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Lymphoma cell-driven IL-16 is expressed in activated B-cell-like diffuse large B-cell lymphomas and regulates the pro-tumor microenvironment

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HAEMATOLOGICA 2025年第2期110卷 425-438页

作者： Guan, xuwen Wang, Yi Fang, Teng Wang, Jingya li, Ru Hao, Mu Qiu, Lugui Chinese Acad Med Sci & Peking Union Med Coll Inst Hematol & Blood Dis Hosp Natl Clin Res Ctr Blood Dis State Key Lab Expt HematolHaihe Lab Cell Ecosyst Tianjin Peoples R China Tianjin Inst Hlth Sci Tianjin Peoples R China Tianjin First Cent Hosp Dept Hematol Tianjin Peoples R China Nankai Univ Affiliated Cent Hosp 1 Dept Hematol Tianjin Peoples R China Tianjin Med Univ Tianjin Med Univ Canc Inst & Hosp Natl Clin Res Ctr Canc Tianjin Peoples R China Tianjin Med Univ Tianjin Canc Inst & Hosp Key Lab Canc Prevent & Therapy Tianjin Peoples R China Tianjin Med Univ Tianjin Canc Inst & Hosp Tianjins Clin Res Ctr Canc Tianjin Peoples R China Tianjin Med Univ Tianjin Canc Inst & Hosp Tianjin Lung Canc Ctr Dept Thorac Oncol Tianjin Peoples R China

The activated B-cell-like subtype of diffuse large B-cell lymphoma (ABC-DLBCL) displays a worse outcome than the germinal center B-cell-like subtype (GCB-DLBCL). Currently, targeting the tumor microenvironment (TME) is the most promising approach to cure DLBCL with profound molecular heterogeneity;however, the factors affecting the tumor-promoting TME of ABC-DLBCL remain elusive. Here, cytokine interleukin-16 (IL-16) is expressed in tumor cells of ABC-DLBCL and secreted by the cleavage of active caspase-3. The serum IL-16 levels are not only a sensitive marker of treatment response, but also positively correlated with unfavorable prognosis in DLBCL patients. While IL-16 shows few direct promotional effects on tumor cell growth in vitro, its bioactive form significantly promotes tumor progression in vivo. Mechanically, IL-16 increases the infiltration of macrophages by the chemotaxis of CD4+ monocytes in the TME, enhancing angiogenesis and the expression of cytokine IL-6 and IL-10, as well as decreasing T-cell infiltration to accelerate tumor progression. This study demonstrates that IL-16 exerts a novel role in co-ordinating the bidirectional interactions between tumor progression and the TME. IMM0306, a fusion protein of CD20 mAb with the CD47 binding domain of SIRP alpha, reverses the tumor-promoting effects of IL-16, providing new insights into treatment strategy in ABC-DLBCL.

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Boosting catalytic performance of N doped porous carbon derived from coal tar pitch: The role of N species and the contribution of 1O2

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JOURNAL OF WATER PROCESS ENGINEERING 2025年 72卷

作者： Huang, linlin Zhang, xuwen Wang, lin liu, Tingting li, Da Sheng, Tao Sun, Caiyu li, lixin Heilongjiang Univ Sci & Technol Coll Environm & Chem Engn Harbin 150022 Peoples R China Harbin Inst Technol State Key Lab Urban Water Resource & Environm Harbin 150090 Peoples R China

In this study, nitrogen-doped carbon material (N-PC-d) derived from coal tar pitch using dicyandiamide as N source was successfully synthesized, exhibiting outstanding catalytic performance in the activation of peroxymonosulfate (PMS) for the degradation of Orange G (OG). By optimizing key parameters such as PMS dosage, NPC dosage, nitrogen source, pH, anions, and PS source, the optimal N-PC-d/PMS system achieved a degradation rate 1.45 times higher than that of the PC/PMS system within a broad pH range (2.0-10.0). Through electron paramagnetic resonance (EPR) and quenching experiments, it was found that singlet oxygen (1O2) was the predominant species accountable for OG degradation, while reactive oxygen species (ROS), including superoxide (O2 & sdot;-), hydroxyl radicals (& sdot;OH), and sulfate radicals (SO4 & sdot;-), played auxiliary roles. Moreover, the structure-activity relationship analysis revealed that functional groups such as C--C, C--O, and pyridine N were mainly involved in PMS activation. The degradation mechanism of OG was further elucidated by high-performance liquid chromatography-mass spectrometry (HPLC-MS). This research presented a cost-efficient N-doped porous carbon material for environmental remediation and provides more profound insights into the mechanisms of PMS activation by N doped carbon-based materials.

关键词： N-doped porous carbon Coal tar pitch PMS Singlet oxygen Orange G

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Finely-Tuning Chemiluminescent Color of CdTe Nanocrystals and Its Application for Near-Infrared Semi-Automatic Immunoassay

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ANALYTICAL CHEMISTRY 2024年第19期96卷 7643-7650页

作者： Ren, Xiaoxuan Tian, Zhijian Gao, xuwen Ai, Yaojia li, Mengwei Zhang, Bin Zou, Guizheng Shandong Univ Sch Chem & Chem Engn Jinan 250100 Peoples R China

Chemiluminescence (CL), especially commercialized CL immunoassay (CliA), is normally performed within the eye-visible region of the spectrum by exploiting the electronic-transition-related emission of the molecule luminophore. Herein, dual-stabilizers-capped CdTe nanocrystals (NCs) is employed as a model of nanoparticulated luminophore to finely tune the CL color with superior color purity. Initialized by oxidizing the CdTe NCs with potassium periodate (KIO4), intermediates of the reactive oxygen species (ROS) tend to charge CdTe NCs in both series-connection and parallel-connection routes and dominate the charge-transfer CL of CdTe NCs. The CdTe NCs/KIO4 system can exhibit color-tunable CL with the maximum emission wavelength shifted from 694 nm to 801 nm, and the red-shift span is over 100 nm. Both PL and CL of each of the CdTe NCs are bandgap-engineered;the change in the NCs surface state via CL reaction enables CL of each of the CdTe NCs to be red-shifted for similar to 20 nm to PL, while the change in the NCs surface state via labeling CdTe NCs to secondary-antibody (Ab(2)) enables CL of the CdTe NCs-Ab(2) conjugates to be red-shifted for another similar to 20 nm to bare CdTe NCs. The CL of CdTe753-Ab(2)/KIO4 is similar to 791 nm, which can perform near-infrared CL immunoassay and semi-automatically determined procalcitonin (PCT) on commercialized in vitro diagnosis (IVD) instruments.

关键词： Color Monomers Oxygen Peptides and proteins Quantum mechanics

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Studies on New Steroidal Saponins from Allii macrostemonis Bulbus and Their Antitumor Activities

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Chemical Research in Chinese Universities 2018年第1期34卷 61-66页

作者： YAO Hua WANG Tong WU Qian liU Ying li Peng li xuwen JIN Yongri Scienttfic Research Center China-Japan Union Hospital of Jilin University Changchun 130033 P. R. China College of Chemistry Jilin University Changchun 130012 P. R. China

Two new steroidal saponms（2, 3） and two known compounds（1, 4） were isolated from 75% ethanol extract ofAllii macrostemonis bulbus by various spectral methods. The two new steroidal saponins were respectively elucidated as （25S）-26-O-β-D-glucopyranosyl-5α-furostanol-2α,3β,22,26-tetrol-3-O-β-D-glucopyranosyl（1→2）-[β-D- glucopyranosyl（1→3）]-β-D-glucopyranosyl（1→4 ）-β-D-galactopyranoside（2 ） and 26-O-β-D-glucopyranosyl-5α- furostanol-25（ 27）-ene-3β,22,26-tetrol-3-O-β-D-glucopyranosyl（ 1→2 ）-[β-D-glucopyranosyl（ 1→3 ）] -β-D-glucopyranosyl- （1→4）-β-D-galactopyranoside（3）. Compound 4 was obtained from this medical plant for the first time. The activity experiments of proliferation inhibition on tumor cells were performed by cell counting kit-8（CCK-8） method for compound 2（25S-configuration） and its isomer（compound 1, 25R-configttration）. The results show that compounds 1 and 2 have weak inhibition on lung cancer A549 cells, melanoma A375 cells and breast cancer MCF-7 cells as well as certain inhibitory effect on liver cancer HepG2 cells, and the inhibitory effect of compound 1 is stronger than that of compound 2.

关键词： Allii macrostemonis bulbus Steroidal saponin Structure identification Proliferation inhibition Cell counting kit-8（CCK-8） method

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The antiallergic activity of flavonoids extracted from Citri Reticulatae Pericarpium

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JOURNAL OF FOOD PROCESSING AND PRESERVATION 2018年第4期42卷 e13588-e13588页

作者： Shi, Xiaolei Niu, liyan Zhao, lina Wang, Bo Jin, Yongri li, xuwen Jilin Univ Dept Food Qual & Safety Coll Food Sci & Engn Changchun 130062 Jilin Peoples R China Jilin Univ Dept Analyt Chem Coll Chem Changchun 130012 Jilin Peoples R China

The fruits of Citrus are popular all over the world. It was reported that the extracts of fruits possessed antiallergic activities. In China, Citri Reticulatae Pericarpium (CRP) is a production of peels. In this study, flavonoids were extracted by solvent method, and enriched by polyamide. Then antiallergic activity of flavonoids was investigated in vivo and in vitro. Under optimal parameters, most abundant compounds of extracts were hesperidin and narirutin, their contents were 232.0325 and 98.7946 mg/g, respectively. In vitro, RBL-2H3 cell line was used to investigate the antiallergic activity. As the results shown, -hexosaminidase release of antigen-induced degranulation was decreased by flavonoids. An ovalbumin-induced allergic asthmatic model was used to test the activity of the flavonoids in vivo. After treated with different concentrations of flavonoids, the levels of IgE, IL-4, and IL-13 decreased significantly. These findings provide evidence that flavonoids extracted from CRP have potential using in antiallergic therapeutic area. Practical applicationsOranges are popular all over the world as fruit, besides a little percent of peels are applied as traditional medicine in China, the others are thrown away as rubbish. To explore the new way to extend the application of peels, we extracted the total flavonoids from Citri Reticulatae Pericarpium (CRP) and evaluated the antiallergic activity of it. Fortunately, the total flavonoids have antiallergic activity in vitro and vivo. The findings provide evidence that extracts from CRP have potential using in antiallergic therapeutic area. It can also afford a theoretical basis for the new application of orange peel.

关键词： Citrus fruits

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Multidisciplinary optimization of electromagnetic linear actuators for direct-drive systems with a combination of static and dynamic performance

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COMPEL-THE INTERNATIONAL JOURNAL FOR COMPUTATION AND MATHEMATICS IN ELECTRICAL AND ELECTRONIC ENGINEERING 2023年第2期42卷 476-493页

作者： Chi, xuwen Tan, Cao li, Bo Lu, Jiayu Gu, Chaofan Fu, Changzhong Shandong Univ Technol Sch Transportat & Vehide Engn Zibo Peoples R China Shandong Zhongbaokang Med Equipment Co Zibo Peoples R China

Purpose The purpose of this paper is to solve the common problems that traditional optimization methods cannot fully improve the performance of electromagnetic linear actuators (EMLAs). Design/methodology/approach In this paper, a multidisciplinary optimization (MDO) method based on the non-dominated sorting genetic algorithm-II (NSGA-II) algorithm was proposed. An electromagnetic-mechanical coupled actuator analysis model of EMLAs was established, and the coupling relationship between static/dynamic performance of the actuator was analyzed. Suitable optimization variables were designed based on fuzzy grayscale theory to address the incompleteness of the actuator data and the uncertainty of the coupling relationship. A multiobjective genetic algorithm was used to obtain the optimal solution set of Pareto with the maximum electromagnetic force, electromagnetic force fluctuation rate, time constant and efficiency as the optimization objectives, the final optimization results were then obtained through a multicriteria decision-making method. Findings The experimental results show that the maximum electromagnetic force, electromagnetic force fluctuation rate, time constants and efficiency are improved by 18.1%, 38.5%, 8.5% and 12%, respectively. Compared with single-discipline optimization, the effectiveness of the multidiscipline optimization method was verified. Originality/value This paper proposes a MDO method for EMLAs that takes into account static/dynamic performance, the proposed method is also applicable to the design and analysis of various electromagnetic actuators.

关键词： Electromagnetic linear actuator Fuzzy grayscale theory Multidisciplinary optimization Performance analysis Multicriteria decision-making Mechatronics Actuators Power losses Pareto optimization Coupled systems

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Luminophore-Surface-Engineering-Enabled Low-Triggering-Potential and Coreactant-Free Electrochemiluminescence for Protein Determination

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ANALYTICAL CHEMISTRY 2023年第17期95卷 6948-6954页

作者： Gao, xuwen Ren, Xiaoxuan Ai, Yaojia li, Mengwei Zhang, Bin Zou, Guizheng Shandong Univ Sch Chem & Chem Engn Jinan 250100 Peoples R China

Coreactant-free electrochemiluminescence (ECL) is promising for removing the exogenous effects of coreactant and simplify the operation procedures and setups of commercialized ECL bioassays. Herein, an electrosterically involved strategy for achieving a low-triggering-potential (+0.21 V vs Ag/AgCl) and coreactant-free ECL from dual-stabilizer-capped CdTe nanocrystals (NCs) is proposed with mercaptopropionic acid (MPA) and hexametaphosphate (HMP) as the capping agents of luminophores. Upon employing the CdTe NCs as the ECL tag for the immunoassay, all the tags in the bioconjugates of the CdTe NCs and the secondary antibody (Ab2|CdTe) as well as in the final achieved sandwich-type immunocomplexes can exhibit efficient coreactant-free ECL with an electrosterically involved triggering potential nature. The bioconjugates of Ab2|CdTe with Ab2 no more than 30 kDa, such as the thyroid stimulating hormone (30 kDa) and the recombinant pro-gastrin releasing peptide (ProGRP, 14 kDa), merely exhibit coreactant-free ECL around +0.24 V, while bioconjugates of Ab2| CdTe with an Ab2 beyond 30 kDa only give off coreactant-free ECL around +0.82 V. Due to the further enhanced electrosteric effect in sandwich-type immunocomplexes, only the ECL immunosensor with ProGRP as the target can give off coreactant-free ECL around +0.24 V. The electrosterically involved and coreactant-free ECL of CdTe NCs is consequently utilized to sensitively and selectively determine the molecular protein ProGRP, which demonstrates a wide linearity range from 0.1 to 2000 pg/mL and a low limit of detection at 0.05 pg/mL (S/N = 3). This low-triggering-potential and coreactant-free combined ECL platform indicates that engineering the surface of CdTe NCs with a protein can improve the performance of ECL tags in a protein-weight-involved electrosterical way.

关键词： Electrochemiluminescence Luminophore

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Assessment of pharmacological effects and abuse potential of 5F-EDMB-PICA, CUMYL-PEGACLONE, and NM-2201 in mice

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PSYCHOPHARMACOLOGY 2025年第3期242卷 533-544页

作者： li, Kaixi Xu, Deli Qiao, Yanling Kuai, lixin Luo, xuwen Di, Bin Xu, Peng China Pharmaceut Univ Sch Pharm Nanjing 210009 Peoples R China Off China Natl Narcot Control Commiss Pharmaceut Univ Joint Lab Key Technol Narcot Contr Beijing 100193 Peoples R China Minist Publ Secur Drug Intelligence & Forens Ctr Key Lab Drug Monitoring & Control Beijing 100193 Peoples R China

Rationale The newly emerging synthetic cannabinoids (SCs) 5F-EDMB-PICA, CUMYL-PEGACLONE, and NM-2201 have been observed to produce effects by activating cannabinoid type 1 (CB1) receptors. Nevertheless, the pharmacological effects and potential for abuse of these three substances remain to be studied. These substances have yet to be regulated in many countries. Objectives We investigated the safety, pharmacological effects, rewarding effects, and cannabinoid withdrawal of 5F-EDMB-PICA, CUMYL-PEGACLONE, and NM-2201. Methods This study evaluated the drug safety and the cannabinoid-specific pharmacological effects of the three substances through acute toxicity experiments (in which the LD50 of each substance was obtained) and tetrad experiments (comprising assessments of hypothermia, analgesia, locomotion inhibition, and catalepsy). Furthermore, the conditioned place preference (CPP) experiments and withdrawal experiments were conducted to evaluate the rewarding effect and cannabinoid withdrawal potential of the substances in question. Results The results demonstrated that all three drugs exhibited certain acute toxic effects and could potentially induce tetrad effects. The data were analyzed using non-linear regression, and the corresponding ED50 values and 95% confidence intervals (CI) were obtained. The rank order of potency was determined to be CUMYL-PEGACLONE > 5F-EDMB-PICA > NM-2201. In the CPP experiments, it was demonstrated that 5F-EDMB-PICA significantly induced an increase in CPP score at a dose of 0.3 mg/kg, while NM-2201 caused an increase in CPP score and a significant aversion effect at a dose of 2 and 3 mg/kg, respectively. It is noteworthy that all three types of SCs were observed to produce a significant biphasic effect, indicating that CPP scores were biphasic for all compounds. Following the administration of the CB1 receptor antagonist rimonabant, a notable increase in head twitches and paw tremors was observed, indicating that these three SCs indu

关键词： 5F-EDMB-PICA CUMYL-PEGACLONE NM-2201 Acute toxicity Tetrad effects CPP Withdrawal

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Beyond transcription, aryl hydrocarbon receptor plays a protective role in periodontitis by interacting with CaMKII

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JOURNAL OF PERIODONTOLOGY 2025年第1期96卷 67-81页

作者： Zeng, xuwen Feng, Meiting Lu, Jiawei Wang, Ruiling Deng, li Yang, Yanan Luo, lijun Tongji Univ Stomatol Hosp Shanghai Engn Res Ctr Tooth Restorat & Regenerat Dept Periodontol Shanghai Peoples R China Tongji Univ Shanghai Engn Res Ctr Tooth Restorat & Regenerat Dent Sch Shanghai Peoples R China Univ Porto Inst Res & Innovat Hlth i3S Inst Invest & Inovacao Saude Porto Portugal Univ Porto Inst Mol & Cell Biol IBMC Inst Biol Mol & Celular Porto Portugal

Background: The aryl hydrocarbon receptor (AhR) has been studied as an intracellular pattern recognition receptor that can identify bacterial pigments. To identify a potential therapeutic target for periodontitis, we investigated the expression of AhR in periodontitis and its role in the pathogenesis of periodontitis. Methods: First, we analyzed AhR expression in a single-cell dataset from human periodontal tissue. Quantitative polymerase chain reaction (qPCR), immunofluorescence, and immunohistochemistry were used to verify the AhR level. Later, we determined the phenotypes of ligature-induced periodontitis in myeloid-specific AhR-deficient mice (Lyz2-Cre(+/-) AhR(fx/fx)), after which RNA sequencing (RNA-seq), qPCR, Western blot, immunofluorescence, and immunohistochemistry were used to investigate the impacts of AhR on periodontitis and its mechanism. Finally, we determined the therapeutic effect of AhR agonist 6-Formylindolo[3,2-b]carbazole (FICZ) administration on murine periodontitis and verified the effects of FICZ on macrophage polarization in vitro. Results: AhR expression was enhanced in macrophages from periodontitis patients. Deletion of AhR from macrophages aggravated ligature-induced periodontitis and promoted the inflammatory response. Calcium/calmodulin-stimulated protein kinase II (CaMKII) phosphorylation was accelerated in AhR-deficient macrophages. Inhibiting CaMKII phosphorylation ameliorated periodontitis in Lyz2-Cre(+/-) AhR(fx/fx) mice. FICZ treatment blocked alveolar bone loss and relieved periodontal inflammation. FICZ diminished M1 macrophage polarization and promoted M2 macrophage polarization upon M1 macrophage induction. Conclusion: AhR played a protective role in the pathogenesis of periodontitis by orchestrating macrophage polarization via interacting with the CaMKII signaling pathway.

关键词： aryl hydrocarbon receptor CaMKII macrophage pattern recognition receptor periodontitis

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Energetic metal salts based on 3-cyano-1,5-(5-nitro-1,2,4-triazolyl) formazan: Synthesis, crystal structure, thermal stability, and catalysis on the thermal decomposition of ammonium perchlorate

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STRUCTURAL CHEMISTRY 2025年 1-11页

作者： Xia, Jianglu Zhang, Guojie li, Bin Duan, xuwen Yan, Biao Sha, Kailei Pei, Chonghua Wu, Bo Southwest Univ Sci & Technol State Key Lab Environm Friendly Energy Mat Mianyang 621000 Peoples R China Luzhou North Chem Ind Co Ltd Luzhou Peoples R China

Ammonium perchlorate (AP) serves as an important component in solid propellants. Adding catalysts to facilitate its thermal decomposition can enhance the combustion performance of solid propellants. Inspiring by the remarkable thermal stability and resistance to mechanical stimuli of the 3-cyano-1,5-(5-nitro-1,2,4-triazolyl) formazan, four energetic metal salts with 3-cyano-1,5-(5-nitro-1,2,4-triazolyl) formazan as energy storage units were synthesized and well characterized. The molecular structures of the compounds 1-2 were confirmed by single-crystal X-ray diffraction. The thermal behaviors and sensitivities of these new four energetic metal salts were determined by the differential scanning calorimetry (DSC) and BAM methods. These new four energetic metal salts possess excellent thermal stability with decomposition peak temperatures over 259 degrees C and low impact and friction sensitivity (IS > 40 J, FS > 360 N). Additionally, the four energetic metal salts exhibited outstanding performance in accelerating the thermal decomposition of AP, the high-temperature peak decreased by 30 to 120 degrees C, and the heat release increased significantly, which was 1.1 to 2.8 times of pure AP. The decomposition activation energy (E-a) of pure AP and AP with 10 wt% compounds 1-4 were calculated using the Kissinger equations, respectively. The AP decomposition activation energy decreased by 9.41 to 18.45 kJmol(-1). These experimental results indicate that the four energetic metal salts are expected to be the alternative additives to accelerate the catalytic decomposition of AP in composite solid propellants.

关键词： Energetic metal salts 3-Cyano-1,5-(5-nitro-1,2,4-triazolyl) formazan Thermal properties Low sensitivity Ammonium perchlorate

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