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激光与光电子学进展 2022年第5期59卷 106-114页

作者：黄竞择梁旭文谢卓辰中国科学院微小卫星创新研究院上海201203 中国科学院大学北京100049

毫米波大规模多输入多输出系统依赖于准确的信道状态信息,然而毫米波的高频率使得用于信道估计的时间变短,以往单独利用其波束域的稀疏性或天线域的低秩特性的高复杂度估计算法不再可行。因此提出了一种新的估计算法,该算法结合了稀疏... 详细信息

毫米波大规模多输入多输出系统依赖于准确的信道状态信息,然而毫米波的高频率使得用于信道估计的时间变短,以往单独利用其波束域的稀疏性或天线域的低秩特性的高复杂度估计算法不再可行。因此提出了一种新的估计算法,该算法结合了稀疏和低秩两种特性,将信道估计看作矩阵完备问题,利用基于增广拉格朗日交替方向非精确牛顿法进行求解。经仿真验证,该算法具有更快的收敛速度和更高的准确度。

关键词：信道估计大规模MIMO 凸优化毫米波矩阵完备化

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Theoretical Analysis and Numerical Simulation of the Motion of RDX Deflagration-Driven Flyer Plate Based on Laser-Initiated Micro-Pyrotechnic Devices

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MICROMACHINES 2023年第5期14卷 917-917页

作者： Xian, Mingchun Zhao, Kang Liu, xuwen Meng, Yangang Xie, Junyao Li, Jingwei Tong, Lele huang, Meng Wu, Lizhi Nanjing Univ Sci & Technol Sch Chem & Chem Engn Nanjing 210094 Peoples R China Sichuan Aerosp Chuannan Pyrotech Co Ltd Luzhou 646000 Peoples R China Jianghan Univ State Key Lab Precis Blasting Wuhan 430056 Peoples R China

Miniaturized laser-initiated pyrotechnic devices have great application prospects in aerospace and modern weapon systems due to their excellent energy output performance and reliability. In order to develop a low-energy insensitive laser detonation technology based on a two-stage charge structure, it is important to deeply analyze the motion law of a titanium flyer plate driven by the deflagration of the first-stage charge (RDX). The effects of the charge mass of RDX, flyer plate mass, and barrel length on the motion law of flyer plates were studied through a numerical simulation method based on the Powder Burn deflagration model. The consistency between the numerical simulation and the experimental results was analyzed using the paired t confidence interval estimation method. The results show that the Powder Burn deflagration model can effectively describe the motion process of the RDX deflagration-driven flyer plate with a 90% confidence level, and its velocity error is =6.7%. The speed of the flyer plate is proportional to the mass of the RDX charge, inversely proportional to the mass of the flyer plate, and exponentially related to its moving distance. As the moving distance of the flyer plate increases, the RDX deflagration products and air in front of the flyer plate are compressed, which inhibits the motion of the flyer plate. In the optimum state (the mass of the RDX charge is 60 mg, the mass of the flyer is 85 mg, and the length of the barrel is 3 mm), the speed of the titanium flyer reaches 583 m/s, and the peak pressure of the RDX deflagration reaches 2182 MPa. This work will provide a theoretical basis for the refined design of a new generation of miniaturized high-performance laser-initiated pyrotechnic devices.

关键词： laser-initiated deflagration-driven flyer plate powder burn

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Multiomics strategy reveals the accumulation and biosynthesis of bitter components in Zanthoxylum schinifolium Sieb. et Zucc

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FOOD RESEARCH INTERNATIONAL 2022年第PartA期162卷 111964页

作者： huang, Shan Wang, Lu Wang, Zhirong Yang, Gang Xiang, xuwen An, Yuanzhe Kan, Jianquan Southwest Univ Coll Food Sci 2 Tiansheng Rd Chongqing 400715 Peoples R China Yangzhou Univ Sch Food Sci & Engn Yangzhou 225127 Jiangsu Peoples R China Minist Agr & Rural Affairs Peoples Republic of Chi Lab Qual & Safety Risk Assessment Agroprod Storage Chongqing 400715 Peoples R China Chinese Hungarian Cooperat Res Ctr Food Sci Chongqing 400715 Peoples R China Chongqing Key Lab Speciality Food Co-Built Sichuan Chongqing 400715 Peoples R China

The perceptible bitterness of Zanthoxylum schinifolium Sieb. et Zucc is an important factor limiting its con-sumption. Metabolomics was used to identify potentially bitter metabolites during the development of Z. schinifolium, and dynamic changes in 17 key bitter components were characterized. The key bitter components in Z. schinifolium at different developmental stages were mainly synthesized through the "phenylpropanoid biosynthesis", "flavonoid biosynthesis", and "flavone and flavonol biosynthesis" pathways. In combination with transcriptomic data, the expression of related genes regulates the accumulation process of these bitter compo-nents;based on this, a biosynthetic pathway of bitter components in Z. schinifolium was constructed. In addition, quercetin-3-galactoside, isoquercitin, quercitrin, kaempferol, and isorhamnetin were identified as the main sources of bitterness in mature Z. schinifolium based on an evaluation of taste activity value. These findings provide valuable information for understanding mechanisms underlying Z. schinifolium bitterness and promoting the further development of high-quality Z. schinifolium.

关键词： Zanthoxylum schinifolium Sieb et Zucc Bitter sensory evaluation Bitter component Transcriptomics Metabolomics Biosynthesis

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Impact of gender and age on 6-Minute Walking Test performance of patients with coronary heart disease compared to healthy elders 43

Impact of gender and age on 6-Minute Walking Test performanc...

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43rd Annual International Conference of the IEEE-Engineering-in-Medicine-and-Biology-Society (IEEE EMBC)

作者： Liu, Lin Ma, Mei Yang, xuwen Yang, Yifan huang, Xiayu Meng, Lin Ming, Dong Tianjin Univ Acad Med Engn & Translat Med Tianjin 300072 Peoples R China Tianjin Univ Chest Hosp Tianjin 300072 Peoples R China Tianjin Univ Int Engn Inst Tianjin 300072 Peoples R China

ISBN: (纸本)9781728111797

The performance of 6-minute walking test (6MWT) of patients with coronary heart disease (CHD) was significantly related to patients' cardiopulmonary functions. The 6MWT may provide prognostic information for patients. However, the impact of gender and age on the 6MWT performance and related cardiopulmonary parameters of patients with CHD compared to the healthy group has not be fully investigated and discussed. In this study, a total of 118 subjects, including 70 CHD patients and 48 healthy elders, were enrolled. The subjects performed the 6MWT while fourteen cardiopulmonary parameters were measured during the task and the walking distance was recorded at the end. Factors of gender, age, and disease on the 6MWT performance were analyzed using multivariate analysis of variance and the parameters between the patients and healthy people in age- and gender-specific subgroups were compared by Pearson's correlation coefficient. Results showed that age (60-65 and >= 65 years) and gender significantly influenced the 6MWT performance of subjects. Featured parameters were observed in older subgroups (>= 65 years) between the patients and healthy people while patients aged 60-65 had similar 6MWT performance with the healthy control group. It would be potential to distinguish patients with CHD from healthy elders based on the 6MWT where factors of age and gender should be considered.

关键词： 6-minute walking test walking distance coronary heart disease cardiopulmonary function

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NIR light-driven photocatalytic NAD(P)H oxidation and H2O2 generation in situ for enhanced chemodynamic therapy and immune response

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NANO TODAY 2023年第1期50卷

作者： Zhang, Chao huang, Jia Guo, Xusheng Da, xuwen Dai, Zhifei Hassan, Moustapha Yu, Yingjie Wang, Xuesong Zhou, Qianxiong Chinese Acad Sci Tech Inst Phys & Chem Key Lab Photochem Convers & Optoelect Mat Beijing 100190 Peoples R China Univ Chinese Acad Sci Beijing 100049 Peoples R China China Japan Friendship Hosp Dept Hepatobiliary Surg Beijing 100029 Peoples R China Peking Univ Coll Future Technol Natl Biomed Imaging Ctr Dept Biomed Engn Beijing Peoples R China Karolinska Inst Dept Lab Med LABMED Div Expt Canc Med SE-14186 Stockholm Sweden Karolinska Univ Hosp Huddinge Clin Res Ctr SE-14186 Stockholm Sweden Karolinska Univ Hosp Huddinge Ctr Allogene Stem Cell Transplantat CAST SE-14186 Stockholm Sweden Beijing Univ Chem Technol State Key Lab Organ Inorgan Composites Beijing Lab Biomed Mat Beijing 100029 Peoples R China

Chemodynamic therapy (CDT) is an appealing cancer treatment that converts endogenous H2O2 into highly toxic hydroxyl radicals to kill cancer cells. However, the limited amount of H2O2 in tumor cells constrains the application of CDT. Therefore, the strategy that can increase H2O2 level in situ could broaden its clinical application. Herein, we synthesized a supramolecule [Ru(bpy)2(Nabpy)](PF6)2 (Ru1) which can efficiently photo-catalyze NAD(P)H oxidation with simultaneous generation of H2O2 with a high yield at 76.4 %. The Ru1 and Fe2+ were then loaded on the mesoporous silica-encapsulated rare earth-doped upconversion nanoparticles (UCSRF), the intracellular H2O2 level can be elevated by 2.8 times upon the irradiation of near-infrared (NIR) light irradiation. Then, the intracellular H2O2 was transformed into hydroxyl radicals through Fenton reaction to achieve efficient CDT both in vitro and in vivo. Furthermore, we demonstrated that UCSRF could effectively enhance immunogenic cell death (ICD) effect, resulting in the reprogramming of the immunosuppressive tumor microenvironment to stimulate immune response. This work represents the first proof-of-concept study on photo-catalytically enhancing H2O2 production in situ upon NIR irradiation for spatiotemporal CDT.(c) 2023 Elsevier Ltd. All rights reserved.

关键词： Chemodynamic therapy Photocatalytic NAD(P)H oxidation Immunotherapy Upconversion nanoparticle

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再生集料沥青混凝土物理力学性能的试验研究

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武汉大学学报（工学版） 2022年第10期55卷 1027-1033页

作者：刘元德安旭文黄天翔甘肃省张掖公路事业发展中心甘肃张掖734000 武汉大学土木建筑工程学院湖北武汉430072 湖北省交通投资集团有限公司湖北武汉430050

根据道路等级、气候条件和路面混凝土的功能要求,以道路废弃混凝土为再生集料,设计了粗粒式密级配AC-25C型、中粒式密级配AC-16C型和玛蹄脂SMA-20型沥青混凝土,以再生集料取代率和沥青用量为试验变化参数,制作了标准的马歇尔试件,分别... 详细信息

根据道路等级、气候条件和路面混凝土的功能要求,以道路废弃混凝土为再生集料,设计了粗粒式密级配AC-25C型、中粒式密级配AC-16C型和玛蹄脂SMA-20型沥青混凝土,以再生集料取代率和沥青用量为试验变化参数,制作了标准的马歇尔试件,分别对再生集料沥青混凝土的密度、稳定度、流值进行了试验研究。结果表明:按建议级配配置的再生集料沥青混凝土,可根据需要用于高速公路、一级公路和其他等级的公路路面。研究成果不仅可为废弃混凝土的再生利用提供试验依据和技术支持,还可为同类工程提供参考。

关键词：废弃混凝土再生集料试验研究沥青混凝土

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电催化反应器内进水方式及电流分布的实验研究

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黑龙江科技大学学报 2025年第1期35卷 59-64页

作者：黄琳琳张绪雯韩继伟黑龙江科技大学环境与化工学院哈尔滨150022 黑龙江省公路桥梁勘测设计院有限公司哈尔滨150090

为优化圆柱形电催化反应器内的进水方式及电极间距,利用CFD和COMSOL模拟反应器内流体流动过程中的速度分布,并通过实验方法验证模拟结果的准确性。结果表明:进水方式为切向时反应器传质性能最佳,此时电极表面速度分布较均匀,利于提高反... 详细信息

为优化圆柱形电催化反应器内的进水方式及电极间距,利用CFD和COMSOL模拟反应器内流体流动过程中的速度分布,并通过实验方法验证模拟结果的准确性。结果表明:进水方式为切向时反应器传质性能最佳,此时电极表面速度分布较均匀,利于提高反应过程中溶液分布的一致性和空间利用率,进水流速为0.062 m/s时切向进水的极限电流为0.032 m/s时的1.25倍,增大进水流速能够提高体系的传质性能;适当增加电极间距能够促进均匀的电流分布,当电极间距为15 mm时,反应2 h后,TOC去除率可达89.7%。

关键词：电催化反应器进水方式电极间距传质性能

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A novel nano-thermite system with BiOF as fluorine-containing oxidant for enhanced energy release performance

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CHEMICAL ENGINEERING JOURNAL 2023年第1期468卷

作者： Li, Jingwei Liu, xuwen huang, Qian Liu, Feifan Xie, Quanmin Hu, Maocong Su, Jiaxin Zhang, Chengchen Zeng, Yuyang Zhu, Chenguang Nanjing Univ Sci & Technol Sch Chem & Chem Engn Nanjing 210094 Peoples R China Jianghan Univ State Key Lab Precis Blasting Wuhan 430113 Peoples R China Shaanxi Appl Phys Chem Res Inst Sci & Technol Appl Phys Chem Lab Xian 710061 Peoples R China

The reduced diffusion distance of nano-thermite results in an exceptionally high energy release rate and intense exothermic reactions upon ignition, which has drawn significant interest from researchers in the field of energetic materials. With the deepening of research, metal fluorides are gradually favored by researchers because of their unique reaction characteristics. This paper presents the synthesis of a new fluorine-containing oxidant, BiOF, and its use in the preparation of a novel nano-thermite with n-Al. BiOF crystals exhibit a unique microscopic morphology and are interlaced into "nanoflower" microspheres, which allows for good interfacial contact between the oxidant and fuel during the recombination process. The resulting n-Al/BiOF system displays excellent ignition and combustion performance, with a combustion temperature higher than the boiling point of its main combustion products, AlF3 and Bi. Compared with n-Al/CuO and n-Al/MoO3 systems, n-Al/BiOF exhibits a higher flame propagation rate under confinement. In addition, the ignition threshold of the n-Al/BiOF system is also smaller than that of the n-Al/CuO and n-Al/MoO3 systems. Furthermore, the paper examines the reaction mechanism of the n-Al/BiOF system through thermal reaction path analysis and combustion and thermal analysis product characterization. The paper discovers a "pre-ignition" reaction mechanism before the ignition temperature, where the strongly electronegative fluorine in BiOF corrodes the Al2O3 shell, promoting the release of aluminum energy. The synergistic and effective interaction between oxygen, fluorine, and fuel aluminum in the n-Al/BiOF system results in efficient energy release performance, making BiOF a promising candidate for n-Al based reactive materials in propellants, explosives, and pyrotechnic products.

关键词： Nano-thermites Nanostructured energetic materials Conformational relationships Fluorinated oxidizing agent Pre-ignition reaction

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High-performance carbon-electrode-based self-powered optoelectronic synaptic devices

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Science China(Information Sciences) 2024年第5期67卷 339-340页

作者： Wen huang xuwen XIA Huixing ZHANG Tenglong GUO Pengjie HANG Bin LI Jiawei TANG Biao LI Chen ZHU Lei WANG Deren YANG Xuegong YU Xing'ao LI Jiangsu Provincial Engineering Research Center of Low Dimensional Physics and New Energy & School of Science Nanjing University of Posts and Telecommunications College of Integrated Circuit Science and Engineering Nanjing University of Posts and Telecommunications State Key Laboratory of Silicon and Advanced Semiconductor Materials Zhejiang University

A two-terminal self-powered optoelectronic structure could mimic synaptic functions of a human brain synapse unit(Figure 1(a)) based on the photovoltaic effects [1], demonstrating the potential for decreasing energy consumption for future computing. However, current self-powered optoelectronic synaptic devices face issues of stability and cost,which mainly arise from noble metal electrodes and independent hole transport layers used in these structures. Substituting low-cost carbon for these metal electrodes and carrier transport layers may promise to solve these challenges.

关键词： electrode devices carbon high based optoelectronic performance self-powered synaptic

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Arbidol/IFN-a2b therapy for patients with corona virus disease 2019: a retrospective multicenter cohort study

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MICROBES AND INFECTION 2020年第4-5期22卷 200-205页

作者： Xu, Ping huang, Jianping Fan, Zhao huang, Wendi Qi, Minghua Lin, xuwen Song, Weidong Yi, Li Peking Univ Shenzhen Hosp Dept Resp & Crit Care Med Shenzhen 518036 Guangdong Peoples R China Hubei Jianli People Hosp Dept Infect Dis Jingzhou 433300 Hubei Peoples R China Peking Univ Dept Emergency Shenzhen Hosp Shenzhen Guangdong Peoples R China Peking Univ Dept Neurol Shenzhen Hosp 1120 Lianhua Rd Futian Area Shenzhen 518036 Guangdong Peoples R China

The spread of COVID-19 is accelerating. At present, there is no specific antiviral drugs for COVID-19 outbreak. This is a multicenter retrospective cohort study of patients with laboratory-confirmed COVID-19 infection pneumonia from 3 hospitals in Hubei and Guangdong province, 141 adults (aged ≥18 years) without ventilation were included. Combined group patients were given Arbidol and IFN-α2b, monotherapy group patients inhaled IFN-α2b for 10-14 days. Of 141 COVID-19 patients, baseline clinical and laboratory characteristics were similar between combined group and monotherapy group, that 30% of the patients leucocytes counts were below the normal range and 36.4% of the patients experienced lymphocytopenia. The duration of viral RNA of respiratory tract in the monotherapy group was not longer than that in the combined therapy group. There was no significant differences between two groups. The absorption of pneumonia in the combined group was faster than that in the monotherapy group. We inferred that Arbidol/IFN - 2 b therapy can be used as an effective method to improve the COVID-19 pneumonia of mild patients, although it helpless with accelerating the virus clearance. These results should be verified in a larger prospective randomized environment.

关键词： COVID-19 2019-nCoV Pneumonia Arbidol IFN-α2b Treatment RNA

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