

作者： Sun, Ge Xu, Qi Zhang, Song Yang, Lin Liu, Guoli Meng, Yu chen, Aiqing Yang, Yimin Li, xuwen Hao, Dongmei Liu, Xiaohong Shao, Jing Beijing Univ Technol Fac Environm & Life Sci Beijing 100124 Peoples R China Beijing Int Sci & Technol Cooperat Base Intellige Beijing 100124 Peoples R China Peking Univ Peoples Hosp Beijing 100044 Peoples R China Beijing Yes Med Devices Co Ltd Beijing 100152 Peoples R China

BACKGROUND: Placental growth factor (PlGF), one of the biomarkers, has a certain predictive effect on hypertensive disorders in pregnancy (HDP). OBJECTIVE: To study the HDP prediction effect of different methods for variable selection and modeling for models containing PlGF. METHODS: For the model containing PlGF, the appropriate range of PlGF parameters needed to be selected. Step-logistic regression and lasso were used to compare the model effect of twice range selection. The PlGF model with good predictive effect and appropriate detecting gestational age was selected for the final prediction. RESULTS: The effect of the model containing PlGF tested at 15-16 weeks was better than the PlGF value without comprehensive screening. The sensitivity of both methods was over 92%. By comprehensive comparison, the final model of lasso method in this study was more effective. CONCLUSIONS: In this study, a variety of methods were used to screen models containing PlGF parameters. According to clinical needs and model effects, the optimal HDP prediction model with PlGF parameters in the second trimester of 15-26 weeks of pregnancy was finally selected.

关键词： Placental growth factor model parameters variable selection

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核桃林下复合种植对土壤培肥效果的影响

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四川农业大学学报 2019年第6期37卷 807-813页

作者：周楷玲陈绪文龚伟王景燕罗永飞杨文龙唐海龙刘江丽李灵聪四川农业大学林学院林业生态工程四川省重点实验室成都611130 四川贡嘎山国家级自然保护区石棉管理处四川雅安625400 石棉县林业局四川雅安625400

【目的】筛选适宜的核桃林下复合种植模式,对发展核桃林下经济具有重要作用。【方法】以核桃林下不同复合种植模式(包括:核桃+甘蓝+甘蓝(简写为HGG)、核桃+甘蓝+马铃薯(简写为HGM)、核桃+白菜+大豆(简写为HBD)、核桃对照(简写为HCK))和... 详细信息

【目的】筛选适宜的核桃林下复合种植模式,对发展核桃林下经济具有重要作用。【方法】以核桃林下不同复合种植模式(包括:核桃+甘蓝+甘蓝(简写为HGG)、核桃+甘蓝+马铃薯(简写为HGM)、核桃+白菜+大豆(简写为HBD)、核桃对照(简写为HCK))和农地对照(玉米+甘蓝,简写为NCK)为对象,研究各模式表层(0~20 cm)土壤物理性质、养分含量、微生物数量和酶活性,采用隶属函数法对各模式土壤肥力进行综合评价。【结果】各核桃林下复合种植模式与农地对照(CK)相比,土壤容重降低4.6%~17.6%,非毛管孔隙、毛管孔隙和总孔隙分别增加2.4%~14.8%、2.8%~29.1%和2.6%~23.1%;有机碳、全氮、碱解氮、全磷和全钾分别增加5.1%~14.9%、3.9%~12.5%、25.1%~112.5%、11.4%~47.1%和0.2%~2.7%;HGG和HGM模式土壤有效磷含量分别增加21.9%和5.0%,而其余模式降低6.1%~28.3%,HCK模式速效钾含量降低17.4%,而其余模式增加20.4%~52.9%;土壤细菌、放线菌、真菌和总微生物数量分别增加21.4%~54.3%、19.2%~58.1%、17.8~58.4%和21.2~54.6%;蔗糖酶、脲酶、磷酸酶、过氧化氢酶、多酚氧化酶和过氧化物酶活性分别增加9.3%~57.8%、16.6%~56.7%、6.2%~30.8%、8.9%~41.1%、4.2%~14.3%和1.4%~38.6%;各模式土壤肥力综合值增加69.6%~431.3%。【结论】核桃林下复合种植均能提高土壤肥力,其中以HGG模式最佳,对发展研究区林下经济和提高土壤肥力具有重要作用。

关键词：农林复合经营核桃培肥效果大渡河干热河谷区

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