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DRL-Based Dynamic Destroy Approaches for Agile-Satellite Mission Planning

REMOTE SENSING 2023年第18期15卷 4503页

作者： huang, Wei Li, Zongwang He, Xiaohe Xiang, Junyan Du, Xu Liang, xuwen ShanghaiTech Univ Sch Informat Sci & Technol Shanghai 201210 Peoples R China Chinese Acad Sci Innovat Acad Microsatellites Shanghai 201306 Peoples R China Univ Chinese Acad Sci Beijing 100039 Peoples R China Henan Acad Sci Inst Math HANS Zhengzhou 450046 Peoples R China

Agile-satellite mission planning is a crucial issue in the construction of satellite constellations. The large scale of remote sensing missions and the high complexity of constraints in agile-satellite mission planning pose challenges in the search for an optimal solution. To tackle the issue, a dynamic destroy deep-reinforcement learning (D3RL) model is designed to facilitate subsequent optimization operations via adaptive destruction to the existing solutions. Specifically, we first perform a clustering and embedding operation to reconstruct tasks into a clustering graph, thereby improving data utilization. Secondly, the D3RL model is established based on graph attention networks (GATs) to enhance the search efficiency for optimal solutions. Moreover, we present two applications of the D3RL model for intensive scenes: the deep-reinforcement learning (DRL) method and the D3RL-based large-neighborhood search method (DRL-LNS). Experimental simulation results illustrate that the D3RL-based approaches outperform the competition in terms of solutions' quality and computational efficiency, particularly in more challenging large-scale scenarios. DRL-LNS outperforms ALNS with an average scheduling rate improvement of approximately 11% in Area instances. In contrast, the DRL approach performs better in World scenarios, with an average scheduling rate that is around 8% higher than that of ALNS.

关键词： agile-satellite mission planning graph attention network deep-reinforcement learning large-neighborhood search dynamic destroy

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Targeting toll-like receptor 7 as a therapeutic development strategy for systemic lupus erythematosus

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Acta Pharmaceutica Sinica B 2024年第11期14卷 4899-4913页

作者： Meng Wang Hekai Chen Tuan Zhang Zhikuan Zhang xuwen Xiang Meng Gao Yilan Guo Shuangshuang Jiang Kejun Yin Mintao Chen Jian huang Xincheng Zhong Umeharu Ohto Jing Li Toshiyuki Shimizu Hang Yin State Key Laboratory of Membrane Biology School of Pharmaceutical SciencesTsinghua-Peking Center for Life SciencesKey Laboratory of Bioorganic Phosphorous Chemistry and Chemical Biology(Ministry of Education)Tsinghua UniversityBeijing 100084China Graduate School of Pharmaceutical Sciences the University of TokyoTokyo 113-0033Japan Department of Rheumatology and Clinical Immunology Peking Union Medical College HospitalChinese Academy of Medical SciencesPeking Union Medical CollegeBeijing 100032China Toll Biotech Co. Ltd.(Beijing)Beijing 102209China

Endosomal TLRs(TLR3/7/8/9)are highly analogous innate immunity sensors for various viral or bacterial RNA/DNA molecular *** them,TLR7,in particular,has been suggested to be a target for various inflammatory disorders and autoimmune diseases including systemic lupus erythematosus(SLE);but few small-molecule inhibitors with elaborated mechanism have been reported in ***,we reported a well-characterized human TLR7-specific small-molecule inhibitor,TH-407b,with promising potency and negligible cytotoxicity through a novel binding ***,TH-407b not only effectively inhibited TLR7-mediated pro-inflammatory signaling in a variety of cultured cell lines but also demonstrated potent inflammation suppressing activities in primary peripheral blood mononuclear cells(PBMCs)derived from SLE ***,TH-407b showed prominent efficacy in vivo,improved survival rate and ameliorated symptoms of SLE model *** obtain molecular insights into the TH-407b derivatives’inhibition mechanism,we performed the structural analysis of TLR7/TH-407b complex using cryogenic electron microscopy(cryo-EM)*** an atomistic resolution cryo-EM structure of the TLR family,it not only of value to facilitate structure-based drug design,but also shed light to methodology development of small proteins using ***,TH-407b has unveiled an inhibition strategy for TLR7 via stabilizing its resting/inactivated *** a resting state could be generally applicable to all TLRs,rendering a useful method for targeting this group of important immunological receptors.

关键词： TLR7 Small-moleculeinhibitor Atomisticresolutioncryo-EM structure Resting state Systemiclupus erythematosus MRL

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Transient Stability Evaluation of Independent Microgrid based on Message Passing Graph Neural Network

Transient Stability Evaluation of Independent Microgrid base...

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International Conference on Electronics Technology (ICET)

作者： Jiubao Zhen Shufan huang xuwen Jia Haocheng Du College of Information and Electrical Engineering China Agricultural University Beijing China Key Laboratory of Power System Intelligent Dispatch and Control of Ministry of Education Shandong University Jinan China

Virtual synchronous generator is used to control independent microgrid to provide inertia and damping support, but it often brings transient stability problems. Due to the large number of nonlinear and non-smooth characteristics of highly electronic independent microgrid, it is difficult to analyze it by the traditional transient stability analysis method. In this paper, the independent microgrid controlled by virtual synchronization is taken as the object. Firstly, we compare the impact of detailed modeling of energy storage and simplified modeling on the transient stability, and then discuss the impact of current limiting link of virtual synchronous machine on the transient stability. Secondary, combined with the idea of graph neural network, we propose an independent microgrid transient stability evaluation model based on message passing graph neural network. The information corresponding to bus and transmission lines in microgrid is aggregated and updated by message passing mechanism, so as to depict the topological connection relationship of microgrid, and then consider the influence of topology structure on transient stability evaluation. Last, a WSCC-9 system with virtual synchronous machine is taken as an example. The results show that considering the energy storage detailed model and current limiting link can effectively improve the accuracy of stability analysis. The proposed method has stronger generalization ability and is more applicable to the microgrid system with variable topological structure.

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Folic acid-decorated vitamin E Poly(ethylene glycol) monoplatinum ester with disulfide bond as theranostic nanoparticle for drug resistant tumor diagnosis and treatment

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MATERIALS RESEARCH EXPRESS 2023年第11期10卷 115404-115404页

作者： Li, Zhuoran Yang, Huikang Xu, Fan Zeng, xuwen huang, Haowei Jiang, Xinqing Jinan Univ Dept Radiol Guangzhou Red Cross Hosp Guangzhou Guangdong Peoples R China South China Univ Technol Guangzhou Peoples Hosp 1 Sch Med Dept Radiol Guangzhou Guangdong Peoples R China Jinan Univ Dept Radiotherapy Guangzhou Red Cross Hosp Guangzhou Guangdong Peoples R China Jinan Univ Guangzhou Peoples Hosp 1 Dept Radiol Guangzhou Guangdong Peoples R China

Vitamin E Poly(ethylene glycol) monoplatinum ester (TPGS) nanoparticles have attracted much attention in recent years for overcome multidrug resistance. Herein, a well-defined folic acid (FA)-conjugated and disulfide bond-linked polymer (FA-SS-TPGS) was synthesized. These polymer nanoparticles were utilized as theranostic agents for tumor-targeted magnetic resonance imaging (MRI) and chemotherapy. By loading doxorubicin (DOX) and superparamagnetic iron oxide (SPIO) particles into TPGS nanoparticles, FA-SS-TPGS@DOX/SPIO nanoparticles are obtained. In vitro drug release studies revealed that under a reducing environment in the presence of glutathione (GSH), approximately 100% of the doxorubicin (DOX) was released from the disulfide bond-linked theranostic nanoparticles within 24 h. DOX and SPIO were efficiently delivered into HepG2-ADM cells due to the folate receptor-mediated endocytosis process of the nanoparticles. Additionally, the presence of glutathione (GSH) triggered the cleaving of the disulfide bonds, further facilitating the delivery of DOX and SPIO into the cells. Furthermore, the FA-SS-TPGS @DOX-SPIO nanoparticles exhibited strong MRI contrast enhancement properties. In conclusion, FA-SS-TPGS@DOX/SPIO are potential nanoparticles for tumor-targeted MRI and chemotherapy, which can also overcome multidrug resistance.

关键词： multidrug resistance TPGS tumor-targeted disulfide bond theranostic nanoparticles

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Discovery of novel small molecules targeting hepatitis B virus core protein from marine natural products with HiBiT-based high-throughput screening

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Acta Pharmaceutica Sinica B 2024年第11期14卷 4914-4933页

作者： Chao huang Yang Jin Panpan Fu Kongying Hu Mengxue Wang Wenjing Zai Ting Hua Xinluo Song Jianyu Ye Yiqing Zhang Gan Luo Haiyu Wang Jiangxia Liu Jieliang Chen xuwen Li Zhenghong Yuan Key Laboratory of Medical Molecular Virology(MOE/NHC) Research Unit of Cure of Chronic Hepatitis B Virus Infection(CAMS)Shanghai Frontiers Science Center of Pathogenic Microbes and InfectionSchool of Basic Medical SciencesShanghai Medical College Fudan UniversityShanghai 200032China State Key Laboratory of Chemical Biology Shanghai Institute of Materia MedicaChinese Academy of SciencesShanghai 201203China Shandong Laboratory of Yantai Drug Discovery Bohai Rim Advanced Research Institute for Drug DiscoveryYantai 264117China Shanghai Institute of Infectious Disease and Biosecurity Shanghai 200032China Guixi Hospital of Chinese Medicine Guixi 335400China

Due to the limitations of current anti-HBV therapies, the HBV core (HBc or HBcAg) protein assembly modulators (CpAMs) are believed to be potential anti-HBV agents. Therefore, discovering safe and efficient CpAMs is of great value. In this study, we established a HiBiT-based high-throughput screening system targeting HBc and screened novel CpAMs from an in-house marine chemicals library. A novel lead compound 8a, a derivative of the marine natural product naamidine J, has been successfully screened for potential anti-HBV activity. Bioactivity-driven synthesis was then conducted, and the structure‒activity relationship was analyzed, resulting in the discovery of the most effective compound 11a (IC50 = 0.24 μmol/L). Furthermore, 11a was found to significantly inhibit HBV replication in multiple cell models and exhibit a synergistic effect with tenofovir disoproxil fumarate (TDF) and IFNa2 in vitro for anti-HBV activity. Treatment with 11a in a hydrodynamic-injection mouse model demonstrated significant anti-HBV activity without apparent hepatotoxicity. These findings suggest that the naamidine J derivative 11a could be used as the HBV core protein assembly modulator to develop safe and effective anti-HBV therapies.

关键词： Anti-HBV HBV coreprotein Coreproteinassembly modulators Marine natural products HiBiT

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Multi-Target Feeding-Behavior Recognition Method for Cows Based on Improved RefineMask

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SENSORS 2024年第10期24卷 2975页

作者： Li, xuwen Gao, Ronghua Li, Qifeng Wang, Rong Liu, Shanghao huang, Weiwei Yang, Liuyiyi Zhuo, Zhenyuan Tianjin Agr Univ Coll Comp & Informat Engn Tianjin 300384 Peoples R China Beijing Acad Agr & Forestry Sci Res Ctr Informat Technol Beijing 100097 Peoples R China Northwest A&F Univ Coll Informat Engn Xianyang 712100 Peoples R China Beijing Univ Agr Coll Intelligent Sci & Engn Beijing 100096 Peoples R China

Within the current process of large-scale dairy-cattle breeding, to address the problems of low recognition-accuracy and significant recognition-error associated with existing visual methods, we propose a method for recognizing the feeding behavior of dairy cows, one based on an improved RefineMask instance-segmentation model, and using high-quality detection and segmentation results to realize the recognition of the feeding behavior of dairy cows. Firstly, the input features are better extracted by incorporating the convolutional block attention module into the residual module of the feature extraction network. Secondly, an efficient channel attention module is incorporated into the neck design to achieve efficient integration of feature extraction while avoiding the surge of parameter volume computation. Subsequently, the GIoU loss function is used to increase the area of the prediction frame to optimize the convergence speed of the loss function, thus improving the regression accuracy. Finally, the logic of using mask information to recognize foraging behavior was designed, and the accurate recognition of foraging behavior was achieved according to the segmentation results of the model. We constructed, trained, and tested a cow dataset consisting of 1000 images from 50 different individual cows at peak feeding times. The method's effectiveness, robustness, and accuracy were verified by comparing it with example segmentation algorithms such as MSRCNN, Point_Rend, Cascade_Mask, and ConvNet_V2. The experimental results show that the accuracy of the improved RefineMask algorithm in recognizing the bounding box and accurately determining the segmentation mask is 98.3%, which is higher than that of the benchmark model by 0.7 percentage points;for this, the model parameter count size was 49.96 M, which meets the practical needs of local deployment. In addition, the technologies under study performed well in a variety of scenarios and adapted to various light environment

关键词： RefineMask instance segmentation feeding behavior behavioral recognition

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End-to-End Individual Pig Detection Based on Transfer Learning

End-to-End Individual Pig Detection Based on Transfer Learni...

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Pattern Recognition and Artificial Intelligence (PRAI), International Conference on

作者： Zihan huang Hao Li Xiaorui Xiong xuwen He Rui Song Mengzhen huang School of Mathematics and Computer Science Wuhan Polytechnic University Wuhan China

Nowadays, monitoring animals manually on a large scale is challenging, while external devices can provide more prosperous and accurate information. Therefore, there are already applications incorporating wearable sensors to monitor individual pigs. With continued breakthroughs in computer vision, low-cost visible light cameras can help monitor pigs. CNN-based object detection methods have been applied to individual pig detection, but most rely on hand-designed components and require prior knowledge. Based on previous researchers' progress, we propose using DETR, an end-to-end object detection method, to detect individual pigs. Also, to adapt to our natural pig farm environment, we trained the model with transfer learning to achieve an AP of 0.995 on our collected dataset.

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Numerical Simulation and Process Optimization on Hot Twist-Stretch Straightening of Ti-6Al-4V Alloy Profile

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MATERIALS 2022年第13期15卷 4522-4522页

作者： Deng, xuwen Hui, Songxiao Ye, Wenjun Liu, Rui huang, Liang GRINM Grp Co Ltd State Key Lab Nonferrous Met & Proc Beijing 100088 Peoples R China GRIMAT Engn Inst Co Ltd Beijing 101407 Peoples R China Gen Res Inst Nonferrous Met Beijing 100088 Peoples R China Huazhong Univ Sci & Technol Sch Mat Sci & Engn State Key Lab Mat Proc & Die & Mould Technol Wuhan 430074 Peoples R China

Ti-6Al-4V profiles prepared by hot extrusion are usually accompanied by bending and twisting. The hot twist-stretch straightening is an effective strategy such that the bending deflection and twisting angle can be simultaneously decreased by a single straightening process. In addition, utilizing stress relaxation effect, the residual stress and springback can be greatly reduced by holding the straightening temperature and strain constant for a period after twist-stretch straightening. In this study, the hot deformation behaviors of the Ti-6Al-4V profile were revealed by experiments. The tensile model was obtained by uniaxial tensile tests within ranges of temperatures (500-700 degrees C) and strain rates (5 x 10(-5)-1 x 10(-3) s(-1)). The creep constitutive model was acquired with stress relaxation experiments in ranges of temperatures (500-700 degrees C) and pre-strain of 1.5%. Then, the coupled thermo-mechanical model of hot twist-stretch straightening was established. Based on orthogonal experiment strategy, the effects of straightening temperature, stretch strain, and holding time on the bending deflection and torsion angle of profile were investigated systematically and the process was optimized. The straightening accuracy is significantly affected by straightening temperature and holding time. By using optimized process parameters in practical straightening experiments, the deflection/length and angle/length after straightening does not exceed 2 parts per thousand and 2.5 parts per thousand degrees/mm, respectively, which is basically consistent with the numerical simulation result.

关键词： Ti-6Al-4V profile hot twist-stretch straightening orthogonal experiment thermo-mechanical coupling model

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Atomically ordered Rh₂P catalysts anchored within hollow mesoporous carbon for efficient hydrogen production

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CHEMICAL COMMUNICATIONS 2021年第92期57卷 12345-12348页

作者： Guo, xuwen Chen, Xin huang, Yanping Min, Xiaowen Kong, Chuncai Tang, Yawen Liu, Ben Nanjing Normal Univ Jiangsu Collaborat Innovat Ctr Biomed Funct Mat Sch Chem & Mat Sci Jiangsu Key Lab New Power Batteries Nanjing 210023 Peoples R China ME Instruments Inc Huahan Sci & Technol Ind Pk Shenzhen 518118 Peoples R China Sichuan Univ Ctr Engn Expt Teaching Sch Chem Engn Chengdu 610065 Peoples R China Sichuan Univ Coll Chem Key Lab Green Chem & Technol Minist Educ Chengdu 610064 Peoples R China Shaanxi Prov Key Lab Adv Funct Mat & Mesoscop Phy Sch Phys Minist EducKey Lab Nonequilibrium Synth & Modula Xian Jiaotong Univ Xian 710049 Peoples R China

Atomically ordered Rh2P nanoclusters encapsulated within a high-surface-area hollow mesoporous carbon nanoreactor are catalytically active for hydrogen production via the electrocatalytic hydrogen evolution reaction a... 详细信息

关键词： Hydrogen production

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RETRACTED: Urban Management in the Dynamic Relationship between the Occurrence of Environmental Pollution Accidents and Economic Development in China (Retracted Article)

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JOURNAL OF ENVIRONMENTAL AND PUBLIC HEALTH 2022年第1期2022卷

作者： Cong, xuwen Wang, Huaixing huang, Jingmei Changchun Univ Sch Adm Changchun 130022 Jilin Peoples R China Northeast Normal Univ Sch Polit & Law Changchun 130024 Jilin Peoples R China

After the reform and opening up, China has developed into a world factory due to the bias of Chinese policies, the need for urban development, and the limitations of science and technology. As a world factory, on the one hand, it expanded the scale of China's economy, raised the level of science and technology, and improved the standard of people's daily life. On the other hand, China's technology level was backward at the beginning of the reform and opening-up period, and the world countries in a competitive relationship could not give China a high-end technology level. Most of the developed countries only transferred their rough industries to China, which led to the "three highs and one low" pattern of China's economic development. The efficiency of resource utilization is very low, which not only wastes resources but also causes great deterioration of the environment. Based on China's environmental development problems, this article summarizes and analyses the relationship between economic development and environmental pollution through the perspective of EKC curve research. Then, using the data of economic growth target published by government work report of 230 prefecture-level cities from 2004 to 2014 collected by hand, the constraint of economic growth target is described from three dimensions. In particular, the study of economic growth target constraints is extended in terms of the portrayal of the characteristics of soft and hard constraints of economic growth targets. Finally, combining with the normative research method, feasible countermeasures are proposed for developed cities as well as less developed cities, providing new insights for the coordinated development of the urban environment and economy in China.

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