检索结果-内蒙古大学图书馆

海洋开发与管理 2021年第2期38卷 81-86页

作者：黄路冯旭文乔正明杨星晨邵浩吴春芳国家海洋技术中心漳州基地筹建办公室厦门361007 自然资源部第二海洋研究所杭州310012 91039部队北京102401

计量检定和海上标校试验是目前船载观测设备在室内和室外开展测量精度评价的2种常用手段。为进一步推进我国计量检定和海上试验建设发展,文章系统归纳和总结室内计量检定和海上标校试验的原理、特点和工作现状,分析当前各自存在的问题,... 详细信息

计量检定和海上标校试验是目前船载观测设备在室内和室外开展测量精度评价的2种常用手段。为进一步推进我国计量检定和海上试验建设发展,文章系统归纳和总结室内计量检定和海上标校试验的原理、特点和工作现状,分析当前各自存在的问题,并提出具体建议。研究结果表明:军、地对于船载观测设备计量检定和海上标校试验的需求越来越迫切,我国虽已基本建成海洋设备计量技术规范体系,并强化海试全过程的质量控制,但仍存在计量标准、评价体系、维修保障和室外检定手段不足,海上试验环境和比测精度不确定以及缺少标准化海上试验设施和平台等问题;计量检定机构应综合分析计量要素的特点、社会效益和难易程度等,研究并制定行之有效的标准规范和保障措施;还应充分发挥海上试验的综合检验评价功能,研究完善比测校准方法,建设标准化的海上试验设施和平台。

关键词：计量检定海上标校试验船载观测设备测量精度评价校准方法

来源：评论

学校读者我要写书评

暂无评论

建筑业技术研究热点和发展趋势分析

引用

土木工程与管理学报 2021年第4期38卷 58-62页

作者：吴文伶刘星罗兰黄乾晋玉洁石敬斌肖绪文中国建筑股份有限公司技术中心北京101300

本文基于CNKI数据库对建筑领域文献进行计量分析,结果表明,文献发表数量反应了建筑技术发展历程,与建筑业发展历程基本吻合,这说明建筑技术从研发到应用转化顺畅高效,建筑技术研发与建筑业发展协同促进效果良好。本文运用科学知识图谱... 详细信息

本文基于CNKI数据库对建筑领域文献进行计量分析,结果表明,文献发表数量反应了建筑技术发展历程,与建筑业发展历程基本吻合,这说明建筑技术从研发到应用转化顺畅高效,建筑技术研发与建筑业发展协同促进效果良好。本文运用科学知识图谱可视化分析和问卷调研,探讨了建筑业研究热点和未来发展趋势,结果表明绿色建造和基于BIM的智慧建造是当今研究热点,建筑绿色化和智慧化是发展趋势。对建筑绿色化和BIM技术进行可视化分析,结果显示:绿色建材、绿色施工、绿色建造对建筑绿色化和产出绿色建筑至关重要;BIM技术不仅对建筑设计有深远影响,对包括施工、项目管理和运行维护在内的建筑全生命周期都有重要意义。

关键词：建筑技术文献计量可视化分析绿色建造智慧建造

来源：评论

学校读者我要写书评

暂无评论

High Q and high gradient performance of the first medium-temperature baking 1.3 GHz cryomodule

引用

Physical Review Accelerators and Beams 2024年第9期27卷 092003页

作者： Weimin Pan Jiyuan Zhai Feisi He Rui Ge Zhenghui Mi Peng Sha Song Jin Ruixiong Han Qunyao Wang Haiying Lin Guangwei Wang xuwen Dai Zhanjun Zhang Mei Li Minjing Sang Liangrui Sun Rui Ye Tongxian Zhao Shaopeng Li Keyu Zhu Baiqi Liu Xiaolong Wang Xiangchen Yang Xiaojuan Bian Xiangzhen Zhang Huizhou Ma Jianbing Zhao Liang Zhang Hui Zhao Runbing Guo Zhihui Mu Conglai Yang Xiaobing Zheng Chao Dong Hongjuan Zheng Zhengze Chang Xiaochen Yang Tongming huang Qiang Ma Zihan Wang Ming Liu Wenzhong Zhou Senyu Chen Chinese Academy of Sciences Beijing 100049 China Beijing 100049 China

The world’s first 1.3 GHz cryomodule containing eight 9-cell superconducting radio-frequency (rf) cavities treated by medium-temperature furnace baking (mid-T bake) was developed at the Institute of High Energy Physics, Chinese Academy of Sciences. The 9-cell cavities in the cryomodule achieved an unprecedented high average intrinsic quality factor (Q0) of 3.8×1010 at 16 MV/m and 3.6×1010 at 21 MV/m in the horizontal test. The cryomodule can operate stably up to a total continuous wave rf voltage greater than 193 MV, with an average cavity usable accelerating gradient of more than 23 MV/m. The results significantly exceed the specifications of Circular Electron Positron Collider and Dalian advanced light source and the other high repetition rate free electron laser facilities [Linac Coherent Light Source II (LCLS-II), LCLS-II-high energy, Shanghai High Repetition Rate X-ray FEL and Extreme Light Facility, Shenzhen Superconducting Soft X-Ray Free Electron Laser, etc.]. There is evidence that the mid-T bake cavity may not require fast cooldown or long processing time in the cryomodule. This paper reviews the cryomodule performance and discusses some important issues in cryomodule assembly and testing.

关键词： Radio frequency techniques Superconducting RF

来源：评论

学校读者我要写书评

暂无评论

广西—东盟背景下高校校园规划设计探讨——以广西东盟学院为例

引用

建筑与文化 2020年第10期 32-35页

作者：杨晓川苏振强黄睿林旭文华南理工大学建筑设计研究院有限公司亚热带建筑科学国家重点实验室华南理工大学建筑学院

自东盟博览会会址2004年永久落户南宁以来,东盟概念的提出与研究日益活跃,建筑和规划设计也在这一领域进行尝试。文章以"广西东盟国际技术学院"(简称东盟学院)设计为契机,结合对东南亚校园的调研与分析,从校园规划结构、建筑... 详细信息

自东盟博览会会址2004年永久落户南宁以来,东盟概念的提出与研究日益活跃,建筑和规划设计也在这一领域进行尝试。文章以"广西东盟国际技术学院"(简称东盟学院)设计为契机,结合对东南亚校园的调研与分析,从校园规划结构、建筑空间、建筑的造型语汇等多方面探讨将"东盟"的建筑文化与广西的地域性相结合的方法和策略,为适应这一主题下的高校校园设计提供有益的参考。

关键词：东盟高校规划地域性时代性符号

来源：评论

学校读者我要写书评

暂无评论

The immunopotentiator CVC1302 enhances immune efficacy and protective ability of foot-and-mouth disease virus vaccine in pigs

引用

VACCINE 2018年第52期36卷 7929-7935页

作者： Chen, Jin Yu, Xiaoming Zheng, Qisheng Hou, Liting Du, Luping Zhang, Yuanpeng Qiao, xuwen Hou, Jibo huang, Kehe Nanjing Agr Univ Coll Vet Med Nanjing 210095 Jiangsu Peoples R China Nanjing Agr Univ China Inst Nutr & Metab Disorders Domest Anim & F Nanjing 210095 Jiangsu Peoples R China Jiangsu Acad Agr Sci Inst Vet Immunol & Engn Nanjing 210014 Jiangsu Peoples R China Jiangsu Coinnovat Ctr Prevent & Control Important Yangzhou 225009 Jiangsu Peoples R China

The immunological enhancement characteristics of the immunopotentiator CVC1302 were evaluated for foot-and-mouth disease virus (FMDV) inactivated vaccine in pigs. Eight-week-old piglets were vaccinated with the foot-and-mouth disease (FMD) vaccine alone (FMD-vaccine group) or with the addition of CVC1302 (FMD-CVC1302 group), and the serum liquid phase blocking ELISA (LPB-ELISA) antibody titers, IgG1 and IgG2 levels, and the levels of four cytokines secreted by peripheral blood lymphocytes were measured at 28 days post vaccination (dpv). In the FMD-CVC1302 group, the LPB-ELISA antibody titers, IgG1, and IgG2 titers, and IL-2, IL-4, IL-6, and IFN-gamma levels at 28 dpv were significantly higher than those in the FMD-vaccine group. The FMD-CVC1302 group had long-lasting antibody titers (>7.8 log(2)), lasting for at least 6 months. In addition, piglets were vaccinated with or without addition of CVC1302 to the FMD vaccine at three different doses (1, 1/3, and 1/9 of the standard vaccine dose) and the serum LPBELISA antibody and serum neutralizing (SN) antibody titers were detected at 28 dpv. Then all pigs were challenged with virulent FMDV for PD50 value, and the levels of FMDV-specific RNA copies for the two full-dose groups at 3 and 10 days post challenge (dpc) were measured. The LPB-ELISA and SN antibody titers for the three doses in the FMD-CVC1302 groups were significantly higher than those in the FMD-vaccine groups at the same doses (p < 0.05). Post-virus challenge, the FMDV-specific RNA copy number in the FMD-CVC1302 group was lower than that in the FMD-vaccine group at 3 and 10 dpc. The PD50 value was 15.85 for the FMD-CVC1302 group, which was obviously higher than that for the FMD-vaccine group (10.96), and in the 1/9-dose of FMD-vaccine group only 3/5 pigs were protected. These results indicate that CVC1302 can enhance the immune efficacy and protective ability of the FMD vaccine in pigs. (C) 2018 Elsevier Ltd. All rights reserved.

关键词： Foot-and-mouth disease virus Inactivated vaccine Immunopotentiator CVC1302 Immune efficacy

来源：评论

学校读者我要写书评

暂无评论

The infection of red seabream iridovirus in mandarin fish (Siniperca chuatsi) and the host immune related gene expression profiles

引用

FISH & SHELLFISH IMMUNOLOGY 2018年 74卷 474-484页

作者： Liu, Xiaodan Chen, Nan Gao, Xiaojian Zhang, Yingying Li, Xixi Zhang, Yue Bing, xuwen huang, Hezhong Zhang, Xiaojun Yangzhou Univ Coll Anim Sci & Technol Yangzhou 225009 Jiangsu Peoples R China Chinese Acad Fishery Sci Freshwater Fisheries Res Ctr Minist Agr Key Lab Freshwater Fisheries & Germplasm Utilizat Wuxi 214081 Peoples R China Soochow Univ Fisheries Res Inst Sch Basic Med & Biol Sci Suzhou 215123 Peoples R China

Red Sea bream iridovirus (RSIV) was initially isolated from marine fish, which belongs to Megalocytivirus, Iridoviridae. It can cause great economic losses in fish culture with high morbidity and mortality. In the present study, the pathogenicity and immune response associated with a RSIV genotype megalocytivirus infection were determined in mandarin fish (Siniperca chuatsi). Fish challenged showed typical clinical signs of iridovirus infection, including acute haemorrhages and enlarged visceral organs. Histopathological analysis revealed that extensive necrosis, vacuolization and inflammation were presented in the stomach, spleen, kidney and liver of the diseased fish. Blood cells counting and phagocytic assay indicated that the numbers of the red and white blood cells in the peripheral blood of infected fish increased significantly compared to the control group and the phagocytic percentage of leukocytes peaked at day 6 post infection. Quantitive real-time PCR (qRT-PCR) was also undertaken to analyse the host defensive response in mandarin fish challenged with RSIV. The expression level of ten genes including interferon-related factors (IRFs) IRF1 and IRF7, Mx, Viperin, JAK1, STAT1, TCR alpha, TNF alpha, and IL-8 during experimental infection were monitored at different point of time in liver, spleen and head kidney. Results revealed varying expression profiles and clear transcriptional activation of these immune related genes in different tissues, which will contribute to better understand the pathogenesis and host defensive system in iridovirus invasion.

关键词： Megalocytivirus Red sea bream iridovirus (RSIV) Mandarin fish Histopathological analysis Immune related genes

来源：评论

学校读者我要写书评

暂无评论

应用型人才培养视域下文科课程实验教学研究——以《公共政策学》课程教学方式改革实证研究为例

引用

长春大学学报 2019年第2期29卷 104-108页

作者：黄晶梅丛旭文长春大学行政学院长春130022

省属本科院校人才培养目标是为地方经济建设培养应用型人才,这为文科课程授课提出新的要求。以公共政策学课程为例,阐述文科课程教学方式改革的必然;文科课程教学方式改革的趋势是增添实验占比,提升理论认知;改革方式是以开展思维教学,... 详细信息

省属本科院校人才培养目标是为地方经济建设培养应用型人才,这为文科课程授课提出新的要求。以公共政策学课程为例,阐述文科课程教学方式改革的必然;文科课程教学方式改革的趋势是增添实验占比,提升理论认知;改革方式是以开展思维教学,创新教学方法为主线;以及文科课程教学方式改革是以破解理论与实践脱节,加强理论与实践转化,以此巩固和加深学生对文科课程知识的掌握。

关键词：应用型人才文科课程教学方式改革实验

来源：评论

学校读者我要写书评

暂无评论

High Q and high gradient performance of the first medium-temperature baking 1.3 GHz cryomodule

arXiv

引用

arXiv 2023年

作者： Zhai, Jiyuan Pan, Weimin He, Feisi Ge, Rui Mi, Zhenghui Sha, Peng Jin, Song Han, Ruixiong Wang, Qunyao Lin, Haiying Wang, Guangwei Li, Mei Sang, Minjing Sun, Liangrui Ye, Rui Zhao, Tongxian Li, Shaopeng Zhu, Keyu Liu, Baiqi Wang, Xiaolong Yang, Xiangchen Bian, Xiaojuan Zhang, Xiangzhen Ma, Huizhou Dai, xuwen Zhang, Zhanjun Zhang, Liang Zhao, Hui Guo, Runbin Mu, Zhihui Yang, Conglai Zheng, Xiaobing Dong, Chao huang, Tongming Ma, Qiang Zheng, Hongjuan Liu, Ming Wang, Zihan Zhou, Wenzhong Institute of High Energy Physics Chinese Academy of Sciences Beijing100049 China Key Laboratory of Particle Acceleration Physics & Technology Institute of High Energy Physics Chinese Academy of Sciences Beijing100049 China Center for Superconducting RF and Cryogenics Institute of High Energy Physics Chinese Academy of Sciences Beijing100049 China University of Chinese Academy of Sciences Beijing100049 China

World’s first 1.3 GHz cryomodule containing eight 9-cell superconducting radio-frequency (RF) cavities treated by medium-temperature furnace baking (mid-T bake) was developed, assembled and tested at IHEP for the Dalian Advanced Light Source (DALS) and CEPC R&D. The 9-cell cavities in the cryomodule achieved an unprecedented highest average Q0 of 3.8 × 1010 at 16 MV/m and 3.6 × 1010 at 21 MV/m in the horizontal test. The cryomodule can operate stably up to a total CW RF voltage greater than 191 MV, with an average cavity CW accelerating gradient of more than 23 MV/m. The results significantly exceed the specifications of CEPC, DALS and the other high repetition rate free electron laser facilities (LCLS-II, LCLS-II-HE, SHINE, S3FEL). There is evidence that the mid-T bake cavity may not require fast cool-down or long processing time in the cryomodule. This paper reviews the cryomodule performance and discusses some important issues in cryomodule assembly and testing. © 2023, CC BY.

关键词： Free electron lasers

来源：评论

学校读者我要写书评

暂无评论

Charge Transfer Platform and Catalytic Amplification of Phenanthroimidazole Derivative: A New Strategy for DNA Bases Recognition

引用

ANALYTICAL CHEMISTRY 2019年第18期91卷 11938-11945页

作者： Lu, Nannan Liu, He huang, Rui Gu, Yue Yan, Xiaoyi Zhang, Tinging Xu, Zhiqian Xu, Haixin Xing, Yue Song, Yu Li, xuwen Zhang, Zhiquan Jilin Univ Coll Chem Changchun 130012 Jilin Peoples R China

Research about DNA composition has been concentrated on DNA damage in the past few decades. However, it still remains a great challenge to construct a rapid, facile, and accurate approach for simultaneously monitoring four DNA bases, guanine (G), adenine (A), thymine (T), and cytosine (C). Herein, a novel electrochemical sensor based on phenanthroimidazole derivative, 2-(4-bromophenyl)-1-phenyl-1H-phenanthro[9,10-d]-imidazole (PPI), is successfully fabricated by a simple electrochemical method. The bromophenyl group in PI could expand their aromatic plane, induce the pi-conjugated extension, and enhance the charge transfer and pi-pi interaction. The phenyl group at N1 position could regulate the intermolecular interaction, which could promote the possibility of intermolecular connection. The PPI polymer (poly(PPI)) with pi-electron enriched conjugation architecture has been applied in simultaneous determination of G, A, T, and C in neutral solution by square wave voltammetry (SWV) method with well-separated peak potentials at 0.714, 1.004, 1.177, and 1.353 V, respectively. The sensor functionalized with poly(PPI) exhibits wide linear response for G, A, T, and C in the concentration ranges of 3-300, 1-300, 30-800, and 20-750 mu M, respectively. With favorable selectivity, stability, and reproducibility, the sensor is successfully utilized to monitor four DNA bases in real samples, displaying a promising prospect for electrochemical sensing devices.

关键词： Cytosine Genetics Electrodes Oxidation Acid and base chemistry

来源：评论

学校读者我要写书评

暂无评论

Structure-Based Drug Design and Identification of H₂O-Soluble and Low Toxic Hexacyclic Camptothecin Derivatives with Improved Efficacy in Cancer and Lethal Inflammation Models in Vivo

引用

JOURNAL OF MEDICINAL CHEMISTRY 2018年第19期61卷 8613-8624页

作者： Pang, Peichen Chen, Jiean Li, Xijian Li, Miyang Yu, Huidong Zhao, Jean J. Ni, Jing Wang, xuwen Sun, Huiyong Tian, Sheng Zhu, Feng Liu, Feng huang, Yong Hou, Tingjun Zhejiang Univ Coll Pharmaceut Sci Hangzhou 310058 Zhejiang Peoples R China Zhejiang Univ State Key Lab CAD&CG Hangzhou 310058 Zhejiang Peoples R China Peking Univ State Key Lab Chem Oncogen Key Lab Chem Genom Shenzhen Grad Sch Shenzhen 518055 Guangdong Peoples R China Rongene Pharma Co Ltd Guangzhou 510663 Guandong Peoples R China Dana Farber Canc Inst Dept Canc Biol Boston MA 02215 USA Harvard Med Sch Dept Biol Chem & Mol Pharmacol Boston MA 02215 USA Soochow Univ Coll Pharmaceut Sci Suzhou 215123 Jiangsu Peoples R China

Camptothecin (CPT) has been shown to block disassembly of the topoisomerase I (Topo I)/DNA cleavable complex. However, the poor aqueous solubility, intrinsic instability, and severe toxicity of CPTs have limited their clinical applications. Herein, we report the design and synthesis of H2O-soluble and orally bioavailable hexacyclic CPT derivatives. By analysis of a virtual chemical library and cytotoxicity screening in vitro, 9 and 11 were identified as potential prodrugs and chosen for further characterization in vivo. Both compounds exhibited remarkable anticancer and anti-inflammation efficacies in animals and improved drug-like profiles.

关键词： Mixtures Rodent models Solubility Genetics Toxicity

来源：评论

学校读者我要写书评

暂无评论

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

请选择保存的检索档案：

请选择收藏分类：

通借通还

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：