We report a case of mycotic keratitis caused by Bipolaris oryzae with predisposing trauma from a foreign body. The fungus was identified by sequencing the internal transcribed spacer region, translation elongation fac...
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We report a case of mycotic keratitis caused by Bipolaris oryzae with predisposing trauma from a foreign body. The fungus was identified by sequencing the internal transcribed spacer region, translation elongation factor 1 alpha (TEFL) gene, and partial glyceraldehyde-3-phosphate dehydrogenase (GPDH) gene, and the species identity was confirmed on the basis of its characteristic conidial phenotype. The patient was treated with surgical intervention and antifungal agents, including intravenous fluconazole (FLC), oral itraconazole, topical 0.15% amphotericin B eye drops, and 0.5% FLC eye drops. To our knowledge, this is the first report of mycotic keratitis caused by B. oryzae worldwide. (C) 2016 Elsevier Inc. All rights reserved.
The normal dose of 17 alpha-methyltestosterone (MT) used in fish farming was 60 mg/L, and now the analysis of residual androgens was carried out in waste water obtained from the Beijing area, which could be detected i...
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The normal dose of 17 alpha-methyltestosterone (MT) used in fish farming was 60 mg/L, and now the analysis of residual androgens was carried out in waste water obtained from the Beijing area, which could be detected in levels ranging from 4.1 to 7.0 ng/L. For the purpose of aquatic early warning, the present study clearly demonstrated that chronic exposure by higher concentration of MT than environmental relevant concentrations could trigger oxidative stress response to juvenile tilapia by modulating hepatic antioxidant enzyme activities and gene transcription. Some antioxidative parameters (T-GSH, GSH/GSSG and MDA) were significant decreased under 0.5 mg/L MT exposure at 7 and 14 days. Some antioxidant enzymes (SOD, CAT and GST) and transcriptional changes (sod and cat) were revealed significant decreases for MT treated groups at 7 days. Total antioxidant capacity was significant increased only in 5 mg/L MT exposure groups, but GR activities were not affected all through the whole exposure period. Almost all of the antioxidant enzymatic genes detected in the present study were showed significant increments for MT exposure both at 14 and 21 days, and the genotoxicity profile of antioxidant enzymatic genes were revealed dose-dependent manner. This study presented evidence that MT could result in oxidative stress response in the early stages of GIFT tilapia.
基于Web of Science和中国知网(CNKI)的数据源,选择对应数据库、设定年限,检索相关文献和专利,运用文献计量学方法,并借助Origin、Excel等绘图制表工具对数据结果进行了统计、分析和对比,比较直观地展现出重金属污染土壤氧化还原修复技...
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基于Web of Science和中国知网(CNKI)的数据源,选择对应数据库、设定年限,检索相关文献和专利,运用文献计量学方法,并借助Origin、Excel等绘图制表工具对数据结果进行了统计、分析和对比,比较直观地展现出重金属污染土壤氧化还原修复技术的总体情况、国内外发展现状和趋势、国内外发展差距,并从关键词的发展演替角度分析研究热点与方向,为氧化还原修复技术相关学科发展与研究等提供决策参考。
By employing six groups of bulk diffusion couples together with electron probe microanalysis technique, the composition dependence of ternary interdiffusion coefficients in Co-rich fcc Co-Mo-W alloys at 1373 K was det...
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By employing six groups of bulk diffusion couples together with electron probe microanalysis technique, the composition dependence of ternary interdiffusion coefficients in Co-rich fcc Co-Mo-W alloys at 1373 K was determined via the Whittle and Green method. The experimental interdiffusion coefficients were critically assessed to obtain the atomic mobilities of Co, Mo and Win fcc Co-Mo-W alloys by using the DICTRA (Diffusion-Controlled TRAnsformations) software package. Comprehensive comparisons between the calculated and experimental data show that a good agreement is obtained for diffusivities in binary Co-Mo and ternary Co-Mo-W systems. In addition, a further verification of the obtained atomic mobilities was carried out through comparing the model-predicted concentration profiles/diffusion paths of several diffusion couples with the corresponding experimental data. The results indicate that the atomic mobilities can reproduce the experiment data reasonably well. This work contributes to the establishment of a Co-based kinetic database for computational design of superalloys. (C) 2015 Elsevier Ltd. All rights reserved.
Provided are a series of BTK inhibitors, and specifically disclosed are a compound, pharmaceutically acceptable salt thereof, tautomer thereof or prodrug thereof represented by formula (I), (II), (III) or (IV).
标准号:
EP3246317(A4)
Provided are a series of BTK inhibitors, and specifically disclosed are a compound, pharmaceutically acceptable salt thereof, tautomer thereof or prodrug thereof represented by formula (I), (II), (III) or (IV).
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