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盐酸氨基葡萄糖对骨关节炎(osteoarthritis,OA)的治疗体会

心理医生 2016年第29期22卷 7-8页

作者：陈旭文黄祚瑶罗原健金牛区人民医院四川成都 610000

目的:探讨和分析氨基葡萄糖对膝骨关节炎(osteoarthritis,DOA)的治疗方法在临床中应用中的疗效体会,为广大骨关节炎病患者的治疗提供参考.方法:选取本院2010年10月-2012年10月期间采用盐酸氨基葡萄糖治疗90例膝D O A患者.男性患者36例... 详细信息

目的:探讨和分析氨基葡萄糖对膝骨关节炎(osteoarthritis,DOA)的治疗方法在临床中应用中的疗效体会,为广大骨关节炎病患者的治疗提供参考.方法:选取本院2010年10月-2012年10月期间采用盐酸氨基葡萄糖治疗90例膝D O A患者.男性患者36例、女性患者54例;年龄均在45岁~75岁,平均年龄60.5岁,病程2个月到6年不等.口服盐酸氨基葡萄糖片、每日三次、每次480毫克,6周为一疗程,4~6个月重复一个疗程.所有患者均经过2个疗程的治疗后,(采用国际DOA的评分标准:Leuesne指数评定膝关节休息疼痛、运动疼痛、压痛、关节活动度、晨僵和活动能力).结果:有85例患者膝关节疼痛、活动度、晨僵均有不同程度的好转,有10例患者在第一疗程后膝关节疼痛消失,有20例患者在第一疗程结束后疼痛、晨僵明显缓减、膝关节活动度明显改善,有15例患者在第二疗程结束后疼痛消失,有52例患者在第二疗程治疗结束后、膝关节疼痛、晨僵等女明显好转、活动度明显改善,有5例患者无效,有3例患者出现胃部不适(既往患者有慢性胃炎史,患者自服奥美拉唑缓减).结论:盐酸氨基葡糖治疗退行性骨性关节炎,可延缓骨关节炎的病理过程,延缓病情的进展、缓减疼痛、肿胀等症状,改善关节功能,延缓关节变性形成,适合在临床上进行推广与应用.

关键词：盐酸氨基葡萄糖膝关节骨性关节炎疗效体会

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Structure-Based Drug Design and Identification of H₂O-Soluble and Low Toxic Hexacyclic Camptothecin Derivatives with Improved Efficacy in Cancer and Lethal Inflammation Models in Vivo

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JOURNAL OF MEDICINAL CHEMISTRY 2018年第19期61卷 8613-8624页

作者： Pang, Peichen chen, Jiean Li, Xijian Li, Miyang Yu, Huidong Zhao, Jean J. Ni, Jing Wang, xuwen Sun, Huiyong Tian, Sheng Zhu, Feng Liu, Feng Huang, Yong Hou, Tingjun Zhejiang Univ Coll Pharmaceut Sci Hangzhou 310058 Zhejiang Peoples R China Zhejiang Univ State Key Lab CAD&CG Hangzhou 310058 Zhejiang Peoples R China Peking Univ State Key Lab Chem Oncogen Key Lab Chem Genom Shenzhen Grad Sch Shenzhen 518055 Guangdong Peoples R China Rongene Pharma Co Ltd Guangzhou 510663 Guandong Peoples R China Dana Farber Canc Inst Dept Canc Biol Boston MA 02215 USA Harvard Med Sch Dept Biol Chem & Mol Pharmacol Boston MA 02215 USA Soochow Univ Coll Pharmaceut Sci Suzhou 215123 Jiangsu Peoples R China

Camptothecin (CPT) has been shown to block disassembly of the topoisomerase I (Topo I)/DNA cleavable complex. However, the poor aqueous solubility, intrinsic instability, and severe toxicity of CPTs have limited their clinical applications. Herein, we report the design and synthesis of H2O-soluble and orally bioavailable hexacyclic CPT derivatives. By analysis of a virtual chemical library and cytotoxicity screening in vitro, 9 and 11 were identified as potential prodrugs and chosen for further characterization in vivo. Both compounds exhibited remarkable anticancer and anti-inflammation efficacies in animals and improved drug-like profiles.

关键词： Mixtures Rodent models Solubility Genetics Toxicity

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改良Burks-Schaffer入路切开复位空心钉固定与关节镜下Endobutton带袢钢板固定治疗后交叉韧带胫骨止点撕脱骨折的疗效比较

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中华创伤骨科杂志 2019年第5期21卷 378-383页

作者：刘炜洁陈峰叶发刚戚超宫海峰张成栋王开钱源李绪文青岛大学附属医院创伤外科 266000

目的通过分析比较改良Burks-Schaffer入路切开复位空心钉固定与关节镜下Endobutton带袢钢板固定治疗后交叉韧带(PCL)胫骨止点撕脱骨折的临床疗效。方法回顾性分析2013年2月至2017年8月青岛大学附属医院创伤外科收治的41例PCL胫骨止点撕... 详细信息

目的通过分析比较改良Burks-Schaffer入路切开复位空心钉固定与关节镜下Endobutton带袢钢板固定治疗后交叉韧带(PCL)胫骨止点撕脱骨折的临床疗效。方法回顾性分析2013年2月至2017年8月青岛大学附属医院创伤外科收治的41例PCL胫骨止点撕脱骨折患者资料。男24例,女17例;年龄18~65岁,平均39岁;左膝22例,右膝19例;根据固定方式不同将患者分为2组:改良切开组23例(行改良Burks-Schaffer入路切开复位空心钉固定),关节镜组18例(行关节镜下Endobutton带袢钢板固定)。术后比较两组患者的手术时间、出血量、膝关节各项客观评分及膝关节活动度(ROM)等情况。结果41例患者术后获23~40个月(平均27.2个月)随访。所有患者均未出现切口感染、骨折畸形愈合或不愈合、固定装置松动等并发症。末次随访时膝关节X线片示撕脱骨折均已达到骨性愈合标准。改良切开组与关节镜组手术时间分别为(52.6±7.3)、(86.8±9.2)min,出血量分别为(63.9±12.7)、(19.7±10.2)mL,以上项目两组间比较差异均有统计学意义(P<0.05)。而两组患者在膝关节各项客观评分及ROM方面差异均无统计学意义(P>0.05)。结论改良Burks-Schaffer入路切开复位空心钉固定与关节镜下Endobutton带袢钢板固定治疗PCL胫骨止点撕脱骨折均能获得满意效果,后者出血少,但前者在手术时间方面更具优势。

关键词：膝关节关节镜检查骨折固定术,内后交叉韧带胫骨止点撕脱骨折改良Burks-Schaffer入路

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Thallium contamination in arable soils and vegetables around a steel plant A newly-found significant source of Tl pollution in South China

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ENVIRONMENTAL POLLUTION 2017年 224卷 445-453页

作者： Liu, Juan Luo, xuwen Wang, Jin Xiao, Tangfu chen, Diyun Sheng, Guodong Yin, Meiling Lippold, Holger Wang, Chunlin chen, Yongheng Guangzhou Univ Innovat Ctr Guangzhou 510006 Guangdong Peoples R China Guangzhou Univ Key Lab Waters Safety & Protect Pearl River Delta Minist Educ Guangzhou 510006 Guangdong Peoples R China Shaoxing Univ Coll Life Sci Coll Chem & Chem Engn Shaoxing 312000 Peoples R China Helmholtz Zentrum Dresden Rossendorf Inst Ressourcenokol D-04318 Leipzig Germany Guangdong Prov Acad Environm Sci Guangzhou 510045 Guangdong Peoples R China

Thallium (Tl) is a highly toxic rare element. Severe Tl poisoning can cause neurological brain damage or even death. The present study was designed to investigate contents of Tl and other associated heavy metals in arable soils and twelve common vegetables cultivated around a steel plant in South China, a newly-found initiator of Tl pollution. Potential health risks of these metals to exposed population via consumption of vegetables were examined by calculating hazard quotients (HQ). The soils showed a significant contamination with Tl at a mean concentration of 1.34 mg/kg. The Tl levels in most vegetables (such as leaf lettuce, chard and pak choy) surpassed the maximum permissible level (0.5 mg/kg) according to the environmental quality standards for food in Germany. Vegetables like leaf lettuce, chard, pak choy, romaine lettuce and Indian beans all exhibited bioconcentration factors (BCF) and transfer factors (TF) for Tl higher than 1, indicating a hyperaccumulation of Tl in these plants. Although the elevated Tl levels in the vegetables at present will not immediately pose significant non-carcinogenic health risks to residents, it highlights the necessity of a permanent monitoring of Tl contamination in the steel-making areas. (C) 2017 Elsevier Ltd. All rights reserved.

关键词： Thallium Soil Vegetable Ecological risk Steel plant

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Rapid with double-turn coil OSH-MPT array for damage detection in composite plate 21

Rapid with double-turn coil OSH-MPT array for damage detecti...

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21st International Conference on Composite Materials, ICCM 2017

作者： Liu, Zenghua Zhong, xuwen chen, Honglei He, Cunfu Wu, Bin College of Mechanical Engineering and Applied Electronics Technology Beijing University of Technology Beijing100124 China

Imaging detection of composite plates is presented based on reconstruction algorithm for the probabilistic inspection of damage (RAPID) and double-turn coil omnidirectional shear-horizontal wave magnetostrictive patch transducer (OSH-MPT) array. The lowest shear-horizontal mode (SH0) can propagate in the composite plate through bonding double-turn coil OSH-MPT. RAPID can realize using the direct wave of SH0 mode to extract the damage information. It is beneficial to detect composite plate in the case that the velocity of direct waves varies with the propagation direction. A small mass which is circular cylinder is bonded to simulate damage. Imaging results are achieved after using modified methods for eliminating the influence of the uneven probability distribution of the array (UPDA) in RAPID. Threshold is selected based on the receiver operating characteristic (ROC) curve for improving RAPID-based imaging accuracy. © 2017 International Committee on Composite Materials. All rights reserved.

关键词： Composite plate Damage imaging Magnetostrictive patch transducer RAPID Shear-horizontal waves

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低灌注压下微造瘘经皮肾镜取石术治疗学龄前儿童上尿路结石的安全性和有效性

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中华泌尿外科杂志 2020年第12期41卷 927-930页

作者：郭全斌阿布力克木·扎克尔史旭文侯江江陈畅艾散江·麦麦提艾克拜尔江·麦麦提艾尼瓦尔·阿不都卡德尔邱智新疆和田地区人民医院泌尿外科新疆和田848000 首都医科大学附属北京朝阳医院泌尿外科北京100020

目的:探讨低灌注压下微造瘘经皮肾镜取石术(mini-percutaneous nephrolithotomy,MPCNL)治疗学龄前儿童上尿路结石的安全性和有效性。方法:回顾性分析新疆和田地区人民医院2015年1月至2020年1月收治的690例上尿路结石学龄前患儿的临床资... 详细信息

目的:探讨低灌注压下微造瘘经皮肾镜取石术(mini-percutaneous nephrolithotomy,MPCNL)治疗学龄前儿童上尿路结石的安全性和有效性。方法:回顾性分析新疆和田地区人民医院2015年1月至2020年1月收治的690例上尿路结石学龄前患儿的临床资料。男466例,女224例。平均年龄(3.7±1.6)(0.6~6.0)岁。690例结石位于左侧293例,右侧282例,双侧115例,共805侧。结石部位:上盏41例(5.9%)、中盏14例(2.0%)、下盏62例(9.0%)、肾盂90例(13.1%)、肾盂输尿管连接处81例(11.7%)、多部位402例(58.3%)。平均结石数量(1.5±1.3)(1~6)枚。结石负荷(2.8±2.1)cm 2,CT值(834.6±478.5)HU。79例存在先天畸形:孤立肾35例(5.1%)、马蹄肾24例(3.5%)、肾旋转不良9例(1.3%),后位结肠11例(1.6%)。690例均全麻下行MPCNL。输尿管镜下于患侧输尿管内置入F5双J管,经尿管持续滴注无菌盐水,建立人工肾积水。超声引导下于腋前线和肩胛下线之间,取第11肋间或第12肋下穿刺目标肾盏的穹窿部。穿刺目标盏:上盏45侧(5.6%)、中后盏719侧(89.3%)、下盏41侧(5.1%)。780侧(96.9%)采用单通道,25侧(3.1%)采用双通道。穿刺成功后扩张建立通道,F12、F14、F16、F18通道分别为56侧(7.0%)、113侧(14.0%)、557侧(69.2%)、79侧(9.8%)。采用生理盐水悬吊在50~70 cm高度重力自然灌注。使用F11.5小儿肾镜行钬激光或气压弹道碎石。16例术后半无管化(不留置肾造瘘,留置双J管)。结果:本组805侧中,一期手术779侧(96.8%);二期手术26侧(3.2%),其中11侧因结石负荷较大,一期术后1周行二期手术,15侧因一期术后1年复查残留结石>1 cm行二期手术。115例双侧肾结石患儿中,28例行一期双侧MPCNL,余87例分期手术。手术时间平均(35.0±15.3)(15~110)min。血红蛋白平均下降(1.3±0.9)g/L。术后出现发热48例(7.0%)、感染中毒性休克3例(0.4%),予亚胺培南、去甲肾上腺素治疗后好转;肾周积液33例(4.8%)、腹腔积液10例(1.4%),予超声引导腹腔穿刺抽出积液后好转。5例(0.7%)术后输注1 U红细胞治疗。无行肾动脉栓塞或肾脏丢失病例,无死亡病例。术后平均住院时间(6.8±4.3)(3~14)d。术后超声复查711侧(88.3%)完全清石。348例获得随访,随访时间6~48个月。超声检查术后结石复发率为39%(136/348),其中83例(61%)术后残留结石和21例(15%)结石复发患儿行二次手术治愈,余115例(85%)保守观察或拒绝手术。306例行结石成分分析,242例(79%)为含钙混合性结石。结论:低灌注压MPCNL治疗学龄前儿童上尿路结石具有微创、并发症少等优点,是一种安全、可行的治疗方法。

关键词：尿路结石经皮肾镜取石术儿童超声

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炙甘草汤的理论梳理及其治疗病毒性心肌炎的研究进展

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陕西中医 2018年第5期39卷 678-681页

作者：张序文陈晓上海中医药大学基础医学院上海201203

目的:探讨炙甘草汤对病毒性心肌炎的治疗效果。方法:简要梳理《伤寒论》炙甘草汤方的适应症、组方及煎煮法;并综述近10年来应用炙甘草汤治疗病毒性心肌炎的基础与临床研究文献。结果:炙甘草汤最初的适应症为伤寒后"脉结代,心动悸&q... 详细信息

目的:探讨炙甘草汤对病毒性心肌炎的治疗效果。方法:简要梳理《伤寒论》炙甘草汤方的适应症、组方及煎煮法;并综述近10年来应用炙甘草汤治疗病毒性心肌炎的基础与临床研究文献。结果:炙甘草汤最初的适应症为伤寒后"脉结代,心动悸",与现代医学对病毒性心肌炎的认识较为符合;实验研究证实炙甘草汤具有抗病毒作用、心肌细胞保护作用以及抗心律失常作用;在临床治疗中,炙甘草汤主要用于病毒性心肌炎的恢复期符合气血阴阳俱虚证者,其在与西药联合应用时疗效明显优于单纯西药组,并且安全无不良反应。

关键词：心肌炎/中医药疗法炙甘草汤/治疗应用综述

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Enhanced soluble production of cholera toxin B subunit in Escherichia coil by co-expression of SKP chaperones

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PROTEIN EXPRESSION AND PURIFICATION 2017年 138卷 1-6页

作者： Zhang, Yuanpeng Qiao, xuwen Yu, Xiaoming chen, Jin Hou, Liting Bi, Zhixiang Zheng, Qisheng Hou, Jibo Jiangsu Acad Agr Sci Natl Res Ctr Engn & Technol Vet Biol 50 Zhong Ling St Nanjing 210014 Jiangsu Peoples R China Jiangsu Co Innovat Ctr Prevent & Control Importan Nanjing Jiangsu Peoples R China

The cholera toxin B subunit (CTB) is a nontoxic portion of the cholera toxin that retains mucosal adjuvant properties. Expression of CTB in Escherichia coli is difficult as CTB aggregates and accumulates as insoluble inclusion bodies. To remedy this problem, the periplasmic chaperone, SKP, was investigated as possible co-expression partner to increase the solubility of recombinant CTB (rCTB) in E. coil. The result showed co-expression of SKP enhanced the soluble expression of rCTB in E. coli. Moreover, soluble rCTB was successfully expressed and secreted into the periplasmic space through the direction of the LTB leader signal. rCTB in periplasm was purified using an immobilized D-galactose resin;GM1-ELISA ex-periments showed that rCTB retains strong GM1 ganglioside-binding activity. Intranasal administration of ovalbumin (OVA) with rCTB significantly induced both mucosal and humoral immune responses specific to OVA. These data indicate that co-expression of the molecular chaperone SKP with CTB increased the solubility of rCTB while maintaining its function. (c) 2017 Elsevier Inc. All rights reserved.

关键词： Recombinant cholera toxin B subunit SKP Chaperones Co-expression

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Effects of dietary resveratrol supplementation on hepatic and serum pro-/anti-inflammatory activity in juvenile GIFT tilapia, Oreochromis niloticus

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DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY 2017年 73卷 220-228页

作者： Zheng, Yao Zhao, Zhixiang Wu, Wei Song, Chao Meng, Shunlong Fan, Limin Bing, xuwen chen, Jiazhang Chinese Acad Fishery Sci Freshwater Fisheries Res Ctr Minist Agr Sci Observing & Expt Stn Fishery Resources & Envi Wuxi 214081 Jiangsu Peoples R China Nanjing Agr Univ Wuxi Fishery Coll Wuxi 214081 Jiangsu Peoples R China

Dietary resveratrol (RES) supplementation may have some pharmacological effects including anti inflammation. Previous studies have shown that Kupffer cell activation and apoptosis induction increases the transcription of pro- and anti-inflammatory cytokines. The main purpose of this study was to investigate the pro- and anti-inflammatory activities of 0.1 or 0.3 g/kg RES as a dietary supplement in juvenile freshwater tilapia (Oreochromis niloticus). The results showed that hepatic and serum immunoglobulin M (IgM) significantly decreased and increased while anti- and pro-inflammatory cytokines significantly increased and decreased, respectively, in the RES-treated groups. The expression of serum and hepatic IgM and anti-inflammatory cytokines [interleukin (IL)-10] and its inverse inhibitor interferon (IFN)-gamma significantly increased while pro-inflammatory cytokine transcription significantly decreased. Hematoxylin-eosin staining and scanning electron microscopy revealed intestinal deformation, irregular goblet cells, and apoptotic cells in the 03 g/kg RES groups. RES (0.3 g/kg) also induced necrosis, apoptosis, reduction in Kupffer cell number, compressed sinusoids, and deformation of epidermal cells in the liver of the treated groups. In conclusion, the results of the present study show that high doses of RES were absorbed in the gut and then damaged the liver and intestinal tissue. (C) 2017 Published by Elsevier Ltd.

关键词： Resveratrol Inflammatory cytokine Gene expression Apoptosis GIFT tilapia

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20(S/R)-人参皂苷Rg_3的制备及调节Th1/Th2免疫失衡活性

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高等学校化学学报 2018年第11期39卷 2419-2424页

作者：刘迎陈妍心吴谦黎鹏李绪文时晓磊金永日吉林大学化学学院长春130012 吉林大学食品科学与工程学院长春130062

采用醋酸溶液作为提取溶剂,使西洋参叶中的二醇组人参皂苷在提取过程中发生降解,从而直接获得20(S)-人参皂苷Rg_3和20(R)-人参皂苷Rg_3,并对其调节Th1/Th2免疫失衡活性进行了研究.正交实验结果表明,当醋酸浓度为50%(体积分数),提取温度... 详细信息

采用醋酸溶液作为提取溶剂,使西洋参叶中的二醇组人参皂苷在提取过程中发生降解,从而直接获得20(S)-人参皂苷Rg_3和20(R)-人参皂苷Rg_3,并对其调节Th1/Th2免疫失衡活性进行了研究.正交实验结果表明,当醋酸浓度为50%(体积分数),提取温度为80℃,提取时间为1 h时,20(S)-人参皂苷Rg_3和20(R)-人参皂苷Rg_3的转化率最高,分别为12. 30%和14. 80%.将20(S)-人参皂苷Rg_3和20(R)-人参皂苷Rg_3处理后的朗格汉斯状树突细胞(LDCs)分别作用于小鼠抗原诱导的Th1/Th2免疫失衡模型,发现细胞上层清液中IL-4的水平均显著降低,说明20(S)-人参皂苷Rg_3和20(R)-人参皂苷Rg_3对小鼠Th1/Th2免疫失衡具有调节作用.本文不仅建立了一种制备20(S)-人参皂苷Rg_3和20(R)-人参皂苷Rg_3的新方法,也为人参皂苷Rg_3在免疫系统疾病中的应用提供了新的科学依据.

关键词：降解提取 20(S/R)-人参皂苷Rg3 Th1/Th2免疫失衡

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