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中国科技论坛 2023年第9期 38-47,101页

作者：何声升迟景明张旭雯大连理工大学高等教育研究院辽宁大连116024

产学研创新生态系统中创新主体适应性行为是实现协同创新的重要方式。基于复杂适应系统理论分析产学研创新主体适应性行为内在逻辑,即产学研创新主体的适应性行为是主体自我选择、自我调节的主动建构过程。产学研创新主体相互适应,生成... 详细信息

产学研创新生态系统中创新主体适应性行为是实现协同创新的重要方式。基于复杂适应系统理论分析产学研创新主体适应性行为内在逻辑,即产学研创新主体的适应性行为是主体自我选择、自我调节的主动建构过程。产学研创新主体相互适应,生成复杂适应系统的复杂动态模式,推动着产学研创新生态系统的不断演化。本文围绕D大学和S集团的探索性案例,采用扎根理论凝练出产学研创新主体适应性行为需经历创造性搜寻、适应性选择、自觉性变异3个阶段的演进路径。因而产学研创新主体适应性行为过程,就是在创造性搜寻、适应性选择、自觉性变异的共同作用下螺旋式前进的过程。

关键词：产学研创新主体创新资源适应性行为创新生态系统

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Quicklime-induced changes of soil properties: Implications for enhanced remediation of volatile chlorinated hydrocarbon contaminated soils via mechanical soil aeration

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CheMOSPheRE 2017年 173卷 435-443页

作者： Ma, Yan Dong, Binbin he, Xiaosong Shi, Yi Xu, Mingyue he, xuwen Du, Xiaoming Li, Fasheng China Univ Min & Technol Sch Chem & Environm Engn Beijing 100083 Peoples R China Chinese Res Inst Environm Sci State Key Lab Environm Criteria & Risk Assessment Dept Soil Pollut Control Beijing 100012 Peoples R China

Mechanical soil aeration is used for soil remediation at sites contaminated by volatile organic compounds. However, the effectiveness of the method is limited by low soil temperature, high soil moisture, and high soil viscosity. Combined with mechanical soil aeration, quicklime has a practical application value related to reinforcement remediation and to its action in the remediation of soil contaminated with volatile organic compounds. In this study, the target pollutant was trichloroethylene, which is a volatile chlorinated hydrocarbon pollutant commonly found in contaminated soils. A restoration experiment was carried out, using a set of mechanical soil-aeration simulation tests, by adding quicklime (mass ratios of 3,10, and 20%) to the contaminated soil. The results clearly indicate that quicklime changed the physical properties of the soil, which affected the environmental behaviour of trichloroethylene in the soil. The addition of CaO increased soil temperature and reduced soil moisture to improve the mass transfer of trichloroethylene. In addition, it improved the macroporous cumulative pore volume and average pore size, which increased soil permeability. As soil pH increased, the clay mineral content in the soils decreased, the cation exchange capacity and the redox potential decreased, and the removal of trichloroethylene from the soil was enhanced to a certain extent. After the addition of quicklime, the functional group COO of soil organic matter could interact with calcium ions, which increased soil polarity and promoted the removal of trichloroethylene.

关键词： Quicklime Mechanical soil aeration Soil Volatile chlorinated hydrocarbons Physical/chemical properties

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Enhanced strategies for depressurization in offshore natural gas hydrate exploitation: An in-depth investigation into pathway optimization and production stability mechanisms

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MARINE AND PETROLEUM GEOLOGY 2024年 170卷

作者： Li, Yuxuan Zhang, Zhaobin Li, Shouding he, Jianming Li, Xiao Xu, Tao Lu, Cheng Qin, xuwen Chinese Acad Sci Key Lab Shale Gas & Geoengn Inst Geol & Geophys Beijing 100029 Peoples R China Chinese Acad Sci Innovat Acad Earth Sci Beijing 100029 Peoples R China Univ Chinese Acad Sci Coll Earth & Planetary Sci Beijing 100049 Peoples R China China Geol Survey Minist Nat Resources Oil & Gas Resources Survey Beijing 100083 Peoples R China China Geol Survey Minist Nat Resources China Ctr Aerial Geophys & Remote Sensing Nat Reso Beijing 100083 Peoples R China

Natural gas hydrates have garnered widespread attention as a high-quality energy resource. Recent offshore extraction experiences suggest that depressurization is a technically mature and economically viable option. However, challenges such as reservoir temperature reduction, reservoir subsidence, secondary hydrate formation, and insufficient dynamics in later-stage hydrate decomposition still require improvements to the depressurization method. This study, based on field data from Japan's first offshore natural gas hydrate extraction, utilizes a self-developed numerical simulator to model and validate reservoirs at the field scale. Long-term production rate stability, total production, secondary hydrate formation, reservoir subsidence, evolution of permeability, and temperature-pressure paths were analyzed and optimized for the three mainstream depressurization modes: steady depressurization, stepwise depressurization, and cyclic depressurization. The results indicate that, under the condition of equal total work done throughout the entire depressurization process, steady depressurization with an effectively lower depressurization rate is the optimal choice. Cyclic depressurization, due to the formation of secondary hydrates reducing the permeability of certain reservoir zones, adversely affects gas production efficiency during the long-term stable production phase. This study enhances insights into the coupled evolution of multiple physical fields during the depressurization of offshore natural gas hydrates, providing valuable guidance for future on-site extraction plan designs.

关键词： Natural gas hydrates Depressurization modes Numerical simulation Multiple physical fields On-site extraction plan

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Transcriptomic and metabolomic analyses reveal the essential nature of Rab1B in Toxoplasma gondii

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PARASITES & VECTORS 2023年第1期16卷 409-409页

作者： he, Kai Wang, Qiangqiang Gao, xuwen Tang, Tao Ding, Huiyong Long, Shaojun China Agr Univ Natl Anim Protozoa Lab Beijing 100193 Peoples R China China Agr Univ Sch Vet Med Beijing 100193 Peoples R China China Agr Univ Sch Vet Med Natl KeyLab Vet Publ Hlth Safety Beijing 100193 Peoples R China

Background The protozoan parasite Toxoplasma gondii encodes a dozen Rab proteins, which are parts of the small GTPase superfamily and regulate intracellular membrane trafficking. Our previous study showed that depletion of Rab1B caused severe defects regarding parasite growth and morphological structure, yet early defects of endocytic trafficking and vesicle sorting to the rhoptry in T. gondii are not expected to have a strong effect. To understand this discrepancy, we performed an integrated analysis at the level of transcriptomics and *** In the study, tetracycline-inducible TATi/Ty-Rab1B parasite line treated with ATc at three different time points (0, 18 and 24 h) was used. We first observed the morphological changes caused by Rab1B depletion via transmission electron technology. Then, high-throughput transcriptome along with non-targeted metabolomics were performed to analyze the RNA expression and metabolite changes in the Rab1B-depleted parasite. The essential nature of Rab1B in the parasite was revealed by the integrated omics *** Transmission electron micrographs showed a strong disorganization of endo-membranes in the Rab1B-depleted parasites. Our deep analysis of transcriptome and metabolome identified 2181 and 2374 differentially expressed genes (DEGs) and 30 and 83 differentially expressed metabolites (DEMs) at 18 and 24 h of induction in the tetracycline-inducible parasite line, respectively. These DEGs included key genes associated with crucial organelles that contain the rhoptry, microneme, endoplasmic reticulum and Golgi apparatus. The analysis of qRT-PCR verified some of the key DEGs identified by RNA-Seq, supporting that the key vesicular regulator Rab1B was involved in biogenesis of multiple parasite organelles. Functional enrichment analyses revealed pathways related to central carbon metabolisms and lipid metabolisms, such as the TCA cycle, glycerophospholipid metabolism and fatty acid biosynthesis and elongation.

关键词： Toxoplasma gondii Transcriptome Metabolome Rab family proteins

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磁絮凝磁选机磁系设计与矿井水处理工艺优化

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水处理技术 2019年第7期45卷 85-88,92页

作者：张晓航何绪文高瑶房鑫卫明史弋中国矿业大学(北京)化学与环境工程学院北京100083 马鞍山市天工科技股份有限公司安徽马鞍山243000 河北政法职业学院河北石家庄056000

为提高磁絮凝工艺中磁性介质回收率,探究了全铁氧体和铁氧体+稀土2种磁材所组成磁系的磁感应强度和磁场梯度的变化规律,并优化了煤炭的开采矿井水的磁絮凝处理工艺。结果表明,全铁氧体磁材磁系更适用于水中磁絮体的回收,铁氧体+稀土磁... 详细信息

为提高磁絮凝工艺中磁性介质回收率,探究了全铁氧体和铁氧体+稀土2种磁材所组成磁系的磁感应强度和磁场梯度的变化规律,并优化了煤炭的开采矿井水的磁絮凝处理工艺。结果表明,全铁氧体磁材磁系更适用于水中磁絮体的回收,铁氧体+稀土磁材磁系更适用于磁种回收。最优混凝剂、絮凝剂分别为聚合氯化铝、阴离聚丙烯酰胺,适宜投加量分别为60、5.25 mg/L。熟化池出水磁场力、重力2种分离磁絮体方案中,重力分离方案出水浊度去除率最高,也最稳定。筛孔96μm磁种对浊度去除效果比180μm更佳;适宜磁种循环量为2 kg;混凝池、注射池、熟化池优化搅拌转速组合为300、100、100 r/min。

关键词：磁絮凝矿井水磁选机磁系磁种

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Crushing behavior on the cylindrical tube based on lotus leaf vein branched structure

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MECHANICS OF MATERIALS 2022年 165卷 104205-104205页

作者： he, Qiang Wang, Yonghui Shi, Xiaona Jing, xuwen Jiang, Yonggang Jiangsu Univ Sci & Technol Sch Mech Engn Zhenjiang 212000 Jiangsu Peoples R China Cssc Huangpu Wenchong Shipbldg Co Ltd Guangzhou 510715 Peoples R China

By imitating the structural characteristics of the lotus leaf, a new excellent energy absorption structure named as the leaf vein branched circular tube (LVBCT) is proposed by referring to lotus leaf vein branched structure. The evolution of its cross-section may be controlled by the number of main veins distributed along the circumference (N) and the ratio of radius of inner circle Rinner to radius of outer circle Router (gamma). To study the crushing behavior of LVBCTs under axial dynamic crushing, the finite element simulation model established by LS-DYNA is first verified by comparing with the experimental results. Following that, a systematic parametric study on geometric parameters N and gamma is carried out with three different wall thicknesses. The mechanical properties of LVBCTs are revealed by analyzing the deformation mechanism and crashworthiness indicators (specific energy absorption per unit mass SEAm and peak crushing force PCF). The numerical results show that the LVBCTs may absorb more impact energy and its energy absorption characteristics are closely related to geometric parameters N, gamma and wall thickness t. The LVBCTs with N = 6 and gamma of 0.5 similar to 0.7 have better crashworthiness. Furthermore, the numerical results show that the thickness matching between main vein and branch vein has influence on the energy absorption ability. The SEAm of LVBCT is improved by 11.3% when the thickness matching between the main vein and the branch vein is 0.92 mm. The results of this study will be helpful to design novel thin-walled structure with better energy absorption ability.

关键词： Leaf vein branched circular tube (LVBCT) Parametric study Crushing behavior Deformation mechanism Energy absorption capability

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银川市社区老年人医养结合服务需求及影响因素研究

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中外女性健康研究 2020年第4期 7-8+17页

作者：仇艳敏刘国莲何旭文牛萌刘赟赟郑连花宁夏医科大学护理学院

目的:了解银川市社区老年人医养结合服务需求及影响因素,为银川市更好地开展医养结合服务提供一定的参考依据。方法:采用便利抽样法,于2019年1至2019年3月选择银川市3个社区卫生站120例符合纳入排除标准的社区老年人为研究对象,采用《... 详细信息

目的:了解银川市社区老年人医养结合服务需求及影响因素,为银川市更好地开展医养结合服务提供一定的参考依据。方法:采用便利抽样法,于2019年1至2019年3月选择银川市3个社区卫生站120例符合纳入排除标准的社区老年人为研究对象,采用《社区老年人医养结合服务需求调查问卷》进行问卷调查。结果:社区老年人医养结合服务需求率为92.7%。多元线性回归结果显示影响社区老年人医养结合服务需求的因素包括婚姻状态、居住状况、家庭月收入、患慢性病情况、半年就诊次数和医养结合知晓度等。结论:银川市社区老年人医养结合需求较高,其中社会福利类需求最高。建议社区卫生机构以社区老年人医养结合服务需求为导向,更好地开展社区老年人医养结合工作。

关键词：社区老年人医养结合影响因素

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Causal Relationship Between Type 2 Diabetes Mellitus and Preeclampsia: A Bidirectional Two-Sample Mendelian Randomized Study

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International Journal of Women's health 2025年 17卷 1725-1737页

作者： xuwen Song Yikang Wang Pengsheng Li Yafei Wang Xinghui Wen Qingwen Nie Wanlu An Huan Wang Fang he Department of Obstetrics and Gynecology Department of Cardiovascular Surgery The Affiliated Hospital of Qingdao University Qingdao Shandong Province People’s Republic of China Department of Obstetrics Affiliated Foshan Maternity & Child Healthcare Hospital Southern Medical University Foshan Guangdong Province People’s Republic of China Department of Obstetrics and Gynecology The Second People’s Hospital of Guiyang Guiyang Guizhou Province People’s Republic of China

BackgroundObservational epidemiologic investigations into the link between diabetes mellitus and preeclampsia (PE) have been conducted, but genetic evidence is still lacking. We utilized a two-sample Mendelian randomization (MR) analysis to shed light on the potential influence of type 2 diabetes mellitus (T2DM) on PE at the genetic prediction *** carried out a two-sample bidirectional MR analysis, utilizing genetic variants associated with T2DM (N=461,920) and PE (N=219,817) from the largest available genome-wide association studies. Using inverse variance weighting (IVW) and five validated approaches—MR-Egger, MR-RAPS, ConMix, weighted median, and weighted mode—we derived a potential causal association between T2DM and PE. The relationship between PE and T2DM was explored using reverse MR *** two-sample MR analysis indicated a causal link between T2DM and PE, with an odds ratio of 1.10 (95% CI, 1.02–1.18; P=0.01). The weighted mode method yielded an odds ratio of 1.22 (95% CI, 1.06–1.40; P=0.019), and the weighted median method produced an odds ratio of 1.19 (95% CI, 1.04–1.36; P=0.022). However, no significant association was detected in the MR-Egger analysis. heterogeneity was noted in the analysis of T2DM and PE, but no significant horizontal pleiotropy was observed. The results of the reverse MR analysis indicated no significant causal association between PE and *** the first time, MR analysis showed a positive causal link from T2DM to PE, but not vice versa. The limited number of SNPs in reverse analysis may affect reliability. Future studies should use more instrumental variables to strengthen findings. Further experiments are also needed to explore underlying mechanisms.

关键词： causal effect type 2 diabetes mellitus preeclampsia genome-wide association study

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基于《水处理工程》的酸性高铁矿井水综合实验设计

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中国矿业 2019年第6期28卷 133-138页

作者：章丽萍马项阳吴胜念薛静雯郑洋何绪文中国矿业大学(北京)化学与环境工程学院

菱镁矿尾矿煅烧后产生的轻烧镁粉对于酸性矿井水的处理具有效果好、操作条件良好、沉渣少等优点。通过对轻烧镁粉的成分分析可知,主要成分氧化镁占比高于90%。以山西某煤矿酸性矿井水为研究对象,对其进行常规水质分析可知,总铁浓度为230... 详细信息

菱镁矿尾矿煅烧后产生的轻烧镁粉对于酸性矿井水的处理具有效果好、操作条件良好、沉渣少等优点。通过对轻烧镁粉的成分分析可知,主要成分氧化镁占比高于90%。以山西某煤矿酸性矿井水为研究对象,对其进行常规水质分析可知,总铁浓度为230.01mg/L、亚铁离子浓度为66.98mg/L、pH值为3.24。采用轻烧镁粉进行酸性矿井水处理,设计正交实验,分析初始pH值、药剂投加量、曝气量、曝气时间等对处理效果的影响。实验结果表明,在投加轻烧镁粉量为0.50~1.00g/L时,酸性矿井水初始pH值可由3.15~3.31提高到6~9左右,缓冲性能较好,较容易控制投加量使pH值控制在6~9;轻烧镁粉处理酸性矿井水时三个主要因素的影响程度大小为:投加量>搅拌时间>搅拌速度,当轻烧镁粉投加量为0.85g/L、搅拌速度为400r/min、搅拌时间为12min时,实验效果较好;利用轻烧镁粉提高酸性矿井水的pH值到7.48时,曝气5min,曝气量为0.5m3/h,聚合氯化铝(PAC)投加量为10mg/L时,经处理矿井水中亚铁离子和总铁浓度可分别降至0.07mg/L和0.17mg/L,满足排放或回用水对总铁的要求,且改善了沉渣的沉降性能,大大缩短了沉降时间。

关键词：轻烧镁粉酸性矿井水总铁 PAC 沉降性能创新实验

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银川市兴庆区家庭医生签约服务现状及影响因素分析

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基层医学论坛 2019年第9期23卷 1199-1201页

作者：何旭文刘国莲王丽牛萌刘赟赟宁夏医科大学护理学院宁夏银川750000 宁夏回族自治区第一人民医院凯尔福邸社区卫生服务站宁夏银川750000

目的了解银川市兴庆区家庭医生签约服务现状,分析其存在的问题和影响因素。方法采用便利抽样法选择银川市兴庆区社区居民212例,于2018年1月—2月采用自行设计的问卷进行调查。结果 212例居民中签约的有74例(34.91%),签约率较低。居民签... 详细信息

目的了解银川市兴庆区家庭医生签约服务现状,分析其存在的问题和影响因素。方法采用便利抽样法选择银川市兴庆区社区居民212例,于2018年1月—2月采用自行设计的问卷进行调查。结果 212例居民中签约的有74例(34.91%),签约率较低。居民签约意愿与其对家庭医生签约服务的了解程度、首诊选择情况、患慢性病情况以及对社区的满意度相关(P<0.05)。结论社区居民对家庭医生签约服务的知晓率、签约率、认知程度普遍不高,提示社区医疗服务机构应加大对家庭医生签约服务的宣传,健全家庭医生签约服务的内容,从而提高居民的知晓率、签约率,促进家庭医生签约服务的健康发展。

关键词：家庭医生签约服务现状影响因素对策

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