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Variations of Siberian High Position under climate change: Impacts on winter pollution over north China

ATMOSPHERIC ENVIRONMENT 2018年 189卷 227-234页

作者： Jia, Beixi Wang, Yuxuan huang, Shan Nan, Yang Zhou, xuwen Tsinghua Univ Dept Earth Syst Sci Beijing Peoples R China Univ Houston Dept Earth & Atmospher Sci Houston TX USA Hebei Climate Ctr Shijiazhuang Hebei Peoples R China

We examined the correlations between winter aerosol optical depth (AOD) in North China (NC) and three synoptic-scale meteorological indices from 2001 to 2016, including the Siberian High intensity (SHI), East Asian Winter Monsoon intensity (EAWMI), and the Siberian High Position index (SHPI). To separate the influences from meteorology and emissions, NC AOD was detrended by subtracting a linear increasing trend from 2001 to 2013 and a decreasing trend from 2014 to 2016, in correspondence with reported changes in Chinese anthropogenic emissions during the same period. The SHPI explains 37% of the variability in the detrended NC AOD and 83% of the high SHPI winters correspond to high AOD. By contrast, the SHI and EAWMI show little correlation with the observed AOD variability. To project the SHPI in the future climate, we used the ensemble of six global circulation models (GCMs) which were found capable of reproducing the climatic spatial distribution and the longitudinal variability of the Siberian High from 1956 to 2005. The ensemble results show that the frequency of high SHPI winters and consequently more polluted conditions would increase by 29%, 61%, and 100% under RCP2.6, RCP4.5 and RCP8.5 until 2099. There are 11 out of the 25 GCMs examined here that project the possibility of high SHPI conditions to increase under RCP8.5. This indicates changes in the Siberian High position induced by increasing global greenhouse gas (GHG) emissions can lead to more winter pollution in North China in the future.

关键词： Synoptic-scale circulation Siberian High Position index North China Winter AOD Future air quality

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Adsorption of PAHs on the Sediments from the Yellow River Delta as a Function of Particle Size and Salinity

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SOIL & SEDIMENT CONTAMINATION 2015年第2期24卷 103-115页

作者： Wang, Jianbing Wang, Can huang, Qiuying Ding, Feng He, xuwen China Univ Min & Technol Sch Chem & Environm Engn Beijing 100083 Peoples R China Henan Polytech Inst Dept Chem Engn Nanyang Peoples R China Minist Environm Protect Appraisal Ctr Environm & Engn Beijing Peoples R China

In a seawater environment, the particle size of sediment and salinity play an important role in the adsorption behaviors of polycyclic aromatic hydrocarbons (PAHs) on sediment. In this study, batch adsorption experiments were carried out with the sediments from the Yellow River Delta (YRD) to explore the effect of particle size and salinity on the adsorption behaviors of phenanthrene (Phe), fluoranthene (Fla), and pyrene (Pyr). Adsorption isotherms of PAHs on different-sized sediments can be described by a Freundlich model with the correlation coefficients ranging from 0.96 to 0.99. The adsorption capacity of PAHs was in reverse proportion to the particle size of the sediments and in direct proportion to salinity. The sediments with smaller particle size possessed higher content of aromatic and fat components, which had strong adsorption capacity toward PAHs. Salinity influenced the adsorption behaviors of PAHs by changing the solubility of PAHs and the physicochemical properties of the sediments. The salting-out constants of Phe, Fla, and Pyr were in the range of 0.292 to 0.296, 0.230 to 0.289, and 0.293 to 0.307 l/mol, respectively. These research findings are of importance to an assessment of the fate and transport of PAHs in seawater-sediment systems.

关键词： fate and transport fluoranthene pyrene Phenanthrene

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Molecular basis and targeted therapies for radioiodine refractory thyroid cancer

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ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY 2023年第3期19卷 279-289页

作者： Yu, Qiuxiao Zhang, xuwen Li, Li Zhang, Chi huang, Jian huang, Wenting Chinese Acad Med Sci & Peking Union Med Coll Natl Canc Ctr Dept Pathol Natl Clin Res Ctr CancCanc Hosp Shenzhen 518116 Guangdong Peoples R China Chinese Acad Med Sci & Peking Union Med Coll Shenzhen Hosp Shenzhen 518116 Guangdong Peoples R China

Patients diagnosed with radioiodine refractory thyroid cancer (RAIR-TC) are not amenable to novel I-131 therapy due to the reduced expression of sodium iodide symporter (Na+/I- symporter, NIS) and/or the impairment of NIS trafficking to the plasma membrane. RAIR-TC patients have a relatively poor prognosis with a mean life expectancy of 3-5 years, contributing to the majority of TC-associated mortality. Identifying RAIR-TC patients and selecting proper treatment strategies remain challenging for clinicians. In this review, we demonstrate the updated clinical scenarios or the so-called "definitions" of RAIR-TC suggested by several associations based on I-131 uptake ability and tumor response post-I-131 therapy. We also discuss current knowledge of the molecular alterations involved in membrane-localized NIS loss, which provides a preclinical basis for the development of targeted therapies, in particular, tyrosine kinase inhibitors (TKIs), redifferentiation approaches, and immune checkpoint inhibitors.

关键词： immune checkpoint inhibitors radioiodine refractory thyroid cancer redifferentiation therapies sodium iodide symporter tyrosine kinase inhibitors

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Differences in Brain Structural Covariance Network Characteristics in Children and Adults With Autism Spectrum Disorder

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AUTISM RESEARCH 2021年第2期14卷 265-275页

作者： Cai, Suping Wang, xuwen Yang, Fan Chen, Dihui huang, Liyu Xidian Univ Sch Life Sci & Technol Xian 710071 Shaanxi Peoples R China

Systematically describing the structural topological configuration of human brain during development is an essential task. Autism spectrum disorder (ASD) represents a powerful challenge for psychiatry and neuroscience researchers. In this study, we investigated variations in the structural covariance network properties of 441 patients with ASD ranging in age from 7 to 45 years and in 426 age-matched healthy controls (HCs) using structural magnetic resonance neuroimaging from the ABIDE database. We applied a sliding window approach to study topological variation during development using comprehensive graph theoretical analysis. The main findings are as follows: (1) Cross-sectional trajectories of the network characteristics exhibited inverted U-shapes in both HCs and participants with ASD, with the latter exhibiting a 7-year delay in reaching the maximum value, (2) network resilience to targeted attacks peaked at 18 ' and 19 ' in the HCs and at 25 ' in the participants with ASD, and the weakest resilience occurred at age 7 ', (3) the HCs and participants with ASD exhibited normalized mean degree differences in the right amygdala, and (4) significant differences in the network characteristics were observed in the 18 ' age group at most of the densities analyzed. We used cross-sectional analysis to infer distinct neurodevelopmental trajectories in ASD in the brain structural connectome. Our findings are consistent with the notion that adolescence is a sensitive period of brain development with strong potential for brain plasticity, offering opportunities for environmental adaptation and social integration and for increasing vulnerability. ASD may be a product of susceptibility. Lay Summary We used cross-sectional analysis to preliminarily infer distinct neurodevelopmental trajectories in ASD in the brain structural connectome. The main findings are as follows: (1) Cross-sectional trajectories of the network characteristics exhibited inverted U-shapes in both HCs and pa

关键词： structure covariance network autism spectrum disorder sliding window analysis graph theoretical analysis brain development structural magnetic resonance neuroimaging

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Cortical thickness differences are associated with cellular component morphogenesis of astrocytes and excitatory neurons in nonsuicidal self-injuring youth

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CEREBRAL CORTEX 2023年第3期33卷 811-822页

作者： Cai, Suping Guo, Zitong Wang, xuwen huang, Kexin Yuan, Kai huang, Liyu Xidian Univ Sch Life Sci & Technol Xian 710071 Shaanxi Peoples R China Xidian Univ Sch Life Sci & Technol Engn Res Ctr Mol & Neuro Imaging Minist Educ Xian 710071 Shaanxi Peoples R China Inner Mongolia Univ Sci & Technol Informat Proc Lab Sch Informat Engn Baotou 014010 Inner Mongolia Peoples R China Xidian Univ Sch Life Sci & Technol Xian Key Lab Intelligent Sensing & Regulat Trans Xian 710126 Shaanxi Peoples R China

Nonsuicidal self-injury (NSSI) generally occurs in youth and probably progresses to suicide. An examination of cortical thickness differences (Delta CT) between NSSI individuals and controls is crucial to investigate potential neurobiological correlates. Notably, Delta CT are influenced by specific genetic factors, and a large proportion of cortical thinning is associated with the expression of genes that overlap in astrocytes and pyramidal cells. However, in NSSI youth, the mechanisms underlying the relations between the genetic and cell type-specific transcriptional signatures to Delta CT are unclear. Here, we studied the genetic association of Delta CT in NSSI youth by performing a partial least-squares regression (PLSR) analysis of gene expression data and 3D-T1 brain images of 45 NSSI youth and 75 controls. We extracted the top-10 Gene Ontology terms for the enrichment results of upregulated PLS component 1 genes related to Delta CT to conduct the cell-type classification and enrichment analysis. Enrichment of cell type-specific genes shows that cellular component morphogenesis of astrocytes and excitatory neurons accounts for the observed NSSI-specific Delta CT. We validated the main results in independent datasets to verify the robustness and specificity. We concluded that the brain Delta CT is associated with cellular component morphogenesis of astrocytes and excitatory neurons in NSSI youth.

关键词： structural magnetic resonance images differences in cortical thickness partial least squares regression cellular component morphogenesis excitatory neuron

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Effects of polyurethane/functionalised carbon nanotube interfacial interactions on tensile and compressive properties - molecular dynamics simulations

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MOLECULAR PHYSICS 2024年第18期122卷

作者： Wang, Zilin Wang, xuwen huang, Xiaoyong Li, Yaqin Wang, Wenfei Fu, Yizheng North Univ China Sch Mat Sci & Engn Taiyuan Peoples R China Shanxi Prov Key Lab Funct Nanocomposites Taiyuan Peoples R China Luoyang Ship Mat Res Inst Luoyang Peoples R China North Univ China Sch Mat Sci & Engn Taiyuan 030051 Peoples R China Shanxi Prov Key Lab Funct Nanocomposites Taiyuan 030051 Peoples R China

In order to understand the enhancement mechanism of the interaction between functionalised carbon nanotubes and polymer matrix, and to investigate the effects of different functionalised carbon nanotubes on the properties of composites at the microscopic level, the models of pure polyurethane (PUR), carbon nanotubes/polyurethane (CNTs/PUR), hydroxyl-functionalised carbon nanotubes/polyurethane (CNTOH/PUR), and carboxyl-functionalised carbon nanotubes/polyurethane (CNTCOOH/PUR) systems were constructed, and molecular dynamics methods were used to simulate the effects of different functionalised carbon nanotubes on the mechanical properties of polyurethane composite systems. The effects of different functionalised carbon nanotubes on the properties of PUR composite systems were compared by analysing the properties of PUR and its composite systems in terms of free volume fraction (FFV), radial distribution function (RDF), binding energy, and density distribution of PUR around different functionalised carbon nanotubes. The effects of intermolecular interactions on the properties of the composite systems were elucidated at the microscopic level. The final simulation results show that the CNTCOOH/PUR composite system with added carboxylated CNTs has the highest tensile yield strength, compressive properties and modulus;the smallest free volume fraction;the strongest bonding energy between CNTCOOH and PUR matrix, the largest density distribution of PUR matrix around CNTCOOH, and the best interfacial interaction. [GRAPHICS] .

关键词： Molecular dynamics simulations PUR functionalised carbon nanotubes interfacial interactions

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Highly Robust,Compressible,Anisotropic,and Fire-Retardant Polyimide/Hydroxyapatite Nanowires/Reduced Graphene Oxide Aerogel for Rapid Adsorption of Viscous Oil Assisted by Sunlight

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Research 2024年第4期7卷 58-70页

作者： Pan huang Yongxiang Sun Lin Yang Haoyu Yang Ying Hu Jifang Liu xuwen Peng Hongbo Zeng Department of Chemical and Materials Engineering University of AlbertaEdmontonAlberta T6G 1H9Canada Heavy Machinery Engineering Research Center of Education Ministry Taiyuan University of Science and TechnologyTaiyuan 030024China Cancer Center The Fifth Affiliated HospitalGuangzhou Medical UniversityGuangzhou 510700China Department of Chemical Engineering Tsinghua UniversityBeijing 10084China

Improving the adsorption efficiency of porous adsorbent materials for organic liquids with high viscosity is crucial for addressing oil spill *** this study,a high-performance aerogel adsorbent composed of polyimide(PI),hydroxyapatite nanowires(HAPnws),and reduced graphene oxide(rGO)has been fabricated,which leverages reduced flow tortuosity through anisotropic structures and solar-assisted viscosity reduction via photothermal *** prepared anisotropic PI/HAP/rGO aerogel,with directional channels,shows unique mechanical properties with high stiffness along the axial direction and compressibility along the radial direction.

关键词： nanowires viscosity adsorbent

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Arbidol/IFN-a2b therapy for patients with corona virus disease 2019: a retrospective multicenter cohort study

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MICROBES AND INFECTION 2020年第4-5期22卷 200-205页

作者： Xu, Ping huang, Jianping Fan, Zhao huang, Wendi Qi, Minghua Lin, xuwen Song, Weidong Yi, Li Peking Univ Shenzhen Hosp Dept Resp & Crit Care Med Shenzhen 518036 Guangdong Peoples R China Hubei Jianli People Hosp Dept Infect Dis Jingzhou 433300 Hubei Peoples R China Peking Univ Dept Emergency Shenzhen Hosp Shenzhen Guangdong Peoples R China Peking Univ Dept Neurol Shenzhen Hosp 1120 Lianhua Rd Futian Area Shenzhen 518036 Guangdong Peoples R China

The spread of COVID-19 is accelerating. At present, there is no specific antiviral drugs for COVID-19 outbreak. This is a multicenter retrospective cohort study of patients with laboratory-confirmed COVID-19 infection pneumonia from 3 hospitals in Hubei and Guangdong province, 141 adults (aged ≥18 years) without ventilation were included. Combined group patients were given Arbidol and IFN-α2b, monotherapy group patients inhaled IFN-α2b for 10-14 days. Of 141 COVID-19 patients, baseline clinical and laboratory characteristics were similar between combined group and monotherapy group, that 30% of the patients leucocytes counts were below the normal range and 36.4% of the patients experienced lymphocytopenia. The duration of viral RNA of respiratory tract in the monotherapy group was not longer than that in the combined therapy group. There was no significant differences between two groups. The absorption of pneumonia in the combined group was faster than that in the monotherapy group. We inferred that Arbidol/IFN - 2 b therapy can be used as an effective method to improve the COVID-19 pneumonia of mild patients, although it helpless with accelerating the virus clearance. These results should be verified in a larger prospective randomized environment.

关键词： COVID-19 2019-nCoV Pneumonia Arbidol IFN-α2b Treatment RNA

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On-Orbit Geometric Calibration and Validation of Optical-1 HR 19

On-Orbit Geometric Calibration and Validation of Optical-1 H...

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19th National Symposium on Remote Sensing of China - Remote Sensing of the Environment

作者： Jiang Yonghua Zhang Guo huang Wenchao Qin xuwen Wuhan Univ Sch Remote Sensing & Informat Engn Wuhan 430079 Peoples R China Wuhan Univ State Key Lab Informat Engn Surveying Mapping & R Wuhan 430079 Peoples R China State Bur Surveying & Mapping Satellite Surveying & Mapping Applicat Ctr Beijing 100083 Peoples R China China Geol Survey Beijing 10037 Peoples R China

ISBN: (纸本)9781628418910

Owing to relatively simplistic domestic hardware technology and a lack of on-orbit geometric calibration, particularly interior calibration, the positioning accuracies of Optical-1 HR satellites can vary greatly depending on the presence of ground control points (GCPs). Without GCPs, accuracies are typically lower than 100 pixels, whereas when GCPs are plentiful, accuracy is higher than one pixel, demonstrating the potential for a large discrepancy between international optical satellites with the same image resolution. This study investigated a new method of geometric calibration for Optical-1 HR satellites. Experiments were conducted to demonstrate the positive effects on positioning accuracy achieved by the calibration method. After calibration by our method, a positioning accuracy of higher than one pixel was obtained with only a small number of GCPs, which is equivalent to the accuracy of advanced international optical satellites with the same image resolution.

关键词： Optical-1 HR geometric calibration offset matrix look angle image stitching

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Interdiffusivities and atomic mobilities in FCC Co-Mo-W alloys

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CALPHAD-COMPUTER COUPLING OF PHASE DIAGRAMS AND THERMOCHEMISTRY 2015年 49卷 35-40页

作者： He, xuwen Zhang, Weibin Yan, Mingyuan Chen, Chong Du, Yong Zhang, Lijun huang, Bai-yun Cent S Univ State Key Lab Powder Met Changsha 410083 Hunan Peoples R China

By employing six groups of bulk diffusion couples together with electron probe microanalysis technique, the composition dependence of ternary interdiffusion coefficients in Co-rich fcc Co-Mo-W alloys at 1373 K was determined via the Whittle and Green method. The experimental interdiffusion coefficients were critically assessed to obtain the atomic mobilities of Co, Mo and Win fcc Co-Mo-W alloys by using the DICTRA (Diffusion-Controlled TRAnsformations) software package. Comprehensive comparisons between the calculated and experimental data show that a good agreement is obtained for diffusivities in binary Co-Mo and ternary Co-Mo-W systems. In addition, a further verification of the obtained atomic mobilities was carried out through comparing the model-predicted concentration profiles/diffusion paths of several diffusion couples with the corresponding experimental data. The results indicate that the atomic mobilities can reproduce the experiment data reasonably well. This work contributes to the establishment of a Co-based kinetic database for computational design of superalloys. (C) 2015 Elsevier Ltd. All rights reserved.

关键词： Diffusion couple Atomic mobility Fcc Co-Mo-W alloys DICTRA Fick's law

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